Aliases for DLG3 Gene
External Ids for DLG3 Gene
Previous GeneCards Identifiers for DLG3 Gene
This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
GeneCards Summary for DLG3 Gene
DLG3 (Discs Large MAGUK Scaffold Protein 3) is a Protein Coding gene. Diseases associated with DLG3 include X-Linked Non-Specific Intellectual Disability and Non-Syndromic Intellectual Disability. Among its related pathways are L1CAM interactions and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and protein C-terminus binding. An important paralog of this gene is DLG1.
UniProtKB/Swiss-Prot for DLG3 Gene
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.