Aliases for DMAP1 Gene
Aliases for DMAP1 Gene
External Ids for DMAP1 Gene
- HGNC: 18291
- Entrez Gene: 55929
- Ensembl: ENSG00000178028
- OMIM: 605077
- UniProtKB: Q9NPF5
Previous GeneCards Identifiers for DMAP1 Gene
- GC01U990334
- GC01P043680
- GC01P044108
- GC01P044092
- GC01P044348
- GC01P044451
- GC01P044680
- GC01P042792
Summaries for DMAP1 Gene
-
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for DMAP1 Gene
DMAP1 (DNA Methyltransferase 1 Associated Protein 1) is a Protein Coding gene. Diseases associated with DMAP1 include X-Linked Hereditary Ataxia and Fragile X-Associated Tremor/Ataxia Syndrome. Among its related pathways are Chromatin organization and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include chromatin binding and RNA polymerase II repressing transcription factor binding.
UniProtKB/Swiss-Prot for DMAP1 Gene
-
Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DMAP1 Gene
Genomics for DMAP1 Gene
GeneHancer (GH) Regulatory Elements for DMAP1 Gene
Promoters and enhancers for DMAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around DMAP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DMAP1 gene promoter:
-
- Pax-5
- c-Ets-1
- CREB
- deltaCREB
- N-Myc
- ATF
- AML1a
Regulatory Element Products
Genomic Locations for DMAP1 Gene
Genomic Locations for DMAP1 Gene
- chr1:44,213,432-44,220,681
- (GRCh38/hg38)
- Size:
- 7,250 bases
- Orientation:
- Plus strand
- chr1:44,679,125-44,686,353
- (GRCh37/hg19)
- Size:
- 7,229 bases
- Orientation:
- Plus strand
Genomic View for DMAP1 Gene
Genes around DMAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.1 by Entrez Gene
- 1p34.1 by HGNC
- 1p34.1 by Ensembl
DMAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DMAP1 Gene
Proteins for DMAP1 Gene
-
Protein details for DMAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NPF5-DMAP1_HUMAN
- Recommended name:
- DNA methyltransferase 1-associated protein 1
- Protein Accession:
- Q9NPF5
- A8K001
- D3DPY8
- Q0JSM4
- Q5TG41
- Q7Z3H7
- Q9H0S8
- Q9P2C2
Protein attributes for DMAP1 Gene
- Size:
- 467 amino acids
- Molecular mass:
- 52993 Da
- Quaternary structure:
-
- Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. DMAP1 also forms a complex with DNMT1 and HDAC2. Throughout S phase it interacts directly with the N-terminus of DNMT1, which serves to recruit DMAP1 to replication foci. DMAP1 interacts with ING1, a component of the mSin3A transcription repressor complex, although this interaction is not required for recruitment of ING1 to heterochromatin. Interacts directly with the transcriptional corepressor TSG101. Interacts with the pro-apoptotic protein DAXX. Interacts with URI1.
- SequenceCaution:
-
- Sequence=BAA92663.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for DMAP1 Gene
Post-translational modifications for DMAP1 Gene
Other Protein References for DMAP1 Gene
Antibody Products
- Novus Biologicals Antibodies for DMAP1
-
Abcam antibodies for DMAP1
- Invitrogen Antibodies for DMAP1 (AFLGC-DMAP1)
- GeneTex DMAP1 Antibody for DMAP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for DMAP1
Protein Products
-
OriGene Purified Proteins for DMAP1
- Search Origene for MassSpec and Protein Over-expression Lysates for DMAP1
- Origene Custom Protein Services for DMAP1
- antibodies-online: Search results for 4 available DMAP1 Proteins ranked by validation data
- Compare Top DMAP1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for DMAP1
-
Abcam proteins for DMAP1
Assay Products
- antibodies-online: Search results for 2 available DMAP1 Elisa Kits ranked by validation data
- Compare Top DMAP1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for DMAP1 Gene
Domains & Families for DMAP1 Gene
Gene Families for DMAP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for DMAP1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DMAP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for DMAP1 Gene
Function for DMAP1 Gene
Molecular function for DMAP1 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.
Phenotypes From GWAS Catalog for DMAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISA | -- |
| GO:0001103 | RNA polymerase II repressing transcription factor binding | IDA | 15367675 |
| GO:0003714 | transcription corepressor activity | IBA,IEA | -- |
| GO:0005515 | protein binding | IPI | 15367675 |
Phenotypes for DMAP1 Gene
- MGI mutant phenotypes for DMAP1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for DMAP1:
-
- Increased G1 DNA content
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased homologous recombination repair frequency
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased viability in esophageal squamous lineage
- Increased circadian period length
- Increased Nanog expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
- Decreased influenza A/WSN/33 replication
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Models for DMAP1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DMAP1
-
CRISPR Products
-
OriGene CRISPR knockouts for DMAP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DMAP1
- genomics-online: gRNA clones - Search results for available DMAP1 gene related products
- Applied Biological Materials CRISPR for DMAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DMAP1
- GenScript: Design CRISPR guide RNA sequences for DMAP1
miRNA for DMAP1 Gene
- miRTarBase miRNAs that target DMAP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DMAP1
- Browse OriGene Inhibitory RNA Products For DMAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DMAP1
- genomics-online: shRNA clones - Search results for available DMAP1 gene related products
Clone Products
-
OriGene ORF clones in human for DMAP1
- RC201071
- RC201071L1
- RC201071L2
- RC201071L3
- RC201071L4
- RC203614
- RC203614L1
- RC203614L2
- RC203614L3
- RC203614L4
- RC222239
- RC222239L1
- RC222239L2
- RC222239L3
- RC222239L4
- RC501071
- RC522239
- RG201071
- RG203614
- RG222239
- RC201071L1V
- RC201071L2V
- RC201071L3V
- RC201071L4V
- RC203614L1V
- RC203614L2V
- RC203614L3V
- RC203614L4V
- RC222239L1V
- RC222239L2V
- RC222239L3V
- RC222239L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DMAP1
- Addgene plasmids for DMAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DMAP1
- genomics-online: cdna clones - Search results for available DMAP1 gene related products
- orf clones - Search results for available DMAP1 gene related products
- Applied Biological Materials Clones for DMAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DMAP1 Gene
Localization for DMAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DMAP1 Gene
- Nucleus. Cytoplasm. Note=Targeted to replication foci throughout S phase by DNMT1.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | NAS | 10888872 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005657 | replication fork | IEA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 15367675 |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for DMAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin organization | ||
| 2 | Chromatin Regulation / Acetylation | ||
| 3 | DNA Damage | ||
Pathways by source for DMAP1 Gene
3 Reactome pathways for DMAP1 Gene
2 Cell Signaling Technology pathways for DMAP1 Gene
Interacting Proteins for DMAP1 Gene
Selected Interacting proteins:
ENSP00000312697
Q9NPF5-DMAP1_HUMAN
for DMAP1 Gene via
STRING
MINT
IID
GPS-Prot Interaction Network for DMAP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 15367675 |
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006306 | DNA methylation | TAS | 10888872 |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006338 | chromatin remodeling | IEA | -- |
No data available for SIGNOR curated interactions for DMAP1 Gene
Transcripts for DMAP1 Gene
mRNA/cDNA for DMAP1 Gene
- (7) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (347) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000361745 1545 bps (uc001clq.2)
- ENST00000446292 1066 bps (uc057fth.1)
- ENST00000440641 909 bps (uc057fti.1)
- ENST00000436069 599 bps (uc057ftj.1)
- ENST00000437511 957 bps (uc057ftk.1)
Unigene Clusters for DMAP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DMAP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DMAP1
- genomics-online: gRNA clones - Search results for available DMAP1 gene related products
- Applied Biological Materials CRISPR for DMAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DMAP1
- GenScript: Design CRISPR guide RNA sequences for DMAP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DMAP1
- Browse OriGene Inhibitory RNA Products For DMAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DMAP1
- genomics-online: shRNA clones - Search results for available DMAP1 gene related products
Clone Products
-
OriGene ORF clones in human for DMAP1
- RC201071
- RC201071L1
- RC201071L2
- RC201071L3
- RC201071L4
- RC203614
- RC203614L1
- RC203614L2
- RC203614L3
- RC203614L4
- RC222239
- RC222239L1
- RC222239L2
- RC222239L3
- RC222239L4
- RC501071
- RC522239
- RG201071
- RG203614
- RG222239
- RC201071L1V
- RC201071L2V
- RC201071L3V
- RC201071L4V
- RC203614L1V
- RC203614L2V
- RC203614L3V
- RC203614L4V
- RC222239L1V
- RC222239L2V
- RC222239L3V
- RC222239L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DMAP1
- Addgene plasmids for DMAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DMAP1
- genomics-online: cdna clones - Search results for available DMAP1 gene related products
- orf clones - Search results for available DMAP1 gene related products
- Applied Biological Materials Clones for DMAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ |
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| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
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| SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP23: |
| ExUns: | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP3: | |||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||
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| SP6: | |||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||
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| SP22: | |||||||||||||||||||||||||
| SP23: |
Expression for DMAP1 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (21.5) and CD8 Tcells (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DMAP1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DMAP1 Gene:
DMAP1SOURCE GeneReport for Unigene cluster for DMAP1 Gene:
Hs.8008Evidence on tissue expression from TISSUES for DMAP1 Gene
- Nervous system(4.8)
- Skin(4.3)
- Intestine(4.2)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for DMAP1
-
OriGene qPCR primer pairs and template standards for DMAP1
- genomics-online: primer clones - Search results for available DMAP1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DMAP1 Gene
Orthologs for DMAP1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DMAP1 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | DMAP1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DMAP1 34 33 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | DMAP1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Dmap1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dmap1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DMAP1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DMAP1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DMAP1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dmap1 33 |
|
||
| Str.296 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3244 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dmap1 34 33 |
|
OneToOne | |
| zgc55593 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | DMAP1 34 33 |
|
OneToOne | |
| CG11132 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007387 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | ekl-4 34 33 |
|
OneToOne | |
| Y105E8A.17 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SWC4 36 36 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT2G47210 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os05g0540800 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| Cin.1946 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.1946 33 |
|
- Species where no ortholog for DMAP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for DMAP1 Gene
- ENSEMBL:
- Gene Tree for DMAP1 (if available)
- TreeFam:
- Gene Tree for DMAP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DMAP1: view image
Paralogs for DMAP1 Gene
No data available for Paralogs for DMAP1 Gene
Variants for DMAP1 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000046346 | -- | 44,220,156(+) | A/G | coding_sequence_variant, synonymous_variant | |
| rs1000541562 | -- | 44,221,045(+) | G/A | downstream_transcript_variant | |
| rs1002855111 | -- | 44,216,258(+) | C/G | intron_variant | |
| rs1003506469 | -- | 44,216,245(+) | TTT/ | intron_variant | |
| rs1004209386 | -- | 44,214,100(+) | T/C | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
Residual Variation Intolerance Score:
24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.36;
26.91% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DMAP1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DMAP1 Gene
Disorders for DMAP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| x-linked hereditary ataxia |
|
|
| fragile x-associated tremor/ataxia syndrome |
|
|
Search DMAP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DMAP1
No data available for UniProtKB/Swiss-Prot and Genatlas for DMAP1 Gene
Publications for DMAP1 Gene
- DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. (PMID: 10888872) Rountree MR … Baylin SB (Nature genetics 2000) 2 3 4 22 58
- Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells. (PMID: 14665632) Xin H … Qin J (The Journal of biological chemistry 2004) 3 4 22 58
- Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PMID: 12963728) Cai Y … Conaway JW (The Journal of biological chemistry 2003) 3 4 22 58
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
Products for DMAP1 Gene
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- antibodies-online: Search results for 60 available DMAP1 Antibodies ranked by validation data
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- GeneTex DMAP1 Antibody for DMAP1
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Sources for DMAP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt