The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppre... See more...

Aliases for DNAJB4 Gene

Aliases for DNAJB4 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B4 2 3 5
  • HLJ1 2 3 4
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 4 2 3
  • Heat Shock 40 KDa Protein 1 Homolog 3 4
  • DnaJ Homolog Subfamily B Member 4 3 4
  • Heat Shock Protein 40 Homolog 3 4
  • Human Liver DnaJ-Like Protein 3 4
  • HSP40 Homolog 3 4
  • DNAJW 3 4
  • DnaJ-Like Heat Shock Protein 40 3
  • DNAJB4 5
  • DjB4 3

External Ids for DNAJB4 Gene

Previous GeneCards Identifiers for DNAJB4 Gene

  • GC01P078623
  • GC01P077417
  • GC01P077835
  • GC01P077893
  • GC01P078182
  • GC01P078444
  • GC01P076602

Summaries for DNAJB4 Gene

Entrez Gene Summary for DNAJB4 Gene

  • The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for DNAJB4 Gene

DNAJB4 (DnaJ Heat Shock Protein Family (Hsp40) Member B4) is a Protein Coding gene. Diseases associated with DNAJB4 include Oculopharyngeal Muscular Dystrophy and Gastric Cancer, Hereditary Diffuse. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and chaperone binding. An important paralog of this gene is DNAJB1.

UniProtKB/Swiss-Prot Summary for DNAJB4 Gene

  • Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).

Gene Wiki entry for DNAJB4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DNAJB4 Gene

Genomics for DNAJB4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DNAJB4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJB4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DNAJB4

Top Transcription factor binding sites by QIAGEN in the DNAJB4 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun
  • FOXJ2
  • Sox5
  • STAT3

Genomic Locations for DNAJB4 Gene

Latest Assembly
chr1:77,979,175-78,017,964
(GRCh38/hg38)
Size:
38,790 bases
Orientation:
Plus strand

Previous Assembly
chr1:78,444,859-78,483,648
(GRCh37/hg19 by Entrez Gene)
Size:
38,790 bases
Orientation:
Plus strand

chr1:78,444,859-78,483,648
(GRCh37/hg19 by Ensembl)
Size:
38,790 bases
Orientation:
Plus strand

Genomic View for DNAJB4 Gene

Genes around DNAJB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB4 Gene

Proteins for DNAJB4 Gene

  • Protein details for DNAJB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDY4-DNJB4_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 4
    Protein Accession:
    Q9UDY4
    Secondary Accessions:
    • B2R824
    • Q13431

    Protein attributes for DNAJB4 Gene

    Size:
    337 amino acids
    Molecular mass:
    37807 Da
    Quaternary structure:
    • Homodimer. The C-terminal section interacts with the C-terminal tail of OPRM1. Interacts also with SDIM1.

neXtProt entry for DNAJB4 Gene

Post-translational modifications for DNAJB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJB4 Gene

Antibodies for research

  • Santa Cruz Biotechnology (SCBT) Antibodies for DNAJB4

No data available for DME Specific Peptides for DNAJB4 Gene

Domains & Families for DNAJB4 Gene

Gene Families for DNAJB4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DNAJB4 Gene

Suggested Antigen Peptide Sequences for DNAJB4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50816, highly similar to DnaJ homolog subfamily B member 4 (B4DNN2_HUMAN)
  • Human liver DnaJ-like protein (DNJB4_HUMAN)
  • DnaJ-like heat shock protein (Q6DKZ0_HUMAN)
genes like me logo Genes that share domains with DNAJB4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DNAJB4 Gene

Function for DNAJB4 Gene

Molecular function for DNAJB4 Gene

UniProtKB/Swiss-Prot Function:
Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).
UniProtKB/Swiss-Prot Induction:
By heat shock.

Phenotypes From GWAS Catalog for DNAJB4 Gene

Gene Ontology (GO) - Molecular Function for DNAJB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 24318877
GO:0005515 protein binding IPI 21255413
GO:0051082 unfolded protein binding TAS,IBA 21873635
GO:0051087 chaperone binding IBA,IPI 21231916
genes like me logo Genes that share ontologies with DNAJB4: view
genes like me logo Genes that share phenotypes with DNAJB4: view

miRNA for DNAJB4 Gene

miRTarBase miRNAs that target DNAJB4

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJB4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB4 Gene

Localization for DNAJB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB4 Gene

Cytoplasm. Cell membrane. Note=Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJB4 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
endoplasmic reticulum 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNAJB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA,IDA 21231916
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DNAJB4: view

Pathways & Interactions for DNAJB4 Gene

PathCards logo

SuperPathways for DNAJB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0006986 response to unfolded protein TAS 9546042
GO:0009408 response to heat TAS 9546042
GO:0032781 positive regulation of ATPase activity IEA --
GO:0051085 chaperone cofactor-dependent protein refolding IBA 21873635
genes like me logo Genes that share ontologies with DNAJB4: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJB4 Gene

Drugs & Compounds for DNAJB4 Gene

No Compound Related Data Available

Transcripts for DNAJB4 Gene

mRNA/cDNA for DNAJB4 Gene

6 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJB4

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for DNAJB4 Gene

GeneLoc Exon Structure for
DNAJB4

Expression for DNAJB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJB4 Gene

This gene is overexpressed in Rectum (7.3), Urinary Bladder (6.7), and Prostate (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DNAJB4 Gene



Protein tissue co-expression partners for DNAJB4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DNAJB4

SOURCE GeneReport for Unigene cluster for DNAJB4 Gene:

Hs.13852

mRNA Expression by UniProt/SwissProt for DNAJB4 Gene:

Q9UDY4-DNJB4_HUMAN
Tissue specificity: Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.

Evidence on tissue expression from TISSUES for DNAJB4 Gene

  • Liver(4.5)
  • Nervous system(4.1)
  • Heart(2.8)
  • Muscle(2.6)
  • Spleen(2.4)
  • Kidney(2.3)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with DNAJB4: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJB4 Gene

Orthologs for DNAJB4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DNAJB4 29 30
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DNAJB4 29 30
  • 95.65 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DNAJB4 29 30
  • 94.56 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dnajb4 29 16 30
  • 90.5 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dnajb4 29
  • 88.53 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB4 30
  • 86 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DNAJB4 30
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DNAJB4 29 30
  • 79.72 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DNAJB4 30
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dnajb4 29
  • 75.66 (n)
Zebrafish
(Danio rerio)
Actinopterygii dnajb4 29 30
  • 67.26 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta DnaJ-1 29 30 31
  • 55.9 (n)
ManyToMany
CG5001 30 31
  • 52 (a)
ManyToMany
CG2887 30 31
  • 45 (a)
ManyToMany
CG12020 31
  • 28 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007107 29
  • 54.82 (n)
Worm
(Caenorhabditis elegans)
Secernentea dnj-13 29 30
  • 55.38 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIS1 32
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G25530 29
  • 50.61 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7032 29
Rice
(Oryza sativa)
Liliopsida Os02g0128400 29
  • 47.41 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 57 (a)
OneToMany
Species where no ortholog for DNAJB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DNAJB4 Gene

ENSEMBL:
Gene Tree for DNAJB4 (if available)
TreeFam:
Gene Tree for DNAJB4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DNAJB4: view image
Alliance of Genome Resources:
Additional Orthologs for DNAJB4

Paralogs for DNAJB4 Gene

(23) SIMAP similar genes for DNAJB4 Gene using alignment to 4 proteins:

  • DNJB4_HUMAN
  • B4DNN2_HUMAN
  • C9JUL4_HUMAN
  • Q6DKZ0_HUMAN
genes like me logo Genes that share paralogs with DNAJB4: view

Variants for DNAJB4 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DNAJB4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DNAJB4 Gene

Variant ID Type Subtype PubMed ID
esv3586533 CNV loss 21293372

Variation tolerance for DNAJB4 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJB4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJB4
Leiden Open Variation Database (LOVD)
DNAJB4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DNAJB4 Gene

Disorders for DNAJB4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DNAJB4 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DNAJB4

genes like me logo Genes that share disorders with DNAJB4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJB4 Gene

Publications for DNAJB4 Gene

  1. Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver. (PMID: 9546042) Hoe KL … Yoo HS (Biochimica et biophysica acta 1998) 2 3 4 22
  2. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. (PMID: 24318877) Rauch JN … Gestwicki JE (The Journal of biological chemistry 2014) 3 4
  3. A novel neuron-enriched protein SDIM1 is down regulated in Alzheimer's brains and attenuates cell death induced by DNAJB4 over-expression in neuro-progenitor cells. (PMID: 21255413) Lei JX … Liu QY (Molecular neurodegeneration 2011) 3 4
  4. [Preparation of the anti-HLJ1 monoclonal antibodies and establishment of method for detection of the antigen]. (PMID: 18837411) Lin X … Wang X (Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2008) 4 22
  5. A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor. (PMID: 16542645) Ancevska-Taneva N … Simon EJ (Brain research 2006) 3 4

Products for DNAJB4 Gene

Sources for DNAJB4 Gene