Aliases for DLX2 Gene
Aliases for DLX2 Gene
External Ids for DLX2 Gene
- HGNC: 2915
- Entrez Gene: 1746
- Ensembl: ENSG00000115844
- OMIM: 126255
- UniProtKB: Q07687
Previous GeneCards Identifiers for DLX2 Gene
- GC02M171016
- GC02M171625
- GC02M172929
- GC02M173166
- GC02M172789
- GC02M172672
- GC02M164844
- GC02M172964
Summaries for DLX2 Gene
-
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]
GeneCards Summary for DLX2 Gene
DLX2 (Distal-Less Homeobox 2) is a Protein Coding gene. Diseases associated with DLX2 include Tooth Agenesis and Split-Hand/Foot Malformation 5. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is DLX5.
UniProtKB/Swiss-Prot for DLX2 Gene
-
Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLX2 Gene
Genomics for DLX2 Gene
GeneHancer (GH) Regulatory Elements for DLX2 Gene
Promoters and enhancers for DLX2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DLX2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DLX2 gene promoter:
Regulatory Element Products
Genomic Locations for DLX2 Gene
Genomic Locations for DLX2 Gene
- chr2:172,099,438-172,102,900
- (GRCh38/hg38)
- Size:
- 3,463 bases
- Orientation:
- Minus strand
- chr2:172,964,166-172,967,628
- (GRCh37/hg19)
Genomic View for DLX2 Gene
Genes around DLX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q31.1 by Entrez Gene
- 2q31.1 by HGNC
- 2q31.1 by Ensembl
DLX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DLX2 Gene
Proteins for DLX2 Gene
-
Protein details for DLX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q07687-DLX2_HUMAN
- Recommended name:
- Homeobox protein DLX-2
- Protein Accession:
- Q07687
- B4DMK4
- B7ZA14
Protein attributes for DLX2 Gene
- Size:
- 328 amino acids
- Molecular mass:
- 34243 Da
- Quaternary structure:
-
- Interacts (via homeobox DNA-binding domain) with POU4F2; this interaction enhances retinal ganglion cell (RGC) differentiation.
Protein Expression for DLX2 Gene
Post-translational modifications for DLX2 Gene
Other Protein References for DLX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DLX2
- Novus Biologicals Antibodies for DLX2
- Invitrogen Antibodies for DLX2
- antibodies-online: Search results for available DLX2 related products ranked by validation data
- GeneTex DLX2 Antibody for DLX2
-
Santa Cruz Biotechnology (SCBT) Antibodies for DLX2
Protein Products
-
OriGene Purified Proteins for DLX2
- Search Origene for MassSpec and Protein Over-expression Lysates for DLX2
- Origene Custom Protein Services for DLX2
- antibodies-online: Search results for available DLX2 related products ranked by validation data
- Search GeneTex for Proteins for DLX2
Assay Products
- antibodies-online: Search results for available DLX2 related products ranked by validation data
No data available for DME Specific Peptides for DLX2 Gene
Domains & Families for DLX2 Gene
Gene Families for DLX2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for DLX2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for DLX2 Gene
Graphical View of Domain Structure for InterPro Entry
Q07687- Family:
-
- Belongs to the distal-less homeobox family.
