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Aliases for DNAJB8 Gene

Aliases for DNAJB8 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B8 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 8 2 3
  • DnaJ Homolog Subfamily B Member 8 3
  • Testicular Tissue Protein Li 56 3
  • CT156 3
  • DJ6 3

External Ids for DNAJB8 Gene

Previous GeneCards Identifiers for DNAJB8 Gene

  • GC03M129502
  • GC03M129663
  • GC03M128181
  • GC03M125565

Summaries for DNAJB8 Gene

Entrez Gene Summary for DNAJB8 Gene

  • The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]

GeneCards Summary for DNAJB8 Gene

DNAJB8 (DnaJ Heat Shock Protein Family (Hsp40) Member B8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and protein binding involved in protein folding. An important paralog of this gene is DNAJB6.

UniProtKB/Swiss-Prot for DNAJB8 Gene

  • Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.

Additional gene information for DNAJB8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB8 Gene

Genomics for DNAJB8 Gene

GeneHancer (GH) Regulatory Elements for DNAJB8 Gene

Promoters and enhancers for DNAJB8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J128463 Promoter 0.8 EPDnew 662.8 +3.7 3741 0.1 ZFHX2 CREB1 ATF2 EGR2 DNAJB8 DNAJB8-AS1 GC03P128459
GH03J128407 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.4 +54.1 54121 10.7 HDGF PKNOX1 SMAD1 ARNT POLR2B ZNF766 FOS DEK REST SMARCB1 GATA2 DNAJB8 ENSG00000244932 RPL32P3 H1FX-AS1 TPRA1 DNAJB8-AS1 EFCC1 EEFSEC LINC01565
GH03J128496 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.4 -30.0 -30012 2.2 HDGF SIN3A ZNF48 YY1 TCF12 POLR2B ZNF213 GATA2 ARID2 ZNF143 DNAJB8 GATA2 DNAJB8-AS1 LINC01565 GATA2-AS1 TMED10P2 ABTB1 EEFSEC LOC90246
GH03J128481 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.6 -20.5 -20501 11.8 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 POLR2B ZNF143 FOS GATA2-AS1 GATA2 ISY1 TPRA1 DNAJB8 RPL32P3 DNAJB8-AS1 H1FX ENSG00000244932 TMED10P2
GH03J129309 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 11.5 -846.7 -846652 8.8 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 H1FX-AS1 HMCES ISY1 ENSG00000248659 MARK2P6 MARK3P3 OR7E129P DNAJB8-AS1 OR7E21P MARK2P17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJB8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJB8 gene promoter:
  • p300
  • c-Ets-1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Evi-1
  • POU3F2

Genomic Locations for DNAJB8 Gene

Genomic Locations for DNAJB8 Gene
4,817 bases
Minus strand
4,810 bases
Minus strand

Genomic View for DNAJB8 Gene

Genes around DNAJB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB8 Gene

Proteins for DNAJB8 Gene

  • Protein details for DNAJB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily B member 8
    Protein Accession:
    Secondary Accessions:
    • B3KWV7

    Protein attributes for DNAJB8 Gene

    232 amino acids
    Molecular mass:
    25686 Da
    Quaternary structure:
    • Interacts with histone deacetylases HDAC4, HDAC6, and SIRT2, HDAC activity is required for antiaggregation.

    Three dimensional structures from OCA and Proteopedia for DNAJB8 Gene

neXtProt entry for DNAJB8 Gene

Post-translational modifications for DNAJB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJB8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJB8 Gene

Domains & Families for DNAJB8 Gene

Gene Families for DNAJB8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DNAJB8 Gene

Suggested Antigen Peptide Sequences for DNAJB8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The antiaggregation activity resides in the serine-rich region and the C-terminus.
  • The antiaggregation activity resides in the serine-rich region and the C-terminus.
genes like me logo Genes that share domains with DNAJB8: view

Function for DNAJB8 Gene

Molecular function for DNAJB8 Gene

UniProtKB/Swiss-Prot Function:
Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.

