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Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different memb... See more...
Aliases for DLX2 Gene
Aliases for DLX2 Gene
External Ids for DLX2 Gene
- HGNC: 2915
- Entrez Gene: 1746
- Ensembl: ENSG00000115844
- OMIM: 126255
- UniProtKB: Q07687
Previous GeneCards Identifiers for DLX2 Gene
- GC02M171016
- GC02M171625
- GC02M172929
- GC02M173166
- GC02M172789
- GC02M172672
- GC02M164844
- GC02M172964
Summaries for DLX2 Gene
-
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]
GeneCards Summary for DLX2 Gene
DLX2 (Distal-Less Homeobox 2) is a Protein Coding gene. Diseases associated with DLX2 include Axenfeld-Rieger Syndrome and Dental Fluorosis. Among its related pathways are Preimplantation Embryo and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is DLX5.
UniProtKB/Swiss-Prot Summary for DLX2 Gene
-
Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
Additional gene information for DLX2 Gene
- HGNC(2915)
- Entrez Gene(1746)
- Ensembl(ENSG00000115844)
- OMIM(126255)
- UniProtKB(Q07687)
- Open Targets Platform(ENSG00000115844)
- Search for DLX2 at DataMed
- Search for DLX2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DLX2 Gene
Genomics for DLX2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DLX2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DLX2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DLX2
- Top Transcription factor binding sites by QIAGEN in the DLX2 gene promoter:
-
- AREB6
- Arnt
- IRF-2
- MAZR
- NF-1
- NF-kappaB1
- Nkx2-5
- Nkx5-1
- POU6F1 (c2)
- RSRFC4
Genomic Locations for DLX2 Gene
Genomic Locations for DLX2 Gene
- chr2:172,099,438-172,102,900
- (GRCh38/hg38)
- Size:
- 3,463 bases
- Orientation:
- Minus strand
- chr2:172,964,166-172,967,628
- (GRCh37/hg19)
- Size:
- 3,463 bases
- Orientation:
- Minus strand
Genomic View for DLX2 Gene
Genes around DLX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q31.1 by HGNC
- 2q31.1 by Entrez Gene
- 2q31.1 by Ensembl
DLX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DLX2 Gene
Proteins for DLX2 Gene
-
Protein details for DLX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q07687-DLX2_HUMAN
- Recommended name:
- Homeobox protein DLX-2
- Protein Accession:
- Q07687
- B4DMK4
- B7ZA14
Protein attributes for DLX2 Gene
- Size:
- 328 amino acids
- Molecular mass:
- 34243 Da
- Quaternary structure:
-
- Interacts (via homeobox DNA-binding domain) with POU4F2; this interaction enhances retinal ganglion cell (RGC) differentiation.
Protein Expression for DLX2 Gene
Post-translational modifications for DLX2 Gene
Other Protein References for DLX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences DLX2 Monoclonal Antibody (LS-B5398) and DLX2 Monoclonal Antibody (LS-B5396)
- Creative Diagnostics Anti-DLX2 monoclonal antibody, clone 3I3
- Creative Biolabs Recombinant Mouse anti-Human DLX2 Monoclonal antibody (EML086)
-
Custom Antibody ServicesOriGene Antibodies for DLX2
- Novus Biologicals Antibodies for DLX2
-
Abcam antibodies for DLX2
- Invitrogen Antibodies for DLX2 (AFLGC-DLX2)
-
Boster Bio Antibodies for DLX2
-
Santa Cruz Biotechnology (SCBT) Antibodies for DLX2
Protein Products
- Creative Biomart Recombinant Human DLX2 Protein, His-tagged
-
OriGene Purified Proteins for DLX2
- Search Origene for MassSpec and Protein Over-expression Lysates for DLX2
- Origene Custom Protein Services for DLX2
-
Abcam proteins for DLX2
No data available for DME Specific Peptides for DLX2 Gene
Domains & Families for DLX2 Gene
Gene Families for DLX2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for DLX2 Gene
- InterPro:
- Blocks:
-
- Lambda and other repressor helix-turn-helix signature
- ProtoNet:
Suggested Antigen Peptide Sequences for DLX2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ79028, highly similar to Homeobox protein DLX-2 (B7ZA14_HUMAN)
- Homeobox protein DLX-2 (DLX2_HUMAN)
- cDNA FLJ75693, highly similar to Homo sapiens distal-less homeo box 2 (DLX2), mRNA (Q53QU7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q07687- Family:
-
- Belongs to the distal-less homeobox family.
Function for DLX2 Gene
Molecular function for DLX2 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
- GENATLAS Biochemistry:
- Drosophila distal less homolog Dlx2,homeo domain encoding gene,expressed in the forebrain,facial and limb primordia
Phenotypes From GWAS Catalog for DLX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA | -- |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for DLX2 Gene
- MGI mutant phenotypes for DLX2:
-
inferred from 3 alleles
- nervous system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for DLX2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DLX2 - Select products 50% OFF >
- * DLX2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DLX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLX2
-
Santa Cruz Biotechnology (SCBT) CRISPR for DLX2
miRNA for DLX2 Gene
- miRTarBase miRNAs that target DLX2
-
- mmu-miR-124-3p (MIRT005080)
- hsa-miR-1296-5p (MIRT036105)
- hsa-miR-324-3p (MIRT042820)
- hsa-miR-331-3p (MIRT043264)
- hsa-miR-6781-5p (MIRT494115)
- hsa-miR-7106-5p (MIRT494116)
- hsa-miR-6797-5p (MIRT494117)
- hsa-miR-765 (MIRT494118)
- hsa-miR-1249-5p (MIRT494119)
- hsa-miR-4707-5p (MIRT494120)
- hsa-miR-6822-5p (MIRT494121)
- hsa-miR-6750-5p (MIRT494122)
- hsa-miR-4779 (MIRT494123)
- hsa-miR-1185-2-3p (MIRT567731)
- hsa-miR-1185-1-3p (MIRT567732)
- hsa-let-7f-2-3p (MIRT567733)
- hsa-miR-4789-5p (MIRT567734)
- hsa-miR-98-3p (MIRT567735)
- hsa-let-7f-1-3p (MIRT567736)
- hsa-let-7b-3p (MIRT567737)
- hsa-let-7a-3p (MIRT567738)
- hsa-miR-496 (MIRT567739)
- hsa-miR-4766-5p (MIRT567740)
- hsa-miR-194-3p (MIRT567741)
- hsa-miR-5693 (MIRT567742)
- hsa-miR-5094 (MIRT567743)
- hsa-miR-4666a-3p (MIRT567744)
- hsa-miR-381-3p (MIRT567745)
- hsa-miR-300 (MIRT567746)
- hsa-miR-551b-5p (MIRT567747)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DLX2
- Browse OriGene Inhibitory RNA Products For DLX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLX2
Clone Products
- Applied Biological Materials (abm): Clones for DLX2 - Select products 50% OFF >
- * DLX2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DLX2
- Addgene plasmids for DLX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLX2
Cell Line Products
-
Horizon Cell Lines for DLX2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DLX2 Gene
Localization for DLX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DLX2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
- Nuclear speckles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA | 21873635 |
Pathways & Interactions for DLX2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Preimplantation Embryo | ||
| 2 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways | ||
Pathways by source for DLX2 Gene
2 BioSystems pathways for DLX2 Gene
Interacting Proteins for DLX2 Gene
Selected Interacting proteins:
Q07687-DLX2_HUMAN
ENSP00000234198
for DLX2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for DLX2
SIGNOR curated interactions for DLX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007420 | brain development | TAS | 7590232 |
Drugs & Compounds for DLX2 Gene
No Compound Related Data Available
Drug Products
- Creative Biomart Recombinant Human DLX2 Protein, His-tagged
Transcripts for DLX2 Gene
mRNA/cDNA for DLX2 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000234198 2454 nts (view in UCSC)
- ENST00000466293 1852 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DLX2 - Select products 50% OFF >
- * DLX2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DLX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLX2
-
Santa Cruz Biotechnology (SCBT) CRISPR for DLX2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DLX2
- Browse OriGene Inhibitory RNA Products For DLX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLX2
Clone Products
- Applied Biological Materials (abm): Clones for DLX2 - Select products 50% OFF >
- * DLX2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DLX2
- Addgene plasmids for DLX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLX2
Relevant External Links for DLX2 Gene
- GeneLoc Exon Structure for
- DLX2
Expression for DLX2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Lateral Ganglionic Eminence Progenitor Cells Lateral Ganglionic Eminence
- Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
- Mature Endothelial Cells Blood Brain Barrier
- Caudal Ganglionic Eminence Progenitor Cells Caudal Ganglionic Eminence
- Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
-
Tooth (Integumentary System)
- Early Ameloblasts Dental Enamel
- Dental Placode Cells Dental Placode
- Dental Papilla Cells Dental Papilla
- Primary Enamel Knot Cells Enamel Knot
- Dental Mesenchymal Cells Branchial Arch 1
-
Neural Tube (Nervous System)
- Lateral Ganglionic Eminence Progenitor Cells Lateral Ganglionic Eminence
- Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
- Caudal Ganglionic Eminence Progenitor Cells Caudal Ganglionic Eminence
- Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
- Telencephalon
-
Eye (Sensory Organs)
- Mature Horizontal Cells Inner Nuclear Layer
- Dopaminergic Amacrine Cells Ganglion Cell Layer
- Dopaminergic Amacrine Cells Inner Nuclear Layer
- Mature Ganglion Cells Ganglion Cell Layer
-
Neurons
- Mature Horizontal Cells Inner Nuclear Layer
- Dopaminergic Amacrine Cells Ganglion Cell Layer
- Dopaminergic Amacrine Cells Inner Nuclear Layer
- Mature Ganglion Cells Ganglion Cell Layer
-
Epithelial Cells
- Early Ameloblasts Dental Enamel
- Dental Placode Cells Dental Placode
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
-
Head Mesenchyme (Muscoskeletal System)
- Mesencephalic Neural Crest Cells Prechordal Mesenchyme
- Diencephalic Neural Crest Cells Prechordal Mesenchyme
