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Aliases for DMRTC1B Gene

Aliases for DMRTC1B Gene

  • DMRT Like Family C1B 2 3 5
  • Doublesex- And Mab-3-Related Transcription Factor C1 3
  • DMRT-Like Family C1B 2
  • DMRT-Like Family C1 3

External Ids for DMRTC1B Gene

Previous GeneCards Identifiers for DMRTC1B Gene

  • GC0XU900857
  • GC0XP071916
  • GC0XP072064

Summaries for DMRTC1B Gene

GeneCards Summary for DMRTC1B Gene

DMRTC1B (DMRT Like Family C1B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and proximal promoter sequence-specific DNA binding. An important paralog of this gene is DMRTC1.

Additional gene information for DMRTC1B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMRTC1B Gene

Genomics for DMRTC1B Gene

GeneHancer (GH) Regulatory Elements for DMRTC1B Gene

Promoters and enhancers for DMRTC1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ072776 Promoter 1 EPDnew Ensembl 650.7 +0.3 292 1 FAM226B DMRTC1B FAM236B
GH0XJ072842 Promoter 0.5 EPDnew 650.2 +65.9 65871 0.1 DMRTC1B FAM236D FAM236C
GH0XJ072837 Promoter 0.5 EPDnew 650.2 +60.0 60033 0.1 DMRTC1B FAM236D FAM236C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DMRTC1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DMRTC1B gene promoter:
  • SRF (504 AA)
  • SRF
  • AP-4
  • POU3F1
  • ARP-1
  • XBP-1
  • Pax-4a
  • RP58
  • En-1
  • MIF-1

Genomic Locations for DMRTC1B Gene

Genomic Locations for DMRTC1B Gene
71,794 bases
Plus strand
71,804 bases
Plus strand

Genomic View for DMRTC1B Gene

Genes around DMRTC1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMRTC1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMRTC1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMRTC1B Gene

Proteins for DMRTC1B Gene

  • Protein details for DMRTC1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Doublesex- and mab-3-related transcription factor C1
    Protein Accession:
    Secondary Accessions:
    • Q5HYR0
    • Q5U5K2
    • Q8N6L3
    • Q96SD3
    • Q5HYR0
    • Q5U5K2
    • Q8N6L3
    • Q96SD3

    Protein attributes for DMRTC1B Gene

    192 amino acids
    Molecular mass:
    20139 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DMRTC1B Gene


neXtProt entry for DMRTC1B Gene

Post-translational modifications for DMRTC1B Gene

No Post-translational modifications

No data available for DME Specific Peptides for DMRTC1B Gene

Domains & Families for DMRTC1B Gene

Gene Families for DMRTC1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for DMRTC1B Gene


Suggested Antigen Peptide Sequences for DMRTC1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DMRT family.
  • Belongs to the DMRT family.
genes like me logo Genes that share domains with DMRTC1B: view

Function for DMRTC1B Gene

Gene Ontology (GO) - Molecular Function for DMRTC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0042803 protein homodimerization activity IBA --
genes like me logo Genes that share ontologies with DMRTC1B: view

Phenotypes for DMRTC1B Gene

genes like me logo Genes that share phenotypes with DMRTC1B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DMRTC1B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DMRTC1B Gene

Localization for DMRTC1B Gene

Gene Ontology (GO) - Cellular Components for DMRTC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DMRTC1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for DMRTC1B Gene

Pathways & Interactions for DMRTC1B Gene

SuperPathways for DMRTC1B Gene

No Data Available

Interacting Proteins for DMRTC1B Gene

Gene Ontology (GO) - Biological Process for DMRTC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007548 sex differentiation IBA --
genes like me logo Genes that share ontologies with DMRTC1B: view

No data available for Pathways by source and SIGNOR curated interactions for DMRTC1B Gene

Drugs & Compounds for DMRTC1B Gene

No Compound Related Data Available

Transcripts for DMRTC1B Gene

mRNA/cDNA for DMRTC1B Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DMRTC1B Gene

DMRT-like family C1B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DMRTC1B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMRTC1B Gene

No ASD Table

Relevant External Links for DMRTC1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DMRTC1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DMRTC1B Gene

mRNA differential expression in normal tissues according to GTEx for DMRTC1B Gene

This gene is overexpressed in Pituitary (x4.6), Brain - Cortex (x4.5), Brain - Hypothalamus (x4.5), Brain - Anterior cingulate cortex (BA24) (x4.1), Brain - Nucleus accumbens (basal ganglia) (x4.1), and Brain - Frontal Cortex (BA9) (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of DMRTC1B Gene:


SOURCE GeneReport for Unigene cluster for DMRTC1B Gene:


mRNA Expression by UniProt/SwissProt for DMRTC1B Gene:

Tissue specificity: Predominantly expressed in kidney, pancreas, ovary and testis. Detected in brain and in many other tissues.
genes like me logo Genes that share expression patterns with DMRTC1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DMRTC1B Gene

Orthologs for DMRTC1B Gene

This gene was present in the common ancestor of mammals.

Orthologs for DMRTC1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
(Mus musculus)
Mammalia Dmrtc1a 34
  • 40 (a)
Dmrtc1b 34
  • 29 (a)
(Canis familiaris)
Mammalia -- 34
  • 37 (a)
-- 34
  • 32 (a)
(Bos Taurus)
Mammalia MGC140080 34
  • 28 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 19 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 17 (a)
Species where no ortholog for DMRTC1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DMRTC1B Gene

Gene Tree for DMRTC1B (if available)
Gene Tree for DMRTC1B (if available)

Paralogs for DMRTC1B Gene

Paralogs for DMRTC1B Gene

(1) SIMAP similar genes for DMRTC1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DMRTC1B: view

Variants for DMRTC1B Gene

Sequence variations from dbSNP and Humsavar for DMRTC1B Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1009696 -- 72,793,108(+) T/G genic_upstream_transcript_variant, intron_variant
rs1011191 -- 72,804,534(+) C/G genic_upstream_transcript_variant, intron_variant
rs1011192 -- 72,804,543(+) A/T genic_upstream_transcript_variant, intron_variant
rs10556407 -- 72,807,290(+) GAGGAGGAGG/GAGGAGG genic_upstream_transcript_variant, intron_variant
rs111254771 -- 72,840,625(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DMRTC1B Gene

Variant ID Type Subtype PubMed ID
esv3574046 CNV loss 25503493
esv3576926 CNV gain 25503493
nsv7450 OTHER inversion 18451855
nsv953429 CNV deletion 24416366

Additional Variant Information for DMRTC1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DMRTC1B Gene

Disorders for DMRTC1B Gene

Additional Disease Information for DMRTC1B

No disorders were found for DMRTC1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DMRTC1B Gene

Publications for DMRTC1B Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination. (PMID: 11863363) Ottolenghi C … McElreavey K (Genomics 2002) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for DMRTC1B Gene

Sources for DMRTC1B Gene

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