Phenotypes From GWAS Catalog for DNAJB8 Gene

Gene Ontology (GO) - Molecular Function for DNAJB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044183 protein binding involved in protein folding IDA 23612975
GO:0051082 unfolded protein binding IDA 21231916
GO:0051087 chaperone binding IPI 21231916
genes like me logo Genes that share ontologies with DNAJB8: view
genes like me logo Genes that share phenotypes with DNAJB8: view

Animal Model Products

miRNA for DNAJB8 Gene

miRTarBase miRNAs that target DNAJB8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB8 Gene

Localization for DNAJB8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJB8 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DNAJB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21231916
GO:0005829 cytosol IDA 21231916
genes like me logo Genes that share ontologies with DNAJB8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for DNAJB8 Gene

Pathways & Interactions for DNAJB8 Gene

SuperPathways for DNAJB8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061077 chaperone-mediated protein folding IDA 23612975
GO:0090084 negative regulation of inclusion body assembly IDA 21231916
genes like me logo Genes that share ontologies with DNAJB8: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJB8 Gene

Drugs & Compounds for DNAJB8 Gene

No Compound Related Data Available

Transcripts for DNAJB8 Gene

mRNA/cDNA for DNAJB8 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNAJB8 Gene

DnaJ (Hsp40) homolog, subfamily B, member 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB8 Gene

ExUns: 1a · 1b ^ 2 ^ 3

Relevant External Links for DNAJB8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJB8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJB8 Gene

mRNA differential expression in normal tissues according to GTEx for DNAJB8 Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for DNAJB8 Gene

This gene is overexpressed in Ovary (33.4), Brain (16.6), Urine (11.3), and Testis (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DNAJB8 Gene

Protein tissue co-expression partners for DNAJB8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJB8 Gene:


SOURCE GeneReport for Unigene cluster for DNAJB8 Gene:

genes like me logo Genes that share expression patterns with DNAJB8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJB8 Gene

Orthologs for DNAJB8 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJB8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNAJB8 34 33
  • 99.14 (n)
(Canis familiaris)
Mammalia DNAJB8 34 33
  • 86.21 (n)
(Bos Taurus)
Mammalia DNAJB8 34 33
  • 84.99 (n)
(Monodelphis domestica)
Mammalia DNAJB8 34
  • 82 (a)
(Rattus norvegicus)
Mammalia Dnajb8 33
  • 78.55 (n)
(Mus musculus)
Mammalia Dnajb8 16 34 33
  • 75.96 (n)
(Ornithorhynchus anatinus)
Mammalia DNAJB8 34
  • 73 (a)
(Gallus gallus)
Aves DNAJB8 34
  • 50 (a)
(Anolis carolinensis)
Reptilia DNAJB8 34
  • 62 (a)
(Danio rerio)
Actinopterygii zgc:152986 34
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta mrj 34
  • 28 (a)
Species where no ortholog for DNAJB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJB8 Gene

Gene Tree for DNAJB8 (if available)
Gene Tree for DNAJB8 (if available)
Evolutionary constrained regions (ECRs) for DNAJB8: view image

Paralogs for DNAJB8 Gene

Paralogs for DNAJB8 Gene

(10) SIMAP similar genes for DNAJB8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DNAJB8: view

Variants for DNAJB8 Gene

Sequence variations from dbSNP and Humsavar for DNAJB8 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000133636 -- 128,468,796(-) G/T upstream_transcript_variant
rs1000551043 -- 128,462,236(-) T/C downstream_transcript_variant
rs1000555678 -- 128,464,411(-) C/T intron_variant
rs1000588358 -- 128,464,656(-) A/G intron_variant
rs1001288816 -- 128,469,088(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJB8 Gene

Variant ID Type Subtype PubMed ID
dgv8565n54 CNV loss 21841781
esv2759176 CNV loss 17122850
nsv470905 CNV loss 18288195
nsv508240 CNV deletion 20534489
nsv516926 CNV loss 19592680

Variation tolerance for DNAJB8 Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJB8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB8 Gene

Disorders for DNAJB8 Gene

Additional Disease Information for DNAJB8

No disorders were found for DNAJB8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB8 Gene

Publications for DNAJB8 Gene

  1. A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. (PMID: 20159555) Hageman J … Kampinga HH (Molecular cell 2010) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 1. (PMID: 29316077) Kusumoto H … Torigoe T (Cancer science 2018) 3 58
  4. Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes. (PMID: 28504929) Nillegoda NB … Bukau B (eLife 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for DNAJB8 Gene

Sources for DNAJB8 Gene

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