Aliases for DLK1 Gene
Aliases for DLK1 Gene
External Ids for DLK1 Gene
- HGNC: 2907
- Entrez Gene: 8788
- Ensembl: ENSG00000185559
- OMIM: 176290
- UniProtKB: P80370
Previous GeneCards Identifiers for DLK1 Gene
- GC14P098584
- GC14P095008
- GC14P099183
- GC14P100263
- GC14P101193
- GC14P081373
- GC14P101197
- GC14P101211
- GC14P101793
- GC14P102086
- GC14P102320
- GC14P102490
- GC14P102665
- GC14P102838
- GC14P103010
Summaries for DLK1 Gene
-
This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015]
GeneCards Summary for DLK1 Gene
DLK1 (Delta Like Non-Canonical Notch Ligand 1) is a Protein Coding gene. Diseases associated with DLK1 include Idiopathic Central Precocious Puberty and Temple Syndrome. Among its related pathways are Adipogenesis and Canonical and Non-canonical Notch signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is DLK2.
UniProtKB/Swiss-Prot for DLK1 Gene
-
May have a role in neuroendocrine differentiation.
Additional gene information for DLK1 Gene
- Monarch Initiative
- Search for DLK1 at DataMed
- Search for DLK1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLK1 Gene
Genomics for DLK1 Gene
GeneHancer (GH) Regulatory Elements for DLK1 Gene
Promoters and enhancers for DLK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DLK1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DLK1 gene promoter:
-
- PPAR-gamma2
- PPAR-gamma1
- GATA-2
- Evi-1
Regulatory Element Products
Genomic Locations for DLK1 Gene
Genomic Locations for DLK1 Gene
- chr14:100,725,705-100,738,224
- (GRCh38/hg38)
- Size:
- 12,520 bases
- Orientation:
- Plus strand
- chr14:101,192,042-101,201,539
- (GRCh37/hg19)
- Size:
- 9,498 bases
- Orientation:
- Plus strand
Genomic View for DLK1 Gene
Genes around DLK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.2 by Entrez Gene
- 14q32.2 by HGNC
- 14q32.2 by Ensembl
DLK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DLK1 Gene
Proteins for DLK1 Gene
-
Protein details for DLK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P80370-DLK1_HUMAN
- Recommended name:
- Protein delta homolog 1
- Protein Accession:
- P80370
- P15803
- Q96DW5
Protein attributes for DLK1 Gene
- Size:
- 383 amino acids
- Molecular mass:
- 41300 Da
- Quaternary structure:
-
- Monomer.
- SequenceCaution:
-
- Sequence=CAA35582.1; Type=Frameshift; Positions=22, 108, 199; Evidence={ECO:0000305};
Protein Expression for DLK1 Gene
Post-translational modifications for DLK1 Gene
- N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
- Glycosylation at Thr269, Ser260, Thr256, posLast=251251, posLast=222222, posLast=214214, Asn172, posLast=165165, posLast=163163, posLast=143143, Asn100, and posLast=9494
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- DLK1_HUMAN (745)
Other Protein References for DLK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for DLK1 (Pref-1/DLK1/FA1)
-
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-
Boster Bio Antibodies for DLK1
-
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-
Santa Cruz Biotechnology (SCBT) Antibodies for DLK1
Protein Products
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-
OriGene Purified Proteins for DLK1
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Assay Products
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for DLK1 (Pref-1/DLK1/FA1)
- antibodies-online: Search results for 11 available DLK1 Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for DLK1 Gene
Domains & Families for DLK1 Gene
Gene Families for DLK1 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for DLK1 Gene
Suggested Antigen Peptide Sequences for DLK1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for DLK1 Gene
Function for DLK1 Gene
Molecular function for DLK1 Gene
- UniProtKB/Swiss-Prot Function:
- May have a role in neuroendocrine differentiation.
- GENATLAS Biochemistry:
- delta (Drosophila)-like 1,member of the EGF-like homeotic family,involved in cell differentiation in a justacrine/paracrine manner and in the pathogenesis of NF1,participating in the control of cell differentiation of several cell type,including small cell lung cancer lines,immune stem cells,B cells and adrenal glumerulose cells
Phenotypes From GWAS Catalog for DLK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005509 | calcium ion binding | IEA | -- |
Phenotypes for DLK1 Gene
- MGI mutant phenotypes for DLK1:
-
inferred from 4 alleles
- cardiovascular system phenotype
- vision/eye phenotype
- homeostasis/metabolism phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for DLK1:
Animal Models for DLK1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
-
OriGene CRISPR knockouts for DLK1
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- genomics-online: gRNA clones - Search results for 132 available DLK1 gene related products
- Overview of 132 available DLK1 gene related products
- Applied Biological Materials CRISPR for DLK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DLK1
- GenScript: Design CRISPR guide RNA sequences for DLK1
miRNA for DLK1 Gene
- miRTarBase miRNAs that target DLK1
-
- hsa-mir-15a-5p (MIRT032077)
- hsa-mir-1-3p (MIRT790113)
- hsa-mir-206 (MIRT790165)
- hsa-mir-3187-3p (MIRT790255)
- hsa-mir-4299 (MIRT790415)
- hsa-mir-4456 (MIRT790461)
- hsa-mir-4529-5p (MIRT790515)
- hsa-mir-4773 (MIRT790631)
- hsa-mir-4802-3p (MIRT790652)
- hsa-mir-548q (MIRT790750)
- hsa-mir-613 (MIRT790828)
- hsa-mir-7978 (MIRT791133)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DLK1
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- genomics-online: shRNA clones - Search results for 132 available DLK1 gene related products
- Overview of 132 available DLK1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for DLK1
- VectorBuilder custom plasmid, inducible vectors for DLK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DLK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DLK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLK1
- Applied Biological Materials Clones for DLK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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Cell Line Products
-
Horizon Cell Lines for DLK1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DLK1 Gene
Localization for DLK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DLK1 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| nucleus | 3 |
| cytoskeleton | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Golgi apparatus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 7925474 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | TAS,IEA | -- |
Pathways & Interactions for DLK1 Gene
Pathways by source for DLK1 Gene
1 Sino Biological pathway for DLK1 Gene
4 BioSystems pathways for DLK1 Gene
4 Reactome pathways for DLK1 Gene
2 R&D Systems pathways for DLK1 Gene
1 Cell Signaling Technology pathway for DLK1 Gene
Interacting Proteins for DLK1 Gene
GPS-Prot Interaction Network for DLK1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030154 | cell differentiation | IEA | -- |
| GO:0045746 | negative regulation of Notch signaling pathway | IDA | 25093684 |
Transcripts for DLK1 Gene
mRNA/cDNA for DLK1 Gene
- (3) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (1111) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000331224 1324 bps (uc001yhu.5)
- ENST00000341267 4722 bps (uc001yhs.5)
- ENST00000392848 555 bps (uc059ffs.1)
- ENST00000555747 538 bps (uc059fft.1)
- ENST00000556051 469 bps (uc059ffu.1)
Unigene Clusters for DLK1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DLK1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLK1
- genomics-online: gRNA clones - Search results for 132 available DLK1 gene related products
- Overview of 132 available DLK1 gene related products
- Applied Biological Materials CRISPR for DLK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DLK1
- GenScript: Design CRISPR guide RNA sequences for DLK1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DLK1
- Browse OriGene Inhibitory RNA Products For DLK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLK1
- genomics-online: shRNA clones - Search results for 132 available DLK1 gene related products
- Overview of 132 available DLK1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for DLK1
- VectorBuilder custom plasmid, inducible vectors for DLK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DLK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DLK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLK1
- Applied Biological Materials Clones for DLK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for DLK1 (Pref-1/DLK1/FA1)
Expression for DLK1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for DLK1 Gene
This gene is overexpressed in Adrenal Gland (x27.7), Pituitary (x17.2), and Ovary (x4.8).
This gene is overexpressed in Fetal Brain (24.4), Urine (22.5), and Fetal ovary (8.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DLK1 Gene
NURSA nuclear receptor signaling pathways regulating expression of DLK1 Gene:
DLK1SOURCE GeneReport for Unigene cluster for DLK1 Gene:
Hs.533717mRNA Expression by UniProt/SwissProt for DLK1 Gene:
P80370-DLK1_HUMAN
Tissue specificity:
Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue.
Evidence on tissue expression from TISSUES for DLK1 Gene
- Adrenal gland(4.7)
- Pancreas(4.4)
- Liver(3)
- Nervous system(3)
- Muscle(2.7)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for DLK1
-
OriGene qPCR primer pairs for DLK1
- genomics-online: primer clones - Search results for 132 available DLK1 gene related products
- Overview of 132 available DLK1 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DLK1 Gene
Orthologs for DLK1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DLK1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DLK1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Dlk1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dlk1 33 |
|
||
| cow (Bos Taurus) |
Mammalia | DLK 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | DLK1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | DLK1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DLK1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DLK1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dlk1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101883341 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | wry 34 |
|
OneToMany |
- Species where no ortholog for DLK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for DLK1 Gene
- ENSEMBL:
- Gene Tree for DLK1 (if available)
- TreeFam:
- Gene Tree for DLK1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DLK1: view image
Paralogs for DLK1 Gene
(13) SIMAP similar genes for DLK1 Gene using alignment to 7 proteins:
- DLK1_HUMAN
- G3V2R7_HUMAN
- G3XAH5_HUMAN
- Q0H2C6_HUMAN
- Q45KX0_HUMAN
- Q4U3E1_HUMAN
- Q969Y6_HUMAN
Variants for DLK1 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000048663 | -- | 100,728,089(+) | T/G | intron_variant | |
| rs1000099586 | -- | 100,727,376(+) | G/C | intron_variant | |
| rs1000244004 | -- | 100,730,825(+) | A/C/G | intron_variant | |
| rs1000316287 | -- | 100,730,642(+) | G/C | intron_variant | |
| rs1000348890 | -- | 100,730,345(+) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv521690 | CNV | loss | 19592680 |
| nsv525723 | CNV | loss | 19592680 |
| nsv565787 | CNV | loss | 21841781 |
| nsv565858 | CNV | loss | 21841781 |
| nsv832876 | CNV | loss | 17160897 |
| nsv483116 | CNV | gain | 15286789 |
| nsv470668 | CNV | loss | 18288195 |
| nsv456428 | CNV | loss | 19166990 |
| nsv1425 | CNV | insertion | 18451855 |
| esv3635516 | CNV | gain | 21293372 |
| esv2751158 | CNV | gain | 17911159 |
Residual Variation Intolerance Score:
25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.97;
68.18% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DLK1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLK1 Gene
Disorders for DLK1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| idiopathic central precocious puberty |
|
|
| temple syndrome |
|
|
| kagami-ogata syndrome |
|
|
| schneiderian carcinoma |
|
|
| angiomatosis |
|
|
Search DLK1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DLK1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for DLK1 Gene
Publications for DLK1 Gene
- Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2. (PMID: 7925474) Jensen CH … Teisner B (European journal of biochemistry 1994) 2 3 4 22 58
- dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA. (PMID: 7711066) Lee YL … Laborda J (Biochimica et biophysica acta 1995) 3 4 22 58
- dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. (PMID: 8095043) Laborda J … Notario V (The Journal of biological chemistry 1993) 2 3 4 58
- Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2. (PMID: 8501199) Jensen CH … Skjødt K (Human reproduction (Oxford, England) 1993) 3 4 22 58
- An upstream insulator regulates DLK1 imprinting in AML. (PMID: 20089961) Khoury H … Minden MD (Blood 2010) 3 22 58
Products for DLK1 Gene
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- VectorBuilder custom plasmid, inducible vectors for DLK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DLK1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DLK1
- antibodies-online: Search results for 180 available DLK1 Antibodies ranked by validation data
- Compare Top DLK1 Antibodies
- antibodies-online: Search results for 11 available DLK1 Elisa Kits ranked by validation data
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- Quality Products:
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- GeneTex DLK1 Antibody for DLK1
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- Overview of 132 available DLK1 gene related products
- genomics-online: primer clones - Search results for 132 available DLK1 gene related products
- Overview of 132 available DLK1 gene related products
- genomics-online: shRNA clones - Search results for 132 available DLK1 gene related products
- Overview of 132 available DLK1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLK1
- GeneCopoeia miRNA 3'UTR Target clone products for DLK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLK1
- Boster Bio Antibodies for DLK1
- Browse Boster Bio ELISA Kits
Sources for DLK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt