Aliases for DMBX1 Gene
External Ids for DMBX1 Gene
Previous HGNC Symbols for DMBX1 Gene
Previous GeneCards Identifiers for DMBX1 Gene
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DMBX1 Gene
DMBX1 (Diencephalon/Mesencephalon Homeobox 1) is a Protein Coding gene. Diseases associated with DMBX1 include Farsightedness and Strabismus. Among its related pathways are Neural Crest Differentiation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ARX.
UniProtKB/Swiss-Prot Summary for DMBX1 Gene
Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development (By similarity).