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Aliases for DLGAP1 Gene
Aliases for DLGAP1 Gene
External Ids for DLGAP1 Gene
- HGNC: 2905
- Entrez Gene: 9229
- Ensembl: ENSG00000170579
- OMIM: 605445
- UniProtKB: O14490
Previous GeneCards Identifiers for DLGAP1 Gene
- GC18P003654
- GC18M003484
Summaries for DLGAP1 Gene
GeneCards Summary for DLGAP1 Gene
DLGAP1 (DLG Associated Protein 1) is a Protein Coding gene. Diseases associated with DLGAP1 include Transient Tic Disorder and Obsessive-Compulsive Disorder. Among its related pathways are Neuroscience and Circadian entrainment. An important paralog of this gene is DLGAP2.
UniProtKB/Swiss-Prot Summary for DLGAP1 Gene
-
Part of the postsynaptic scaffold in neuronal cells.
Additional gene information for DLGAP1 Gene
- HGNC(2905)
- Entrez Gene(9229)
- Ensembl(ENSG00000170579)
- OMIM(605445)
- UniProtKB(O14490)
- Open Targets Platform(ENSG00000170579)
- Search for DLGAP1 at DataMed
- Search for DLGAP1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DLGAP1 Gene
Genomics for DLGAP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DLGAP1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH18J004453 | Promoter/Enhancer | 1.6 | FANTOM5 Ensembl ENCODE CraniofacialAtlas | 607 | +0.8 | 841 | 3.2 | CTCF BACH1 LARP7 POLR2A ZNF561 KLF9 ZSCAN29 RAD21 DPF2 GATAD2B | DLGAP1 lnc-AKAIN1-9 lnc-TGIF1-12 lnc-AKAIN1-8 | |
| GH18J004248 | Promoter/Enhancer | 0.7 | EPDnew Ensembl | 600.1 | +206.5 | 206540 | 0.6 | HDGF MLLT1 | DLGAP1 lnc-TGIF1-9 lnc-MYOM1-12 lnc-AKAIN1-9 TGIF1 | |
| GH18J003880 | Promoter | 0.5 | EPDnew | 600 | +575.3 | 575337 | 0.1 | GABPA GABPB1 | piR-50889 DLGAP1 MIR6718 DLGAP1-AS3 TGIF1 | |
| GH18J003845 | Promoter | 0.3 | EPDnew | 600 | +610.1 | 610063 | 0.1 | lnc-MYOM1-8 DLGAP1 DLGAP1-AS3 TGIF1 | ||
| GH18J003816 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE | 16.1 | +638.2 | 638228 | 2.4 | CREB1 PRDM10 ZNF629 ZNF692 SP1 CEBPA CEBPB ETS1 RFX1 JUND | DLGAP1 TGIF1 SNODB924 lnc-MYOM1-8 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DLGAP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DLGAP1
- Top Transcription factor binding sites by QIAGEN in the DLGAP1 gene promoter:
-
- ARP-1
- c-Myc
- FOXF2
- FOXO1
- FOXO1a
- HTF
- LCR-F1
- Max1
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for DLGAP1 Gene
Genomic Locations for DLGAP1 Gene
- chr18:3,496,032-4,455,441
- (GRCh38/hg38)
- Size:
- 959,410 bases
- Orientation:
- Minus strand
- chr18:3,496,030-4,455,335
- (GRCh37/hg19)
- Size:
- 959,306 bases
- Orientation:
- Minus strand
Genomic View for DLGAP1 Gene
Genes around DLGAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18p11.31 by HGNC
- 18p11.31 by Entrez Gene
- 18p11.31 by Ensembl
DLGAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DLGAP1 Gene
Proteins for DLGAP1 Gene
-
Protein details for DLGAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14490-DLGP1_HUMAN
- Recommended name:
- Disks large-associated protein 1
- Protein Accession:
- O14490
- A8MWN8
- B2RMU8
- B7WPA1
- B7Z2H2
- B7Z2I2
- B7Z9Y4
- O14489
- P78335
Protein attributes for DLGAP1 Gene
- Size:
- 977 amino acids
- Molecular mass:
- 108873 Da
- Quaternary structure:
-
- Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1. Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3. Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3. Found in a complex with DLG4 and BEGAIN. Interacts with DYL2 and LRFN1 (By similarity). Interacts with MPP2 (via the SH3-Guanylate kinase-like sub-module) (By similarity).
Protein Expression for DLGAP1 Gene
Post-translational modifications for DLGAP1 Gene
Other Protein References for DLGAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005258228.1
- XP_005258229.1
- XP_005258230.2
- XP_005258231.1
- XP_006722430.1
- XP_011524072.1
- XP_011524073.1
- XP_016881569.1
- XP_016881570.1
- XP_016881571.1
- XP_016881572.1
- XP_016881573.1
- XP_016881574.1
- XP_024307056.1
- NP_001003809.1
- NP_001229690.1
- NP_001229691.1
- NP_001229692.1
- NP_001229693.1
- NP_001229694.1
- NP_001229695.1
- NP_001295319.1
- NP_004737.2
Antibody Products
- G Biosciences Immunotag™ DLGP1 Antibody
- HUABIO Anti-GKAP Antibody
- BioLegend Purified anti-SAPAP (pan reactive)
-
Custom Antibody ServicesOriGene Antibodies for DLGAP1
- Novus Biologicals Antibodies for DLGAP1
- Invitrogen Antibodies for DLGAP1 (AFLGC-Dlgap1)
-
Custom Antibody ServicesProSci Antibodies for DLGAP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for DLGAP1
- Sino Biological Antibodies for DLGAP1
Protein Products
-
OriGene Purified Proteins for DLGAP1
- Search Origene for MassSpec and Protein Over-expression Lysates for DLGAP1
- Origene Custom Protein Services for DLGAP1
- Novus Biologicals proteins for DLGAP1
- antibodies-online: Show 3 available DLGAP1 Proteins ranked by validation data
- Compare Top DLGAP1 Proteins
-
Quality Products:
-
Abcam proteins for DLGAP1
Assay Products
-
Boster Bio ELISA Kits for DLGAP1
-
Signalway ELISA kits for DLGAP1
No data available for DME Specific Peptides for DLGAP1 Gene
Domains & Families for DLGAP1 Gene
Gene Families for DLGAP1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for DLGAP1 Gene
Suggested Antigen Peptide Sequences for DLGAP1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ54734, highly similar to Disks large-associated protein 1 (A8MWN8_HUMAN)
- cDNA FLJ54702, highly similar to Disks large-associated protein 1 (B7Z2H2_HUMAN)
- cDNA FLJ53319, highly similar to Disks large-associated protein 1 (B7Z2I2_HUMAN)
- cDNA, FLJ78998, highly similar to Disks large-associated protein 1 (B7Z9Y4_HUMAN)
- SAP90/PSD-95-associated protein 1 (DLGP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O14490- Family:
-
- Belongs to the SAPAP family.
Function for DLGAP1 Gene
Molecular function for DLGAP1 Gene
- UniProtKB/Swiss-Prot Function:
- Part of the postsynaptic scaffold in neuronal cells.
- GENATLAS Biochemistry:
- Drosophila disc large homolog-associated protein 1,binding the guanylate kinase-like domain of DLG4,major constituans of the postsynaptic density (PSD) at the synaptic junction
Phenotypes From GWAS Catalog for DLGAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17474147 |
| GO:0044877 | protein-containing complex binding | ISS | -- |
Phenotypes for DLGAP1 Gene
- MGI mutant phenotypes for DLGAP1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for DLGAP1:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 25%
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Mitotic spindle defects
- Two nuclei (binuclear)
- Decreased Tat-dependent transcription
Animal Models for DLGAP1 Gene
- MGI Knock Outs for DLGAP1:
-
- Dlgap1 Dlgap1<tm1Grnt>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DLGAP1 - Select products 50% OFF >
- * DLGAP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DLGAP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLGAP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for DLGAP1
miRNA for DLGAP1 Gene
- miRTarBase miRNAs that target DLGAP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DLGAP1
- Browse OriGene Inhibitory RNA Products For DLGAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLGAP1
Clone Products
- Applied Biological Materials (abm): Clones for DLGAP1 - Select products 50% OFF >
- * DLGAP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG211400
- MG226203
- MG226208
- MG226211
- MR211400
- MR211400L3
- MR211400L4
- MR226203
- MR226203L3
- MR226203L4
- MR226208
- MR226208L3
- MR226208L4
- MR226211
- MR226211L3
- MR226211L4
- RC221722
- RC221722L3
- RC221722L4
- RC221856
- RC221856L3
- RC221856L4
- RC234599
- RC234665
- RC234712
- RC234714
- RC234738
- RC235046
- RG221722
- RG221856
- RG234599
- RG234665
- RG234712
- RG234714
- RG234738
- RG235046
- RR202516
- RR202516L3
- RR202516L4
- MR211400L3V
- MR211400L4V
- MR226203L3V
- MR226203L4V
- MR226208L3V
- MR226208L4V
- MR226211L3V
- MR226211L4V
- RC221722L3V
- RC221722L4V
- RC221856L3V
- RC221856L4V
- RR202516L3V
- RR202516L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DLGAP1
- Addgene plasmids for DLGAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLGAP1
Cell Line Products
-
Horizon Cell Lines for DLGAP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DLGAP1 Gene
Localization for DLGAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DLGAP1 Gene
- Cell membrane. Peripheral membrane protein. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0014069 | postsynaptic density | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0030054 | cell junction | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for DLGAP1 Gene
Pathways & Interactions for DLGAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Protein-protein interactions at synapses | ||
| 2 | Neuroscience | ||
| 3 | Circadian entrainment | ||
| 4 | Transmission across Chemical Synapses |
.62
|
|
Pathways by source for DLGAP1 Gene
3 Reactome pathways for DLGAP1 Gene
1 KEGG pathway for DLGAP1 Gene
1 Cell Signaling Technology pathway for DLGAP1 Gene
Interacting Proteins for DLGAP1 Gene
Selected Interacting proteins:
O14490-DLGP1_HUMAN
ENSP00000316377
for DLGAP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for DLGAP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007268 | chemical synaptic transmission | IEA,NAS | 9286858 |
| GO:0023052 | signaling | IEA | -- |
No data available for SIGNOR curated interactions for DLGAP1 Gene
Transcripts for DLGAP1 Gene
mRNA/cDNA for DLGAP1 Gene
- 9 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000400147 5258 nts (view in UCSC)
- ENST00000400149 5203 nts (view in UCSC)
- ENST00000400155 5257 nts (view in UCSC)
- ENST00000400150 5332 nts (view in UCSC)
- ENST00000315677 6655 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DLGAP1 - Select products 50% OFF >
- * DLGAP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DLGAP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DLGAP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for DLGAP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DLGAP1
- Browse OriGene Inhibitory RNA Products For DLGAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLGAP1
Clone Products
- Applied Biological Materials (abm): Clones for DLGAP1 - Select products 50% OFF >
- * DLGAP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG211400
- MG226203
- MG226208
- MG226211
- MR211400
- MR211400L3
- MR211400L4
- MR226203
- MR226203L3
- MR226203L4
- MR226208
- MR226208L3
- MR226208L4
- MR226211
- MR226211L3
- MR226211L4
- RC221722
- RC221722L3
- RC221722L4
- RC221856
- RC221856L3
- RC221856L4
- RC234599
- RC234665
- RC234712
- RC234714
- RC234738
- RC235046
- RG221722
- RG221856
- RG234599
- RG234665
- RG234712
- RG234714
- RG234738
- RG235046
- RR202516
- RR202516L3
- RR202516L4
- MR211400L3V
- MR211400L4V
- MR226203L3V
- MR226203L4V
- MR226208L3V
- MR226208L4V
- MR226211L3V
- MR226211L4V
- RC221722L3V
- RC221722L4V
- RC221856L3V
- RC221856L4V
- RR202516L3V
- RR202516L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DLGAP1
- Addgene plasmids for DLGAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DLGAP1
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for DLGAP1 Gene
- GeneLoc Exon Structure for
- DLGAP1
Expression for DLGAP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Heart (Cardiovascular System)
- Atrioventricular Node Cells Atrioventricular Node
- Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for DLGAP1 Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x10.1), Brain - Anterior cingulate cortex (BA24) (x8.1), Brain - Cortex (x6.9), Brain - Cerebellar Hemisphere (x5.0), and Brain - Hippocampus (x4.3).
This gene is overexpressed in Frontal cortex (40.1) and Brain (26.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DLGAP1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DLGAP1
SOURCE GeneReport for Unigene cluster for DLGAP1 Gene:
Hs.594640mRNA Expression by UniProt/SwissProt for DLGAP1 Gene:
O14490-DLGP1_HUMAN
Tissue specificity:
Expressed in brain.
Evidence on tissue expression from TISSUES for DLGAP1 Gene
- Nervous system(4.9)
- Skin(2.6)
- Kidney(2.3)
Primer Products
-
OriGene qPCR primer pairs for DLGAP1
-
OriGene qPCR primer pairs and template standards for DLGAP1
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DLGAP1 Gene
Orthologs for DLGAP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DLGAP1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DLGAP1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | DLGAP1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DLGAP1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Dlgap1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dlgap1 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | DLGAP1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| LOC100859693 30 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | DLGAP1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dlgap1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | dlgap1a 30 31 |
|
OneToMany | |
| dlgap1b 31 |
|
OneToMany | |||
| otx5 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | vlc 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2669 31 |
|
OneToMany |
- Species where no ortholog for DLGAP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for DLGAP1 Gene
- ENSEMBL:
- Gene Tree for DLGAP1 (if available)
- TreeFam:
- Gene Tree for DLGAP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DLGAP1: view image
Paralogs for DLGAP1 Gene
Variants for DLGAP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DLGAP1 Gene
| SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 727983 | Likely Benign: not provided | 3,534,426(-) | A/G | SYNONYMOUS_VARIANT | |
| 771503 | Benign: not provided | 3,879,217(-) | G/T | SYNONYMOUS_VARIANT | |
| 777265 | Benign: not provided | 3,879,181(-) | C/T | SYNONYMOUS_VARIANT | |
| 788613 | Benign: not provided | 3,534,201(-) | G/A | SYNONYMOUS_VARIANT | |
| 790190 | Benign: not provided | 3,567,570(-) | A/G | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
1.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.21;
39.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DLGAP1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLGAP1 Gene
Disorders for DLGAP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| transient tic disorder |
|
|
| obsessive-compulsive disorder |
|
|
| trichotillomania |
|
|
| myasthenic syndrome, congenital, 7, presynaptic |
|
|
| fraser syndrome 1 |
|
|
Search DLGAP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DLGAP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for DLGAP1 Gene
Publications for DLGAP1 Gene
- GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. (PMID: 9024696) Kim E … Sheng M (The Journal of cell biology 1997) 2 3 4 23
- DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95. (PMID: 9286858) Satoh K … Akiyama T (Genes to cells : devoted to molecular & cellular mechanisms 1997) 2 3 4
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. (PMID: 15729360) Sabio G … Cuenda A (The EMBO journal 2005) 3 23
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Sources for DLGAP1 Gene
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