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Aliases for DNAJA4 Gene

Aliases for DNAJA4 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member A4 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily A, Member 4 2 3
  • DnaJ Homolog Subfamily A Member 4 3
  • MSTP104 3
  • PRO1472 3
  • MST104 3

External Ids for DNAJA4 Gene

Previous GeneCards Identifiers for DNAJA4 Gene

  • GC15P074635
  • GC15P071646
  • GC15P076132
  • GC15P076272
  • GC15P076343
  • GC15P078556
  • GC15P055314

Summaries for DNAJA4 Gene

GeneCards Summary for DNAJA4 Gene

DNAJA4 (DnaJ Heat Shock Protein Family (Hsp40) Member A4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is DNAJA1.

Additional gene information for DNAJA4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJA4 Gene

Genomics for DNAJA4 Gene

GeneHancer (GH) Regulatory Elements for DNAJA4 Gene

Promoters and enhancers for DNAJA4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J078263 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 660 +1.6 1639 4.1 CTCF SREBF2 MAX SIN3A ZNF335 TCF12 E2F1 ZNF121 ELK1 POLR2A DNAJA4 LOC105370911 CRABP1 ADAMTS7P3 IREB2 ENSG00000259562 LOC645752 LOC105370910 GC15M078021
GH15J078298 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 6.2 +35.4 35402 2.5 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 ENSG00000277482 WDR61 ENSG00000259562 ENSG00000259322 IREB2 LOC645752 DNAJA4 GC15M078021
GH15J078373 Enhancer 1.1 Ensembl ENCODE 8.4 +110.5 110467 3.1 PKNOX1 ATF1 FOXA2 SIN3A DMAP1 YY1 GLIS2 ZNF207 FOS ATF7 LOC105370912 DNAJA4 LOC645752 CSPG4P13 GC15P078347 GC15M078021
GH15J078315 Enhancer 0.9 Ensembl ENCODE 8.9 +52.4 52399 2.2 BCOR CTCF RB1 NFRKB MAX ZNF140 TSC22D4 ZMYM3 ZIC2 BRCA1 IREB2 ENSG00000259562 WDR61 ENSG00000260988 CRABP1 ACSBG1 ENSG00000259322 HYKK CHRNA5 DNAJA4
GH15J078305 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 4.7 +42.4 42378 2.1 HDGF SMAD1 ARNT E2F8 ZFP91 ATF7 NCOA1 ZNF592 GMEB1 SMARCA4 WDR61 CRABP1 IREB2 HYKK DNAJA4 GC15P078331 GC15M078021
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJA4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJA4 gene promoter:
  • LyF-1
  • POU6F1 (c2)
  • Pax-5
  • c-Myb

Genomic Locations for DNAJA4 Gene

Genomic Locations for DNAJA4 Gene
chr15:78,264,086-78,282,196
(GRCh38/hg38)
Size:
18,111 bases
Orientation:
Plus strand
chr15:78,556,428-78,574,538
(GRCh37/hg19)
Size:
18,111 bases
Orientation:
Plus strand

Genomic View for DNAJA4 Gene

Genes around DNAJA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJA4 Gene

Proteins for DNAJA4 Gene

  • Protein details for DNAJA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW22-DNJA4_HUMAN
    Recommended name:
    DnaJ homolog subfamily A member 4
    Protein Accession:
    Q8WW22
    Secondary Accessions:
    • E9PDM9
    • Q6AW87
    • Q8N5Z4
    • Q8N7P2

    Protein attributes for DNAJA4 Gene

    Size:
    397 amino acids
    Molecular mass:
    44798 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH21720.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH31044.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJA4 Gene

Post-translational modifications for DNAJA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for DNAJA4
  • Boster Bio Antibodies for DNAJA4
  • Santa Cruz Biotechnology (SCBT) Antibodies for DNAJA4

No data available for DME Specific Peptides for DNAJA4 Gene

Domains & Families for DNAJA4 Gene

Gene Families for DNAJA4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DNAJA4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJA4: view

No data available for UniProtKB/Swiss-Prot for DNAJA4 Gene

Function for DNAJA4 Gene

Phenotypes From GWAS Catalog for DNAJA4 Gene

Gene Ontology (GO) - Molecular Function for DNAJA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25036637
GO:0005524 ATP binding IEA --
GO:0031072 heat shock protein binding IEA --
GO:0046872 metal ion binding IEA --
GO:0051082 unfolded protein binding IDA 21231916
genes like me logo Genes that share ontologies with DNAJA4: view
genes like me logo Genes that share phenotypes with DNAJA4: view

Animal Models for DNAJA4 Gene

MGI Knock Outs for DNAJA4:
  • Dnaja4 Dnaja4<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJA4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJA4 Gene

Localization for DNAJA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJA4 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJA4 gene
Compartment Confidence
cytosol 5
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNAJA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA,IEA 21231916
genes like me logo Genes that share ontologies with DNAJA4: view

Pathways & Interactions for DNAJA4 Gene

SuperPathways for DNAJA4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0009408 response to heat IEA --
GO:0042026 protein refolding IDA 21231916
GO:0090084 negative regulation of inclusion body assembly IDA 21231916
genes like me logo Genes that share ontologies with DNAJA4: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJA4 Gene

Drugs & Compounds for DNAJA4 Gene

No Compound Related Data Available

Transcripts for DNAJA4 Gene

Unigene Clusters for DNAJA4 Gene

DnaJ (Hsp40) homolog, subfamily A, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJA4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJA4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6:
SP7:

Relevant External Links for DNAJA4 Gene

GeneLoc Exon Structure for
DNAJA4
ECgene alternative splicing isoforms for
DNAJA4

Expression for DNAJA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJA4 Gene

This gene is overexpressed in Testis (15.9) and Bone marrow mesenchymal stem cell (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DNAJA4 Gene



Protein tissue co-expression partners for DNAJA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJA4 Gene:

DNAJA4

SOURCE GeneReport for Unigene cluster for DNAJA4 Gene:

Hs.513053

Evidence on tissue expression from TISSUES for DNAJA4 Gene

  • Nervous system(4.7)
  • Heart(2.6)
genes like me logo Genes that share expression patterns with DNAJA4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJA4 Gene

Orthologs for DNAJA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJA4 34 33
  • 99.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJA4 34 33
  • 92.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJA4 34 33
  • 91.18 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dnaja4 16 34 33
  • 90.09 (n)
rat
(Rattus norvegicus)
Mammalia Dnaja4 33
  • 90.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJA4 34
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJA4 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJA4 34 33
  • 76.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJA4 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnaja4.1 33
  • 70.37 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC64353 33
zebrafish
(Danio rerio)
Actinopterygii dnaja 33
  • 67.34 (n)
DNAJA4 34
  • 62 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10348 33
fruit fly
(Drosophila melanogaster)
Insecta Droj2 34 33
  • 62.84 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005981 33
  • 60.25 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-12 34 33
  • 56.57 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YDJ1 34
  • 47 (a)
OneToMany
CAJ1 36
rice
(Oryza sativa)
Liliopsida Os02g0656500 33
  • 54.91 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.2672 33
corn
(Zea mays)
Liliopsida Zm.14501 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10384 34
  • 60 (a)
OneToMany
Species where no ortholog for DNAJA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJA4 Gene

ENSEMBL:
Gene Tree for DNAJA4 (if available)
TreeFam:
Gene Tree for DNAJA4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DNAJA4: view image

Paralogs for DNAJA4 Gene

Paralogs for DNAJA4 Gene

(24) SIMAP similar genes for DNAJA4 Gene using alignment to 7 proteins:

  • DNJA4_HUMAN
  • C9JDE6_HUMAN
  • F5GWV1_HUMAN
  • F5H170_HUMAN
  • F5H300_HUMAN
  • F8WF76_HUMAN
  • Q9P1H1_HUMAN
genes like me logo Genes that share paralogs with DNAJA4: view

Variants for DNAJA4 Gene

Sequence variations from dbSNP and Humsavar for DNAJA4 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs142025971 likely-benign, not specified 78,266,243(+) AT/ frameshift, initiator_codon_variant, intron_variant
rs1000192761 -- 78,267,104(+) G/C intron_variant
rs1000267205 -- 78,277,312(+) C/T intron_variant
rs1000306479 -- 78,263,291(+) A/T upstream_transcript_variant
rs1000394290 -- 78,277,843(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJA4 Gene

Variant ID Type Subtype PubMed ID
nsv1116464 OTHER inversion 24896259
nsv570200 CNV loss 21841781

Variation tolerance for DNAJA4 Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJA4 Gene

Disorders for DNAJA4 Gene

Additional Disease Information for DNAJA4

No disorders were found for DNAJA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJA4 Gene

Publications for DNAJA4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K … Hata M (Cell stress & chaperones 2000) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly. (PMID: 26831064) Ertych N … Bastians H (Proceedings of the National Academy of Sciences of the United States of America 2016) 3 58

Products for DNAJA4 Gene

Sources for DNAJA4 Gene

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