Aliases for DNAJA2 Gene
External Ids for DNAJA2 Gene
Previous GeneCards Identifiers for DNAJA2 Gene
The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. [provided by RefSeq, Jul 2008]
GeneCards Summary for DNAJA2 Gene
DNAJA2 (DnaJ Heat Shock Protein Family (Hsp40) Member A2) is a Protein Coding gene. Diseases associated with DNAJA2 include Subacute Bacterial Endocarditis. Among its related pathways are Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is DNAJA1.
UniProtKB/Swiss-Prot for DNAJA2 Gene
Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).