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Aliases for DNAJB1 Gene

Aliases for DNAJB1 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B1 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 1 2 3
  • Heat Shock 40 KDa Protein 1 3 4
  • DnaJ Protein Homolog 1 3 4
  • Human DnaJ Protein 1 3 4
  • Hsp40 3 4
  • HSPF1 3 4
  • Hdj1 3 4
  • Radial Spoke 16 Homolog B (Chlamydomonas) 2
  • DnaJ Homolog Subfamily B Member 1 3
  • Radial Spoke 16 Homolog B 3
  • Heat Shock Protein 40 4
  • RSPH16B 3
  • DNAJ1 4
  • HDj-1 4
  • Sis1 3

External Ids for DNAJB1 Gene

Previous HGNC Symbols for DNAJB1 Gene

  • HSPF1

Previous GeneCards Identifiers for DNAJB1 Gene

  • GC19M014980
  • GC19M014470
  • GC19M014625
  • GC19M014195

Summaries for DNAJB1 Gene

Entrez Gene Summary for DNAJB1 Gene

  • This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for DNAJB1 Gene

DNAJB1 (DnaJ Heat Shock Protein Family (Hsp40) Member B1) is a Protein Coding gene. Diseases associated with DNAJB1 include Fibrolamellar Carcinoma and Mixed Fibrolamellar Hepatocellular Carcinoma. Among its related pathways are CCR5 Pathway in Macrophages and Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and ATPase binding. An important paralog of this gene is DNAJB4.

UniProtKB/Swiss-Prot for DNAJB1 Gene

  • Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).

Gene Wiki entry for DNAJB1 Gene

Additional gene information for DNAJB1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB1 Gene

Genomics for DNAJB1 Gene

GeneHancer (GH) Regulatory Elements for DNAJB1 Gene

Promoters and enhancers for DNAJB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I014525 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 561.5 +1.6 1579 5.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B DNAJB1 TECR GC19P014530 GC19P014531 PIR54842 MIR639 CCDC130 AKAP8 MRI1 BRD4
GH19I014512 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 562.9 +11.2 11240 12 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC TECR DNAJB1 NOTCH3 SYDE1 AKAP8 SNRPGP15 BRD4 ENSG00000273218 GIPC1 IL27RA
GH19I014415 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.2 +111.8 111848 5.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 POLR2B DDX39A AKAP8 BRD4 DCAF15 RFX1 CCDC130 GIPC1 ADGRE2 ZNF333 DNAJB1
GH19I014502 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +24.2 24239 6.8 PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B ZNF143 FOS DNAJB1 ENSG00000268189 GIPC1 PKN1 ADGRE5 TECR SNRPGP15 IL27RA DDX39A GC19P014515
GH19I014111 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.9 +413.6 413636 9.3 HDGF PKNOX1 ARNT ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B YY1 ZNF766 PRKACA DDX39A DCAF15 LOC284454 RFX1 CCDC130 ADGRE5 PALM3 DNAJB1 PKN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DNAJB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJB1 gene promoter:

Genomic Locations for DNAJB1 Gene

Genomic Locations for DNAJB1 Gene
chr19:14,514,764-14,529,770
(GRCh38/hg38)
Size:
15,007 bases
Orientation:
Minus strand
chr19:14,625,582-14,640,582
(GRCh37/hg19)

Genomic View for DNAJB1 Gene

Genes around DNAJB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB1 Gene

Proteins for DNAJB1 Gene

  • Protein details for DNAJB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25685-DNJB1_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 1
    Protein Accession:
    P25685
    Secondary Accessions:
    • B4DX52

    Protein attributes for DNAJB1 Gene

    Size:
    340 amino acids
    Molecular mass:
    38044 Da
    Quaternary structure:
    • Interacts with DNAJC3 (PubMed:9920933). Interacts with HSF1 (via transactivation domain); this interaction results in the inhibition of heat shock- and HSF1-induced transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401).
    SequenceCaution:
    • Sequence=CAA44287.1; Type=Frameshift; Positions=11, 28, 81, 136; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNAJB1 Gene

    Alternative splice isoforms for DNAJB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJB1 Gene

Post-translational modifications for DNAJB1 Gene

  • Ubiquitination at Lys3 and posLast=286286

Antibody Products

  • R&D Systems Antibodies for DNAJB1 (HSP40/DNAJB1)
  • Cell Signaling Technology (CST) Antibodies for DNAJB1 (HSP40)
  • Abcam antibodies for DNAJB1

No data available for DME Specific Peptides for DNAJB1 Gene

Domains & Families for DNAJB1 Gene

Gene Families for DNAJB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for DNAJB1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJB1: view

No data available for UniProtKB/Swiss-Prot for DNAJB1 Gene

Function for DNAJB1 Gene

Molecular function for DNAJB1 Gene

UniProtKB/Swiss-Prot Function:
Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).
UniProtKB/Swiss-Prot Induction:
By heat shock.

Phenotypes From GWAS Catalog for DNAJB1 Gene

Gene Ontology (GO) - Molecular Function for DNAJB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IDA 9499401
GO:0001671 ATPase activator activity TAS --
GO:0005515 protein binding IPI 9499401
GO:0030544 Hsp70 protein binding IPI 23921388
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with DNAJB1: view
genes like me logo Genes that share phenotypes with DNAJB1: view

Animal Models for DNAJB1 Gene

MGI Knock Outs for DNAJB1:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJB1 Gene

Localization for DNAJB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJB1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 2
endoplasmic reticulum 2
plasma membrane 1
cytoskeleton 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNAJB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA,IEA 25468996
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DNAJB1: view

Pathways & Interactions for DNAJB1 Gene

genes like me logo Genes that share pathways with DNAJB1: view

Pathways by source for DNAJB1 Gene

1 GeneGo (Thomson Reuters) pathway for DNAJB1 Gene
1 Qiagen pathway for DNAJB1 Gene

SIGNOR curated interactions for DNAJB1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DNAJB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0006986 response to unfolded protein TAS 8975727
GO:0032781 positive regulation of ATPase activity IDA 23921388
GO:0051085 chaperone cofactor-dependent protein refolding IEA,IDA 18620420
GO:0090084 negative regulation of inclusion body assembly IDA 21231916
genes like me logo Genes that share ontologies with DNAJB1: view

Drugs & Compounds for DNAJB1 Gene

(2) Drugs for DNAJB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DNAJB1: view

Transcripts for DNAJB1 Gene

Unigene Clusters for DNAJB1 Gene

DnaJ (Hsp40) homolog, subfamily B, member 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB1 Gene

No ASD Table

Relevant External Links for DNAJB1 Gene

GeneLoc Exon Structure for
DNAJB1
ECgene alternative splicing isoforms for
DNAJB1

Expression for DNAJB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJB1 Gene

This gene is overexpressed in Whole Blood (x5.3), Brain - Cerebellum (x4.6), and Brain - Cerebellar Hemisphere (x4.4).

Protein differential expression in normal tissues from HIPED for DNAJB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJB1 Gene



Protein tissue co-expression partners for DNAJB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DNAJB1 Gene:

DNAJB1

SOURCE GeneReport for Unigene cluster for DNAJB1 Gene:

Hs.515210

Evidence on tissue expression from TISSUES for DNAJB1 Gene

  • Nervous system(5)
  • Lung(4.8)
  • Liver(4.6)
  • Intestine(3.5)
  • Kidney(3.2)
  • Skin(3.1)
  • Pancreas(2.9)
  • Eye(2.8)
  • Muscle(2.5)
  • Heart(2.3)
  • Spleen(2.2)
  • Adrenal gland(2.1)
  • Gall bladder(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with DNAJB1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJB1 Gene

Orthologs for DNAJB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJB1 33 34
  • 98.92 (n)
dog
(Canis familiaris)
Mammalia DNAJB1 33 34
  • 93.92 (n)
cow
(Bos Taurus)
Mammalia DNAJB1 33 34
  • 93.53 (n)
-- 34
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dnajb1 33
  • 92.06 (n)
mouse
(Mus musculus)
Mammalia Dnajb1 33 16 34
  • 90.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB1 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858808 33
  • 71.08 (n)
lizard
(Anolis carolinensis)
Reptilia DNAJB1 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb1 33
  • 67.26 (n)
zebrafish
(Danio rerio)
Actinopterygii dnajb1b 34
  • 66 (a)
OneToMany
dnajb1a 33 34
  • 65.46 (n)
wufd19c10 33
fruit fly
(Drosophila melanogaster)
Insecta DnaJ-1 35 34
  • 52 (a)
CG5001 35 34
  • 48 (a)
CG2887 35 34
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea dnj-13 34
  • 54 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL008W 33
  • 48.89 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04818g 33
  • 47.44 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIS1 33
  • 46.31 (n)
rice
(Oryza sativa)
Liliopsida Os01g0239100 33
  • 54.43 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.9199 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes psi1 33
  • 51.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU03732 33
  • 49.39 (n)
Species where no ortholog for DNAJB1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNAJB1 Gene

ENSEMBL:
Gene Tree for DNAJB1 (if available)
TreeFam:
Gene Tree for DNAJB1 (if available)

Paralogs for DNAJB1 Gene

Paralogs for DNAJB1 Gene

Pseudogenes.org Pseudogenes for DNAJB1 Gene

genes like me logo Genes that share paralogs with DNAJB1: view

Variants for DNAJB1 Gene

Sequence variations from dbSNP and Humsavar for DNAJB1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs776469956 uncertain-significance, not specified 14,529,721(-) G/A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000239745 -- 14,523,143(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000277920 -- 14,525,491(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000700558 -- 14,529,351(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000881421 -- 14,526,977(-) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJB1 Gene

Variant ID Type Subtype PubMed ID
nsv961185 CNV duplication 23825009

Variation tolerance for DNAJB1 Gene

Residual Variation Intolerance Score: 8.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB1 Gene

Disorders for DNAJB1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DNAJB1 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
fibrolamellar carcinoma
  • fibrolamellar hepatocellular carcinoma
mixed fibrolamellar hepatocellular carcinoma
antenatal bartter syndrome
  • bartter syndrome, furosemide type
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DNAJB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DNAJB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJB1 Gene

Publications for DNAJB1 Gene

  1. Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2. (PMID: 8975727) Hata M … Ohtsuka K (Genomics 1996) 2 3 4 22 58
  2. The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. (PMID: 9920933) Melville MW … Katze MG (The Journal of biological chemistry 1999) 3 4 22 58
  3. Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ. (PMID: 8250930) Ohtsuka K (Biochemical and biophysical research communications 1993) 2 3 4 58
  4. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. (PMID: 24318877) Rauch JN … Gestwicki JE (The Journal of biological chemistry 2014) 3 4 58
  5. Gentamicin inhibits HSP70-assisted protein folding by interfering with substrate recognition. (PMID: 20026329) Yamamoto S … Itoh H (FEBS letters 2010) 3 22 58

Products for DNAJB1 Gene

Sources for DNAJB1 Gene

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