Aliases for DLX2 Gene
External Ids for DLX2 Gene
Previous GeneCards Identifiers for DLX2 Gene
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]
GeneCards Summary for DLX2 Gene
DLX2 (Distal-Less Homeobox 2) is a Protein Coding gene. Diseases associated with DLX2 include Axenfeld-Rieger Syndrome and Dental Fluorosis. Among its related pathways are Preimplantation Embryo and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is DLX5.
UniProtKB/Swiss-Prot Summary for DLX2 Gene
Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.