DLGAP1 Gene (Protein Coding)

DLG Associated Protein 1

GC18M003488
GIFtS:
43

Aliases for DLGAP1 Gene

Aliases for DLGAP1 Gene

  • DLG Associated Protein 1 2 3 5
  • Discs Large Homolog Associated Protein 1 2 3
  • Guanylate Kinase-Associated Protein 3 4
  • SAP90/PSD-95-Associated Protein 1 3 4
  • Disks Large-Associated Protein 1 3 4
  • SAPAP1 3 4
  • DAP-1 3 4
  • DAP1 3 4
  • GKAP 3 4
  • Discs, Large (Drosophila) Homolog-Associated Protein 1 2
  • PSD-95/SAP90 Binding Protein 1 3
  • PSD-95/SAP90-Binding Protein 1 4
  • DAP-1-ALPHA 3
  • DAP-1-BETA 3
  • DLGAP1A 3
  • DLGAP1B 3
  • HGKAP 4

External Ids for DLGAP1 Gene

Previous GeneCards Identifiers for DLGAP1 Gene

  • GC18P003654
  • GC18M003484

Summaries for DLGAP1 Gene

GeneCards Summary for DLGAP1 Gene

DLGAP1 (DLG Associated Protein 1) is a Protein Coding gene. Diseases associated with DLGAP1 include Transient Tic Disorder and Obsessive-Compulsive Disorder. Among its related pathways are Circadian entrainment and Protein-protein interactions at synapses. An important paralog of this gene is DLGAP2.

UniProtKB/Swiss-Prot Summary for DLGAP1 Gene

Gene Wiki entry for DLGAP1 Gene

Additional gene information for DLGAP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DLGAP1 Gene

Genomics for DLGAP1 Gene

GeneHancer (GH) Regulatory Elements for DLGAP1 Gene

Promoters and enhancers for DLGAP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH18J004453 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas 507 +0.7 710 3.2 MYC USF1 CTCF ZBTB26 SAP30 EZH2 POLR2A HDAC2 KLF9 SMC3 DLGAP1 lnc-AKAIN1-9 lnc-TGIF1-12 lnc-AKAIN1-8
GH18J004248 Promoter/Enhancer 0.7 EPDnew Ensembl 500.1 +206.4 206409 0.6 HDGF MLLT1 DLGAP1 lnc-TGIF1-9 lnc-MYOM1-12 lnc-AKAIN1-9
GH18J003880 Promoter 0.6 EPDnew 500 +575.2 575206 0.1 GABPA GABPB1 ELF1 piR-50889 DLGAP1 MIR6718 DLGAP1-AS3
GH18J003845 Promoter 0.3 EPDnew 500 +609.9 609932 0.1 lnc-MYOM1-8 DLGAP1 DLGAP1-AS3
GH18J003816 Enhancer 1.2 FANTOM5 Ensembl ENCODE 16 +638.1 638097 2.4 TCF12 JUND FOS RFX1 CUX1 EP300 ZEB1 FOXA2 RBM25 CREB1 DLGAP1 TGIF1 RF01210-175 lnc-MYOM1-8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DLGAP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DLGAP1

Top Transcription factor binding sites by QIAGEN in the DLGAP1 gene promoter:
  • ARP-1
  • c-Myc
  • FOXF2
  • FOXO1
  • FOXO1a
  • HTF
  • LCR-F1
  • Max1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for DLGAP1 Gene

Genomic Locations for DLGAP1 Gene
chr18:3,496,032-4,455,310
(GRCh38/hg38)
Size:
959,279 bases
Orientation:
Minus strand
chr18:3,496,030-4,455,335
(GRCh37/hg19)
Size:
959,306 bases
Orientation:
Minus strand

Genomic View for DLGAP1 Gene

Genes around DLGAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLGAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLGAP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DLGAP1 Gene

Proteins for DLGAP1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DLGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14490-DLGP1_HUMAN
    Recommended name:
    Disks large-associated protein 1
    Protein Accession:
    O14490
    Secondary Accessions:
    • A8MWN8
    • B2RMU8
    • B7WPA1
    • B7Z2H2
    • B7Z2I2
    • B7Z9Y4
    • O14489
    • P78335

    Protein attributes for DLGAP1 Gene

    Size:
    977 amino acids
    Molecular mass:
    108873 Da
    Quaternary structure:
    • Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1. Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3. Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3. Found in a complex with DLG4 and BEGAIN. Interacts with DYL2 and LRFN1 (By similarity). Interacts with MPP2 (via the SH3-Guanylate kinase-like sub-module) (By similarity).

    Three dimensional structures from OCA and Proteopedia for DLGAP1 Gene

    Alternative splice isoforms for DLGAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLGAP1 Gene

Protein Expression for DLGAP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DLGAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLGAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DLGAP1 Gene

Domains & Families for DLGAP1 Gene

Gene Families for DLGAP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DLGAP1 Gene

Blocks:
  • Guanylate-kinase-associated protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DLGAP1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54734, highly similar to Disks large-associated protein 1 (A8MWN8_HUMAN)
  • cDNA FLJ54702, highly similar to Disks large-associated protein 1 (B7Z2H2_HUMAN)
  • cDNA FLJ53319, highly similar to Disks large-associated protein 1 (B7Z2I2_HUMAN)
  • cDNA, FLJ78998, highly similar to Disks large-associated protein 1 (B7Z9Y4_HUMAN)
  • SAP90/PSD-95-associated protein 1 (DLGP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14490

UniProtKB/Swiss-Prot:

DLGP1_HUMAN :
  • Belongs to the SAPAP family.
Family:
  • Belongs to the SAPAP family.
genes like me logo Genes that share domains with DLGAP1: view

Function for DLGAP1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for DLGAP1 Gene

UniProtKB/Swiss-Prot Function:
Part of the postsynaptic scaffold in neuronal cells.
GENATLAS Biochemistry:
Drosophila disc large homolog-associated protein 1,binding the guanylate kinase-like domain of DLG4,major constituans of the postsynaptic density (PSD) at the synaptic junction

Phenotypes From GWAS Catalog for DLGAP1 Gene

Gene Ontology (GO) - Molecular Function for DLGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0044877 protein-containing complex binding ISS --
genes like me logo Genes that share ontologies with DLGAP1: view
genes like me logo Genes that share phenotypes with DLGAP1: view

Animal Models for DLGAP1 Gene

MGI Knock Outs for DLGAP1:

Animal Model Products

CRISPR Products

miRNA for DLGAP1 Gene

miRTarBase miRNAs that target DLGAP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DLGAP1 Gene

Localization for DLGAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLGAP1 Gene

Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic density. Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DLGAP1 gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytoskeleton 2
cytosol 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DLGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane TAS --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with DLGAP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DLGAP1 Gene

Pathways & Interactions for DLGAP1 Gene

genes like me logo Genes that share pathways with DLGAP1: view

Pathways by source for DLGAP1 Gene

1 KEGG pathway for DLGAP1 Gene
1 Cell Signaling Technology pathway for DLGAP1 Gene

Gene Ontology (GO) - Biological Process for DLGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 chemical synaptic transmission IEA,NAS 9286858
GO:0023052 signaling IEA --
genes like me logo Genes that share ontologies with DLGAP1: view

No data available for SIGNOR curated interactions for DLGAP1 Gene

Drugs & Compounds for DLGAP1 Gene

Products:

  1. Drug

(1) Drugs for DLGAP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for DLGAP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DLGAP1: view

Transcripts for DLGAP1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DLGAP1 Gene

9 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLGAP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: -
SP6:
SP7:

Relevant External Links for DLGAP1 Gene

GeneLoc Exon Structure for
DLGAP1

Expression for DLGAP1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DLGAP1 Gene

mRNA expression in normal human tissues for DLGAP1 Gene
mRNA expression by GTEx for DLGAP1 GenemRNA expression by BioGPS for DLGAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLGAP1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x10.1), Brain - Anterior cingulate cortex (BA24) (x8.1), Brain - Cortex (x6.9), Brain - Cerebellar Hemisphere (x5.0), and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for DLGAP1 Gene

This gene is overexpressed in Frontal cortex (40.1) and Brain (26.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DLGAP1 Gene



Protein tissue co-expression partners for DLGAP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DLGAP1

SOURCE GeneReport for Unigene cluster for DLGAP1 Gene:

Hs.594640

mRNA Expression by UniProt/SwissProt for DLGAP1 Gene:

O14490-DLGP1_HUMAN
Tissue specificity: Expressed in brain.

Evidence on tissue expression from TISSUES for DLGAP1 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with DLGAP1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DLGAP1 Gene

Orthologs for DLGAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLGAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia DLGAP1 31 30
  • 99.68 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia DLGAP1 31 30
  • 93.45 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia DLGAP1 31
  • 93 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia DLGAP1 31 30
  • 91.47 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Dlgap1 17 31 30
  • 90.16 (n)
rat
(Rattus norvegicus)
 Mammalia Dlgap1 30
  • 89.92 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia DLGAP1 31
  • 81 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves -- 31
  • 93 (a)
 OneToMany
-- 31
  • 89 (a)
 OneToMany
LOC100859693 30
  • 79.46 (n)
lizard
(Anolis carolinensis)
 Reptilia DLGAP1 31
  • 86 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia dlgap1 30
  • 72.25 (n)
zebrafish
(Danio rerio)
 Actinopterygii dlgap1a 31 30
  • 72.42 (n)
 OneToMany
dlgap1b 31
  • 67 (a)
 OneToMany
otx5 30
fruit fly
(Drosophila melanogaster)
 Insecta vlc 31
  • 21 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.2669 31
  • 25 (a)
 OneToMany
Species where no ortholog for DLGAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLGAP1 Gene

ENSEMBL:
Gene Tree for DLGAP1 (if available)
TreeFam:
Gene Tree for DLGAP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DLGAP1: view image

Paralogs for DLGAP1 Gene

Paralogs for DLGAP1 Gene

(3) SIMAP similar genes for DLGAP1 Gene using alignment to 4 proteins:

  • DLGP1_HUMAN
  • A8MXQ8_HUMAN
  • A8MYR7_HUMAN
  • Q6IS01_HUMAN
genes like me logo Genes that share paralogs with DLGAP1: view

Variants for DLGAP1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DLGAP1 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs35822832 - p.Arg816Gln

Additional dbSNP identifiers (rs#s) for DLGAP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DLGAP1 Gene

Variant ID Type Subtype PubMed ID
dgv134e55 CNV gain 17911159
dgv1538n106 CNV deletion 24896259
dgv184n21 CNV gain 19592680
dgv3315n100 CNV gain 25217958
dgv3316n100 CNV loss 25217958
dgv52n6 CNV deletion 16902084
dgv540n67 CNV loss 20364138
dgv541n67 CNV loss 20364138
dgv577e199 CNV deletion 23128226
dgv578e199 CNV deletion 23128226
esv1053603 CNV deletion 17803354
esv1436100 CNV deletion 17803354
esv1587054 CNV deletion 17803354
esv1608190 CNV insertion 17803354
esv1733623 CNV deletion 17803354
esv2023494 CNV deletion 18987734
esv2166992 CNV deletion 18987734
esv22513 CNV loss 19812545
esv2282661 CNV deletion 18987734
esv2421665 CNV deletion 20811451
esv2432132 CNV deletion 19546169
esv2490559 CNV insertion 19546169
esv2559439 CNV insertion 19546169
esv2577067 CNV deletion 19546169
esv2637001 CNV deletion 19546169
esv2656305 CNV loss 23635498
esv2658035 CNV deletion 23128226
esv2660589 CNV deletion 23128226
esv2662406 CNV deletion 23128226
esv2662794 CNV deletion 23128226
esv2663849 CNV deletion 23128226
esv2663925 CNV deletion 23128226
esv2665888 CNV deletion 23128226
esv2667735 CNV deletion 23128226
esv2669815 CNV deletion 23128226
esv2673616 CNV deletion 23128226
esv2674074 CNV deletion 23128226
esv2674781 CNV deletion 23128226
esv2675505 CNV deletion 23128226
esv2676958 CNV deletion 23128226
esv2716689 CNV deletion 23290073
esv2716690 CNV deletion 23290073
esv2716691 CNV deletion 23290073
esv2716692 CNV deletion 23290073
esv2716693 CNV deletion 23290073
esv2716694 CNV deletion 23290073
esv2716697 CNV deletion 23290073
esv2716698 CNV deletion 23290073
esv2716699 CNV deletion 23290073
esv2716700 CNV deletion 23290073
esv2716701 CNV deletion 23290073
esv2716702 CNV deletion 23290073
esv2716703 CNV deletion 23290073
esv2716704 CNV deletion 23290073
esv2716705 CNV deletion 23290073
esv2758710 CNV gain 17122850
esv2760470 CNV loss 21179565
esv2762877 CNV loss 21179565
esv28168 CNV loss 19812545
esv29392 CNV loss 19812545
esv3144901 CNV deletion 24192839
esv3211494 CNV deletion 24192839
esv3211507 CNV deletion 24192839
esv3303118 CNV mobile element insertion 20981092
esv3345835 CNV insertion 20981092
esv3393114 CNV insertion 20981092
esv3415246 CNV insertion 20981092
esv3554971 CNV deletion 23714750
esv3554973 CNV deletion 23714750
esv3554974 CNV deletion 23714750
esv3554975 CNV deletion 23714750
esv3554976 CNV deletion 23714750
esv3582946 CNV loss 25503493
esv3582947 CNV loss 25503493
esv3641599 CNV loss 21293372
esv3641600 CNV loss 21293372
esv3641601 CNV loss 21293372
esv3641602 CNV loss 21293372
esv3641603 CNV loss 21293372
esv3641604 CNV loss 21293372
esv3641605 CNV loss 21293372
esv3641608 CNV loss 21293372
esv3641609 CNV loss 21293372
esv3641610 CNV loss 21293372
esv3641611 CNV gain 21293372
esv3641612 CNV loss 21293372
esv3641614 CNV loss 21293372
esv3641616 CNV loss 21293372
esv3641617 CNV loss 21293372
esv3641619 CNV loss 21293372
esv3641621 CNV loss 21293372
esv3641622 CNV loss 21293372
esv3641623 CNV loss 21293372
esv3641625 CNV loss 21293372
esv3893064 CNV loss 25118596
esv3893065 CNV gain 25118596
esv3893066 CNV gain 25118596
esv4964 CNV loss 18987735
esv5302 CNV loss 18987735
esv7766 CNV loss 19470904
nsv1059696 CNV gain 25217958
nsv1060485 CNV loss 25217958
nsv1061891 CNV gain 25217958
nsv1066089 CNV loss 25217958
nsv1071426 CNV deletion 25765185
nsv1071826 CNV deletion 25765185
nsv1072771 CNV deletion 25765185
nsv1113902 CNV deletion 24896259
nsv1116249 CNV deletion 24896259
nsv1116525 OTHER inversion 24896259
nsv1123154 CNV deletion 24896259
nsv1127611 CNV deletion 24896259
nsv1134691 CNV deletion 24896259
nsv1141944 OTHER inversion 24896259
nsv1142909 CNV tandem duplication 24896259
nsv1146733 CNV deletion 26484159
nsv131065 CNV deletion 16902084
nsv131453 CNV deletion 16902084
nsv131465 CNV deletion 16902084
nsv2191 CNV deletion 18451855
nsv438276 CNV loss 16468122
nsv458014 CNV loss 19166990
nsv458015 CNV loss 19166990
nsv510446 OTHER sequence alteration 20534489
nsv516032 CNV loss 19592680
nsv516152 CNV loss 19592680
nsv517765 CNV loss 19592680
nsv517856 CNV loss 19592680
nsv520546 CNV loss 19592680
nsv523068 CNV loss 19592680
nsv523341 CNV loss 19592680
nsv525905 CNV loss 19592680
nsv528429 CNV gain 19592680
nsv576316 CNV loss 21841781
nsv576317 CNV loss 21841781
nsv576318 CNV loss 21841781
nsv817779 CNV loss 17921354
nsv817780 CNV loss 17921354
nsv833582 CNV loss 17160897
nsv952402 CNV duplication 24416366
nsv954132 CNV deletion 24416366
nsv954143 CNV insertion 24416366
nsv954941 CNV deletion 24416366
nsv9601 CNV gain 18304495
nsv960245 CNV duplication 23825009
nsv960246 CNV duplication 23825009
nsv9603 CNV loss 18304495

Variation tolerance for DLGAP1 Gene

Residual Variation Intolerance Score: 1.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DLGAP1 Gene

Human Gene Mutation Database (HGMD)
DLGAP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DLGAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLGAP1 Gene

Disorders for DLGAP1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for DLGAP1 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DLGAP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DLGAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLGAP1 Gene

Publications for DLGAP1 Gene

  1. GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. (PMID: 9024696) Kim E … Sheng M (The Journal of cell biology 1997) 2 3 4 23 54
  2. DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95. (PMID: 9286858) Satoh K … Akiyama T (Genes to cells : devoted to molecular & cellular mechanisms 1997) 2 3 4 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  5. p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. (PMID: 15729360) Sabio G … Cuenda A (The EMBO journal 2005) 3 23 54

ExternalLinks

View latest publications for DLGAP1 gene in Mastermind

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