Aliases for DLL4 Gene
Aliases for DLL4 Gene
External Ids for DLL4 Gene
- HGNC: 2910
- Entrez Gene: 54567
- Ensembl: ENSG00000128917
- OMIM: 605185
- UniProtKB: Q9NR61
Previous GeneCards Identifiers for DLL4 Gene
- GC15P036589
- GC15P034117
- GC15P038800
- GC15P038937
- GC15P039008
- GC15P041221
- GC15P018070
Summaries for DLL4 Gene
-
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]
GeneCards Summary for DLL4 Gene
DLL4 (Delta Like Canonical Notch Ligand 4) is a Protein Coding gene. Diseases associated with DLL4 include Adams-Oliver Syndrome 6 and Adams-Oliver Syndrome. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Notch signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is DLL1.
UniProtKB/Swiss-Prot for DLL4 Gene
-
Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).
Additional gene information for DLL4 Gene
- Monarch Initiative
- Search for DLL4 at DataMed
- Search for DLL4 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLL4 Gene
Genomics for DLL4 Gene
GeneHancer (GH) Regulatory Elements for DLL4 Gene
Promoters and enhancers for DLL4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DLL4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for DLL4 Gene
Genomic Locations for DLL4 Gene
- chr15:40,929,333-40,939,072
- (GRCh38/hg38)
- Size:
- 9,740 bases
- Orientation:
- Plus strand
- chr15:41,221,531-41,231,258
- (GRCh37/hg19)
Genomic View for DLL4 Gene
Genes around DLL4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q15.1 by Entrez Gene
- 15q15.1 by HGNC
- 15q15.1 by Ensembl
DLL4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DLL4 Gene
Proteins for DLL4 Gene
-
Protein details for DLL4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NR61-DLL4_HUMAN
- Recommended name:
- Delta-like protein 4
- Protein Accession:
- Q9NR61
- Q3KP23
- Q9NQT9
Protein attributes for DLL4 Gene
- Size:
- 685 amino acids
- Molecular mass:
- 74605 Da
- Quaternary structure:
-
- Interacts with NOTCH4. Interacts (via N-terminal DSL and MNNL domains) with NOTCH1 (via EGF-like domains).
Protein Expression for DLL4 Gene
Post-translational modifications for DLL4 Gene
Other Protein References for DLL4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for DLL4 (DLL4)
-
Custom Antibody ServicesOriGene Antibodies for DLL4
- Novus Biologicals Antibodies for DLL4
- Invitrogen Antibodies for DLL4
- antibodies-online: Search results for 214 available DLL4 Antibodies ranked by validation data
- Compare Top DLL4 Antibodies
-
Recommended
- 103 WB Antibodies (anti-human)
- 27 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 Func Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 2 MA Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 38 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 10 FACS Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 CC Antibody (anti-mouse)
- 24 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- GeneTex DLL4 Antibody for DLL4
-
Custom Antibody ServicesProSci Antibodies for DLL4
-
Santa Cruz Biotechnology (SCBT) Antibodies for DLL4
- Sino Biological Antibodies for DLL4
Protein Products
- R&D Systems Proteins and Enzymes for DLL4
-
OriGene Purified Proteins for DLL4
- Search Origene for MassSpec and Protein Over-expression Lysates for DLL4
- Origene Custom Protein Services for DLL4
- Novus Biologicals proteins for DLL4
- Sino Biological Cell Lysates for DLL4
- Sino Biological Recombinant Proteins for DLL4
- GeneTex Proteins for DLL4
No data available for DME Specific Peptides for DLL4 Gene
Domains & Families for DLL4 Gene
Gene Families for DLL4 Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted membrane proteins
Protein Domains for DLL4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for DLL4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NR61UniProtKB/Swiss-Prot:
DLL4_HUMAN :- The Delta-Serrate-Lag2 (DSL) domain is required for binding to the Notch receptor.
- Domain:
-
- The Delta-Serrate-Lag2 (DSL) domain is required for binding to the Notch receptor.
Function for DLL4 Gene
Molecular function for DLL4 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).
LifeMap Function Summary for DLL4 Gene
During embryonic development, DLL4 as signaling molecule is secreted from the following cells
- Eye
- Endothelium
It affects the following cells:
- Endothelium
Phenotypes From GWAS Catalog for DLL4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005112 | Notch binding | TAS,IEA | -- |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 24025447 |
Phenotypes for DLL4 Gene
- MGI mutant phenotypes for DLL4:
- inferred from 8 alleles
- GenomeRNAi human phenotypes for DLL4:
Animal Models for DLL4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DLL4
-
CRISPR Products
-
OriGene CRISPR knockouts for DLL4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLL4
- genomics-online: gRNA clones - Search results for 116 available DLL4 gene related products
- Overview of 116 available DLL4 gene related products
- Applied Biological Materials CRISPR for DLL4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DLL4
- GenScript: Design CRISPR guide RNA sequences for DLL4
miRNA for DLL4 Gene
- miRTarBase miRNAs that target DLL4
-
- hsa-mir-30b-5p (MIRT054328)
- hsa-mir-30c-5p (MIRT054329)
- hsa-mir-4743-5p (MIRT491283)
- hsa-mir-4533 (MIRT491284)
- hsa-mir-4313 (MIRT491285)
- hsa-mir-1225-3p (MIRT491286)
- hsa-mir-6125 (MIRT491287)
- hsa-mir-1203 (MIRT491288)
- hsa-mir-345-3p (MIRT491289)
- hsa-mir-3943 (MIRT491290)
- hsa-mir-130a-3p (MIRT732639)
- rno-mir-130a-3p (MIRT732640)
- hsa-mir-125a-5p (MIRT732710)
- mmu-mir-30e-5p (MIRT732757)
- hsa-mir-296-5p (MIRT734908)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DLL4
- Browse OriGene Inhibitory RNA Products For DLL4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLL4
- genomics-online: shRNA clones - Search results for 116 available DLL4 gene related products
- Overview of 116 available DLL4 gene related products
Clone Products
- GenScript: Custom all cDNA clones Services for DLL4
- Sino Biological Human cDNA Clone for DLL4
- VectorBuilder custom plasmid, inducible vectors for DLL4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DLL4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLL4
- Applied Biological Materials Clones for DLL4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for DLL4
Cell Line Products
-
Horizon Cell Lines for DLL4
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DLL4 Gene
Localization for DLL4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DLL4 Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for DLL4 Gene
Pathways & Interactions for DLL4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NOTCH1 | ||
| 2 | NOTCH2 Activation and Transmission of Signal to the Nucleus | ||
| 3 | Notch signaling pathway (KEGG) | ||
| 4 | HIV Life Cycle |
.45
|
|
| 5 | Gastric cancer |
.62
|
|
Pathways by source for DLL4 Gene
2 GeneTex pathways for DLL4 Gene
6 BioSystems pathways for DLL4 Gene
19 Reactome pathways for DLL4 Gene
5 KEGG pathways for DLL4 Gene
1 GeneGo (Thomson Reuters) pathway for DLL4 Gene
1 R&D Systems pathway for DLL4 Gene
2 Cell Signaling Technology pathways for DLL4 Gene
Interacting Proteins for DLL4 Gene
Selected Interacting proteins:
Q9NR61-DLL4_HUMAN
ENSP00000249749
for DLL4 Gene via
IID
UniProtKB
STRING
GPS-Prot Interaction Network for DLL4
SIGNOR curated interactions for DLL4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISS | -- |
| GO:0001525 | angiogenesis | ISS | -- |
| GO:0001569 | branching involved in blood vessel morphogenesis | IEA,ISS | -- |
| GO:0001974 | blood vessel remodeling | IEA,ISS | -- |
| GO:0003208 | cardiac ventricle morphogenesis | IEA,ISS | -- |
Drugs & Compounds for DLL4 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for DLL4 Gene
mRNA/cDNA for DLL4 Gene
- (84) Selected AceView cDNA sequences:
- (7) Additional mRNA sequences :
- (1) REFSEQ mRNAs :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000249749 3372 bps (uc001zng.3)
- ENST00000557876 1439 bps (uc059hwh.1)
- ENST00000559440 1273 bps (uc059hwi.1)
Unigene Clusters for DLL4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DLL4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLL4
- genomics-online: gRNA clones - Search results for 116 available DLL4 gene related products
- Overview of 116 available DLL4 gene related products
- Applied Biological Materials CRISPR for DLL4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DLL4
- GenScript: Design CRISPR guide RNA sequences for DLL4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DLL4
- Browse OriGene Inhibitory RNA Products For DLL4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLL4
- genomics-online: shRNA clones - Search results for 116 available DLL4 gene related products
- Overview of 116 available DLL4 gene related products
Clone Products
- GenScript: Custom all cDNA clones Services for DLL4
- Sino Biological Human cDNA Clone for DLL4
- VectorBuilder custom plasmid, inducible vectors for DLL4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DLL4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLL4
- Applied Biological Materials Clones for DLL4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for DLL4
Expression for DLL4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Heart (Cardiovascular System)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Angioblasts Embryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Angioblasts Embryonic Capillary Plexus
-
Primitive Streak (Early Embryonic Tissues)
- Notochord Cells Notochord
-
Cartilage (Muscoskeletal System)
- Notochord Cells Notochord
-
Dermis (Integumentary System)
- Dermal Fibroblasts Dorsal Dermis
-
Fibroblasts
- Dermal Fibroblasts Dorsal Dermis
-
Lung (Respiratory System)
This gene is overexpressed in Fetal gut (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DLL4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DLL4 Gene:
DLL4SOURCE GeneReport for Unigene cluster for DLL4 Gene:
Hs.511076mRNA Expression by UniProt/SwissProt for DLL4 Gene:
Q9NR61-DLL4_HUMAN
Tissue specificity:
Expressed in vascular endothelium.
Evidence on tissue expression from TISSUES for DLL4 Gene
- Nervous system(4.3)
- Heart(2.8)
- Bone marrow(2.1)
- Lung(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for DLL4 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cerebellum
- cerebrospinal fluid
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- meninges
- mouth
- nose
- outer ear
- scalp
- skull
Thorax:
- aorta
- breast
- chest wall
- heart
- heart valve
- lung
- rib
- rib cage
- sternum
Abdomen:
- abdominal wall
Pelvis:
- placenta
- uterus
Limb:
- ankle
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood
- blood vessel
- hair
- peripheral nervous system
- skin
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for DLL4
-
OriGene qPCR primer pairs and template standards for DLL4
- genomics-online: primer clones - Search results for 116 available DLL4 gene related products
- Overview of 116 available DLL4 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for DLL4 Gene
Orthologs for DLL4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DLL4 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DLL4 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DLL4 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Dll4 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Dll4 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DLL4 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | DLL4 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DLL4 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DLL4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dll4 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dll4 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG15388 35 |
|
|
|
| C901 35 |
|
|
|||
| Dl 34 35 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | apx-1 35 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7799 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for DLL4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for DLL4 Gene
- ENSEMBL:
- Gene Tree for DLL4 (if available)
- TreeFam:
- Gene Tree for DLL4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DLL4: view image
Paralogs for DLL4 Gene
Variants for DLL4 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs61750844 | pathogenic, Adams-Oliver syndrome, Adams-Oliver syndrome 6 | 40,936,659(+) | C/T | coding_sequence_variant, stop_gained | |
| rs796065344 | pathogenic, Adams-Oliver syndrome, Adams-Oliver syndrome 6 | 40,936,647(+) | C/T | coding_sequence_variant, stop_gained | |
| rs796065345 | pathogenic, Adams-Oliver syndrome, Adams-Oliver syndrome 6 (AOS6) [MIM:616589] | 40,936,352(+) | C/G | coding_sequence_variant, missense_variant | |
| rs796065346 | pathogenic, Adams-Oliver syndrome, Adams-Oliver syndrome 6, Adams-Oliver syndrome 6 (AOS6) [MIM:616589] | 40,935,046(+) | G/A | coding_sequence_variant, missense_variant | |
| rs796065347 | pathogenic, Adams-Oliver syndrome, Adams-Oliver syndrome 6, Adams-Oliver syndrome 6 (AOS6) [MIM:616589] | 40,935,045(+) | T/C | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.25;
24.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DLL4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLL4 Gene
Disorders for DLL4 Gene
(6) MalaCards diseases for DLL4 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| adams-oliver syndrome 6 |
|
|
| adams-oliver syndrome |
|
|
| aplasia cutis congenita, nonsyndromic |
|
|
| oliver syndrome |
|
|
| aplasia cutis congenita |
|
|
Search DLL4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
DLL4_HUMAN- Adams-Oliver syndrome 6 (AOS6) [MIM:616589]: A form of Adams-Oliver syndrome, a disorder characterized by the congenital absence of skin (aplasia cutis congenita) in combination with transverse limb defects. Aplasia cutis congenita can be located anywhere on the body, but in the vast majority of the cases, it is present on the posterior parietal region where it is often associated with an underlying defect of the parietal bones. Limb abnormalities are typically limb truncation defects affecting the distal phalanges or entire digits (true ectrodactyly). Only rarely, metatarsals/metacarpals or more proximal limb structures are also affected. Apart from transverse limb defects, syndactyly, most commonly of second and third toes, can also be observed. The clinical features are highly variable and can also include cardiovascular malformations, brain abnormalities and vascular defects such as cutis marmorata and dilated scalp veins. {ECO:0000269 PubMed:26299364}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for DLL4
No data available for Genatlas for DLL4 Gene
Publications for DLL4 Gene
- Dll4, a novel Notch ligand expressed in arterial endothelium. (PMID: 10837024) Shutter JR … Stark KL (Genes & development 2000) 2 3 4 22 58
- Heterozygous Loss-of-Function Mutations in DLL4 Cause Adams-Oliver Syndrome. (PMID: 26299364) Meester JA … Wuyts W (American journal of human genetics 2015) 3 4 58
- Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. (PMID: 20616313) Brütsch R … Fischer A (Circulation research 2010) 3 4 58
- [Influence of Delta-like ligand 4/Notch signal transduction pathway upon the biological behavior of human umbilical vein endothelial cells]. (PMID: 20193271) Chen L … Li T (Zhonghua yi xue za zhi 2009) 3 22 58
- Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells. (PMID: 18339870) Williams CK … Harris AL (Cancer research 2008) 3 22 58
Products for DLL4 Gene
- R&D Systems Antibodies for DLL4 (DLL4)
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- Custom Antibody ServicesOriGene Antibodies for DLL4
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- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for DLL4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DLL4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 214 available DLL4 Antibodies ranked by validation data
- Compare Top DLL4 Antibodies
- Recommended
- 103 WB Antibodies (anti-human)
- 27 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 Func Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 2 MA Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 38 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 10 FACS Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 CC Antibody (anti-mouse)
- 24 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Search results for 24 available DLL4 Elisa Kits ranked by validation data
- Compare Top DLL4 Elisa Kits
- antibodies-online: Search results for 29 available DLL4 Proteins ranked by validation data
- Compare Top DLL4 Proteins
- GeneTex DLL4 Antibody for DLL4
- GeneTex Proteins for DLL4
- Santa Cruz Biotechnology (SCBT) Antibodies for DLL4
- Search Santa Cruz Biotechnology (SCBT) for DLL4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DLL4
- Custom Antibody ServicesProSci Antibodies for DLL4
- Horizon Cell Lines for DLL4
- genomics-online: cdna clones - Search results for 116 available DLL4 gene related products
- Overview of 116 available DLL4 gene related products
- orf clones - Search results for 116 available DLL4 gene related products
- Overview of 116 available DLL4 gene related products
- genomics-online: gRNA clones - Search results for 116 available DLL4 gene related products
- Overview of 116 available DLL4 gene related products
- genomics-online: primer clones - Search results for 116 available DLL4 gene related products
- Overview of 116 available DLL4 gene related products
- genomics-online: shRNA clones - Search results for 116 available DLL4 gene related products
- Overview of 116 available DLL4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLL4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLL4
- GeneCopoeia miRNA 3'UTR Target clone products for DLL4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLL4
Sources for DLL4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio