This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell grow... See more...

Aliases for DMTF1 Gene

Aliases for DMTF1 Gene

  • Cyclin D Binding Myb Like Transcription Factor 1 2 3 5
  • HDMP1 2 3 4
  • DMP1 2 3 4
  • Cyclin-D-Binding Myb-Like Transcription Factor 1 3 4
  • Cyclin-D-Interacting Myb-Like Protein 1 3 4
  • Cyclin D-Binding Myb-Like Protein 2 3
  • HDMTF1 3 4
  • DMTF 2 3
  • MRUL 2 3
  • Cyclin D Binding Myb-Like Transcription Factor 1 2
  • DMTF1 5

External Ids for DMTF1 Gene

Previous GeneCards Identifiers for DMTF1 Gene

  • GC07P085317
  • GC07P086379
  • GC07P086393
  • GC07P086426
  • GC07P086620
  • GC07P086781
  • GC07P081392

Summaries for DMTF1 Gene

Entrez Gene Summary for DMTF1 Gene

  • This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for DMTF1 Gene

DMTF1 (Cyclin D Binding Myb Like Transcription Factor 1) is a Protein Coding gene. Diseases associated with DMTF1 include Gastric Cancer and Lung Cancer. Among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is SNAPC4.

UniProtKB/Swiss-Prot Summary for DMTF1 Gene

  • Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.

Gene Wiki entry for DMTF1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DMTF1 Gene

Genomics for DMTF1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DMTF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DMTF1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DMTF1

Top Transcription factor binding sites by QIAGEN in the DMTF1 gene promoter:
  • c-Ets-1
  • NRF-2
  • p53
  • Pax-5

Genomic Locations for DMTF1 Gene

Genomic Locations for DMTF1 Gene
chr7:87,152,361-87,196,337
(GRCh38/hg38)
Size:
43,977 bases
Orientation:
Plus strand
chr7:86,781,677-86,825,653
(GRCh37/hg19)
Size:
43,977 bases
Orientation:
Plus strand

Genomic View for DMTF1 Gene

Genes around DMTF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMTF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMTF1 Gene

Proteins for DMTF1 Gene

  • Protein details for DMTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y222-DMTF1_HUMAN
    Recommended name:
    Cyclin-D-binding Myb-like transcription factor 1
    Protein Accession:
    Q9Y222
    Secondary Accessions:
    • B2RBE1
    • B4DJS5
    • Q05C48
    • Q59G79
    • Q6IS13
    • Q969T2
    • Q9H2Z2
    • Q9H2Z3

    Protein attributes for DMTF1 Gene

    Size:
    760 amino acids
    Molecular mass:
    84471 Da
    Quaternary structure:
    • Interacts with the D-type cyclins CCND1, CCND2 and CCND3. Interaction with D-type cyclins may modulate transcriptional activation by this protein.
    SequenceCaution:
    • Sequence=BAD92467.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DMTF1 Gene

    Alternative splice isoforms for DMTF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DMTF1 Gene

Post-translational modifications for DMTF1 Gene

  • Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DMTF1 Gene

Domains & Families for DMTF1 Gene

Gene Families for DMTF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for DMTF1 Gene

Suggested Antigen Peptide Sequences for DMTF1 Gene

GenScript: Design optimal peptide antigens:
  • Cyclin-D-interacting Myb-like protein 1 (DMTF1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y222

UniProtKB/Swiss-Prot:

DMTF1_HUMAN :
  • Belongs to the DMTF1 family.
Family:
  • Belongs to the DMTF1 family.
genes like me logo Genes that share domains with DMTF1: view

Function for DMTF1 Gene

Molecular function for DMTF1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.

Phenotypes From GWAS Catalog for DMTF1 Gene

Gene Ontology (GO) - Molecular Function for DMTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS 10095122
genes like me logo Genes that share ontologies with DMTF1: view
genes like me logo Genes that share phenotypes with DMTF1: view

Animal Models for DMTF1 Gene

MGI Knock Outs for DMTF1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DMTF1

Clone Products

  • Addgene plasmids for DMTF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DMTF1 Gene

Localization for DMTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMTF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DMTF1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DMTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10095122
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with DMTF1: view

Pathways & Interactions for DMTF1 Gene

genes like me logo Genes that share pathways with DMTF1: view

Pathways by source for DMTF1 Gene

1 GeneTex pathway for DMTF1 Gene

Gene Ontology (GO) - Biological Process for DMTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 10095122
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with DMTF1: view

No data available for SIGNOR curated interactions for DMTF1 Gene

Drugs & Compounds for DMTF1 Gene

No Compound Related Data Available

Transcripts for DMTF1 Gene

mRNA/cDNA for DMTF1 Gene

3 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
38 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DMTF1

Clone Products

  • Addgene plasmids for DMTF1

Alternative Splicing Database (ASD) splice patterns (SP) for DMTF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a ·
SP1:
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: -
SP7:
SP8:
SP9: - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - -
SP13:
SP14: - - - -
SP15: - - - - -
SP16: - - -
SP17:
SP18: - - -
SP19:
SP20:
SP21:
SP22:

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21: - - - -
SP22:

Relevant External Links for DMTF1 Gene

GeneLoc Exon Structure for
DMTF1

Expression for DMTF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DMTF1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DMTF1

SOURCE GeneReport for Unigene cluster for DMTF1 Gene:

Hs.196129

mRNA Expression by UniProt/SwissProt for DMTF1 Gene:

Q9Y222-DMTF1_HUMAN
Tissue specificity: Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate and small intestine, and at higher levels in spleen, testis and thymus. Expressed in multiple regions of the brain and CNS including amygdala, caudate, corpus callosum, hippocampus, substantia nigra and subthalamic nucleus. Isoform 1 is the predominant isoform in monocytes, macrophages and neutrophils, isoform 2 is most strongly expressed in peripheral blood leukocytes and quiescent CD34 positive cells, and isoform 3 is expressed at low levels in all hematopoietic cell types. Expression is frequently reduced in non-small-cell lung carcinomas (NSCLC) due to hemizygous gene deletion, strongly suggesting that this locus is haploinsufficient for tumor suppression. Loss of this locus frequently occurs in tumors which retain wild-type CDKN2A/ARF and p53/TP53 loci. Hemizygous gene deletion has also been observed in leukemic blasts from patients with abnormalities of the long arm of chromosome 7.

Evidence on tissue expression from TISSUES for DMTF1 Gene

  • Nervous system(4.9)
  • Muscle(4.3)
  • Skin(2.3)
  • Lymph node(2.2)
  • Intestine(2.2)
  • Lung(2.1)
  • Stomach(2.1)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with DMTF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DMTF1 Gene

Orthologs for DMTF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DMTF1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DMTF1 30 31
  • 99.74 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DMTF1 30 31
  • 94.64 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DMTF1 30 31
  • 93.76 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DMTF1 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Dmtf1 30 17 31
  • 91.84 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DMTF1 31
  • 88 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DMTF1 30 31
  • 80.81 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DMTF1 31
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dmtf1 30
  • 69.28 (n)
Zebrafish
(Danio rerio)
Actinopterygii dmtf1 30 31
  • 67.34 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NSI1 33
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
OneToMany
Species where no ortholog for DMTF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DMTF1 Gene

ENSEMBL:
Gene Tree for DMTF1 (if available)
TreeFam:
Gene Tree for DMTF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DMTF1: view image

Paralogs for DMTF1 Gene

Paralogs for DMTF1 Gene

genes like me logo Genes that share paralogs with DMTF1: view

Variants for DMTF1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DMTF1 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
749224 Likely Benign: not provided 87,166,487(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
781038 Benign: not provided 87,193,844(+) A/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs1558049 - p.Val479Ile

Additional dbSNP identifiers (rs#s) for DMTF1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DMTF1 Gene

Variant ID Type Subtype PubMed ID
esv3373567 CNV insertion 20981092
nsv1016761 CNV gain 25217958
nsv483124 CNV gain 15286789
nsv527889 CNV gain 19592680

Variation tolerance for DMTF1 Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.60; 56.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DMTF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DMTF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMTF1 Gene

Disorders for DMTF1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DMTF1 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • gastric cancer, somatic
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards
Search DMTF1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DMTF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with DMTF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DMTF1 Gene

Publications for DMTF1 Gene

  1. Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1). (PMID: 10095122) Bodner SM … Look AT (Gene 1999) 2 3 4 23
  2. Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. (PMID: 17936562) Mallakin A … Inoue K (Cancer cell 2007) 3 4 23
  3. Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns. (PMID: 12917399) Tschan MP … Torbett BE (The Journal of biological chemistry 2003) 3 4 23
  4. Long noncoding RNA MRUL promotes ABCB1 expression in multidrug-resistant gastric cancer cell sublines. (PMID: 24958102) Wang Y … Fan D (Molecular and cellular biology 2014) 2 3
  5. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. (PMID: 20351715) Liu Y … Wellcome Trust Case-Control Consortium (Molecular psychiatry 2011) 3 41

Products for DMTF1 Gene

  • Signalway ELISA kits for DMTF1

Sources for DMTF1 Gene