DNAI4 Gene (Protein Coding)

Dynein Axonemal Intermediate Chain 4

GC01M066813
GIFtS:
24
See more...

Aliases for DNAI4 Gene

Aliases for DNAI4 Gene

  • Dynein Axonemal Intermediate Chain 4 2 3
  • WD Repeat Domain 78 2 3 5
  • WD Repeat-Containing Protein 78 3 4
  • WDR78 3 5
  • DIC4 2 3
  • FLJ23129 2

External Ids for DNAI4 Gene

Previous HGNC Symbols for DNAI4 Gene

  • WDR78

Summaries for DNAI4 Gene

GeneCards Summary for DNAI4 Gene

DNAI4 (Dynein Axonemal Intermediate Chain 4) is a Protein Coding gene. An important paralog of this gene is DNAI1.

Additional gene information for DNAI4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DNAI4 Gene

Genomics for DNAI4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for DNAI4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J066923 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 626.2 -0.6 -568 4.4 ZNF221 SP1 HNRNPL GATAD2A TEAD4 PRDM10 REST ZNF629 RFX1 LEF1 MIER1 DNAI4 TCTEX1D1 SERBP1 MN308949 SLC35D1
GH01J066929 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 25.7 -7.6 -7615 6.9 PRDM10 ZNF629 ZNF512 IKZF1 KDM1A POLR2A BACH1 LARP7 PRDM1 ZNF143 MIER1 DNAI4 TCTEX1D1 SLC35D1 MN308949
GH01J066954 Enhancer 1 Ensembl ENCODE 25.6 -30.2 -30166 1.6 IKZF1 JUND MTA2 MTA1 ZNF24 DPF2 HDAC1 SOX6 TCF12 EP300 DNAI4 SLC35D1 MN308949 MIER1
GH01J066996 Enhancer 0.8 ENCODE 26.4 -71.4 -71357 0.2 CTCF FOXA1 PRDM1 ZNF143 REST RAD21 TRIM22 YY1 PKNOX1 GATAD2B DNAI4 ENSG00000252433 RNU6-586P MN308949 SLC35D1 MIER1
GH01J067018 Enhancer 0.8 Ensembl ENCODE 25.2 -94.8 -94845 2.6 ZNF629 ZNF692 PKNOX1 CEBPB FOXA2 NR2F2 HIC1 HNF4A JUN MEIS2 DNAI4 C1orf141 ENSG00000252433 MIER1 SLC35D1 MN308949
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAI4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DNAI4

Genomic Locations for DNAI4 Gene

Genomic Locations for DNAI4 Gene
chr1:66,812,885-66,924,856
(GRCh38/hg38)
Size:
111,972 bases
Orientation:
Minus strand
chr1:67,278,568-67,390,570
(GRCh37/hg19)
Size:
112,003 bases
Orientation:
Minus strand

Genomic View for DNAI4 Gene

Genes around DNAI4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAI4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAI4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DNAI4 Gene

Proteins for DNAI4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DNAI4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTH9-WDR78_HUMAN
    Recommended name:
    WD repeat-containing protein 78
    Protein Accession:
    Q5VTH9
    Secondary Accessions:
    • A8K9W5
    • B5MDT3
    • H7BY80
    • Q5VTI0
    • Q8N5G5
    • Q9H5R9
    • Q9UF44

    Protein attributes for DNAI4 Gene

    Size:
    848 amino acids
    Molecular mass:
    94573 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DNAI4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAI4 Gene

Post-translational modifications for DNAI4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAI4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAI4 Gene

Domains & Families for DNAI4 Gene

Gene Families for DNAI4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DNAI4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAI4 Gene

GenScript: Design optimal peptide antigens:
  • WD repeat domain 78 (A0AVI9_HUMAN)
  • WD repeat domain 78 (Q5TAD8_HUMAN)
  • WD repeat-containing protein 78 (WDR78_HUMAN)
genes like me logo Genes that share domains with DNAI4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DNAI4 Gene

Function for DNAI4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for DNAI4 Gene

Gene Ontology (GO) - Molecular Function for DNAI4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0045503 dynein light chain binding IBA 21873635
GO:0045504 dynein heavy chain binding IBA 21873635
genes like me logo Genes that share ontologies with DNAI4: view
genes like me logo Genes that share phenotypes with DNAI4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAI4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DNAI4 Gene

Localization for DNAI4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAI4 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
endosome 1

Gene Ontology (GO) - Cellular Components for DNAI4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005858 axonemal dynein complex IBA 21873635
genes like me logo Genes that share ontologies with DNAI4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for DNAI4 Gene

Pathways & Interactions for DNAI4 Gene

PathCards logo

SuperPathways for DNAI4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAI4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0003341 cilium movement IBA 21873635
GO:0007018 microtubule-based movement IBA 21873635
genes like me logo Genes that share ontologies with DNAI4: view

No data available for Pathways by source and SIGNOR curated interactions for DNAI4 Gene

Drugs & Compounds for DNAI4 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for DNAI4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DNAI4 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAI4

Alternative Splicing Database (ASD) splice patterns (SP) for DNAI4 Gene

No ASD Table

Relevant External Links for DNAI4 Gene

GeneLoc Exon Structure for
DNAI4

Expression for DNAI4 Gene

Products:

  1. Primer

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DNAI4

SOURCE GeneReport for Unigene cluster for DNAI4 Gene:

Hs.49421

Evidence on tissue expression from TISSUES for DNAI4 Gene

  • Lung(4.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with DNAI4: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAI4 Gene

Orthologs for DNAI4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAI4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia WDR78 30
  • 99.21 (n)
Dog
(Canis familiaris)
 Mammalia WDR78 30 31
  • 86.11 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia WDR78 30 31
  • 85.32 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Wdr78 30 17 31
  • 79.7 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Wdr78 30
  • 78.59 (n)
Oppossum
(Monodelphis domestica)
 Mammalia WDR78 31
  • 64 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia WDR78 31
  • 60 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves WDR78 30 31
  • 63.16 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia WDR78 31
  • 52 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia wdr78 30
  • 61.6 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.15133 30
Zebrafish
(Danio rerio)
 Actinopterygii wdr78 30 31
  • 56.93 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP006036 30
  • 39.34 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta Dic61B 30
  • 38.58 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 47 (a)
 OneToOne
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.13511 30
Species where no ortholog for DNAI4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DNAI4 Gene

ENSEMBL:
Gene Tree for DNAI4 (if available)
TreeFam:
Gene Tree for DNAI4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DNAI4: view image

Paralogs for DNAI4 Gene

Paralogs for DNAI4 Gene

genes like me logo Genes that share paralogs with DNAI4: view

Variants for DNAI4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DNAI4 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1886686 - p.Gly16Ala
rs3008858 - p.Cys33Trp
rs482082 - p.Arg832Gln

Additional dbSNP identifiers (rs#s) for DNAI4 Gene

Structural Variations from Database of Genomic Variants (DGV) for DNAI4 Gene

Variant ID Type Subtype PubMed ID
esv2677491 CNV deletion 23128226
esv3586302 CNV loss 21293372
esv3586303 CNV loss 21293372
esv3893634 CNV loss 25118596
nsv519580 CNV loss 19592680
nsv546443 CNV loss 21841781
nsv546444 CNV loss 21841781
nsv818200 CNV gain 17921354
nsv830093 CNV gain 17160897

Variation tolerance for DNAI4 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAI4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAI4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAI4 Gene

Disorders for DNAI4 Gene

Additional Disease Information for DNAI4

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for DNAI4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAI4 Gene

Publications for DNAI4 Gene

  1. A unified taxonomy for ciliary dyneins. (PMID: 21953912) Hom EF … King SM (Cytoskeleton (Hoboken, N.J.) 2011) 2 3
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein. (PMID: 22199357) Meng X … Leslie KK (The Journal of biological chemistry 2012) 3

ExternalLinks

View latest publications for DNAI4 gene in Mastermind

Products for DNAI4 Gene

Sources for DNAI4 Gene