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Aliases for DNAJB5 Gene

Aliases for DNAJB5 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B5 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 5 2 3
  • Heat Shock Protein Cognate 40 3 4
  • Heat Shock Protein Hsp40-2 3 4
  • Heat Shock Protein Hsp40-3 3 4
  • Hsc40 3 4
  • DnaJ Homolog Subfamily B Member 5 3
  • Heat Shock Cognate 40 3

External Ids for DNAJB5 Gene

Previous GeneCards Identifiers for DNAJB5 Gene

  • GC09P035301
  • GC09P035159
  • GC09P034979
  • GC09P034990
  • GC09P034944

Summaries for DNAJB5 Gene

Entrez Gene Summary for DNAJB5 Gene

  • This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins. The encoded protein contains an N-terminal DNAJ domain and a C-terminal substrate binding domain but lacks the cysteine-rich domain found in other DNAJ family members. In mice, a multi-protein complex containing this protein, thioredoxin 1, and histone deacetylase 4, serves as a master negative regulator of cardiac hypertrophy. [provided by RefSeq, Mar 2017]

GeneCards Summary for DNAJB5 Gene

DNAJB5 (DnaJ Heat Shock Protein Family (Hsp40) Member B5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and chaperone binding. An important paralog of this gene is DNAJB4.

Additional gene information for DNAJB5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB5 Gene

Genomics for DNAJB5 Gene

GeneHancer (GH) Regulatory Elements for DNAJB5 Gene

Promoters and enhancers for DNAJB5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I034987 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.1 +3.9 3911 10.6 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A YY1 ZNF207 ZNF143 FOS DNAJB5 UBAP2 VCP FANCG PIGO FAM205A C9orf131 ATP8B5P RPP25L FAM205C
GH09I035025 Enhancer 1 Ensembl ENCODE 11.7 +37.9 37903 4.1 PKNOX1 ATF1 TCF12 ZNF766 CREM CAVIN1 REST ZEB2 HDAC8 ZNF592 PIGO FANCG TMEM8B DNAJB5 ENSG00000230074 SPAG8 PHF24 STOML2 ENSG00000234181 CREB3
GH09I035904 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.6 +918.8 918798 7.4 FOXA2 ZNF48 YY1 ZNF121 FOS DEK SP3 RXRA REST PPARG HRCT1 SPAAR TMEM8B PIGO OR13J1 FAM221B NDUFA5P4 ENSG00000227388 NPR2 FANCG
GH09I034700 Enhancer 1.1 Ensembl ENCODE 4.4 -287.4 -287449 1.9 ARID4B KLF17 ZNF76 ZNF2 ZBTB7B RAD21 YY1 ZNF335 ELK1 EGR1 RPP25L DNAJB5 CCL21 CCL19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DNAJB5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJB5 gene promoter:

Genomic Locations for DNAJB5 Gene

Genomic Locations for DNAJB5 Gene
9,532 bases
Plus strand

Genomic View for DNAJB5 Gene

Genes around DNAJB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB5 Gene

Proteins for DNAJB5 Gene

  • Protein details for DNAJB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily B member 5
    Protein Accession:
    Secondary Accessions:
    • B3KN14
    • B4DSA6
    • J3KQM9
    • J3KR08
    • Q5T656
    • Q8TDR7
    • Q96EM4

    Protein attributes for DNAJB5 Gene

    348 amino acids
    Molecular mass:
    39133 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH12115.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJB5 Gene


neXtProt entry for DNAJB5 Gene

Post-translational modifications for DNAJB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DNAJB5 Gene

Domains & Families for DNAJB5 Gene

Gene Families for DNAJB5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DNAJB5 Gene

Suggested Antigen Peptide Sequences for DNAJB5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJB5: view

No data available for UniProtKB/Swiss-Prot for DNAJB5 Gene

Function for DNAJB5 Gene

Molecular function for DNAJB5 Gene

UniProtKB/Swiss-Prot Induction:
Expressed under normal conditions, its expression can further be increased after various stress treatments.

Phenotypes From GWAS Catalog for DNAJB5 Gene

Gene Ontology (GO) - Molecular Function for DNAJB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18457437
GO:0051082 unfolded protein binding IEA --
GO:0051087 chaperone binding IPI 21231916
genes like me logo Genes that share ontologies with DNAJB5: view
genes like me logo Genes that share phenotypes with DNAJB5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB5 Gene

Localization for DNAJB5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJB5 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNAJB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IDA 21231916
genes like me logo Genes that share ontologies with DNAJB5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DNAJB5 Gene

Pathways & Interactions for DNAJB5 Gene

SuperPathways for DNAJB5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006457 protein folding IEA --
GO:0006986 response to unfolded protein IEP 10570961
genes like me logo Genes that share ontologies with DNAJB5: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJB5 Gene

Drugs & Compounds for DNAJB5 Gene

No Compound Related Data Available

Transcripts for DNAJB5 Gene

Unigene Clusters for DNAJB5 Gene

DnaJ (Hsp40) homolog, subfamily B, member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - -
SP8: -

Relevant External Links for DNAJB5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJB5 Gene

This gene is overexpressed in Muscle - Skeletal (x6.3).

Protein differential expression in normal tissues from HIPED for DNAJB5 Gene

This gene is overexpressed in Colon (13.7), Urinary Bladder (11.8), Breast (10.2), Cardia (7.5), Prostate (7.5), and Fetal Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNAJB5 Gene

NURSA nuclear receptor signaling pathways regulating expression of DNAJB5 Gene:


SOURCE GeneReport for Unigene cluster for DNAJB5 Gene:


Evidence on tissue expression from TISSUES for DNAJB5 Gene

  • Nervous system(4.7)
  • Intestine(4.2)
  • Skin(4.1)
  • Muscle(2.8)
genes like me logo Genes that share expression patterns with DNAJB5: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJB5 Gene

Orthologs for DNAJB5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNAJB5 33 34
  • 99.57 (n)
(Monodelphis domestica)
Mammalia DNAJB5 34
  • 95 (a)
(Canis familiaris)
Mammalia DNAJB5 33 34
  • 94.73 (n)
(Bos Taurus)
Mammalia DNAJB5 33 34
  • 93.77 (n)
(Rattus norvegicus)
Mammalia Dnajb5 33
  • 93.63 (n)
(Mus musculus)
Mammalia Dnajb5 33 16 34
  • 93.49 (n)
(Ornithorhynchus anatinus)
Mammalia DNAJB5 34
  • 76 (a)
(Gallus gallus)
Aves DNAJB5 33 34
  • 78.3 (n)
(Anolis carolinensis)
Reptilia DNAJB5 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb5 33
  • 77.81 (n)
Str.18193 33
(Danio rerio)
Actinopterygii dnajb5 33 34
  • 71.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5001 35 33 34
  • 57.07 (n)
DnaJ-1 35 34
  • 50 (a)
CG2887 35 34
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010239 33
  • 54.91 (n)
(Caenorhabditis elegans)
Secernentea dnj-13 34
  • 56 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20560 33
  • 53.17 (n)
(Glycine max)
eudicotyledons Gma.1940 33
(Oryza sativa)
Liliopsida Os05g0562300 33
  • 57.14 (n)
Os.35463 33
(Hordeum vulgare)
Liliopsida Hv.3521 33
(Triticum aestivum)
Liliopsida Ta.9254 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
Species where no ortholog for DNAJB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNAJB5 Gene

Gene Tree for DNAJB5 (if available)
Gene Tree for DNAJB5 (if available)

Paralogs for DNAJB5 Gene

Variants for DNAJB5 Gene

Sequence variations from dbSNP and Humsavar for DNAJB5 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs774909609 likely-pathogenic, Peripheral neuropathy, Skeletal myopathy 34,990,673(+) C/T coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant
rs1000233810 -- 34,987,806(+) CTCCTCCTC/CTCCTC upstream_transcript_variant
rs1000289376 -- 34,997,714(+) A/G 3_prime_UTR_variant
rs1000403034 -- 34,992,708(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000835903 -- 34,989,195(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJB5 Gene

Variant ID Type Subtype PubMed ID
esv999515 CNV loss 20482838
nsv1077101 CNV deletion 25765185
nsv1125318 OTHER inversion 24896259
nsv6527 CNV insertion 18451855
nsv972665 CNV duplication 23825009

Variation tolerance for DNAJB5 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJB5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB5 Gene

Disorders for DNAJB5 Gene

Additional Disease Information for DNAJB5

No disorders were found for DNAJB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB5 Gene

Publications for DNAJB5 Gene

  1. Hsc40, a new member of the hsp40 family, exhibits similar expression profile to that of hsc70 in mammalian cells. (PMID: 10570961) Chen MS … Laszlo A (Gene 1999) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K … Hata M (Cell stress & chaperones 2000) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for DNAJB5 Gene

Sources for DNAJB5 Gene

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