Aliases for DNAI3 Gene

Aliases for DNAI3 Gene

  • Dynein Axonemal Intermediate Chain 3 2 3
  • WD Repeat Domain 63 2 3 5
  • WD Repeat-Containing Protein 63 3 4
  • NYD-SP29 2 3
  • WDR63 3 5
  • DIC3 2 3
  • Testis Development Protein NYD-SP29 (NYD-SP29) 3
  • Testis Development Protein NYD-SP29 4
  • Testicular Tissue Protein Li 225 3
  • FLJ30067 2

External Ids for DNAI3 Gene

Previous HGNC Symbols for DNAI3 Gene

  • WDR63

Summaries for DNAI3 Gene

GeneCards Summary for DNAI3 Gene

DNAI3 (Dynein Axonemal Intermediate Chain 3) is a Protein Coding gene. Diseases associated with DNAI3 include Hemometra and Occipital Encephalocele. An important paralog of this gene is DNAI2.

Additional gene information for DNAI3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DNAI3 Gene

Genomics for DNAI3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DNAI3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J084994 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -2.4 -2350 5.4 ZNF692 POLR2A BACH1 LARP7 PRDM1 RELA ZIC2 PATZ1 SMAD5 IKZF2 MCOLN2 DNAI3 lnc-MCOLN2-1 lnc-WDR63-1 MCOLN3 LPAR3 RF00994-034
GH01J085061 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 608 +63.2 63153 1.8 SP1 CREB1 ATF7 PRDM10 ZNF629 RFX1 RFX5 ZNF692 FOS PRDM1 DNAI3 MCOLN2 MCOLN3 hsa-miR-5095-028 SYDE2
GH01J084971 Enhancer 0.9 Ensembl ENCODE 12.6 -25.5 -25536 4 TCF12 IKZF2 TRIM22 SCRT2 RELA CEBPB TCF7L2 DPF2 RELB ZXDB MCOLN2 DNAI3 LPAR3 piR-50444-025 lnc-MCOLN2-1 lnc-LPAR3-1
GH01J084968 Enhancer 0.8 ENCODE 12.2 -29.4 -29443 1.8 SP1 RELA TCF12 IKZF2 TRIM22 EED ARID3A PAX8 DPF2 RELB MCOLN2 MCOLN3 DNAI3 LPAR3 piR-50444-025 lnc-MCOLN2-1 lnc-LPAR3-1
GH01J085132 Enhancer 0.9 Ensembl ENCODE 8.1 +135.5 135454 5.6 CEBPG CREB1 GATAD2A FOXA1 RFX1 CEBPA ZBTB44 CEBPB EZH2 ZNF23 MIR4423 SYDE2 SPATA1 DNAI3 MCOLN2 ENSG00000280099 lnc-SYDE2-1 MCOLN3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAI3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DNAI3

Genomic Locations for DNAI3 Gene

Genomic Locations for DNAI3 Gene
chr1:84,999,147-85,133,138
(GRCh38/hg38)
Size:
133,992 bases
Orientation:
Plus strand
chr1:85,464,830-85,598,821
(GRCh37/hg19)
Size:
133,992 bases
Orientation:
Plus strand

Genomic View for DNAI3 Gene

Genes around DNAI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAI3 Gene

Proteins for DNAI3 Gene

  • Protein details for DNAI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWG1-WDR63_HUMAN
    Recommended name:
    WD repeat-containing protein 63
    Protein Accession:
    Q8IWG1
    Secondary Accessions:
    • A8K988
    • Q96L72
    • Q96NU4

    Protein attributes for DNAI3 Gene

    Size:
    891 amino acids
    Molecular mass:
    102935 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DNAI3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAI3 Gene

Post-translational modifications for DNAI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAI3 Gene

No data available for DME Specific Peptides for DNAI3 Gene

Domains & Families for DNAI3 Gene

Gene Families for DNAI3 Gene

Protein Domains for DNAI3 Gene

Suggested Antigen Peptide Sequences for DNAI3 Gene

GenScript: Design optimal peptide antigens:
  • Testis development protein NYD-SP29 (WDR63_HUMAN)
genes like me logo Genes that share domains with DNAI3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DNAI3 Gene

Function for DNAI3 Gene

Phenotypes From GWAS Catalog for DNAI3 Gene

Gene Ontology (GO) - Molecular Function for DNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0045503 dynein light chain binding IBA 21873635
GO:0045504 dynein heavy chain binding IBA 21873635
genes like me logo Genes that share ontologies with DNAI3: view
genes like me logo Genes that share phenotypes with DNAI3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAI3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DNAI3 Gene

