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This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]
DLL4 (Delta Like Canonical Notch Ligand 4) is a Protein Coding gene. Diseases associated with DLL4 include Adams-Oliver Syndrome 6 and Adams-Oliver Syndrome. Among its related pathways are Signaling by GPCR and Notch Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is DLL1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005112 | Notch binding | TAS,IBA | 21873635 |
GO:0005509 | calcium ion binding | IEA | -- |
GO:0005515 | protein binding | IPI | 24025447 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by NOTCH1 | ||
2 | NOTCH2 Activation and Transmission of Signal to the Nucleus | ||
3 | Notch Signaling Pathway (WikiPathways) | ||
4 | HIV Life Cycle |
.45
|
|
5 | Angiogenesis (CST) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,ISS | -- |
GO:0001525 | angiogenesis | ISS | -- |
GO:0001569 | branching involved in blood vessel morphogenesis | IEA,ISS | -- |
GO:0001974 | blood vessel remodeling | IEA,ISS | -- |
GO:0003180 | aortic valve morphogenesis | IC | 26491108 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DLL4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DLL4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DLL4 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dll4 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Dll4 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DLL4 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DLL4 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DLL4 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DLL4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dll4 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dll4 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG15388 32 |
|
|
|
C901 32 |
|
|
|||
Dl 31 32 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | apx-1 32 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7799 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
708693 | Likely Benign: not provided | 40,932,340(+) | G/A | MISSENSE_VARIANT | |
713007 | Benign: not provided | 40,932,184(+) | G/A | SYNONYMOUS_VARIANT | |
713286 | Benign: not provided | 40,936,548(+) | G/A | MISSENSE_VARIANT | |
717715 | Likely Benign: not provided | 40,934,702(+) | T/C | SYNONYMOUS_VARIANT | |
722549 | Likely Benign: not provided | 40,929,936(+) | C/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
adams-oliver syndrome 6 |
|
|
adams-oliver syndrome |
|
|
aplasia cutis congenita, nonsyndromic |
|
|
oliver syndrome |
|
|
cerebral cavernous malformations |
|
|