Aliases for DLG4 Gene
Aliases for DLG4 Gene
External Ids for DLG4 Gene
- HGNC: 2903
- Entrez Gene: 1742
- Ensembl: ENSG00000132535
- OMIM: 602887
- UniProtKB: P78352
Previous GeneCards Identifiers for DLG4 Gene
- GC17M007484
- GC17M007822
- GC17M007036
- GC17M007293
- GC17M007033
- GC17M006984
- GC17M007094
Summaries for DLG4 Gene
-
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DLG4 Gene
DLG4 (Discs Large MAGUK Scaffold Protein 4) is a Protein Coding gene. Diseases associated with DLG4 include Diabetic Encephalopathy and Usher Syndrome, Type Ic. Among its related pathways are RET signaling and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include receptor binding and protein C-terminus binding. An important paralog of this gene is DLG1.
UniProtKB/Swiss-Prot for DLG4 Gene
-
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
Additional gene information for DLG4 Gene
- Monarch Initiative
- Search for DLG4 at DataMed
- Search for DLG4 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLG4 Gene
Genomics for DLG4 Gene
GeneHancer (GH) Regulatory Elements for DLG4 Gene
Promoters and enhancers for DLG4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DLG4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DLG4 gene promoter:
Regulatory Element Products
Genomic Locations for DLG4 Gene
Genomic Locations for DLG4 Gene
- chr17:7,189,890-7,220,050
- (GRCh38/hg38)
- Size:
- 30,161 bases
- Orientation:
- Minus strand
- chr17:7,093,209-7,123,369
- (GRCh37/hg19)
Genomic View for DLG4 Gene
Genes around DLG4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.1 by Ensembl
- 17p13.1 by Entrez Gene
- 17p13.1 by HGNC
DLG4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DLG4 Gene
Proteins for DLG4 Gene
-
Protein details for DLG4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P78352-DLG4_HUMAN
- Recommended name:
- Disks large homolog 4
- Protein Accession:
- P78352
- B7Z1S1
- G5E939
- Q92941
- Q9UKK8
Protein attributes for DLG4 Gene
- Size:
- 724 amino acids
- Molecular mass:
- 80495 Da
- Quaternary structure:
-
- Interacts through its PDZ domains with ANO2 and NETO1 (By similarity). Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D (By similarity). Interacts with ASIC3 (By similarity). Interacts with SEMA4C (By similarity). Interacts with CXADR (By similarity). Interacts with KCND2 (By similarity). Interacts with SYNGAP1 (By similarity). Interacts with LRRC4 and LRRC4B (By similarity). Interacts with ERBB4 (PubMed:10725395). Interacts with KCNA1, KCNA2, KCNA3 and KCNA4 (PubMed:7477295). Interacts through its first PDZ domain with GRIK2, KCNA4 and CRIPT (PubMed:11744724). Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of CAPON (By similarity). Interacts through its third PDZ domain with NLGN1 and CRIPT, and probably with NLGN2 and NLGN3 (PubMed:9278515). Interacts through its guanylate kinase-like domain with KIF13B (PubMed:10859302). Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A, BEGAIN and SIPA1L1 (By similarity). Isoform 2 interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK (PubMed:12151521). Interacts with ADR1B and ANKS1B (By similarity). May interact with HTR2A (By similarity). Interacts with ADAM22, KLHL17 and LGI1 (By similarity). Interacts with FRMPD4 (via C-terminus) (PubMed:19118189). Interacts with LRFN1, LRFN2 and LRFN4 (PubMed:16630835). Interacts (via N-terminal tandem pair of PDZ domains) with GPER1 (via C-terminus tail motif); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner (By similarity). Interacts (via N-terminus tandem pair of PDZ domains) with NOS1 (via N-terminal domain) (By similarity). Interacts with SHANK3 (By similarity). Interacts with KCNJ4 (By similarity). Interacts with GPR85 (PubMed:25780553). Interacts with CACNG2 and MPP2 (via the SH3-Guanylate kinase-like sub-module) (By similarity). Interacts with ADGRB1 (PubMed:23782696). Found in a complex with PRR7 and GRIN1 (By similarity). Interacts (via PDZ3 domain and to lesser degree via PDZ2 domain) with PRR7 (By similarity).
Three dimensional structures from OCA and Proteopedia for DLG4 Gene
Protein Expression for DLG4 Gene
Post-translational modifications for DLG4 Gene
- Palmitoylation of isoform 1 is required for targeting to postsynaptic density.
- Ubiquitinated by MDM2 in response to NMDA receptor activation, leading to proteasome-mediated degradation of DLG4 which is required for AMPA receptor endocytosis.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for DLG4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for DLG4 (PSD-95)
- Novus Biologicals Antibodies for DLG4
-
Abcam antibodies for DLG4
- Invitrogen Antibodies for DLG4
- antibodies-online: Search results for 255 available DLG4 Antibodies ranked by validation data
- Compare Top DLG4 Antibodies
-
Recommended
- 5 IHC (p) Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 147 WB Antibodies (anti-human)
- 2 FACS Antibodies (anti-rat)
- 2 FACS Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 171 WB Antibodies (anti-rat)
- 2 FACS Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 163 WB Antibodies (anti-mouse)
- GeneTex DLG4 antibody for DLG4
-
Santa Cruz Biotechnology (SCBT) Antibodies for DLG4
Protein Products
-
OriGene Purified Proteins for DLG4
- Search Origene for MassSpec and Protein Over-expression Lysates for DLG4
- Origene Custom Protein Services for DLG4
- Search GeneTex for Proteins for DLG4
-
ProSci Proteins for DLG4
-
Abcam proteins for DLG4
Assay Products
No data available for DME Specific Peptides for DLG4 Gene
Domains & Families for DLG4 Gene
Gene Families for DLG4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
- Transporters
Protein Domains for DLG4 Gene
Suggested Antigen Peptide Sequences for DLG4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P78352UniProtKB/Swiss-Prot:
DLG4_HUMAN :- The PDZ domain 3 mediates interaction with ADR1B.
- Belongs to the MAGUK family.
- Domain:
-
- The PDZ domain 3 mediates interaction with ADR1B.
- The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density.
- Family:
-
- Belongs to the MAGUK family.
Function for DLG4 Gene
Molecular function for DLG4 Gene
- GENATLAS Biochemistry:
- Drosophila tumor suppressor gene,discs large (Dlg) homolog 4,expressed in neuronal and nonneuronal tissues at postsynaptic sites,heterodimerizing with DLG2,recruited into the same NMDA receptor and Shaker-type potassium channel clusters
- UniProtKB/Swiss-Prot Function:
- Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
Phenotypes From GWAS Catalog for DLG4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004385 | guanylate kinase activity | IBA | -- |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 7477295 |
| GO:0008022 | protein C-terminus binding | IPI | 7477295 |
| GO:0015276 | ligand-gated ion channel activity | TAS | -- |
Phenotypes for DLG4 Gene
- MGI mutant phenotypes for DLG4:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for DLG4:
-
- Increased vaccinia virus (VACV) infection
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Synthetic lethal with Ras
- Decreased viability ratio
- Decreased viability
- Increased shRNA abundance (Z-score > 2)
- Decreased Salmonella enterica Typhimurium ruffling
- Decreased Salmonella enterica Typhimurium invasion
- Decreased Salmonella enterica Typhimurium effector injection
- Decreased homologous recombination repair frequency
- Increased viability with SS1P at EC90
- Decreased shRNA abundance (Z-score < -2)
- Decreased Salmonella-containing vacuole maturation
- Decreased Salmonella enterica Typhimurium membrane closure
- Decreased viability with paclitaxel
- Decreased telomerase activity
Animal Models for DLG4 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for DLG4
- Cyagen custom Knockout/knockin (KOKI) mouse models for DLG4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for DLG4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DLG4 gene
- Search ViGene Biosciences for DLG4
CRISPR Products
-
OriGene CRISPR knockouts for DLG4
- genomics-online: gRNA clones - Search results for available DLG4 gene related products
- Applied Biological Materials CRISPR for DLG4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DLG4
- GenScript: Design CRISPR guide RNA sequences for DLG4
miRNA for DLG4 Gene
- miRTarBase miRNAs that target DLG4
miRNA Products
- Search ViGene Biosciences for DLG4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DLG4
- Browse OriGene Inhibitory RNA Products For DLG4
- genomics-online: shRNA clones - Search results for available DLG4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DLG4 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for DLG4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DLG4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available DLG4 gene related products
- orf clones - Search results for available DLG4 gene related products
- Applied Biological Materials Clones for DLG4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DLG4
-
ViGene Biosciences adenoviral particle packaged cDNA for DLG4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DLG4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DLG4 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DLG4 Gene
Localization for DLG4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DLG4 Gene
- Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell junction, synapse. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| endoplasmic reticulum | 4 |
| mitochondrion | 3 |
| nucleus | 2 |
| extracellular | 1 |
| golgi apparatus | 1 |
| endosome | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | ISS,IEA | -- |
| GO:0005783 | endoplasmic reticulum | ISS,IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS,ISS | -- |
| GO:0008021 | synaptic vesicle | IEA,ISS | -- |
Pathways & Interactions for DLG4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Post NMDA receptor activation events | ||
| 3 | Presynaptic function of Kainate receptors | ||
| 4 | Transmission across Chemical Synapses |
.62
|
|
| 5 | Developmental Biology |
.51
|
|
Pathways by source for DLG4 Gene
2 BioSystems pathways for DLG4 Gene
69 Reactome pathways for DLG4 Gene
4 KEGG pathways for DLG4 Gene
1 R&D Systems pathway for DLG4 Gene
2 Qiagen pathways for DLG4 Gene
1 Cell Signaling Technology pathway for DLG4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0002091 | negative regulation of receptor internalization | ISS | -- |
| GO:0006461 | protein complex assembly | IDA | 15496675 |
| GO:0007165 | signal transduction | TAS | 10364559 |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | ISS | -- |
Transcripts for DLG4 Gene
mRNA/cDNA for DLG4 Gene
- (13) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (138) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DLG4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DLG4
- genomics-online: gRNA clones - Search results for available DLG4 gene related products
- Applied Biological Materials CRISPR for DLG4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DLG4
- GenScript: Design CRISPR guide RNA sequences for DLG4
miRNA Products
- Search ViGene Biosciences for DLG4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DLG4
- Browse OriGene Inhibitory RNA Products For DLG4
- genomics-online: shRNA clones - Search results for available DLG4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DLG4 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for DLG4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DLG4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available DLG4 gene related products
- orf clones - Search results for available DLG4 gene related products
- Applied Biological Materials Clones for DLG4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - |
| ExUns: | 21b | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | - | ||||||||||
| SP6: |
Expression for DLG4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Eye (Sensory Organs)
- Mature S Cone Cells Outer Nuclear Layer
- Mature L Cone Cells Outer Nuclear Layer
- Mature M Cone Cells Outer Nuclear Layer
- Mature Rod Cells Outer Nuclear Layer
- Mature M-S Cone Cells Outer Nuclear Layer
-
Neurons
- Mature S Cone Cells Outer Nuclear Layer
- Mature L Cone Cells Outer Nuclear Layer
- Mature M Cone Cells Outer Nuclear Layer
- Mature Rod Cells Outer Nuclear Layer
- Mature M-S Cone Cells Outer Nuclear Layer
mRNA differential expression in normal tissues according to GTEx for DLG4 Gene
This gene is overexpressed in Brain - Cortex (x4.7), Brain - Nucleus accumbens (basal ganglia) (x4.3), Brain - Anterior cingulate cortex (BA24) (x4.2), and Brain - Frontal Cortex (BA9) (x4.1).
This gene is overexpressed in Brain (31.4), Frontal cortex (26.2), and Retina (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DLG4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DLG4 Gene:
DLG4SOURCE GeneReport for Unigene cluster for DLG4 Gene:
Hs.463928mRNA Expression by UniProt/SwissProt for DLG4 Gene:
P78352-DLG4_HUMAN
Tissue specificity:
Brain.
Evidence on tissue expression from TISSUES for DLG4 Gene
- Nervous system(4.9)
- Eye(2.6)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for DLG4
- genomics-online: primer clones - Search results for available DLG4 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DLG4 Gene
Orthologs for DLG4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DLG4 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | DLG4 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DLG4 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dlg4 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Dlg4 33 16 34 |
|
||
| dog (Canis familiaris) |
Mammalia | DLG4 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DLG4 34 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.31985 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | DLG4 (2 of 2) 34 |
|
OneToMany | |
| dlg4b 34 |
|
OneToMany | |||
| dlg4 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | dlg1 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | dlg-1 35 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5033 34 |
|
OneToMany |
- Species where no ortholog for DLG4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for DLG4 Gene
Paralogs for DLG4 Gene
(55) SIMAP similar genes for DLG4 Gene using alignment to 10 proteins:
- DKFZp761P0818
- DLG1
- DLG3
- DLG2
- SNTB2
- SYNJ2BP
- MPP4
- DVL3
- DVL2
- DVL1
- LIN7A
- DFNB31
- TJP1
- TJP2
- MPDZ
- PDZD2
- USH1C
- PTPN13
- PCLO
- INADL
- SCRIB
- IL16
- PDZRN3
- DLG5
- PARD3
- TJP3
- SNTG2
- RADIL
- MLLT4
- GOPC
- FLJ10324
- MAGI2
- PARD3B
- PPP1R9B
- PPP1R9A
- PDZK1P2
- PDZK1P1
- PDZD4
- FRMPD2
- DKFZp686J1497
- LIN7C
- PDZRN4
- MAGIX
- GRID2IP
- STXBP4
- SNTG1
- MAGI1
- GUK1
- GRIP1
- TAX1BP3
- ERBB2IP
- DKFZp666D023
- LRRC7
- ALS2CR19
- DKFZp666F1010
Variants for DLG4 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1057516369 | likely-pathogenic, Very long chain acyl-CoA dehydrogenase deficiency | 7,221,557(-) | TC/ | upstream_transcript_variant | |
| rs1057516714 | likely-pathogenic, Very long chain acyl-CoA dehydrogenase deficiency | 7,221,970(-) | TCTGTCT/TCT | upstream_transcript_variant | |
| rs1057516817 | likely-pathogenic, Very long chain acyl-CoA dehydrogenase deficiency | 7,220,199(-) | T/C | upstream_transcript_variant | |
| rs1057516979 | likely-pathogenic, Very long chain acyl-CoA dehydrogenase deficiency | 7,220,795(-) | AAA/A | upstream_transcript_variant | |
| rs1057517012 | likely-pathogenic, Very long chain acyl-CoA dehydrogenase deficiency | 7,220,677(-) | G/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2422288 | CNV | deletion | 17116639 |
| esv2665200 | CNV | deletion | 23128226 |
| esv2715598 | CNV | deletion | 23290073 |
| esv2715599 | CNV | deletion | 23290073 |
| esv3639861 | CNV | loss | 21293372 |
| nsv1071329 | CNV | deletion | 25765185 |
| nsv1143846 | CNV | deletion | 24896259 |
| nsv1144788 | CNV | deletion | 24896259 |
| nsv1962 | CNV | insertion | 18451855 |
| nsv457659 | CNV | loss | 19166990 |
| nsv574322 | CNV | loss | 21841781 |
| nsv952118 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
6.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.45;
28.41% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DLG4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLG4 Gene
Disorders for DLG4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diabetic encephalopathy |
|
|
| usher syndrome, type ic |
|
|
| cerebral degeneration |
|
|
| huntington disease |
|
|
| autism spectrum disorder |
|
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Search DLG4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DLG4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator