Aliases for DNAH17 Gene
External Ids for DNAH17 Gene
Previous HGNC Symbols for DNAH17 Gene
Previous GeneCards Identifiers for DNAH17 Gene
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. DNAH17 is a heavy chain associated with axonemal dynein (Milisav and Affara, 1998 [PubMed 9545504]).[supplied by OMIM, Mar 2008]
GeneCards Summary for DNAH17 Gene
DNAH17 (Dynein Axonemal Heavy Chain 17) is a Protein Coding gene. Diseases associated with DNAH17 include Amyotrophic Neuralgia and Brachial Plexus Neuropathy. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is DNAH9.
UniProtKB/Swiss-Prot Summary for DNAH17 Gene
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).