DLG4 Gene (Protein Coding)

Discs Large MAGUK Scaffold Protein 4

GC17M007189
GIFtS:
48
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling protein... See more...

Aliases for DLG4 Gene

Aliases for DLG4 Gene

  • Discs Large MAGUK Scaffold Protein 4 2 3 5
  • Synapse-Associated Protein 90 3 4
  • Disks Large Homolog 4 3 4
  • Discs Large Homolog 4 2 3
  • SAP-90 3 4
  • PSD95 3 4
  • SAP90 3 4
  • Discs, Large Homolog 4 (Drosophila) 2
  • Post-Synaptic Density Protein 95 3
  • Postsynaptic Density Protein 95 4
  • Tax Interaction Protein 15 3
  • PSD-95 4

External Ids for DLG4 Gene

Previous GeneCards Identifiers for DLG4 Gene

  • GC17M007484
  • GC17M007822
  • GC17M007036
  • GC17M007293
  • GC17M007033
  • GC17M006984
  • GC17M007094

Summaries for DLG4 Gene

Entrez Gene Summary for DLG4 Gene

  • This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DLG4 Gene

DLG4 (Discs Large MAGUK Scaffold Protein 4) is a Protein Coding gene. Diseases associated with DLG4 include Pearson Marrow-Pancreas Syndrome and Acyl-Coa Dehydrogenase Deficiency. Among its related pathways are RET signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protein C-terminus binding. An important paralog of this gene is DLG1.

UniProtKB/Swiss-Prot Summary for DLG4 Gene

  • Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression.

Gene Wiki entry for DLG4 Gene

Additional gene information for DLG4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DLG4 Gene

Genomics for DLG4 Gene

GeneHancer (GH) Regulatory Elements for DLG4 Gene

Promoters and enhancers for DLG4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J007213 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 773.2 +1.4 1360 10.6 SIN3A SP1 CTCF SREBF1 SIX5 ZBTB6 FOXA1 RBPJ POLR2A USF2 DLG4 ACADVL HSALNG0114265 ELP5 CLDN7 CNTROB DVL2 ATP1B2 WRAP53 VAMP2
GH17J007192 Promoter 0.6 EPDnew 750.3 +27.7 27716 0.1 POLR2A ZNF366 NFXL1 ENSG00000279812 lnc-DLG4-1 DLG4
GH17J007833 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.8 -619.4 -619392 13.1 ZNF785 SIN3A SP1 ZBTB40 CTCF SREBF1 ZBTB6 FOXA1 MLX RBPJ KDM6B CHD3 lnc-NAA38-5 lnc-KDM6B-1 DVL2 PFAS CTC1 POLR2A CNTROB WRAP53
GH17J007233 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 17.1 -18.2 -18209 12.1 PPP1R10 ZNF785 SIN3A ZNF24 SP1 ZBTB40 SREBF1 SIX5 ZBTB6 LCORL DVL2 GABARAP PHF23 lnc-GABARAP-2 CNTROB SNORD10 POLR2A WRAP53 SNORA48 EIF4A1
GH17J008172 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 16.8 -954.9 -954917 5.2 PPP1R10 FOXK2 ZNF785 SIN3A ZNF24 ZBTB40 SP1 LCORL FOXA1 MLX VAMP2 ENSG00000266824 LOC105371520 TMEM107 SNORD118 lnc-VAMP2-5 DVL2 CNTROB WRAP53 CTC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DLG4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DLG4 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2

Genomic Locations for DLG4 Gene

Genomic Locations for DLG4 Gene
chr17:7,187,169-7,220,050
(GRCh38/hg38)
Size:
32,882 bases
Orientation:
Minus strand
chr17:7,093,209-7,123,369
(GRCh37/hg19)
Size:
30,161 bases
Orientation:
Minus strand

Genomic View for DLG4 Gene

Genes around DLG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLG4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DLG4 Gene

Proteins for DLG4 Gene

Products:

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  • Protein details for DLG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78352-DLG4_HUMAN
    Recommended name:
    Disks large homolog 4
    Protein Accession:
    P78352
    Secondary Accessions:
    • B7Z1S1
    • G5E939
    • Q92941
    • Q9UKK8

    Protein attributes for DLG4 Gene

    Size:
    724 amino acids
    Molecular mass:
    80495 Da
    Quaternary structure:
    • Interacts through its PDZ domains with ANO2 and NETO1 (By similarity). Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D (By similarity). Interacts with ASIC3 (By similarity). Interacts with SEMA4C (By similarity). Interacts with CXADR (By similarity). Interacts with KCND2 (By similarity). Interacts with SYNGAP1 (By similarity). Interacts with LRRC4 and LRRC4B (By similarity). Interacts with ERBB4 (PubMed:10725395). Interacts with KCNA1, KCNA2, KCNA3 and KCNA4 (PubMed:7477295). Interacts through its first PDZ domain with GRIK2, KCNA4 and CRIPT (PubMed:11744724). Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of CAPON (By similarity). Interacts through its third PDZ domain with NLGN1 and CRIPT, and probably with NLGN2 and NLGN3 (PubMed:9278515). Interacts through its guanylate kinase-like domain with KIF13B (PubMed:10859302). Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A, BEGAIN and SIPA1L1 (By similarity). Isoform 2 interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK (PubMed:12151521). Interacts with ADR1B and ANKS1B (By similarity). May interact with HTR2A (By similarity). Interacts with ADAM22 (PubMed:27066583). Interacts with KLHL17 and LGI1 (By similarity). Interacts with FRMPD4 (via C-terminus) (PubMed:19118189). Interacts with LRFN1, LRFN2 and LRFN4 (PubMed:16630835). Interacts (via N-terminal tandem pair of PDZ domains) with GPER1 (via C-terminus tail motif); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner (By similarity). Interacts (via N-terminus tandem pair of PDZ domains) with NOS1 (via N-terminal domain) (By similarity). Interacts with SHANK3 (By similarity). Interacts with KCNJ4 (By similarity). Interacts with GPR85 (PubMed:25780553). Interacts with CACNG2 and MPP2 (via the SH3-Guanylate kinase-like sub-module) (By similarity). Interacts with ADGRB1 (PubMed:23782696). Found in a complex with PRR7 and GRIN1 (By similarity). Interacts (via PDZ3 domain and to lesser degree via PDZ2 domain) with PRR7 (By similarity). Component of the postsynaptic hippocampal AMPA-type glutamate receptor (AMPAR) complex, at least composed of pore forming AMPAR subunits GRIA1, GRIA2 and GRIA3 and AMPAR auxiliary proteins SHISA6 and SHISA7. Interacts (via its first two PDZ domains) with SHISA6 and SHISA7 (via PDZ-binding motif); the interaction is direct (By similarity). Interacts with RPH3A and GRIN2A; this ternary complex regulates NMDA receptor composition at postsynaptic membranes (By similarity). Interacts with ABR and BCR (PubMed:20962234).

    Three dimensional structures from OCA and Proteopedia for DLG4 Gene

    Alternative splice isoforms for DLG4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLG4 Gene

Protein Expression for DLG4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DLG4 Gene

  • Palmitoylated (PubMed:26701913). Palmitoylation is required for targeting to postsynaptic density, plasma membrane and synapses (By similarity). Palmitoylation may play a role in glutamate receptor GRIA1 synapse clustering (By similarity). Depalmitoylated by ABHD17A and ABHD17B and to a lesser extent by ABHD17C, ABHD12, ABHD13, LYPLA1 and LYPLA2 (PubMed:26701913). Undergoes rapid synaptic palmitoylation/depalmitoylation cycles during neuronal development which slow down in mature neurons (By similarity).
  • Ubiquitinated by MDM2 in response to NMDA receptor activation, leading to proteasome-mediated degradation of DLG4 which is required for AMPA receptor endocytosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLG4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for DLG4

No data available for DME Specific Peptides for DLG4 Gene

Domains & Families for DLG4 Gene

Gene Families for DLG4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for DLG4 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DLG4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60612, highly similar to Discs large homolog 4 (B7Z3U2_HUMAN)
  • cDNA, FLJ78995, highly similar to Discs large homolog 4 (B7Z647_HUMAN)
  • Discs, large homolog 4 (Drosophila), isoform CRA_c (B9EGL1_HUMAN)
  • Synapse-associated protein 90 (DLG4_HUMAN)
  • Tax interaction protein 15 (O14909_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P78352

UniProtKB/Swiss-Prot:

DLG4_HUMAN :
  • The PDZ domain 3 mediates interaction with ADR1B.
  • Belongs to the MAGUK family.
Domain:
  • The PDZ domain 3 mediates interaction with ADR1B.
  • The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density.
Family:
  • Belongs to the MAGUK family.
genes like me logo Genes that share domains with DLG4: view

Function for DLG4 Gene

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  1. Animal Model
  2. CRISPR
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  6. Cell Line

Molecular function for DLG4 Gene

UniProtKB/Swiss-Prot Function:
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression.
GENATLAS Biochemistry:
Drosophila tumor suppressor gene,discs large (Dlg) homolog 4,expressed in neuronal and nonneuronal tissues at postsynaptic sites,heterodimerizing with DLG2,recruited into the same NMDA receptor and Shaker-type potassium channel clusters

Phenotypes From GWAS Catalog for DLG4 Gene

Gene Ontology (GO) - Molecular Function for DLG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 7477295
GO:0008022 protein C-terminus binding IPI 7477295
GO:0019900 kinase binding IDA 21119615
GO:0019903 protein phosphatase binding ISS --
GO:0030165 PDZ domain binding ISS --
genes like me logo Genes that share ontologies with DLG4: view
genes like me logo Genes that share phenotypes with DLG4: view

Animal Models for DLG4 Gene

MGI Knock Outs for DLG4:
  • Dlg4 Dlg4<tm2.1Grnt>
  • Dlg4 Dlg4<tm1e(EUCOMM)Wtsi>
  • Dlg4 Dlg4<tm1.1Tdoi>
  • Dlg4 Dlg4<tm1Grnt>
  • Dlg4 Dlg4<tm1Rlh>

Animal Model Products

  • Taconic Biosciences Mouse Models for DLG4

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLG4

Clone Products

  • Addgene plasmids for DLG4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DLG4 Gene

Localization for DLG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLG4 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse. Cytoplasm. Cell projection, axon. Cell projection, dendritic spine. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. {ECO:0000250 UniProtKB:P31016}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DLG4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 4
mitochondrion 3
endoplasmic reticulum 3
nucleus 2
extracellular 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DLG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane ISS,TAS --
GO:0008021 synaptic vesicle ISS --
genes like me logo Genes that share ontologies with DLG4: view

Pathways & Interactions for DLG4 Gene

PathCards logo

SuperPathways for DLG4 Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Post NMDA receptor activation events
Activation of NMDA receptor upon glutamate binding and postsynaptic events
.90
Post NMDA receptor activation events
.90
CREB phosphorylation through the activation of Ras
.78
CREB phosphorylation through the activation of CaMKII
.01
Ras activation uopn Ca2+ infux through NMDA receptor
.01
Unblocking of NMDA receptor, glutamate binding and activation
.01
3 Presynaptic function of Kainate receptors
Activation of Kainate Receptors upon glutamate binding
.66
Ionotropic activity of Kainate Receptors
.38
Activation of Ca-permeable Kainate Receptor
.01
4 Transmission across Chemical Synapses
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
.67
Transmission across Chemical Synapses
.67
Neuronal System
.62
5 Developmental Biology
Axon guidance
.51
Developmental Biology
.51
genes like me logo Genes that share pathways with DLG4: view

Pathways by source for DLG4 Gene

2 BioSystems pathways for DLG4 Gene
2 Qiagen pathways for DLG4 Gene
  • Huntington's Disease Pathway
  • nNOS Signaling at Neuronal Synapses
1 Cell Signaling Technology pathway for DLG4 Gene

SIGNOR curated interactions for DLG4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DLG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0002091 negative regulation of receptor internalization ISS --
GO:0007165 signal transduction TAS 10364559
GO:0007204 positive regulation of cytosolic calcium ion concentration ISS --
GO:0007268 chemical synaptic transmission IBA,TAS 21873635
genes like me logo Genes that share ontologies with DLG4: view

Drugs & Compounds for DLG4 Gene

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(13) Drugs for DLG4 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanidine Approved Pharma Target 0
Guanosine monophosphate Experimental Pharma Target 0

(8) Additional Compounds for DLG4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DLG4: view

Transcripts for DLG4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DLG4 Gene

(7) REFSEQ mRNAs :
(19) Additional mRNA sequences :
(138) Selected AceView cDNA sequences:
(24) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLG4

Clone Products

  • Addgene plasmids for DLG4

Alternative Splicing Database (ASD) splice patterns (SP) for DLG4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5:
SP6: -

ExUns: 21b ^ 22 ^ 23 ^ 24 ^ 25a · 25b
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:

Relevant External Links for DLG4 Gene

GeneLoc Exon Structure for
DLG4
ECgene alternative splicing isoforms for
DLG4

Expression for DLG4 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DLG4 Gene

mRNA expression in normal human tissues for DLG4 Gene
mRNA expression by BioGPS for DLG4 GenemRNA expression by GTEx for DLG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLG4 Gene

This gene is overexpressed in Brain - Cortex (x4.7), Brain - Nucleus accumbens (basal ganglia) (x4.3), Brain - Anterior cingulate cortex (BA24) (x4.2), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for DLG4 Gene

This gene is overexpressed in Brain (31.4), Frontal cortex (26.2), and Retina (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DLG4 Gene



Protein tissue co-expression partners for DLG4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DLG4 Gene:

DLG4

SOURCE GeneReport for Unigene cluster for DLG4 Gene:

Hs.463928

mRNA Expression by UniProt/SwissProt for DLG4 Gene:

P78352-DLG4_HUMAN
Tissue specificity: Brain.

Evidence on tissue expression from TISSUES for DLG4 Gene

  • Nervous system(4.9)
  • Eye(2.6)
  • Kidney(2)
genes like me logo Genes that share expression patterns with DLG4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DLG4 Gene

Orthologs for DLG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia DLG4 33 32
  • 99.61 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia DLG4 33
  • 97 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia DLG4 33 32
  • 94.48 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Dlg4 32
  • 93.58 (n)
mouse
(Mus musculus)
 Mammalia Dlg4 17 33 32
  • 93.16 (n)
dog
(Canis familiaris)
 Mammalia DLG4 33 32
  • 92.68 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia DLG4 33
  • 84 (a)
 OneToOne
African clawed frog
(Xenopus laevis)
 Amphibia Xl.31985 32
zebrafish
(Danio rerio)
 Actinopterygii DLG4 (2 of 2) 33
  • 83 (a)
 OneToMany
dlg4b 33
  • 80 (a)
 OneToMany
dlg4 32
  • 72.42 (n)
fruit fly
(Drosophila melanogaster)
 Insecta dlg1 33 34
  • 28 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea dlg-1 33 34
  • 35 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.5033 33
  • 50 (a)
 OneToMany
Species where no ortholog for DLG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DLG4 Gene

ENSEMBL:
Gene Tree for DLG4 (if available)
TreeFam:
Gene Tree for DLG4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DLG4: view image

Paralogs for DLG4 Gene

Paralogs for DLG4 Gene

(55) SIMAP similar genes for DLG4 Gene using alignment to 10 proteins:

  • DLG4_HUMAN
  • B7Z647_HUMAN
  • B9EGL1_HUMAN
  • C9JWP9_HUMAN
  • C9JYG3_HUMAN
  • K7EKP9_HUMAN
  • K7EKU8_HUMAN
  • K7EQM6_HUMAN
  • O14909_HUMAN
  • Q3ZCU5_HUMAN
genes like me logo Genes that share paralogs with DLG4: view

Variants for DLG4 Gene

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Sequence variations from dbSNP and Humsavar for DLG4 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1032857886 uncertain-significance, Very long chain acyl-CoA dehydrogenase deficiency 7,221,020(-) C/T upstream_transcript_variant
rs1057516369 likely-pathogenic, Very long chain acyl-CoA dehydrogenase deficiency 7,221,557(-) TC/ upstream_transcript_variant
rs1057516714 likely-pathogenic, Very long chain acyl-CoA dehydrogenase deficiency 7,221,970(-) TCTGTCT/TCT upstream_transcript_variant
rs1057516817 likely-pathogenic, Very long chain acyl-CoA dehydrogenase deficiency 7,220,199(-) T/C upstream_transcript_variant
rs1057516979 likely-pathogenic, Very long chain acyl-CoA dehydrogenase deficiency 7,220,795(-) AAA/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DLG4 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv2665200 CNV deletion 23128226
esv2715598 CNV deletion 23290073
esv2715599 CNV deletion 23290073
esv3639861 CNV loss 21293372
nsv1071329 CNV deletion 25765185
nsv1143846 CNV deletion 24896259
nsv1144788 CNV deletion 24896259
nsv1962 CNV insertion 18451855
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for DLG4 Gene

Residual Variation Intolerance Score: 6.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DLG4 Gene

Human Gene Mutation Database (HGMD)
DLG4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DLG4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLG4 Gene

Disorders for DLG4 Gene

MalaCards: The human disease database

(13) MalaCards diseases for DLG4 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pearson marrow-pancreas syndrome
  • sideroblastic anemia with marrow cell vacuolization and exocrine pancreatic dysfunction
acyl-coa dehydrogenase deficiency
sciatic neuropathy
lesion of sciatic nerve
  • nerve lesion sciatic
huntington disease
  • hd
- elite association - COSMIC cancer census association via MalaCards
Search DLG4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DLG4