Aliases for DLL1 Gene
Aliases for DLL1 Gene
External Ids for DLL1 Gene
- HGNC: 2908
- Entrez Gene: 28514
- Ensembl: ENSG00000198719
- OMIM: 606582
- UniProtKB: O00548
Previous GeneCards Identifiers for DLL1 Gene
- GC06M169786
- GC06M170206
- GC06M170447
- GC06M170508
- GC06M168099
- GC06M170591
Summaries for DLL1 Gene
-
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]
GeneCards Summary for DLL1 Gene
DLL1 (Delta Like Canonical Notch Ligand 1) is a Protein Coding gene. Diseases associated with DLL1 include Alobar Holoprosencephaly and Septopreoptic Holoprosencephaly. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Gene regulatory network modelling somitogenesis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is DLL4.
UniProtKB/Swiss-Prot for DLL1 Gene
-
Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:11006133). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (By similarity). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:11581320). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway. At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway. Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis. Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell. Plays a role in immune systeme development, namely the development of all T-cells and marginal zone (MZ) B-cells (By similarity). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (PubMed:11581320). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation. Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression. During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression. Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium. Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels. During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression. Controls sprouting angiogenesis and subsequent vertical branch formation througth regulation on tip cell differentiation. Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine. Plays a role during inner ear development; negatively regulates auditory hair cell differentiation. Plays a role during nephron development through Notch signaling pathway. Regulates growth, blood pressure and energy homeostasis (By similarity).
Additional gene information for DLL1 Gene
- Monarch Initiative
- Search for DLL1 at DataMed
- Search for DLL1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLL1 Gene
Genomics for DLL1 Gene
GeneHancer (GH) Regulatory Elements for DLL1 Gene
Promoters and enhancers for DLL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DLL1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for DLL1 Gene
Genomic Locations for DLL1 Gene
- chr6:170,282,200-170,306,565
- (GRCh38/hg38)
- Size:
- 24,366 bases
- Orientation:
- Minus strand
- chr6:170,591,294-170,599,697
- (GRCh37/hg19)
Genomic View for DLL1 Gene
Genes around DLL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q27 by Entrez Gene
- 6q27 by HGNC
- 6q27 by Ensembl
DLL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DLL1 Gene
Proteins for DLL1 Gene
-
Protein details for DLL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00548-DLL1_HUMAN
- Recommended name:
- Delta-like protein 1
- Protein Accession:
- O00548
- B2RAK7
- B5M0B3
- Q9NU41
- Q9UJV2
Protein attributes for DLL1 Gene
- Size:
- 723 amino acids
- Molecular mass:
- 78056 Da
- Quaternary structure:
-
- Homodimer. Interacts with TJP1. Interacts with MAGI1 (via PDZ domain); forms a complex with CTNNB1 and CDH2 and promotes recruitment to the adherens junction and stabilization on the cell surface. Interacts with PSEN1; undergoes a presenilin-dependent gamma-secretase cleavage that releases a Dll1-intracellular form. Interacts with MFAP5. Interacts with MIB1. Interacts with NEURL1B; leads to ubiquitination. Interacts with NEURL1 (By similarity). Interacts with SYNJ2BP; enhances DLL1 protein stability, and promotes Notch signaling in endothelial cells (PubMed:24025447). Interacts with MAGI1, MAGI2, MAGI3 and MPDZ (PubMed:15509766). Interacts (via ubiquitin) with EPN1 (via IUM domain); binding with NOTCH1 attached to neighboring cell, promotes ligand ubiquitination and EPN1 interaction, leading to NECD transendocytosis and Notch signaling. Interacts with NOTCH1 (By similarity).
Post-translational modifications for DLL1 Gene
- Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation (By similarity). Ubiquitinated; promotes recycling back to the plasma membrane and confers a strong affinity for NOTCH1. Multi-ubiquitination of LYS-613 by MIB1 promotes both cis and trans-interaction with NOTCH1, as well as activation of Notch signaling. Ubiquitinated by NEURL1B (By similarity).
- Phosphorylated in a membrane association-dependent manner. Phosphorylation at Ser-697 requires the presence of Ser-694, whereas phosphorylation at Ser-694 occurs independently of the other site. Phosphorylation is required for full ligand activity in vitro and affects surface presentation, ectodomain shedding, and endocytosis.
- O-fucosylated. Can be elongated to a disaccharide by MFNG.
- Glycosylation at Asn477
- Modification sites at PhosphoSitePlus
Other Protein References for DLL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for DLL1 (DLL1)
-
Custom Antibody ServicesOriGene Antibodies for DLL1
- Novus Biologicals Antibodies for DLL1
- Invitrogen Antibodies for DLL1
- antibodies-online: Search results for 189 available DLL1 Antibodies ranked by validation data
- Compare Top DLL1 Antibodies
-
Recommended
- 34 WB Antibodies (anti-mouse)
- 19 IHC (p) Antibodies (anti-mouse)
- 10 FACS Antibodies (anti-mouse)
- 6 IHC Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 79 WB Antibodies (anti-human)
- 24 FACS Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 EIA Antibody (anti-human)
- 22 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 1 EIA Antibody (anti-rat)
- GeneTex DLL1 Antibody for DLL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for DLL1
- Sino Biological Antibodies for DLL1
Protein Products
- R&D Systems Proteins and Enzymes for DLL1
-
OriGene Purified Proteins for DLL1
- Search Origene for MassSpec and Protein Over-expression Lysates for DLL1
- Origene Custom Protein Services for DLL1
- Sino Biological Cell Lysates for DLL1
- Sino Biological Recombinant Proteins for DLL1
- GeneTex Proteins for DLL1
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for DLL1
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for DLL1 (DLL1)
-
Boster Bio ELISA Kits for DLL1
- Sino Biological Assays for DLL1
No data available for DME Specific Peptides for DLL1 Gene
Domains & Families for DLL1 Gene
Gene Families for DLL1 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for DLL1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for DLL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for DLL1 Gene
Function for DLL1 Gene
Molecular function for DLL1 Gene
- UniProtKB/Swiss-Prot Function:
- Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:11006133). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (By similarity). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:11581320). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway. At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway. Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis. Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell. Plays a role in immune systeme development, namely the development of all T-cells and marginal zone (MZ) B-cells (By similarity). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (PubMed:11581320). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation. Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression. During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression. Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium. Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels. During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression. Controls sprouting angiogenesis and subsequent vertical branch formation througth regulation on tip cell differentiation. Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine. Plays a role during inner ear development; negatively regulates auditory hair cell differentiation. Plays a role during nephron development through Notch signaling pathway. Regulates growth, blood pressure and energy homeostasis (By similarity).
LifeMap Function Summary for DLL1 Gene
During embryonic development, DLL1 as signaling molecule is secreted from the following cells
- Kidney
It affects the following cells:
- Somite
Phenotypes From GWAS Catalog for DLL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005112 | Notch binding | IPI | 10079256 |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 10079256 |
| GO:0030957 | Tat protein binding | IPI | 15509766 |
| GO:0097110 | scaffold protein binding | IEA | -- |
Phenotypes for DLL1 Gene
- MGI mutant phenotypes for DLL1:
-
inferred from 9 alleles
- cardiovascular system phenotype
- limbs/digits/tail phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for DLL1:
Animal Model Products
-
Taconic Biosciences Mouse Models for DLL1
- Cyagen custom Knockout/knockin (KOKI) mouse models for DLL1
-
CRISPR Products
-
OriGene CRISPR knockouts for DLL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLL1
- genomics-online: gRNA clones - Search results for 121 available DLL1 gene related products
- Overview of 121 available DLL1 gene related products
- Applied Biological Materials CRISPR for DLL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DLL1
- GenScript: Design CRISPR guide RNA sequences for DLL1
miRNA for DLL1 Gene
- miRTarBase miRNAs that target DLL1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DLL1
- Browse OriGene Inhibitory RNA Products For DLL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLL1
- genomics-online: shRNA clones - Search results for 121 available DLL1 gene related products
- Overview of 121 available DLL1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for DLL1
- VectorBuilder custom plasmid, inducible vectors for DLL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DLL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DLL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLL1
- Applied Biological Materials Clones for DLL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for DLL1
Cell Line Products
-
Horizon Cell Lines for DLL1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DLL1 Gene
Localization for DLL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DLL1 Gene
- Apical cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction. Membrane raft. Note=Distributed around adherens junction in the apical endfeet through interactions with MAGI1. {ECO:0000250 UniProtKB:Q61483}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 2 |
| peroxisome | 1 |
| nucleus | 1 |
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | NAS | 11823422 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | NAS | 10079256 |
| GO:0005912 | adherens junction | ISS | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for DLL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NOTCH1 | ||
| 2 | NOTCH2 Activation and Transmission of Signal to the Nucleus | ||
| 3 | Notch signaling pathway (KEGG) | ||
| 4 | HIV Life Cycle |
.45
|
|
| 5 | Development NOTCH1-mediated pathway for NF-KB activity modulation | ||
Pathways by source for DLL1 Gene
1 GeneTex pathway for DLL1 Gene
9 BioSystems pathways for DLL1 Gene
19 Reactome pathways for DLL1 Gene
5 KEGG pathways for DLL1 Gene
2 GeneGo (Thomson Reuters) pathways for DLL1 Gene
1 R&D Systems pathway for DLL1 Gene
1 Qiagen pathway for DLL1 Gene
1 Cell Signaling Technology pathway for DLL1 Gene
Interacting Proteins for DLL1 Gene
GPS-Prot Interaction Network for DLL1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001709 | cell fate determination | NAS | 11581320 |
| GO:0001756 | somitogenesis | IEA,ISS | -- |
| GO:0001757 | somite specification | IEA | -- |
| GO:0001947 | heart looping | IEA,ISS | -- |
| GO:0002315 | marginal zone B cell differentiation | IEA,ISS | -- |
Transcripts for DLL1 Gene
mRNA/cDNA for DLL1 Gene
- (70) Selected AceView cDNA sequences:
- (4) Additional mRNA sequences :
- (2) REFSEQ mRNAs :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000366756 3174 bps (uc003qxm.4)
- ENST00000630500 548 bps (uc063taz.1)
Unigene Clusters for DLL1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DLL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLL1
- genomics-online: gRNA clones - Search results for 121 available DLL1 gene related products
- Overview of 121 available DLL1 gene related products
- Applied Biological Materials CRISPR for DLL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DLL1
- GenScript: Design CRISPR guide RNA sequences for DLL1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DLL1
- Browse OriGene Inhibitory RNA Products For DLL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLL1
- genomics-online: shRNA clones - Search results for 121 available DLL1 gene related products
- Overview of 121 available DLL1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for DLL1
- VectorBuilder custom plasmid, inducible vectors for DLL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DLL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DLL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLL1
- Applied Biological Materials Clones for DLL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for DLL1
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||
| SP4: |
Expression for DLL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Kidney (Urinary System)
- S-shaped Body Cells S-shaped Body
- Comma-shaped Body Cells Comma-shaped Body
- S-shaped Body Medial Cells S-shaped Body Medial Segment
- Distal Renal Vesicle Cells Renal Vesicle
- Renal Vesicle
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Stylopod
- Mesenchymal Condensate Cells Zeugopod
- Autopod
- Stylopod
- Zeugopod
- Brain (Nervous System)
-
Epithelial Cells
- Basal Cells Trachea
- Neuroendocrine Cells Stem Bronchi
- Primary Hair Placode Cells Hair Follicle
- Basal Keratinocytes Embryonic Epidermis
-
Lung (Respiratory System)
- Neuroendocrine Cells Trachea
- Basal Cells Trachea
- Neuroendocrine Cells Stem Bronchi
-
Paraxial Mesoderm (Gastrulation Derivatives)
- Presegmented Somitic Mesenchyme Cells Presomitic Mesoderm
- Paraxial Mesoderm Cells Paraxial Mesoderm
- Presomitic Mesoderm
-
Cartilage (Muscoskeletal System)
- Notochord Cells Notochord
- Mesenchymal Condensate Cells Stylopod
- Mesenchymal Condensate Cells Zeugopod
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Stylopod
- Mesenchymal Condensate Cells Zeugopod
- Zeugopod Long Bone
-
Endothelium (Cardiovascular System)
- Arterial Endothelial Cells Arteries
- Arterial Endothelial Cells Dorsal Aorta
-
Hair (Integumentary System)
- Primary Hair Placode Cells Hair Follicle
- Basal Keratinocytes Embryonic Epidermis
- Gut Tube (Gastrointestinal Tract)
-
Somite (Muscoskeletal System)
- Presegmented Somitic Mesenchyme Cells Presomitic Mesoderm
-
Primitive Streak (Early Embryonic Tissues)
- Notochord Cells Notochord
-
Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Paraxial Mesoderm
-
Heart (Cardiovascular System)
- Arterial Endothelial Cells Dorsal Aorta
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
- Umbilical Cord (Extraembryonic Tissues)
- Neural Ectoderm (Nervous System)
- NULL (Uncategorized)
- Neurons
mRNA differential expression in normal tissues according to GTEx for DLL1 Gene
This gene is overexpressed in Spleen (x5.2).
NURSA nuclear receptor signaling pathways regulating expression of DLL1 Gene:
DLL1SOURCE GeneReport for Unigene cluster for DLL1 Gene:
Hs.379912mRNA Expression by UniProt/SwissProt for DLL1 Gene:
O00548-DLL1_HUMAN
Tissue specificity:
Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.
Evidence on tissue expression from TISSUES for DLL1 Gene
- Nervous system(3.7)
- Blood(2.7)
- Spleen(2.2)
- Heart(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for DLL1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- endocrine
- integumentary
- nervous
- reproductive
- respiratory
- skeleton
Regions:
Head and neck:
- brain
- eye
- face
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- nose
- pharynx
- pituitary gland
- skull
- tooth
General:
- skin
Primer Products
-
OriGene qPCR primer pairs for DLL1
- genomics-online: primer clones - Search results for 121 available DLL1 gene related products
- Overview of 121 available DLL1 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DLL1 Gene
Orthologs for DLL1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DLL1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DLL1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DLL1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Dll1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dll1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DLL1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | DLL1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DLL1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DLL1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dll1 33 |
|
||
| Str.15072 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC52561 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dld 34 33 33 |
|
OneToMany | |
| dla 34 |
|
OneToMany | |||
| dlb 34 |
|
OneToMany | |||
| dlc 34 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3500 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Dl 34 35 33 |
|
OneToMany | |
| CG15388 35 |
|
|
|||
| C901 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010265 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | apx-1 35 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7799 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for DLL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for DLL1 Gene
- ENSEMBL:
- Gene Tree for DLL1 (if available)
- TreeFam:
- Gene Tree for DLL1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DLL1: view image
Paralogs for DLL1 Gene
Variants for DLL1 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193920766 | uncertain-significance, Malignant tumor of prostate | 170,283,568(-) | G/T | coding_sequence_variant, intron_variant, missense_variant | |
| rs573197356 | uncertain-significance, Holoprosencephaly | 170,283,475(-) | TGT/ | coding_sequence_variant, inframe_indel, intron_variant | |
| rs760189276 | uncertain-significance, alobar holoprosencephaly | 170,283,037(-) | G/A | coding_sequence_variant, missense_variant | |
| rs1000206263 | -- | 170,285,197(-) | A/G | intron_variant | |
| rs1000216858 | -- | 170,284,199(-) | G/A | intron_variant |
Residual Variation Intolerance Score:
29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.72;
46.52% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DLL1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLL1 Gene
Disorders for DLL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| alobar holoprosencephaly |
|
|
| septopreoptic holoprosencephaly |
|
|
| midline interhemispheric variant of holoprosencephaly |
|
|
| microform holoprosencephaly |
|
|
| lobar holoprosencephaly |
|
|
Search DLL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DLL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for DLL1 Gene
Publications for DLL1 Gene
- Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. (PMID: 11006133) Shimizu K … Hirai H (Biochemical and biophysical research communications 2000) 3 4 22 58
- Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. (PMID: 24025447) Adam MG … Fischer A (Circulation research 2013) 3 4 58
- Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site. (PMID: 19906316) Wang P … Ma D (BMC genomics 2009) 3 4 58
- Notch1 induces enhanced expression of Delta-like-1 in the U251MG glioma cell line. (PMID: 19724883) Qian CF … You YP (International journal of molecular medicine 2009) 3 22 58
- Genetic variation in healthy oldest-old. (PMID: 19680556) Halaschek-Wiener J … Brooks-Wilson AR (PloS one 2009) 3 44 58
Products for DLL1 Gene
- R&D Systems Antibodies for DLL1 (DLL1)
- R&D Systems Proteins and Enzymes for DLL1
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for DLL1 (DLL1)
- R&D Systems cDNA Clones for DLL1
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for DLL1
- Custom Assay ServicesOriGene ELISA Kits for DLL1
- OriGene Purified Proteins for DLL1
- Search Origene for MassSpec and Protein Over-expression Lysates for DLL1
- Origene Custom Protein Services for DLL1
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DLL1
- Browse OriGene Inhibitory RNA Products For DLL1
- OriGene qPCR primer pairs for DLL1
- OriGene CRISPR knockouts for DLL1
- OriGene ORF clones in human for DLL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DLL1
- GenScript: Next-day shipping of latest version cDNA ORF clones for DLL1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for DLL1
- GenScript Custom Assay Services for DLL1
- GenScript Custom overexpressing Cell Line Services for DLL1
- GenScript: Design CRISPR guide RNA sequences for DLL1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for DLL1
- Sino Biological Human cDNA Clone for DLL1
- Sino Biological Cell Lysates for DLL1
- Sino Biological Recombinant Proteins for DLL1
- Sino Biological Antibodies for DLL1
- Sino Biological Assays for DLL1
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for DLL1
- Novus Biologicals proteins and lysates for DLL1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for DLL1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- VectorBuilder custom plasmid, inducible vectors for DLL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DLL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DLL1
- antibodies-online: Search results for 189 available DLL1 Antibodies ranked by validation data
- Compare Top DLL1 Antibodies
- Recommended
- 34 WB Antibodies (anti-mouse)
- 19 IHC (p) Antibodies (anti-mouse)
- 10 FACS Antibodies (anti-mouse)
- 6 IHC Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 79 WB Antibodies (anti-human)
- 24 FACS Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 EIA Antibody (anti-human)
- 22 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 1 EIA Antibody (anti-rat)
- antibodies-online: Search results for 35 available DLL1 Elisa Kits ranked by validation data
- Compare Top DLL1 Elisa Kits
- antibodies-online: Search results for 31 available DLL1 Proteins ranked by validation data
- Compare Top DLL1 Proteins
- GeneTex DLL1 Antibody for DLL1
- GeneTex Proteins for DLL1
- Santa Cruz Biotechnology (SCBT) Antibodies for DLL1
- Search Santa Cruz Biotechnology (SCBT) for DLL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DLL1
- Horizon Cell Lines for DLL1
- genomics-online: cdna clones - Search results for 121 available DLL1 gene related products
- Overview of 121 available DLL1 gene related products
- orf clones - Search results for 121 available DLL1 gene related products
- Overview of 121 available DLL1 gene related products
- genomics-online: gRNA clones - Search results for 121 available DLL1 gene related products
- Overview of 121 available DLL1 gene related products
- genomics-online: primer clones - Search results for 121 available DLL1 gene related products
- Overview of 121 available DLL1 gene related products
- genomics-online: shRNA clones - Search results for 121 available DLL1 gene related products
- Overview of 121 available DLL1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLL1
- GeneCopoeia miRNA 3'UTR Target clone products for DLL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLL1
Sources for DLL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio