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Aliases for DMC1 Gene

Aliases for DMC1 Gene

  • DNA Meiotic Recombinase 1 2 3 5
  • DMC1H 3 4
  • LIM15 3 4
  • DMC1 (Dosage Suppressor Of Mck1, Yeast Homolog) Meiosis-Specific Homologous Recombination 2
  • DMC1 Dosage Suppressor Of Mck1 Homolog, Meiosis-Specific Homologous Recombination (Yeast) 2
  • DMC1 Dosage Suppressor Of Mck1 Homolog, Meiosis-Specific Homologous Recombination 3
  • Meiotic Recombination Protein DMC1/LIM15 Homolog 3
  • Disrupted Meiotic CDNA1, Yeast, Homolog Of 3
  • DJ199H16.1 3

External Ids for DMC1 Gene

Previous GeneCards Identifiers for DMC1 Gene

  • GC22M035529
  • GC22M037157
  • GC22M037239
  • GC22M038914
  • GC22M021880
  • GC22M038518
  • GC22M038622
  • GC22M038814
  • GC22M039934
  • GC22M040622
  • GC22M041064
  • GC22M041465
  • GC22M041876

Summaries for DMC1 Gene

Entrez Gene Summary for DMC1 Gene

  • This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for DMC1 Gene

DMC1 (DNA Meiotic Recombinase 1) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Meiosis. Gene Ontology (GO) annotations related to this gene include nucleotide binding and DNA-dependent ATPase activity.

UniProtKB/Swiss-Prot for DMC1 Gene

  • May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.

Gene Wiki entry for DMC1 Gene

Additional gene information for DMC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMC1 Gene

Genomics for DMC1 Gene

GeneHancer (GH) Regulatory Elements for DMC1 Gene

Promoters and enhancers for DMC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J038567 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.9 898 4.7 PKNOX1 GLI4 ZNF2 YY1 ZNF213 E2F8 KLF7 ATF7 RUNX3 ZNF263 DMC1 LOC105373031 FAM227A DDX17 SNORD83B RPL3 JOSD1 TAB1 PLA2G6 ENSG00000230149
GH22J038549 Enhancer 0.9 Ensembl ENCODE 0.3 +20.3 20286 1.2 ESRRA NEUROD1 BMI1 ZSCAN5C ATF7 RCOR1 IKZF2 SMARCE1 SRF ZNF521 KDELR3 KCNJ4 CSNK1E DMC1 GC22P038507
GH22J038550 Enhancer 0.7 ENCODE 0.3 +21.0 21015 0.2 ESRRA NEUROD1 CTBP1 GATA3 ZSCAN5C RCOR1 TCF7L2 SMARCE1 ZNF521 DPF2 KDELR3 KCNJ4 CSNK1E DMC1 GC22P038507
GH22J038531 Enhancer 0.6 Ensembl ENCODE 0.3 +38.4 38441 1.5 HMBOX1 SPI1 KDELR3 KCNJ4 GC22P038507 DMC1
GH22J038512 Enhancer 0.7 ENCODE 0.2 +56.7 56741 1.1 ELF3 CTCF IRF2 KLF1 SAP130 ARID4B SIN3A ZIC2 RAD21 TEAD3 JOSD1 GC22P038507 DMC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DMC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DMC1 gene promoter:
  • Sox9
  • C/EBPalpha
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • E2F-1
  • E2F
  • STAT5B
  • aMEF-2

Genomic Locations for DMC1 Gene

Genomic Locations for DMC1 Gene
61,133 bases
Minus strand
51,338 bases
Minus strand

Genomic View for DMC1 Gene

Genes around DMC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DMC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DMC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DMC1 Gene

Proteins for DMC1 Gene

  • Protein details for DMC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Meiotic recombination protein DMC1/LIM15 homolog
    Protein Accession:
    Secondary Accessions:
    • A8K9A2
    • B4DMW6
    • Q08AI1
    • Q99498
    • Q9UH11

    Protein attributes for DMC1 Gene

    340 amino acids
    Molecular mass:
    37681 Da
    Quaternary structure:
    • Interacts with the MND1-PSMC3IP heterodimer (By similarity). Double stacked ring-shaped homooctamer. Interacts with BRCA2.

    Three dimensional structures from OCA and Proteopedia for DMC1 Gene

    Alternative splice isoforms for DMC1 Gene


neXtProt entry for DMC1 Gene

Post-translational modifications for DMC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DMC1 Gene

Domains & Families for DMC1 Gene

Gene Families for DMC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DMC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RecA family. DMC1 subfamily.
  • Belongs to the RecA family. DMC1 subfamily.
genes like me logo Genes that share domains with DMC1: view

Function for DMC1 Gene

Molecular function for DMC1 Gene

UniProtKB/Swiss-Prot Function:
May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
GENATLAS Biochemistry:
DMC1,dosage suppressor of MCK1,S cerevisiae homolog,E Coli Rec-A like gene,forming mixed complexes with RAD51 associated with mouse meiotic chromosomes core and synaptonemal complexes,meiosis-specific homologous recombination gene

Phenotypes From GWAS Catalog for DMC1 Gene

Gene Ontology (GO) - Molecular Function for DMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000150 recombinase activity IBA --
GO:0000166 nucleotide binding IEA --
GO:0000400 four-way junction DNA binding IBA --
GO:0003677 DNA binding TAS,IEA 8602360
GO:0003690 double-stranded DNA binding IBA --
genes like me logo Genes that share ontologies with DMC1: view
genes like me logo Genes that share phenotypes with DMC1: view

Animal Models for DMC1 Gene

MGI Knock Outs for DMC1:

Animal Model Products

CRISPR Products

Targeted motifs for DMC1 Gene
HOMER Transcription Factor Regulatory Elements motif DMC1
  • Consensus sequence: ACTYKNATTCGTGNTACTTC Submotif: canonical Cell Type: Testis GEO ID: GSE24438

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DMC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA and Transcription Factor Targets for DMC1 Gene

Localization for DMC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DMC1 Gene

Nucleus. Chromosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DMC1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA --
GO:0000794 condensed nuclear chromosome IBA --
GO:0005634 nucleus IDA 22899867
GO:0005654 nucleoplasm IBA --
GO:0005657 replication fork IBA --
genes like me logo Genes that share ontologies with DMC1: view

Pathways & Interactions for DMC1 Gene

genes like me logo Genes that share pathways with DMC1: view

Pathways by source for DMC1 Gene

1 BioSystems pathway for DMC1 Gene
3 Reactome pathways for DMC1 Gene

Gene Ontology (GO) - Biological Process for DMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000707 meiotic DNA recombinase assembly IBA --
GO:0000730 DNA recombinase assembly IBA --
GO:0001541 ovarian follicle development IEA --
GO:0001556 oocyte maturation IEA --
GO:0006259 DNA metabolic process IEA --
genes like me logo Genes that share ontologies with DMC1: view

No data available for SIGNOR curated interactions for DMC1 Gene

Drugs & Compounds for DMC1 Gene

(3) Drugs for DMC1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Imidazole Experimental, Investigational Pharma Target 37
genes like me logo Genes that share compounds with DMC1: view

Transcripts for DMC1 Gene

mRNA/cDNA for DMC1 Gene

(9) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DMC1 Gene

DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DMC1

Alternative Splicing Database (ASD) splice patterns (SP) for DMC1 Gene

No ASD Table

Relevant External Links for DMC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DMC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DMC1 Gene

mRNA differential expression in normal tissues according to GTEx for DMC1 Gene

This gene is overexpressed in Testis (x13.9).

Protein differential expression in normal tissues from HIPED for DMC1 Gene

This gene is overexpressed in Ovary (28.2), Fetal ovary (26.8), and Testis (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DMC1 Gene

Protein tissue co-expression partners for DMC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DMC1 Gene:


SOURCE GeneReport for Unigene cluster for DMC1 Gene:


Evidence on tissue expression from TISSUES for DMC1 Gene

  • Heart(4.1)
genes like me logo Genes that share expression patterns with DMC1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DMC1 Gene

Orthologs for DMC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DMC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DMC1 34 33
  • 99.71 (n)
(Canis familiaris)
Mammalia DMC1 34 33
  • 94.71 (n)
(Bos Taurus)
Mammalia DMC1 34 33
  • 94.31 (n)
(Monodelphis domestica)
Mammalia DMC1 34
  • 94 (a)
(Mus musculus)
Mammalia Dmc1 16 34 33
  • 91.96 (n)
(Rattus norvegicus)
Mammalia Dmc1 33
  • 91.67 (n)
(Ornithorhynchus anatinus)
Mammalia DMC1 34
  • 88 (a)
(Gallus gallus)
Aves DMC1 34 33
  • 82.54 (n)
(Anolis carolinensis)
Reptilia DMC1 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dmc1 33
  • 79.23 (n)
(Danio rerio)
Actinopterygii dmc1 34 33
  • 74.16 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11957g 33
  • 58.86 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DMC1 36 34 33
  • 58.52 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR101C 33
  • 57.25 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons DMC1 33
  • 60.29 (n)
(Glycine max)
eudicotyledons Gma.8429 33
(Oryza sativa)
Liliopsida Os12g0143800 33
  • 60.68 (n)
(Hordeum vulgare)
Liliopsida Hv.2446 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 77 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dmc1 33
  • 59.24 (n)
Species where no ortholog for DMC1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DMC1 Gene

Gene Tree for DMC1 (if available)
Gene Tree for DMC1 (if available)
Evolutionary constrained regions (ECRs) for DMC1: view image

Paralogs for DMC1 Gene

(1) SIMAP similar genes for DMC1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DMC1: view

No data available for Paralogs for DMC1 Gene

Variants for DMC1 Gene

Sequence variations from dbSNP and Humsavar for DMC1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000021132 -- 38,558,809(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000026804 -- 38,544,478(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000097479 -- 38,552,183(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000099582 -- 38,518,381(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000132675 -- 38,509,007(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DMC1 Gene

Variant ID Type Subtype PubMed ID
esv1003190 OTHER inversion 20482838
esv28829 CNV loss 19812545
esv3647737 CNV loss 21293372
nsv1131658 CNV deletion 24896259
nsv1136678 CNV deletion 24896259
nsv3624 CNV deletion 18451855

Variation tolerance for DMC1 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DMC1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DMC1 Gene

Disorders for DMC1 Gene

Additional Disease Information for DMC1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DMC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DMC1 Gene

Publications for DMC1 Gene

  1. The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis. (PMID: 8602360) Habu T … Morita T (Nucleic acids research 1996) 2 3 4 22 58
  2. Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1. (PMID: 17541404) Thorslund T … West SC (The EMBO journal 2007) 2 3 22 58
  3. Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1. (PMID: 15125839) Kinebuchi T … Yokoyama S (Molecular cell 2004) 3 4 22 58
  4. Expression profiles of a human gene identified as a structural homologue of meiosis-specific recA-like genes. (PMID: 8590282) Sato S … Tabata S (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 2 3 4 58
  5. Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. (PMID: 19714462) Loizidou MA … Kyriacou K (Breast cancer research and treatment 2010) 3 44 58

Products for DMC1 Gene

Sources for DMC1 Gene

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