Function for DLX2 Gene
Molecular function for DLX2 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
- GENATLAS Biochemistry:
- Drosophila distal less homolog Dlx2,homeo domain encoding gene,expressed in the forebrain,facial and limb primordia
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
Phenotypes for DLX2 Gene
- MGI mutant phenotypes for DLX2:
-
inferred from 3 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- craniofacial phenotype
- skeleton phenotype
- hearing/vestibular/ear phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for DLX2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DLX2
-
CRISPR Products
-
OriGene CRISPR knockouts for DLX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLX2
- genomics-online: gRNA clones - Search results for available DLX2 gene related products
- Applied Biological Materials CRISPR for DLX2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DLX2
- GenScript: Design CRISPR guide RNA sequences for DLX2
miRNA for DLX2 Gene
- miRTarBase miRNAs that target DLX2
-
- hsa-mir-1296-5p (MIRT036105)
- hsa-mir-324-3p (MIRT042820)
- hsa-mir-331-3p (MIRT043264)
- hsa-mir-6781-5p (MIRT494115)
- hsa-mir-7106-5p (MIRT494116)
- hsa-mir-6797-5p (MIRT494117)
- hsa-mir-765 (MIRT494118)
- hsa-mir-1249-5p (MIRT494119)
- hsa-mir-4707-5p (MIRT494120)
- hsa-mir-6822-5p (MIRT494121)
- hsa-mir-6750-5p (MIRT494122)
- hsa-mir-4779 (MIRT494123)
- hsa-mir-1185-2-3p (MIRT567731)
- hsa-mir-1185-1-3p (MIRT567732)
- hsa-let-7f-2-3p (MIRT567733)
- hsa-mir-4789-5p (MIRT567734)
- hsa-mir-98-3p (MIRT567735)
- hsa-let-7f-1-3p (MIRT567736)
- hsa-let-7b-3p (MIRT567737)
- hsa-let-7a-3p (MIRT567738)
- hsa-mir-496 (MIRT567739)
- hsa-mir-4766-5p (MIRT567740)
- hsa-mir-194-3p (MIRT567741)
- hsa-mir-5693 (MIRT567742)
- hsa-mir-5094 (MIRT567743)
- hsa-mir-4666a-3p (MIRT567744)
- hsa-mir-381-3p (MIRT567745)
- hsa-mir-300 (MIRT567746)
- hsa-mir-551b-5p (MIRT567747)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DLX2
- Browse OriGene Inhibitory RNA Products For DLX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLX2
- genomics-online: shRNA clones - Search results for available DLX2 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for DLX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DLX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DLX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLX2
- genomics-online: cdna clones - Search results for available DLX2 gene related products
- orf clones - Search results for available DLX2 gene related products
- Applied Biological Materials Clones for DLX2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DLX2
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DLX2 Gene
Localization for DLX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DLX2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 1 |
- Nuclear speckles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for DLX2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Preimplantation Embryo | ||
| 2 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways | ||
Pathways by source for DLX2 Gene
2 BioSystems pathways for DLX2 Gene
Interacting Proteins for DLX2 Gene
Selected Interacting proteins:
Q07687-DLX2_HUMAN
ENSP00000234198
for DLX2 Gene via
IID
UniProtKB
STRING
GPS-Prot Interaction Network for DLX2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
No data available for SIGNOR curated interactions for DLX2 Gene
Transcripts for DLX2 Gene
mRNA/cDNA for DLX2 Gene
- (18) Selected AceView cDNA sequences:
- (6) Additional mRNA sequences :
- (1) REFSEQ mRNAs :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000234198 2453 bps (uc002uhn.4)
- ENST00000466293 1852 bps (uc010zdx.2)
CRISPR Products
-
OriGene CRISPR knockouts for DLX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLX2
- genomics-online: gRNA clones - Search results for available DLX2 gene related products
- Applied Biological Materials CRISPR for DLX2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DLX2
- GenScript: Design CRISPR guide RNA sequences for DLX2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DLX2
- Browse OriGene Inhibitory RNA Products For DLX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLX2
- genomics-online: shRNA clones - Search results for available DLX2 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for DLX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DLX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DLX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLX2
- genomics-online: cdna clones - Search results for available DLX2 gene related products
- orf clones - Search results for available DLX2 gene related products
- Applied Biological Materials Clones for DLX2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for DLX2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Deep Cerebellar Nucleus
- Striatum
- Cerebellum
- Endothelial Cells Blood Brain Barrier
- Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
-
Tooth (Integumentary System)
- Ameloblasts Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
- Stellate Reticulum Cells Dental Core
- Inner Enamel Epithelial Cells Dental Enamel
- Dental Mesenchymal Cells Branchial Arch 1
-
Neural Tube (Nervous System)
- Diencephalon
- Telencephalon
- Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
- Caudal Ganglionic Eminence Progenitor Cells Caudal Ganglionic Eminence
- Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
-
Eye (Sensory Organs)
- Mature Horizontal Cells Inner Nuclear Layer
- Mature Ganglion Cells Ganglion Cell Layer
- Dopaminergic Amacrine Cells Inner Nuclear Layer
- Dopaminergic Amacrine Cells Ganglion Cell Layer
-
Epithelial Cells
- Outer Enamel Epithelial Cells Dental Enamel
- Inner Enamel Epithelial Cells Dental Enamel
- Dental Placode Cells Dental Placode
- Early Ameloblasts Dental Enamel
-
Head Mesenchyme (Muscoskeletal System)
- Cranial Neural Crest Cells Branchial Arch 2
- Dental Mesenchymal Cells Branchial Arch 1
- Diencephalic Neural Crest Cells Prechordal Mesenchyme
- Mesencephalic Neural Crest Cells Prechordal Mesenchyme
-
Neurons
- Mature Ganglion Cells Ganglion Cell Layer
- Dopaminergic Amacrine Cells Inner Nuclear Layer
- Dopaminergic Amacrine Cells Ganglion Cell Layer
- Mature Horizontal Cells Inner Nuclear Layer
-
Neural Crest (Gastrulation Derivatives)
- Cranial Neural Crest Cells Branchial Arch 2
- Diencephalic Neural Crest Cells Prechordal Mesenchyme
- Mesencephalic Neural Crest Cells Prechordal Mesenchyme
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
- Mature Endothelial Cells Blood Brain Barrier
- Gut Tube (Gastrointestinal Tract)
-
Heart (Cardiovascular System)
- Cardiac Crescent Cells Cardiac Crescent
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
mRNA differential expression in normal tissues according to GTEx for DLX2 Gene
This gene is overexpressed in Brain - Hypothalamus (x7.6), Brain - Anterior cingulate cortex (BA24) (x4.7), and Brain - Cortex (x4.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DLX2 Gene
NURSA nuclear receptor signaling pathways regulating expression of DLX2 Gene:
DLX2SOURCE GeneReport for Unigene cluster for DLX2 Gene:
Hs.419Evidence on tissue expression from TISSUES for DLX2 Gene
- Nervous system(4.5)
- Intestine(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for DLX2
-
OriGene qPCR primer pairs for DLX2
- genomics-online: primer clones - Search results for available DLX2 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DLX2 Gene
Orthologs for DLX2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DLX2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DLX2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DLX2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Dlx2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dlx2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DLX2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | DLX2 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DLX2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dlx2 33 |
|
||
| Str.9796 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.721 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dlx2a 34 33 33 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3918 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Dll 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | ceh-43 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| CSA.6494 34 |
|
ManyToMany |
- Species where no ortholog for DLX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for DLX2 Gene
- ENSEMBL:
- Gene Tree for DLX2 (if available)
- TreeFam:
- Gene Tree for DLX2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DLX2: view image
Paralogs for DLX2 Gene
Variants for DLX2 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000356188 | -- | 172,099,263(-) | C/G/T | downstream_transcript_variant | |
| rs1001472089 | -- | 172,101,303(-) | C/ | intron_variant | |
| rs1001589175 | -- | 172,100,824(-) | A/G | coding_sequence_variant, missense_variant | |
| rs1002206531 | -- | 172,099,249(-) | G/A | downstream_transcript_variant | |
| rs1002856405 | -- | 172,102,576(-) | T/A | 5_prime_UTR_variant |
Residual Variation Intolerance Score:
63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.86;
58.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DLX2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DLX2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DLX2 Gene
Disorders for DLX2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| tooth agenesis |
|
|
| split-hand/foot malformation 5 |
|
|
| hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate |
|
|
| split-hand/foot malformation 2 |
|
|
| split-hand/foot malformation 4 |
|
|
Search DLX2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DLX2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for DLX2 Gene
Publications for DLX2 Gene
- The DLX1and DLX2 genes and susceptibility to autism spectrum disorders. (PMID: 18728693) Liu X … Holden JJ (European journal of human genetics : EJHG 2009) 3 22 44 58
- Cloning and characterization of two members of the vertebrate Dlx gene family. (PMID: 7907794) Simeone A … Huebner K (Proceedings of the National Academy of Sciences of the United States of America 1994) 3 4 22 58
- The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue. (PMID: 7901126) Selski DJ … Rogers KE (Gene 1993) 3 4 22 58
- DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2. (PMID: 1354641) Ozçelik T … Francke U (Genomics 1992) 2 3 22 58
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 44 58
Products for DLX2 Gene
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- VectorBuilder custom plasmid, inducible vectors for DLX2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DLX2
- antibodies-online: Search results for available DLX2 related products ranked by validation data
- antibodies-online: Search results for available DLX2 related products ranked by validation data
- antibodies-online: Search results for available DLX2 related products ranked by validation data
- GeneTex DLX2 Antibody for DLX2
- Search GeneTex for Proteins for DLX2
- Santa Cruz Biotechnology (SCBT) Antibodies for DLX2
- Search Santa Cruz Biotechnology (SCBT) for DLX2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DLX2
- Horizon Cell Lines for DLX2
- genomics-online: cdna clones - Search results for available DLX2 gene related products
- orf clones - Search results for available DLX2 gene related products
- genomics-online: gRNA clones - Search results for available DLX2 gene related products
- genomics-online: primer clones - Search results for available DLX2 gene related products
- genomics-online: shRNA clones - Search results for available DLX2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLX2
- GeneCopoeia miRNA 3'UTR Target clone products for DLX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLX2
Sources for DLX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio