Aliases for DNAJB4 Gene
External Ids for DNAJB4 Gene
Previous GeneCards Identifiers for DNAJB4 Gene
The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for DNAJB4 Gene
DNAJB4 (DnaJ Heat Shock Protein Family (Hsp40) Member B4) is a Protein Coding gene. Diseases associated with DNAJB4 include Oculopharyngeal Muscular Dystrophy and Gastric Cancer, Hereditary Diffuse. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and chaperone binding. An important paralog of this gene is DNAJB1.
UniProtKB/Swiss-Prot Summary for DNAJB4 Gene
Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).