Aliases for DLL3 Gene
External Ids for DLL3 Gene
Previous GeneCards Identifiers for DLL3 Gene
This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DLL3 Gene
DLL3 (Delta Like Canonical Notch Ligand 3) is a Protein Coding gene. Diseases associated with DLL3 include Spondylocostal Dysostosis 1, Autosomal Recessive and Spondylocostal Dysostosis, Autosomal Recessive. Among its related pathways are NOTCH1 regulation of human endothelial cell calcification and Notch Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is CD93.
UniProtKB/Swiss-Prot Summary for DLL3 Gene
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).