Aliases for DLG3 Gene
External Ids for DLG3 Gene
Previous GeneCards Identifiers for DLG3 Gene
This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
GeneCards Summary for DLG3 Gene
DLG3 (Discs Large MAGUK Scaffold Protein 3) is a Protein Coding gene. Diseases associated with DLG3 include Non-Syndromic X-Linked Intellectual Disability and Alacrima, Achalasia, And Mental Retardation Syndrome. Among its related pathways are Transmission across Chemical Synapses and Hippo signaling pathway. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and protein C-terminus binding. An important paralog of this gene is DLG2.
UniProtKB/Swiss-Prot Summary for DLG3 Gene
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.