- Dental Mesenchymal Cells Branchial Arch 1
- Cranial Neural Crest Cells Branchial Arch 2
-
Neural Crest (Gastrulation Derivatives)
- Mesencephalic Neural Crest Cells Prechordal Mesenchyme
- Diencephalic Neural Crest Cells Prechordal Mesenchyme
- Cranial Neural Crest Cells Branchial Arch 2
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Heart (Cardiovascular System)
- Cardiac Crescent Cells Cardiac Crescent
- Gut Tube (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for DLX2 Gene
This gene is overexpressed in Brain - Hypothalamus (x7.6), Brain - Anterior cingulate cortex (BA24) (x4.7), and Brain - Cortex (x4.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DLX2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DLX2
SOURCE GeneReport for Unigene cluster for DLX2 Gene:
Hs.419Evidence on tissue expression from TISSUES for DLX2 Gene
- Nervous system(4.6)
- Intestine(4.4)
- Skin(2.7)
- Kidney(2.2)
Primer Products
-
OriGene qPCR primer pairs for DLX2
-
OriGene qPCR primer pairs and template standards for DLX2
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DLX2 Gene
Orthologs for DLX2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DLX2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DLX2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DLX2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Dlx2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dlx2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | DLX2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | DLX2 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | DLX2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dlx2 30 |
|
||
| Str.9796 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.721 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | dlx2a 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3918 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Dll 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | ceh-43 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| CSA.6494 31 |
|
ManyToMany |
- Species where no ortholog for DLX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for DLX2 Gene
- ENSEMBL:
- Gene Tree for DLX2 (if available)
- TreeFam:
- Gene Tree for DLX2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DLX2: view image
Paralogs for DLX2 Gene
Variants for DLX2 Gene
Residual Variation Intolerance Score:
63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.86;
58.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DLX2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DLX2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DLX2 Gene
Disorders for DLX2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| axenfeld-rieger syndrome |
|
|
| dental fluorosis |
|
|
| tooth agenesis |
|
|
| acrofacial dysostosis, cincinnati type |
|
|
| syngnathia |
|
|
Search DLX2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DLX2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for DLX2 Gene
Publications for DLX2 Gene
- The DLX1and DLX2 genes and susceptibility to autism spectrum disorders. (PMID: 18728693) Liu X … Holden JJ (European journal of human genetics : EJHG 2009) 3 23 41
- Cloning and characterization of two members of the vertebrate Dlx gene family. (PMID: 7907794) Simeone A … Huebner K (Proceedings of the National Academy of Sciences of the United States of America 1994) 3 4 23
- The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue. (PMID: 7901126) Selski DJ … Rogers KE (Gene 1993) 3 4 23
- DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2. (PMID: 1354641) Ozçelik T … Francke U (Genomics 1992) 2 3 23
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41
ExternalLinks
Products for DLX2 Gene
- Custom Antibody ServicesOriGene Antibodies for DLX2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for DLX2
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- Origene Custom Protein Services for DLX2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DLX2
- Browse OriGene Inhibitory RNA Products For DLX2
- OriGene qPCR primer pairs for DLX2
- OriGene qPCR primer pairs and template standards for DLX2
- OriGene CRISPR knockouts for DLX2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DLX2
- Sino Biological Human cDNA Clone for DLX2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for DLX2
- Novus Biologicals proteins and lysates for DLX2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for DLX2
- Abcam proteins for DLX2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for DLX2 (AFLGC-DLX2)
- VectorBuilder Custom and pre-made DNA vectors for DLX2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for DLX2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for DLX2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for DLX2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for DLX2
- Addgene plasmids for DLX2
- antibodies-online: Show 23 available Distal-Less Homeobox Protein 2 Antibodies ranked by validation data
- antibodies-online: Search results for available Distal-Less Homeobox Protein 2 related products ranked by validation data
- antibodies-online: Search results for available Distal-Less Homeobox Protein 2 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for DLX2
- Search Santa Cruz Biotechnology (SCBT) for DLX2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DLX2
- Horizon Cell Lines for DLX2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLX2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DLX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLX2
- Boster Bio Antibodies for DLX2
- Browse Boster Bio ELISA Kits
Sources for DLX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB