Aliases for DMRTC2 Gene

Aliases for DMRTC2 Gene

  • DMRT Like Family C2 2 3 5
  • Doublesex- And Mab-3-Related Transcription Factor C2 3 4
  • DMRT-Like Family C2 2

External Ids for DMRTC2 Gene

Previous GeneCards Identifiers for DMRTC2 Gene

  • GC19P042988
  • GC19P042740
  • GC19P047025
  • GC19P047041
  • GC19P047043
  • GC19P047044
  • GC19P042349
  • GC19P038780

Summaries for DMRTC2 Gene

GeneCards Summary for DMRTC2 Gene

DMRTC2 (DMRT Like Family C2) is a Protein Coding gene. Diseases associated with DMRTC2 include Cryptorchidism, Unilateral Or Bilateral. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is DMRTC1.

UniProtKB/Swiss-Prot Summary for DMRTC2 Gene

Additional gene information for DMRTC2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DMRTC2 Gene

Genomics for DMRTC2 Gene

GeneHancer (GH) Regulatory Elements for DMRTC2 Gene

Promoters and enhancers for DMRTC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J041845 Promoter 0.7 EPDnew 750.6 0.0 -40 0.1 L3MBTL2 SP2 MGA ZNF395 ZBTB33 KLF1 DMRTC2 LYPD4 piR-58768
GH19J041844 Promoter 0.6 EPDnew 750.6 -0.2 -153 0.1 ZNF395 ZBTB33 L3MBTL2 KLF1 DMRTC2 LYPD4 piR-58768
GH19J041846 Promoter 0.5 EPDnew 750.6 +0.3 280 0.1 L3MBTL2 ZBTB33 DMRTC2 LYPD4 RPS19
GH19J042267 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 +426.1 426127 6.9 ZNF785 SIN3A SP1 ZBTB40 SIX5 FOXA1 MLX RBPJ SMARCE1 POLR2A CIC piR-36065 ZNF526 ZNF574 CCDC97 MEGF8 ARHGEF1 TMEM145 DEDD2 CEACAM3
GH19J041802 Enhancer 1 FANTOM5 ENCODE dbSUPER 25.1 -42.5 -42480 1.7 HDAC1 SOX6 ZFHX2 CTCF WT1 KLF17 EBF1 YY2 LOC100422623 HSALNG0126230 CEACAM3 CEACAM4 DMRTC2 DEDD2 LYPD4 CEACAM6 CEACAM21 TMEM91
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DMRTC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DMRTC2 gene promoter:
  • c-Myc
  • Egr-3
  • GR
  • GR-alpha
  • GR-beta
  • HEN1
  • Max1
  • NRSF form 2
  • PPAR-alpha

Genomic Locations for DMRTC2 Gene

Genomic Locations for DMRTC2 Gene
7,591 bases
Plus strand
7,596 bases
Plus strand

Genomic View for DMRTC2 Gene

Genes around DMRTC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMRTC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMRTC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMRTC2 Gene

Proteins for DMRTC2 Gene

  • Protein details for DMRTC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Doublesex- and mab-3-related transcription factor C2
    Protein Accession:
    Secondary Accessions:
    • Q8N6Q2
    • Q96M39
    • Q96SD4

    Protein attributes for DMRTC2 Gene

    367 amino acids
    Molecular mass:
    39124 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DMRTC2 Gene


neXtProt entry for DMRTC2 Gene

Post-translational modifications for DMRTC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DMRTC2 Gene

Domains & Families for DMRTC2 Gene

Gene Families for DMRTC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for DMRTC2 Gene

Suggested Antigen Peptide Sequences for DMRTC2 Gene

GenScript: Design optimal peptide antigens:
  • Doublesex- and mab-3-related transcription factor C2 (DMRTD_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DMRT family.
  • Belongs to the DMRT family.
genes like me logo Genes that share domains with DMRTC2: view

Function for DMRTC2 Gene

Molecular function for DMRTC2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in sexual development.

Gene Ontology (GO) - Molecular Function for DMRTC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0042803 protein homodimerization activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with DMRTC2: view
genes like me logo Genes that share phenotypes with DMRTC2: view

Animal Models for DMRTC2 Gene

MGI Knock Outs for DMRTC2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DMRTC2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DMRTC2 Gene

Localization for DMRTC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMRTC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DMRTC2 gene
Compartment Confidence
nucleus 4
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DMRTC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001741 XY body IEA --
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA,IEA 21873635
genes like me logo Genes that share ontologies with DMRTC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DMRTC2 Gene

Pathways & Interactions for DMRTC2 Gene

PathCards logo

SuperPathways for DMRTC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DMRTC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007141 male meiosis I IEA --
GO:0007290 spermatid nucleus elongation IEA --
GO:0007548 sex differentiation IEA --
genes like me logo Genes that share ontologies with DMRTC2: view

No data available for Pathways by source and SIGNOR curated interactions for DMRTC2 Gene

Drugs & Compounds for DMRTC2 Gene

No Compound Related Data Available

Transcripts for DMRTC2 Gene

mRNA/cDNA for DMRTC2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DMRTC2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMRTC2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: -

Relevant External Links for DMRTC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DMRTC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DMRTC2 Gene

mRNA differential expression in normal tissues according to GTEx for DMRTC2 Gene

This gene is overexpressed in Testis (x51.4).

Protein differential expression in normal tissues from HIPED for DMRTC2 Gene

This gene is overexpressed in Testis (54.1) and Fetal ovary (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DMRTC2 Gene

Protein tissue co-expression partners for DMRTC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DMRTC2 Gene:


SOURCE GeneReport for Unigene cluster for DMRTC2 Gene:


mRNA Expression by UniProt/SwissProt for DMRTC2 Gene:

Tissue specificity: Expressed in testis and pancreas.

Evidence on tissue expression from TISSUES for DMRTC2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with DMRTC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DMRTC2 Gene

Orthologs for DMRTC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DMRTC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DMRTC2 33 32
  • 99.55 (n)
(Bos Taurus)
Mammalia DMRTC2 33 32
  • 85.79 (n)
(Mus musculus)
Mammalia Dmrtc2 17 33 32
  • 85.47 (n)
(Canis familiaris)
Mammalia DMRTC2 33 32
  • 85.47 (n)
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 50 (a)
(Monodelphis domestica)
Mammalia -- 33
  • 48 (a)
Species where no ortholog for DMRTC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DMRTC2 Gene

Gene Tree for DMRTC2 (if available)
Gene Tree for DMRTC2 (if available)
Evolutionary constrained regions (ECRs) for DMRTC2: view image

Paralogs for DMRTC2 Gene

Paralogs for DMRTC2 Gene

(1) SIMAP similar genes for DMRTC2 Gene using alignment to 5 proteins:

  • B4DX56_HUMAN
  • M0R1Z9_HUMAN
  • M0R2D7_HUMAN
genes like me logo Genes that share paralogs with DMRTC2: view

Variants for DMRTC2 Gene

Sequence variations from dbSNP and Humsavar for DMRTC2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000189887 -- 41,847,796(+) A/G 5_prime_UTR_variant, coding_sequence_variant, synonymous_variant
rs1000560049 -- 41,845,743(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1003742123 -- 41,844,359(+) C/T upstream_transcript_variant
rs1004270385 -- 41,850,172(+) A/G genic_downstream_transcript_variant, intron_variant
rs1004332060 -- 41,844,100(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DMRTC2 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV gain 19592680

Variation tolerance for DMRTC2 Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DMRTC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMRTC2 Gene

Disorders for DMRTC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DMRTC2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cryptorchidism, unilateral or bilateral
  • undescended testis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DMRTC2

genes like me logo Genes that share disorders with DMRTC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DMRTC2 Gene

Publications for DMRTC2 Gene

  1. Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PMID: 11863363) Ottolenghi C … McElreavey K (Genomics 2002) 2 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 56

Products for DMRTC2 Gene

Sources for DMRTC2 Gene