DLK2 Gene (Protein Coding)

Delta Like Non-Canonical Notch Ligand 2

GC06M043450
GIFtS:
34

Aliases for DLK2 Gene

Aliases for DLK2 Gene

  • Delta Like Non-Canonical Notch Ligand 2 2 3 5
  • Epidermal Growth Factor-Like Protein 9 3 4
  • EGF-Like-Domain, Multiple 9 2 3
  • Protein Delta Homolog 2 3 4
  • EGF-Like Protein 9 3 4
  • EGFL9 3 4
  • DLK-2 3 4
  • Delta-Like 2 Homolog (Drosophila) 2
  • Delta-Like 2 Homolog 3

External Ids for DLK2 Gene

Previous HGNC Symbols for DLK2 Gene

  • EGFL9

Previous GeneCards Identifiers for DLK2 Gene

  • GC06M043528
  • GC06M043418
  • GC06M043136

Summaries for DLK2 Gene

GeneCards Summary for DLK2 Gene

DLK2 (Delta Like Non-Canonical Notch Ligand 2) is a Protein Coding gene. Among its related pathways are P38 MAPK Signaling Pathway (sino) and Canonical and Non-canonical Notch signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is DLL3.

UniProtKB/Swiss-Prot Summary for DLK2 Gene

Additional gene information for DLK2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DLK2 Gene

Genomics for DLK2 Gene

GeneHancer (GH) Regulatory Elements for DLK2 Gene

Promoters and enhancers for DLK2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DLK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DLK2 gene promoter:
  • HEN1
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • STAT3

Genomic Locations for DLK2 Gene

Genomic Locations for DLK2 Gene
chr6:43,450,352-43,456,632
(GRCh38/hg38)
Size:
6,281 bases
Orientation:
Minus strand
chr6:43,418,090-43,424,370
(GRCh37/hg19)
Size:
6,281 bases
Orientation:
Minus strand

Genomic View for DLK2 Gene

Genes around DLK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLK2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DLK2 Gene

Proteins for DLK2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DLK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UY11-DLK2_HUMAN
    Recommended name:
    Protein delta homolog 2
    Protein Accession:
    Q6UY11
    Secondary Accessions:
    • B3KNZ7
    • Q5T3T8
    • Q9BQ54

    Protein attributes for DLK2 Gene

    Size:
    383 amino acids
    Molecular mass:
    40548 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DLK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLK2 Gene

Post-translational modifications for DLK2 Gene

  • Glycosylation at Asn157
  • Modification sites at PhosphoSitePlus

Other Protein References for DLK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DLK2 Gene

Domains & Families for DLK2 Gene

Gene Families for DLK2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for DLK2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DLK2 Gene

GenScript: Design optimal peptide antigens:
  • Epidermal growth factor-like protein 9 (DLK2_HUMAN)
  • EGF-like-domain, multiple 9 (Q5T3U1_HUMAN)
genes like me logo Genes that share domains with DLK2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DLK2 Gene

Function for DLK2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for DLK2 Gene

UniProtKB/Swiss-Prot Function:
Regulates adipogenesis.

Phenotypes From GWAS Catalog for DLK2 Gene

Gene Ontology (GO) - Molecular Function for DLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005112 Notch binding IBA 21873635
GO:0005509 calcium ion binding IEA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with DLK2: view
genes like me logo Genes that share phenotypes with DLK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DLK2

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DLK2 Gene

Localization for DLK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLK2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DLK2 gene
Compartment Confidence
plasma membrane 4
extracellular 2
mitochondrion 0
nucleus 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DLK2: view

Pathways & Interactions for DLK2 Gene

genes like me logo Genes that share pathways with DLK2: view

Pathways by source for DLK2 Gene

1 Sino Biological pathway for DLK2 Gene
1 BioSystems pathway for DLK2 Gene

SIGNOR curated interactions for DLK2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045598 regulation of fat cell differentiation IEA --
GO:0045746 negative regulation of Notch signaling pathway IDA 25093684
genes like me logo Genes that share ontologies with DLK2: view

Drugs & Compounds for DLK2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for DLK2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DLK2 Gene

(4) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(35) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLK2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: -
SP6: -

Relevant External Links for DLK2 Gene

GeneLoc Exon Structure for
DLK2
ECgene alternative splicing isoforms for
DLK2

Expression for DLK2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DLK2 Gene

mRNA expression in normal human tissues for DLK2 Gene
mRNA expression by BioGPS for DLK2 GenemRNA expression by GTEx for DLK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLK2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of DLK2 Gene:

DLK2

SOURCE GeneReport for Unigene cluster for DLK2 Gene:

Hs.337251

Evidence on tissue expression from TISSUES for DLK2 Gene

  • Nervous system(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with DLK2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DLK2 Gene

Orthologs for DLK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia DLK2 33 32
  • 99.56 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia DLK2 33 32
  • 89.38 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Dlk2 17 33 32
  • 89.18 (n)
rat
(Rattus norvegicus)
 Mammalia Dlk2 32
  • 89.18 (n)
cow
(Bos Taurus)
 Mammalia DLK2 33 32
  • 88.95 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia DLK2 33
  • 57 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves DLK2 33 32
  • 66.03 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia DLK2 33
  • 57 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii dlk2 33 32
  • 58.1 (n)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta wry 33
  • 7 (a)
 OneToMany
Species where no ortholog for DLK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLK2 Gene

ENSEMBL:
Gene Tree for DLK2 (if available)
TreeFam:
Gene Tree for DLK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DLK2: view image

Paralogs for DLK2 Gene

Paralogs for DLK2 Gene

(7) SIMAP similar genes for DLK2 Gene using alignment to 4 proteins:

  • DLK2_HUMAN
  • H0Y5P1_HUMAN
  • Q5T3T9_HUMAN
  • Q5T3U0_HUMAN
genes like me logo Genes that share paralogs with DLK2: view

Variants for DLK2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for DLK2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000752713 -- 43,454,561(-) G/C intron_variant
rs1000838366 -- 43,454,578(-) A/G intron_variant
rs1000908391 -- 43,454,252(-) A/G intron_variant
rs1001140674 -- 43,457,943(-) CATC/C upstream_transcript_variant
rs1001274998 -- 43,457,674(-) /A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DLK2 Gene

Variant ID Type Subtype PubMed ID
nsv1074396 CNV deletion 25765185
nsv1144143 CNV deletion 24896259
nsv603000 CNV loss 21841781
nsv950172 CNV deletion 24416366

Variation tolerance for DLK2 Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DLK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DLK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLK2 Gene

Disorders for DLK2 Gene

Additional Disease Information for DLK2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DLK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DLK2 Gene

Publications for DLK2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 56
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

ExternalLinks

View latest publications for DLK2 gene in Mastermind

Products for DLK2 Gene

Sources for DLK2 Gene