DLGAP2 Gene - DLG Associated Protein 2

Protein Coding (Updated: Nov 13, 2025)
The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only the paternal allele is expressed in the testis (PMID:18055845). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, J... See more...

Aliases for DLGAP2 Gene

Aliases for DLGAP2 Gene

  • GeneCards Symbol: DLGAP2 2
  • DLG Associated Protein 2 2 3 5
  • ERICH1-AS1 3 4 5
  • C8orf68 3 4 5
  • DAP-2 2 4 5
  • ERICH1 Antisense RNA 1 (Non-Protein Coding) 2 3
  • Discs Large Homolog Associated Protein 2 2 3
  • SAP90/PSD-95-Associated Protein 2 3 4
  • Disks Large-Associated Protein 2 3 4
  • PSD-95/SAP90-Binding Protein 2 3 4
  • SAPAP2 3 4
  • DAP2 3 4
  • Discs, Large (Drosophila) Homolog-Associated Protein 2 2
  • Chromosome 8 Open Reading Frame 68 2
  • Discs Large-Associated Protein 2 3
  • ERICH1 Antisense Gene Protein 1 3
  • Putative DAP-2 Like Protein 3
  • ERICH1 Antisense RNA 1 2

External Ids for DLGAP2 Gene

Previous HGNC Symbols for DLGAP2 Gene

  • ERICH1-AS1
  • C8orf68

Previous GeneCards Identifiers for DLGAP2 Gene

  • GC08P001260
  • GC08P001555
  • GC08P001436
  • GC08P000927
  • GC08P000739
  • GC08P000771
  • GC08P000810
  • GC08P000881
  • GC08P000934
  • GC08P000986

Summaries for DLGAP2 Gene

NCBI Gene Summary for DLGAP2 Gene

  • The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only the paternal allele is expressed in the testis (PMID:18055845). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2014]

GeneCards Summary for DLGAP2 Gene

DLGAP2 (DLG Associated Protein 2) is a Protein Coding gene. Diseases associated with DLGAP2 include Autism Spectrum Disorder and Epilepsy. An important paralog of this gene is DLGAP1.

UniProtKB/Swiss-Prot Summary for DLGAP2 Gene

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. ( DLGP2_HUMAN,Q9P1A6 )

Gene Wiki entry for DLGAP2 Gene

PharmGKB Summary for DLGAP2 Gene

Additional gene information for DLGAP2 Gene

No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for DLGAP2 Gene

Genomics for DLGAP2 Gene

Subsections:

  1. Promoters/Enhancers
  2. Location

GeneHancer (GH) Regulatory Elements (see citations)

Download GeneHancer 2017 data
Promoters and enhancers for DLGAP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08J000737 Promoter/Enhancer 0.9 EPDnew Ensembl 300.70 261.04 -0.1 1 0.6 ZBTB26 EZH2 ZNF335 DLGAP2 ERICH1 LOC124902044 LOC401442 ENSG00000309319 ENSG00000309333 HSALNG0062904 lnc-CLN8-11 lnc-DLGAP2-3 lnc-ERICH1-7
GH08J000740 Promoter 0.5 Ensembl 300.70 153.79 +0.9 2 0.1 ZBTB26 KLF1 ZBTB8A EZH2 DLGAP2 ERICH1 LOC124902044 LOC401442 ENSG00000309319 HSALNG0062904 lnc-CLN8-11 lnc-ERICH1-7 LOC105379585
GH08J000741 Enhancer 0.4 Ensembl 300.70 121.57 +1.1 3 0.3 ZBTB26 KLF1 ZBTB8A EZH2 DLGAP2 ERICH1 LOC124902044 LOC401442 ENSG00000309319 HSALNG0062904 lnc-CLN8-11 lnc-ERICH1-7 HSALNG0150323 LOC105379585
GH08J001548 Promoter 0.2 EPDnew 311.90 77.97 +811.1 105 0.1 DLGAP2 HSALNG0062941 piR-38423-068 LOC105379585 CLN8
GH08J000738 Enhancer 0.3 Ensembl 300.70 76.82 -0.4 3 0.1 EZH2 DLGAP2 ERICH1 LOC124902044 LOC401442 ENSG00000309319 ENSG00000309333 HSALNG0062904 lnc-CLN8-11 lnc-DLGAP2-3 lnc-ERICH1-7

GeneHancers around DLGAP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from The Signaling Pathways Project (SPP) (The Signaling Pathways Project) for DLGAP2

Top Transcription factor binding sites by QIAGEN in the DLGAP2 gene promoter:
  • AML1a
  • C/EBPalpha
  • Cart-1
  • Elk-1
  • GATA-1
  • HNF-1
  • HNF-1A
  • PPAR-gamma1
  • PPAR-gamma2
  • S8

Genomic Locations for DLGAP2 Gene

Latest Assembly
chr8:737,628-1,708,476
(GRCh38/hg38)
Size:
970,849 bases
Orientation:
Plus strand

Previous Assembly
chr8:687,628-1,656,642
(GRCh37/hg19 by NCBI Gene)
Size:
969,015 bases
Orientation:
Plus strand

chr8:1,449,532-1,656,642
(GRCh37/hg19 by Ensembl)
Size:
207,111 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr8(ALT_REF_LOCI_1):19,219-106,180 (+)
  • chr8(ALT_REF_LOCI_2):112,159-317,743 (+)
  • chr8(ALT_REF_LOCI_3):40,124-121,138 (+)

Genomic View for DLGAP2 Gene

Genes around DLGAP2 on UCSC Golden Path with GeneCards custom tracks (GRCh38/hg38, GRCh37/hg19)

Cytogenetic band:
DLGAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or NCBI Gene and/or Ensembl if different)
Genomic Location for DLGAP2 Gene
Genomic Neighborhood
•
Exon Structure
•
Gene Densities

Proteins for DLGAP2 Gene

Subsections:

  1. 3D Structures
  2. Alternative Splicing
  3. Protein References
  4. Post-Translational Modifications

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  3. Assay products

  • Protein details for DLGAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1A6-DLGP2_HUMAN
    Recommended name:
    Disks large-associated protein 2
    Protein Accession:
    Q9P1A6
    Secondary Accessions:
    • A1QCF8
    • A1QCF9
    • A5D8Y2
    • O14488
    • O14664
    • Q9P1A7

    Protein attributes for DLGAP2 Gene

    Size:
    1054 amino acids
    Molecular mass:
    117620 Da
    Protein existence level:
    PE1
    Quaternary structure:

    • Interacts with DLG1 and DLG4/PSD-95.
    Sequence caution:

    • The sequence EAW51475.1 differs from that shown. Reason: Erroneous gene model prediction {ECO:0000305}

    Three dimensional structures from AlphaFold (predicted) for DLGAP2 Gene

    Model Confidence:
    Very high (pLDDT > 90)
    Confident (90 > pLDDT > 70)
    Low (70 > pLDDT > 50)
    Very low (pLDDT < 50)
    Identifier Method Resolution PDBe RCSB-PDB OCA Proteopedia
    GeneCards.Business.Types.Common.LinkDto Predicted

    Alternative splice isoforms for DLGAP2 Gene from UniProtKB/Swiss-Prot

    produced by Alternative splicing

Protein Expression for DLGAP2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DLGAP2 Gene

  • Modification sites at PhosphoSitePlus ( Q9P1A6 )
  • Modification sites at neXtProt ( NX_Q9P1A6 )
  • Glycosylation from GlyGen (Q9P1A6) 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

Other Protein References for DLGAP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

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No data available for DME Specific Peptides for DLGAP2 Gene

Domains & Families for DLGAP2 Gene

Gene Families for DLGAP2 Gene

The Human Protein Atlas (HPA):
  • Nuclear receptors
  • Predicted intracellular proteins

Protein Domains for DLGAP2 Gene

InterPro:
Blocks:
  • Guanylate-kinase-associated protein

Suggested Antigen Peptide Sequences for DLGAP2 Gene

GenScript: Design optimal peptide antigens:
  • Putative DAP-2 like protein C8orf68 (CH068_HUMAN)
  • SAP90/PSD-95-associated protein 2 (DLGP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9P1A6

UniProtKB/Swiss-Prot:

DLGP2_HUMAN :
  • Belongs to the SAPAP family.
Family:
  • Belongs to the SAPAP family.
Genes that share domains with DLGAP2: view

Function for DLGAP2 Gene

Subsections:

  1. GWAS Phenotypes
  2. GO Terms
  3. MGI/GenomeRNAi Phenotypes

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  3. Inhibitory RNAs
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Molecular function for DLGAP2 Gene according to UniProtKB/Swiss-Prot

