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Aliases for DMKN Gene

Aliases for DMKN Gene

  • Dermokine 2 3 3 5
  • Epidermis-Specific Secreted Protein SK30/SK89 3 4
  • ZD52F10 3
  • UNQ729 3

External Ids for DMKN Gene

Previous GeneCards Identifiers for DMKN Gene

  • GC19M040680
  • GC19M035988
  • GC19M032493
  • GC19M035765
  • GC19M035922
  • GC19M035948
  • GC19M036818
  • GC19M037437
  • GC19M037776
  • GC19M038076

Summaries for DMKN Gene

Entrez Gene Summary for DMKN Gene

  • This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for DMKN Gene

DMKN (Dermokine) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DMKN Gene

  • May act as a soluble regulator of keratinocyte differentiation.

Additional gene information for DMKN Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMKN Gene

Genomics for DMKN Gene

GeneHancer (GH) Regulatory Elements for DMKN Gene

Promoters and enhancers for DMKN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I035508 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 550.8 +3.8 3803 2.5 SMAD1 MLX ARID4B SIN3A ZNF2 ZBTB7B IRF4 SLC30A9 ZNF143 KLF13 DMKN ZFP82 CLIP3 ARHGAP33 TMEM147-AS1 LINC00665 ZNF566 PROSER3 KMT2B ZNF599
GH19I035513 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 560.2 -0.5 -537 1.3 CTCF PKNOX1 KLF1 USF1 ZNF473 KLF17 SIN3A ZIC2 ZNF514 ZFHX2 DMKN ZNF599 ZNF146 TMEM147-AS1 LRFN3 HAUS5 ENSG00000267049 ZBTB32 SDHAF1 PROSER3
GH19I035514 Promoter 0.9 EPDnew 550.8 +0.3 252 0.1 HIC1 GLIS2 ZNF473 GLIS1 ZNF416 ZIC2 ZNF514 WT1 ZBTB20 DMKN ZNF599 ZNF146 TMEM147-AS1 LRFN3 HAUS5 ENSG00000267049 ZBTB32 SDHAF1 PROSER3
GH19I035501 Promoter 0.9 EPDnew 550.4 +11.7 11737 0.1 MAZ CEBPB KLF17 ZIC2 ZNF148 FOSL1 GLIS2 ZFHX2 IKZF1 EGR2 DMKN KRTDAP
GH19I035328 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 +182.6 182633 5.1 HDGF PKNOX1 SMAD1 RB1 BMI1 KLF5 IRF4 TCF12 ZNF207 ATF7 CD22 ENSG00000269553 MAG KRTDAP DMKN HAMP ENSG00000233214 FAM187B TMEM147 TMEM147-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DMKN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DMKN gene promoter:

Genomic Locations for DMKN Gene

Genomic Locations for DMKN Gene
chr19:35,497,217-35,513,668
(GRCh38/hg38)
Size:
16,452 bases
Orientation:
Minus strand
chr19:35,988,119-36,004,560
(GRCh37/hg19)

Genomic View for DMKN Gene

Genes around DMKN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMKN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMKN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMKN Gene

Proteins for DMKN Gene

  • Protein details for DMKN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6E0U4-DMKN_HUMAN
    Recommended name:
    Dermokine
    Protein Accession:
    Q6E0U4
    Secondary Accessions:
    • A3EZ79
    • A3EZ80
    • A3EZ81
    • A3EZ82
    • A3EZ83
    • C9J4P6
    • C9J5N8
    • C9JAL3
    • Q32W58
    • Q32W62
    • Q32W63
    • Q32W64
    • Q32W65
    • Q32W66
    • Q32W67
    • Q6E0U5
    • Q6UXC7
    • Q96EW8
    • Q9BSY6

    Protein attributes for DMKN Gene

    Size:
    476 amino acids
    Molecular mass:
    47082 Da
    Quaternary structure:
    • Homooligomer. Seems to be able to homodimerize and homotrimerize.
    SequenceCaution:
    • Sequence=AAX48757.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DMKN Gene

neXtProt entry for DMKN Gene

Post-translational modifications for DMKN Gene

Other Protein References for DMKN Gene

No data available for DME Specific Peptides for DMKN Gene

Domains & Families for DMKN Gene

Gene Families for DMKN Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for DMKN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DMKN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6E0U4

UniProtKB/Swiss-Prot:

DMKN_HUMAN :
  • Belongs to the dermokine family.
Family:
  • Belongs to the dermokine family.
genes like me logo Genes that share domains with DMKN: view

Function for DMKN Gene

Molecular function for DMKN Gene

UniProtKB/Swiss-Prot Function:
May act as a soluble regulator of keratinocyte differentiation.

Phenotypes From GWAS Catalog for DMKN Gene

Gene Ontology (GO) - Molecular Function for DMKN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22735594
genes like me logo Genes that share ontologies with DMKN: view

Phenotypes for DMKN Gene

genes like me logo Genes that share phenotypes with DMKN: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DMKN Gene

Localization for DMKN Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMKN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DMKN gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytosol 2
golgi apparatus 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DMKN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with DMKN: view

Pathways & Interactions for DMKN Gene

No Data Available

Gene Ontology (GO) - Biological Process for DMKN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903575 cornified envelope assembly IEA --
genes like me logo Genes that share ontologies with DMKN: view

No data available for Pathways by source and SIGNOR curated interactions for DMKN Gene

Drugs & Compounds for DMKN Gene

No Compound Related Data Available

Transcripts for DMKN Gene

Unigene Clusters for DMKN Gene

Dermokine:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DMKN Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - - - - - -
SP17: - - - - - - -
SP18: - - - - - - - - - - - -
SP19: - - - - - - - -
SP20: - - - - - - - - - -
SP21: - - - - - - - - -
SP22: - - - - - - - - -
SP23: - - - - - - -
SP24: - - - - - - - - - - - -
SP25: - - - - - - - - - -
SP26: - - - - - - - - -
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:

ExUns: 17b · 17c ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b · 23c · 23d
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - -
SP8:
SP9:
SP10:
SP11: - - - -
SP12: - - - - - - - -
SP13: - - - -
SP14:
SP15: - - - -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:

Relevant External Links for DMKN Gene

GeneLoc Exon Structure for
DMKN
ECgene alternative splicing isoforms for
DMKN

Expression for DMKN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DMKN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DMKN Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x22.4) and Skin - Not Sun Exposed (Suprapubic) (x19.0).

Protein differential expression in normal tissues from HIPED for DMKN Gene

This gene is overexpressed in Skin (51.8) and Serum (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DMKN Gene



NURSA nuclear receptor signaling pathways regulating expression of DMKN Gene:

DMKN

SOURCE GeneReport for Unigene cluster for DMKN Gene:

Hs.417795

mRNA Expression by UniProt/SwissProt for DMKN Gene:

Q6E0U4-DMKN_HUMAN
Tissue specificity: Expressed in epidermis; in the spinous and granular layers and in placenta. Also found in the epithelia of the small intestine, macrophages of the lung and endothelial cells of the lung. Isoform 15 is expressed in epidermis and placenta. Isoform 1 is expressed in epidermis.

Evidence on tissue expression from TISSUES for DMKN Gene

  • Skin(5)
  • Heart(2.7)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with DMKN: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DMKN Gene

Orthologs for DMKN Gene

This gene was present in the common ancestor of mammals.

Orthologs for DMKN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DMKN 33
  • 98.14 (n)
mouse
(Mus musculus)
Mammalia Dmkn 33 16 34
  • 72.29 (n)
dog
(Canis familiaris)
Mammalia DMKN 34
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DMKN 34
  • 58 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DMKN 34
  • 52 (a)
OneToOne
Species where no ortholog for DMKN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DMKN Gene

ENSEMBL:
Gene Tree for DMKN (if available)
TreeFam:
Gene Tree for DMKN (if available)

Paralogs for DMKN Gene

No data available for Paralogs for DMKN Gene

Variants for DMKN Gene

Sequence variations from dbSNP and Humsavar for DMKN Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
VAR_042720 A colorectal cancer sample p.Ala13Asp
rs1000069130 -- 35,508,695(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000884190 -- 35,509,538(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000953684 -- 35,515,197(-) C/A upstream_transcript_variant
rs1001015825 -- 35,503,766(-) G/A genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DMKN Gene

Variant ID Type Subtype PubMed ID
dgv1040e212 CNV loss 25503493
esv1008611 CNV deletion 20482838
esv2718494 CNV deletion 23290073
esv2718495 CNV deletion 23290073
esv2718497 CNV deletion 23290073
esv3222023 CNV deletion 24192839
esv3556330 CNV deletion 23714750
nsv1116326 CNV deletion 24896259
nsv1116615 CNV deletion 24896259
nsv138144 CNV deletion 16902084
nsv833811 CNV gain 17160897
nsv978907 CNV duplication 23825009

Variation tolerance for DMKN Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.00; 93.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DMKN Gene

Human Gene Mutation Database (HGMD)
DMKN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DMKN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMKN Gene

Disorders for DMKN Gene

Additional Disease Information for DMKN

No disorders were found for DMKN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DMKN Gene

Publications for DMKN Gene

  1. The human dermokine gene: description of novel isoforms with different tissue-specific expression and subcellular location. (PMID: 16374476) Toulza E … Guerrin M (The Journal of investigative dermatology 2006) 2 3 4 58
  2. Dermokine: an extensively differentially spliced gene expressed in epithelial cells. (PMID: 17380110) Naso MF … Amegadzie BY (The Journal of investigative dermatology 2007) 3 4 58
  3. Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1. (PMID: 15234001) Matsui T … Tsukita S (Genomics 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for DMKN Gene

Sources for DMKN Gene

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