Localization for DNAI3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAI3 gene
Compartment Confidence
cytoskeleton 3
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036156 inner dynein arm IBA 21873635
genes like me logo Genes that share ontologies with DNAI3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for DNAI3 Gene

Pathways & Interactions for DNAI3 Gene

PathCards logo

SuperPathways for DNAI3 Gene

No Data Available

Interacting Proteins for DNAI3 Gene

Gene Ontology (GO) - Biological Process for DNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IBA 21873635
GO:0036159 inner dynein arm assembly IBA 21873635
GO:0060294 cilium movement involved in cell motility IBA 21873635
genes like me logo Genes that share ontologies with DNAI3: view

No data available for Pathways by source and SIGNOR curated interactions for DNAI3 Gene

Drugs & Compounds for DNAI3 Gene

No Compound Related Data Available

Transcripts for DNAI3 Gene

mRNA/cDNA for DNAI3 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAI3

Alternative Splicing Database (ASD) splice patterns (SP) for DNAI3 Gene

No ASD Table

Relevant External Links for DNAI3 Gene

GeneLoc Exon Structure for
DNAI3

Expression for DNAI3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DNAI3

SOURCE GeneReport for Unigene cluster for DNAI3 Gene:

Hs.97933

Evidence on tissue expression from TISSUES for DNAI3 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with DNAI3: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAI3 Gene

Orthologs for DNAI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAI3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WDR63 30 31
  • 99.4 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WDR63 30 31
  • 87.48 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WDR63 31
  • 87 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wdr63 30
  • 80.52 (n)
Mouse
(Mus musculus)
Mammalia Wdr63 30 17 31
  • 79.82 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WDR63 31
  • 67 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia WDR63 31
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WDR63 30 31
  • 65.2 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WDR63 31
  • 54 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wdr63 30
  • 64.67 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100333131 30
  • 54.62 (n)
WDR63 31
  • 44 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12489 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG14838 30 31
  • 43.56 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009027 30
  • 40.92 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 48 (a)
OneToOne
Species where no ortholog for DNAI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DNAI3 Gene

ENSEMBL:
Gene Tree for DNAI3 (if available)
TreeFam:
Gene Tree for DNAI3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DNAI3: view image

Paralogs for DNAI3 Gene

Paralogs for DNAI3 Gene

genes like me logo Genes that share paralogs with DNAI3: view

Variants for DNAI3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DNAI3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
714072 Benign: not provided 85,081,367(+) C/T SYNONYMOUS_VARIANT
728642 Benign: not provided 85,086,039(+) G/A INTRON_VARIANT
735408 Likely Benign: not provided 85,071,998(+) A/G SYNONYMOUS_VARIANT
736742 Benign: not provided 85,126,503(+) G/T INTRON_VARIANT
747783 Likely Benign: not provided 85,082,326(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for DNAI3 Gene

Structural Variations from Database of Genomic Variants (DGV) for DNAI3 Gene

Variant ID Type Subtype PubMed ID
esv2763574 CNV loss 21179565
esv34165 CNV loss 18971310
esv3586676 CNV gain 21293372
esv3586677 CNV loss 21293372
nsv462383 CNV gain 19166990
nsv470724 CNV gain 18288195
nsv521770 CNV loss 19592680
nsv523150 CNV loss 19592680
nsv546700 CNV gain 21841781
nsv830459 CNV loss 17160897
nsv947434 CNV duplication 23825009

Variation tolerance for DNAI3 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.52; 82.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAI3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAI3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAI3 Gene

Disorders for DNAI3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DNAI3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hemometra
  • hematometra
occipital encephalocele
- elite association - COSMIC cancer census association via MalaCards
Search DNAI3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with DNAI3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAI3 Gene

Publications for DNAI3 Gene

  1. A unified taxonomy for ciliary dyneins. (PMID: 21953912) Hom EF … King SM (Cytoskeleton (Hoboken, N.J.) 2011) 2 3
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Targeted copy number screening highlights an intragenic deletion of WDR63 as the likely cause of human occipital encephalocele and abnormal CNS development in zebrafish. (PMID: 29285825) Hofmeister W … Lindstrand A (Human mutation 2018) 3

Products for DNAI3 Gene

Sources for DNAI3 Gene