Function:
  • May play a role in the molecular organization of synapses and neuronal cell signaling.
    Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton.
    May induce enrichment of PSD-95/SAP90 at the plasma membrane. DLGP2_HUMAN,Q9P1A6

Molecular function for DLGAP2 Gene according to GENATLAS

Biochemistry:
  • Drosophila discslarge homolog-associated protein 2,binding the guanylate kinase-like domains of DLG2,DLG4,localized at postsynaptic density (PSD) in neuronal cells DLGAP2

Phenotypes From GWAS Catalog for DLGAP2 Gene

Phenotype Gene Relation Best Score Mean Score # of Snps # of Studies SNP IDs
bone tissue density
  • GWAS
300.0 106.7993 3 2
body height 35.3 21.95598 3 1
rho guanine nucleotide exchange factor 10 measurement
  • GWAS
16.5 15.61092 2 1
covid-19
  • GeneExon ,
  • GWAS
12.7 8.090101 5 2
daytime rest measurement
  • GWAS
12.5 12.52288 1 1

Gene Ontology (GO) - Molecular Function for DLGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 3 5 enables protein binding IPI 17474147
GO:0060090 3 5 enables molecular adaptor activity IBA
Genes that share ontologies with DLGAP2: view
Genes that share phenotypes with DLGAP2: view

Animal Models for DLGAP2 Gene

MGI Knock Outs for DLGAP2:

miRNA for DLGAP2 Gene

miRTarBase miRNAs that target DLGAP2

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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , NCBI Functional elements , Transcription Factor Targeted Genes and HOMER Transcription for DLGAP2 Gene

Localization for DLGAP2 Gene

Subsections:

  1. Cellular Components

Subcellular locations from UniProtKB/Swiss-Prot for DLGAP2 Gene

Protein: DLGP2_HUMAN

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DLGAP2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
cytosol 3
nucleus 3
endoplasmic reticulum 1
mitochondrion 1
extracellular 1

Gene Ontology (GO) - Cellular Components for DLGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005883 3 5 located_in neurofilament NAS 10759891
GO:0005886 3 5 located_in plasma membrane TAS, IEA
GO:0014069 3 5 located_in postsynaptic density IEA
GO:0016020 3 5 located_in membrane IEA
GO:0045202 3 5 located_in synapse IEA
Genes that share ontologies with DLGAP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DLGAP2 Gene

Pathways & Interactions for DLGAP2 Gene

Subsections:

  1. String Interactions
  2. Interacting Proteins
  3. Curated Interactions
  4. GO Terms

Additional Pathway Information for DLGAP2 Gene

SIGNOR curated interactions for DLGAP2 Gene

Activates:

Gene Ontology (GO) - Biological Process for DLGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007270 3 5 involved_in neuron-neuron synaptic transmission NAS
GO:0023052 3 5 involved_in signaling IEA
GO:0050804 3 5 involved_in modulation of chemical synaptic transmission IBA
Genes that share ontologies with DLGAP2: view

No data available for Pathways by source for DLGAP2 Gene

Drugs & Compounds for DLGAP2 Gene

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No Compound Related Data Available

Transcripts for DLGAP2 Gene

Subsections:

  1. Alternative Splicing

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  3. Inhibitory RNAs
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mRNA/cDNA for DLGAP2 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

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Alternative Splicing Database (ASD) splice patterns (SP) for DLGAP2 Gene

No ASD Table

Exon structure for DLGAP2 gene

Exon Structure

Expression for DLGAP2 Gene

Subsections:

  1. Protein expression
  2. Co-Expression partners

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  1. Primer products

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DLGAP2 Gene

mRNA expression in normal human tissues for DLGAP2 Gene
mRNA expression by GTEx for DLGAP2 GenemRNA expression by BioGPS for DLGAP2 Gene

mRNA differential expression in normal tissues according to GTEx for DLGAP2 Gene

This gene is overexpressed in Testis (x29.5), Brain - Cortex (x7.6), Brain - Frontal Cortex (BA9) (x7.6), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Nucleus accumbens (basal ganglia) (x4.6), Brain - Putamen (basal ganglia) (x4.3), and Brain - Caudate (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for DLGAP2 Gene

This gene is overexpressed in Frontal cortex (61.4) and Retina (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DLGAP2 Gene



Protein tissue co-expression partners for DLGAP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DLGAP2

mRNA Expression by UniProt/SwissProt for DLGAP2 Gene:

Q9P1A6-DLGP2_HUMAN
Tissue specificity: Expressed in brain and kidney.

Evidence on tissue expression from TISSUES for DLGAP2 Gene

  • Nervous system(4.6)

Bgee gene expression patterns for DLGAP2 gene:

  • Expressed in left testis, right testis, primordial germ cell in gonad and 89 other cell types or tissues.
Genes that share expression patterns with DLGAP2: view

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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DLGAP2 Gene

Orthologs for DLGAP2 Gene

Subsections:

  1. CladeOScope co-evolved genes

This gene was present in the common ancestor of animals.

Orthologs for DLGAP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)		 Mammalia DLGAP2 27 28
  • 99.2 (n)
OneToOne
Lizard
(Anolis carolinensis)		 Reptilia DLGAP2 28
  • 88 (a)
OneToOne
Oppossum
(Monodelphis domestica)		 Mammalia DLGAP2 28
  • 86 (a)
OneToOne
Dog
(Canis familiaris)		 Mammalia DLGAP2 27 28
  • 85.02 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)		 Mammalia DLGAP2 28
  • 85 (a)
OneToOne
Species where no ortholog for DLGAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DLGAP2 Gene

ENSEMBL:
Gene Tree for DLGAP2 (if available)
TreeFam:
Gene Tree for DLGAP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DLGAP2: view image
Alliance of Genome Resources:
Additional Orthologs for DLGAP2

CladeOScope co-evolved genes for DLGAP2 gene

Clade Top 10 Co-Evolved Genes Normalized Phylogenetic Profile HeatMap (PPH)
Top Genes From All Clades
Archelosauria
Arthropoda
Chordata
Ecdysozoa
Eukaryota
Mammalia
Nematoda
Platyhelminthes

Paralogs for DLGAP2 Gene

Paralogs for DLGAP2 Gene

(3) SIMAP paralogs for DLGAP2 Gene using alignment to 3 proteins:

  • DLGP2_HUMAN
  • H0YBY6_HUMAN
  • ERAS1_HUMAN
Genes that share paralogs with DLGAP2: view

Variants for DLGAP2 Gene

Subsections:

  1. Variation Tolerance
  2. External Links

Sequence variations, with clinical significance, from ClinVar and UniProt Humsavar, with links to dbSNP and Ensembl, for DLGAP2 Gene

Accession rsID Clinical significance and condition Chr 08 pos Variation Name Ref/Alt AA Chg Type
1686633 5 rs2130517378

Uncertain significance: not specified

1,549,232(+) NM_001346810.2(DLGAP2):c.779A>C (p.Asp260Ala) A/C D260A missense variant
2203889 5 rs369795477

Uncertain significance: not specified

1,668,602(+) NM_001346810.2(DLGAP2):c.2084G>A (p.Arg695Gln) G/A R695Q missense variant
2210958 5 rs200490199

Uncertain significance: not specified

1,633,011(+) NM_001346810.2(DLGAP2):c.1775C>T (p.Pro592Leu) C/T P592L missense variant
2219840 5 rs772505544

Uncertain significance: not specified

1,697,217(+) NM_001346810.2(DLGAP2):c.2867T>C (p.Ile956Thr) T/C I956T missense variant
2229999 5 rs1417836296

Uncertain significance: not specified

1,549,629(+) NM_001346810.2(DLGAP2):c.1176G>C (p.Lys392Asn) G/C K392N missense variant

Identifiers for variants without clinical significance from dbSNP and UniProt Humsavar for DLGAP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DLGAP2 Gene

Variant ID Type Subtype PubMed ID
nsv609452 CNV loss 21841781
esv3615771 CNV gain 21293372
nsv4153146 CNV duplication 32461652
dgv6795n100 CNV gain 25217958
nsv4155127 CNV duplication 32461652
SVs/CNVs around DLGAP2 on UCSC Golden Path with GeneCards custom tracks (GRCh38/hg38, GRCh37/hg19)

Variation tolerance for DLGAP2 Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DLGAP2 Gene

Human Gene Mutation Database (HGMD)
DLGAP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DLGAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLGAP2 Gene

Disorders for DLGAP2 Gene

Subsections:

  1. External links

4 diseases for DLGAP2 Gene - From: GTR, GeneCards, DISEASES, and ClinVar

(click the icon to the left of a disorder to see descriptions and symptoms)

Disorder Aliases PubMed IDs
Autism Spectrum Disorder 1 63 99
  • Autism Spectrum Disorders
  • Asd
  • Autistic Continuum
  • Pervasive Developmental Disorder
  • Pervasive Development Disorder
  • Autistic Behavior
  • Autistic Disorder
  • Autistic
  • Autistic Disorder Of Childhood Onset
  • Infantile Autism
  • Childhood Autism
  • Kanner Syndrome
  • Pervasive Developmental Delay Nos
  • Pervasive Developmental Disorder, Not Otherwise Specified
  • Autism Spectrum Disorder Without Disorder Of Intellectual Development And With Mild Or No Impairment Of Functional Language
  • Autism Spectrum Disorder With Disorder Of Intellectual Development And With Mild Or No Impairment Of Functional Language
  • Autism Spectrum Disorder Without Disorder Of Intellectual Development And With Impaired Functional Language
  • Autism Spectrum Disorder With Disorder Of Intellectual Development And With Impaired Functional Language
  • Autism Spectrum Disorder With Disorder Of Intellectual Development And With Absence Of Functional Language
  • Other Specified Autism Spectrum Disorder
  • Autism Spectrum Disorder, Unspecified
Epilepsy 1 63 99
  • Epilepsy Syndrome
  • Epileptic Syndrome
  • Epilepsies
  • Epilepsy Due To Structural Or Metabolic Conditions Or Diseases
  • Symptomatic Epilepsies
  • Epilepsy Due To Prenatal Or Perinatal Brain Insults
  • Epilepsy Due To Prenatal Or Perinatal Vascular Insults
  • Epilepsy Due To Neonatal Hypoxic Ischemic Encephalopathy
  • Epilepsy Due To Other Prenatal Or Perinatal Brain Insults
  • Epilepsy Due To Unspecified Prenatal Or Perinatal Brain Insults
  • Epilepsy Due To Cerebrovascular Disorders
  • Epilepsy Due To Degenerative Brain Disorders
  • Epilepsy Due To Dementias
  • Epilepsy Due To Central Nervous System Infections Or Infestations
  • Epilepsy Due To Injuries To The Head
  • Post Traumatic Epilepsy
  • Traumatic Epilepsy
  • Traumatic Epileptic
  • Epilepsy Due To Tumours Of The Nervous System
  • Epilepsy With Mesial Temporal Sclerosis
  • Epilepsy Due To Hippocampal Sclerosis
  • Epilepsy With Ammon'S Horn Sclerosis
  • Epilepsy Due To Immune Disorders
  • Epilepsy Due To Abnormalities Of Brain Development
  • Epilepsy Due To Cortical Dysplasia
  • Epilepsy Due To Neuronal Migration Disorders
  • Epilepsy Due To Genetic Syndromes With Widespread Or Progressive Effects
  • Epilepsy Due To Multiple Sclerosis Or Other Demyelinating Disorders
  • Epilepsy Due To Other Structural Or Metabolic Condition Or Disease
  • Epilepsy Due To Unspecified Structural Or Metabolic Condition Or Disease
Schizophrenia 1 63 107
  • SCZD
  • Schizophrenia With Or Without An Affective Disorder
  • Schizophrenia-1
  • Dementia Praecox
  • Schizophrenia, Susceptibility To
  • Schizophrenia 12
  • Schizophrenia 1
 30208311
Alacrima, Achalasia, And Impaired Intellectual Development Syndrome 99
  • AAMR
  • Alacrima, Achalasia, And Mental Retardation Syndrome
  • Alacrima, Achalasia, And Intellectual Disability Syndrome
  • Intellectual Disability
- elite association - COSMIC cancer census association via MalaCards

12 text mining disease associations for DLGAP2 Gene - From: GeneCards and DISEASES

Disorder Aliases PubMed IDs
Tardive Dyskinesia 1
  • Drug-Induced Tardive Dyskinesia
  • Lingual-Facial-Buccal Dyskinesia
  • Neuroleptic-Induced Tardive Dyskinesia
Obsessive-Compulsive Disorder 1 63
  • OCD
  • Anancastic Neurosis
  • Anankastic Neurosis
  • Obsessive-Compulsive Neurosis
  • Obsessive Compulsive Disorder
  • Obsessive-Compulsive Disorder, Susceptibility To
  • Obsessive Compulsive Behavior
  • Obsessive-Compulsive Disorder With Fair To Good Insight
  • Obsessive-Compulsive Disorder With Poor To Absent Insight
  • Obsessive-Compulsive Disorder, Unspecified
Ceroid Lipofuscinosis, Neuronal, 8, Northern Epilepsy Variant 63
  • Neuronal Ceroid Lipofuscinosis 8 Northern Epilepsy Variant
  • Northern Epilepsy
  • Epmr
  • Progressive Epilepsy-Intellectual Disability Syndrome, Finnish Type
  • Northern Epilepsy Variant, Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant
  • Cln8 Disease, Northern Epilepsy Variant
  • Early Onset Familial Encephalopathy With Neuroserpin Inclusion Bodies
  • Ncl, Northern Epilepsy Variant
  • Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant
  • Progressive Myoclonic Epilepsy With Neuroserpin Inclusion Bodies
  • Northern Epilepsy Syndrome
  • Epilepsy, Progressive, With Mental Retardation
  • Progressive Epilepsy With Mental Retardation, Northern Epilepsy
  • Progressive Epilepsy With Intellectual Disability, Northern Epilepsy
  • Progressive Epilepsy With Mental Retardation
  • Progressive Epilepsy-Intellectual Disability Syndrome Finnish Type
  • CLN8NE
  • Ceroid Lipofuscinosis, Neuronal, 8
Mobitz Type Ii Atrioventricular Block 63
  • Mobitz Ii Atrioventricular Block
  • Mobitz Ii Atrioventricular Block
N Syndrome 63
  • NSX
- COSMIC cancer census association via MalaCards

Additional Disease Information for DLGAP2

Human Genome Epidemiology Literature Finder
(Human Genome Epidemiology Literature Finder)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
The FABRIC Cancer Portal
(FABRIC)
Genes that share disorders with DLGAP2: view

No data available for UniProtKB/Swiss-Prot and GENATLAS for DLGAP2 Gene

Publications for DLGAP2 Gene

Publications for DLGAP2 from MalaCards, NCBI Gene, PubMed, ClinVar, GAD, UniProtKB/Swiss-Prot, HGNC, SIGNOR

(click the icon to the left of a publication to see abstract and related MeSH terms)

Title Association Year # Cit
Positional cloning and characterisation of the human DLGAP2 gene and its exclusion in progressive epilepsy with mental retardation.
(European journal of human genetics : EJHG) Ranta S … Lehesjoki AE (10854099) 		Publication 49 Protein 4 Gene 2 3 2000 15
DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95.
(Genes to cells : devoted to molecular & cellular mechanisms) Satoh K … Akiyama T (9286858) 		Protein 4 Gene 2 3 1997 28
DNA Methylation Near DLGAP2 May Mediate the Relationship between Family History of Type 1 Diabetes and Type 1 Diabetes Risk.
(Pediatric diabetes) Johnson RK … Norris JM (38765731) 		Publication 49 Gene 3 2023 1
Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm.
(Epigenetics) Schrott R … Murphy SK (31451081) 		Publication 49 Gene 3 2020 57
Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia.
(Cell reports) Ouellette AR … Kaczorowski CC (32877673) 		Publication 49 Gene 3 2020 22
Quantitative DNA Methylation Analysis of DLGAP2 Gene using Pyrosequencing in Schizophrenia with Tardive Dyskinesia: A Linear Mixed Model Approach.
(Scientific reports) Li Y … Tan Y (30504779) 		Publication 49 Gene 3 2018 9
Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights.
(Cell reports) Kushima I … Ozaki N (30208311) 		Disorder 69 GeneVariant 107 2018 131
Genetic variation in imprinted genes is associated with risk of late-onset Alzheimer's disease.
(Journal of Alzheimer's disease : JAD) Chaudhry M … Kamboh MI (25391383) 		Publication 49 Gene 3 2015 17
Role of the DLGAP2 gene encoding the SAP90/PSD-95-associated protein 2 in schizophrenia.
(PloS one) Li JM … Chen CH (24416398) 		Publication 49 Gene 3 2014 26
Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: a preliminary study.
(Psychiatry research) Wu K … Arnold PD (23154099) 		Publication 49 Gene 3 2013 31

Products for DLGAP2 Gene

Sources for DLGAP2 Gene