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DLGAP1 (DLG Associated Protein 1) is a Protein Coding gene. Diseases associated with DLGAP1 include Transient Tic Disorder and Obsessive-Compulsive Disorder. Among its related pathways are Neuroscience and Circadian entrainment. An important paralog of this gene is DLGAP2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH18J004453 | Promoter/Enhancer | 1.6 | FANTOM5 Ensembl ENCODE CraniofacialAtlas | 607 | +0.8 | 841 | 3.2 | CTCF BACH1 LARP7 POLR2A ZNF561 KLF9 ZSCAN29 RAD21 DPF2 GATAD2B | DLGAP1 lnc-AKAIN1-9 lnc-TGIF1-12 lnc-AKAIN1-8 | |
GH18J004248 | Promoter/Enhancer | 0.7 | EPDnew Ensembl | 600.1 | +206.5 | 206540 | 0.6 | HDGF MLLT1 | DLGAP1 lnc-TGIF1-9 lnc-MYOM1-12 lnc-AKAIN1-9 TGIF1 | |
GH18J003880 | Promoter | 0.5 | EPDnew | 600 | +575.3 | 575337 | 0.1 | GABPA GABPB1 | piR-50889 DLGAP1 MIR6718 DLGAP1-AS3 TGIF1 | |
GH18J003845 | Promoter | 0.3 | EPDnew | 600 | +610.1 | 610063 | 0.1 | lnc-MYOM1-8 DLGAP1 DLGAP1-AS3 TGIF1 | ||
GH18J003816 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE | 16.1 | +638.2 | 638228 | 2.4 | CREB1 PRDM10 ZNF629 ZNF692 SP1 CEBPA CEBPB ETS1 RFX1 JUND | DLGAP1 TGIF1 SNODB924 lnc-MYOM1-8 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 17474147 |
GO:0044877 | protein-containing complex binding | ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005575 | cellular_component | ND | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0014069 | postsynaptic density | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0030054 | cell junction | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Protein-protein interactions at synapses | ||
2 | Neuroscience | ||
3 | Circadian entrainment | ||
4 | Transmission across Chemical Synapses |
.62
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007268 | chemical synaptic transmission | IEA,NAS | 9286858 |
GO:0023052 | signaling | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DLGAP1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DLGAP1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DLGAP1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DLGAP1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dlgap1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dlgap1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | DLGAP1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
LOC100859693 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | DLGAP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dlgap1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dlgap1a 30 31 |
|
OneToMany | |
dlgap1b 31 |
|
OneToMany | |||
otx5 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | vlc 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2669 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
727983 | Likely Benign: not provided | 3,534,426(-) | A/G | SYNONYMOUS_VARIANT | |
771503 | Benign: not provided | 3,879,217(-) | G/T | SYNONYMOUS_VARIANT | |
777265 | Benign: not provided | 3,879,181(-) | C/T | SYNONYMOUS_VARIANT | |
788613 | Benign: not provided | 3,534,201(-) | G/A | SYNONYMOUS_VARIANT | |
790190 | Benign: not provided | 3,567,570(-) | A/G | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
transient tic disorder |
|
|
obsessive-compulsive disorder |
|
|
trichotillomania |
|
|
myasthenic syndrome, congenital, 7, presynaptic |
|
|
fraser syndrome 1 |
|
|