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Aliases for DLG2 Gene

Aliases for DLG2 Gene

  • Discs Large MAGUK Scaffold Protein 2 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 58 2 3
  • Channel-Associated Protein Of Synapse-110 3 4
  • Postsynaptic Density Protein PSD-93 3 4
  • Chapsyn-110 3 4
  • Discs, Large Homolog 2, Chapsyn-110 (Drosophila) 2
  • Channel-Associated Protein Of Synapses, 110kDa 3
  • Discs, Large Homolog 2, Chapsyn-110 3
  • Discs, Large Homolog 2 (Drosophila) 2
  • Disks Large Homolog 2 3
  • Discs Large Homolog 2 2
  • DLG2 Protein Isoform 3
  • PPP1R58 3
  • PSD-93 3
  • PSD93 3

External Ids for DLG2 Gene

Previous GeneCards Identifiers for DLG2 Gene

  • GC11M085497
  • GC11M084709
  • GC11M082896
  • GC11M082847
  • GC11M083166
  • GC11M079462

Summaries for DLG2 Gene

Entrez Gene Summary for DLG2 Gene

  • This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]

GeneCards Summary for DLG2 Gene

DLG2 (Discs Large MAGUK Scaffold Protein 2) is a Protein Coding gene. Diseases associated with DLG2 include Chronic Pain and Bilateral Retinoblastoma. Among its related pathways are Protein-protein interactions at synapses and Tight junction. Gene Ontology (GO) annotations related to this gene include kinase binding and guanylate kinase activity. An important paralog of this gene is DLG1.

UniProtKB/Swiss-Prot for DLG2 Gene

  • Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).

Gene Wiki entry for DLG2 Gene

Additional gene information for DLG2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLG2 Gene

Genomics for DLG2 Gene

GeneHancer (GH) Regulatory Elements for DLG2 Gene

Promoters and enhancers for DLG2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J085626 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 659.9 +0.3 258 3 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 DLG2 TMEM126B CREBZF EED TMEM126A SYTL2 RNU6-1292P
GH11J084923 Promoter 0.5 EPDnew 650 +705.1 705098 0.1 DLG2 ENSG00000255555 ENSG00000276179
GH11J085646 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 8.7 -19.3 -19288 3.2 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B ZNF766 TMEM126A CREBZF CCDC89 DLG2 SYTL2 TMEM126B
GH11J085316 Enhancer 0.7 ENCODE 7.5 +311.4 311360 1.2 BACH1 STAT5A BMI1 BATF IRF4 BCLAF1 IKZF2 RUNX3 CREM CBFB DLG2 TMEM126A LOC100419092 HNRNPCP6
GH11J085695 Enhancer 0.5 ENCODE 10.1 -66.0 -66029 0.1 SRF CTCF ZNF654 SMC3 RAD21 CCDC83 TMEM126B DLG2 HIKESHI CCDC89 SYTL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DLG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DLG2 gene promoter:
  • RORalpha1
  • FOXO1a
  • TBP
  • Nkx2-5
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2

Genomic Locations for DLG2 Gene

Genomic Locations for DLG2 Gene
2,173,523 bases
Minus strand
2,172,912 bases
Minus strand

Genomic View for DLG2 Gene

Genes around DLG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLG2 Gene

Proteins for DLG2 Gene

  • Protein details for DLG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disks large homolog 2
    Protein Accession:
    Secondary Accessions:
    • B7WNY8
    • F8W9V6
    • Q59G57
    • Q5H9Q4
    • Q68CQ8
    • Q6ZTA8

    Protein attributes for DLG2 Gene

    870 amino acids
    Molecular mass:
    97552 Da
    Quaternary structure:
    • Interacts through its PDZ domains with NETO1 (By similarity). Interacts with NOS1/nNOS through second PDZ domain (By similarity). Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains (PubMed:15304517). Interacts with KCNJ4 (By similarity), Interacts with FRMPD4 (via C-terminus) (PubMed:19118189). Interacts with LRFN1, LRFN2 and LRFN4 (PubMed:16630835). Interacts with FASLG (PubMed:19807924). Interacts with KCNJ4 (By similarity). Interacts with ADAM22 (By similarity).
    • Sequence=BAD92489.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DLG2 Gene

    Alternative splice isoforms for DLG2 Gene


neXtProt entry for DLG2 Gene

Post-translational modifications for DLG2 Gene

  • Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DLG2 Gene

Domains & Families for DLG2 Gene

Graphical View of Domain Structure for InterPro Entry



  • An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27.
  • Belongs to the MAGUK family.
  • An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27.
  • Belongs to the MAGUK family.
genes like me logo Genes that share domains with DLG2: view

Function for DLG2 Gene

Molecular function for DLG2 Gene

UniProtKB/Swiss-Prot Function:
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).
GENATLAS Biochemistry:
Drosophila tumor suppressor gene,discs large (Dlg),expressed in neuronal tissues at postsynaptic sites,heterodimerizing with DLG4 and recruited into the same NMDA receptor and Shaker-type potassium channel clusters

Phenotypes From GWAS Catalog for DLG2 Gene

Gene Ontology (GO) - Molecular Function for DLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004385 guanylate kinase activity TAS 8755482
GO:0005515 protein binding IPI 15304517
GO:0019900 kinase binding IDA 21119615
GO:0035255 ionotropic glutamate receptor binding IBA --
genes like me logo Genes that share ontologies with DLG2: view
genes like me logo Genes that share phenotypes with DLG2: view

Animal Models for DLG2 Gene

MGI Knock Outs for DLG2:

Animal Model Products

CRISPR Products

miRNA for DLG2 Gene

miRTarBase miRNAs that target DLG2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLG2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DLG2 Gene

Localization for DLG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLG2 Gene

Cell membrane; Lipid-anchor. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Membrane. Cell projection, axon. Note=Concentrated in soma and postsynaptic density of a subset of neurons. {ECO:0000250 UniProtKB:Q63622}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DLG2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS 8755482
GO:0008076 colocalizes_with voltage-gated potassium channel complex ISS --
GO:0008328 colocalizes_with ionotropic glutamate receptor complex IBA --
GO:0014069 postsynaptic density IBA,ISS --
genes like me logo Genes that share ontologies with DLG2: view

Pathways & Interactions for DLG2 Gene

genes like me logo Genes that share pathways with DLG2: view

Pathways by source for DLG2 Gene

Gene Ontology (GO) - Biological Process for DLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 chemical synaptic transmission IBA --
GO:0007399 nervous system development IBA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0019233 sensory perception of pain IEA --
GO:0035865 cellular response to potassium ion ISS --
genes like me logo Genes that share ontologies with DLG2: view

No data available for SIGNOR curated interactions for DLG2 Gene

Drugs & Compounds for DLG2 Gene

(1) Drugs for DLG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for DLG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DLG2: view

Transcripts for DLG2 Gene

Unigene Clusters for DLG2 Gene

Discs, large homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DLG2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLG2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - - - -
SP2: - - - -
SP3: -

ExUns: 24a · 24b ^ 25a · 25b
SP1: -

Relevant External Links for DLG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DLG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DLG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLG2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Hippocampus (x4.9), Brain - Frontal Cortex (BA9) (x4.8), Brain - Cortex (x4.5), and Brain - Amygdala (x4.4).

Protein differential expression in normal tissues from HIPED for DLG2 Gene

This gene is overexpressed in Brain (27.3), Frontal cortex (16.0), and Urine (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DLG2 Gene

Protein tissue co-expression partners for DLG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DLG2 Gene:


SOURCE GeneReport for Unigene cluster for DLG2 Gene:


Evidence on tissue expression from TISSUES for DLG2 Gene

  • Nervous system(5)
  • Eye(4.3)
  • Bone(2.3)
genes like me logo Genes that share expression patterns with DLG2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DLG2 Gene

Orthologs for DLG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DLG2 34 33
  • 99.76 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 99 (a)
-- 34
  • 82 (a)
(Bos Taurus)
Mammalia DLG2 34
  • 95 (a)
(Canis familiaris)
Mammalia DLG2 34 33
  • 94.34 (n)
(Mus musculus)
Mammalia Dlg2 16 34 33
  • 91.21 (n)
(Rattus norvegicus)
Mammalia Dlg2 33
  • 91.21 (n)
(Ornithorhynchus anatinus)
Mammalia DLG2 34
  • 81 (a)
(Gallus gallus)
Aves DLG2 34 33
  • 84.37 (n)
(Anolis carolinensis)
Reptilia DLG2 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dlg2 33
  • 80.8 (n)
(Danio rerio)
Actinopterygii dlg2 34 33
  • 74.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta dlg1 34 35
  • 32 (a)
(Caenorhabditis elegans)
Secernentea dlg-1 34 35 33
  • 51.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5033 34
  • 57 (a)
Species where no ortholog for DLG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DLG2 Gene

Gene Tree for DLG2 (if available)
Gene Tree for DLG2 (if available)
Evolutionary constrained regions (ECRs) for DLG2: view image

Paralogs for DLG2 Gene

(25) SIMAP similar genes for DLG2 Gene using alignment to 19 proteins:

  • B7Z264_HUMAN
  • B7Z2T4_HUMAN
  • E9PN83_HUMAN
  • F5H5P1_HUMAN
  • F8W750_HUMAN
  • H7C325_HUMAN
  • L8E8R0_HUMAN
genes like me logo Genes that share paralogs with DLG2: view

Variants for DLG2 Gene

Sequence variations from dbSNP and Humsavar for DLG2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs201235627 likely-benign, not specified 83,874,444(-) A/G coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs1000001999 -- 84,891,218(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000002687 -- 85,532,623(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000003294 -- 83,547,834(-) G/A intron_variant
rs1000006483 -- 83,978,318(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DLG2 Gene

Variant ID Type Subtype PubMed ID
dgv1244n100 CNV loss 25217958
dgv2039n54 CNV loss 21841781
dgv214e214 CNV gain 21293372
dgv228e199 CNV deletion 23128226
dgv229e199 CNV deletion 23128226
dgv397e212 CNV gain 25503493
dgv681n106 CNV deletion 24896259
dgv682n106 CNV deletion 24896259
dgv70e215 CNV deletion 23714750
dgv75n21 CNV loss 19592680
esv1005592 CNV insertion 20482838
esv1421802 CNV insertion 17803354
esv1506583 CNV deletion 17803354
esv1959476 CNV deletion 18987734
esv2202413 CNV deletion 18987734
esv22170 CNV loss 19812545
esv2281631 CNV deletion 18987734
esv2421768 CNV deletion 20811451
esv2456833 CNV deletion 19546169
esv2471612 CNV deletion 19546169
esv2544219 CNV loss 19546169
esv2544867 CNV deletion 19546169
esv2589653 CNV deletion 19546169
esv26008 CNV loss 19812545
esv2617997 CNV deletion 19546169
esv2618406 CNV deletion 19546169
esv2622674 CNV deletion 19546169
esv2657074 CNV deletion 23128226
esv2657415 CNV deletion 23128226
esv2657838 CNV deletion 23128226
esv2661588 CNV deletion 23128226
esv2664740 CNV deletion 23128226
esv2665612 CNV deletion 23128226
esv2673432 CNV deletion 23128226
esv2673933 CNV deletion 23128226
esv2675105 CNV deletion 23128226
esv2740842 CNV deletion 23290073
esv2744839 CNV deletion 23290073
esv2744840 CNV deletion 23290073
esv2744842 CNV deletion 23290073
esv2744843 CNV deletion 23290073
esv2744844 CNV deletion 23290073
esv2744845 CNV deletion 23290073
esv2744846 CNV deletion 23290073
esv2744847 CNV deletion 23290073
esv2751034 CNV gain 17911159
esv2759844 CNV loss 17122850
esv2759845 CNV gain+loss 17122850
esv2760388 CNV loss 21179565
esv2760422 CNV gain 21179565
esv2761687 CNV loss 21179565
esv2761689 CNV loss 21179565
esv32962 CNV loss 17666407
esv3303436 CNV mobile element insertion 20981092
esv3305832 CNV mobile element insertion 20981092
esv3309219 CNV mobile element insertion 20981092
esv3323061 CNV insertion 20981092
esv3332328 CNV duplication 20981092
esv33531 CNV loss 17666407
esv3361269 CNV insertion 20981092
esv3369868 CNV duplication 20981092
esv3399341 CNV insertion 20981092
esv3425097 CNV insertion 20981092
esv3428351 CNV insertion 20981092
esv3434658 CNV insertion 20981092
esv3436907 CNV insertion 20981092
esv3548081 CNV deletion 23714750
esv3548083 CNV deletion 23714750
esv3579775 CNV loss 25503493
esv3579776 CNV loss 25503493
esv3579777 CNV loss 25503493
esv3627021 CNV loss 21293372
esv3627024 CNV loss 21293372
esv3627025 CNV loss 21293372
esv3627026 CNV loss 21293372
esv3627031 CNV loss 21293372
esv3627032 CNV loss 21293372
esv3627033 CNV gain 21293372
esv3627035 CNV loss 21293372
esv3627037 CNV loss 21293372
esv3627038 CNV loss 21293372
esv3627040 CNV loss 21293372
esv3627041 CNV loss 21293372
esv3627042 CNV loss 21293372
esv3627043 CNV loss 21293372
esv3627044 CNV loss 21293372
esv3627045 CNV loss 21293372
esv3627046 CNV loss 21293372
esv3627047 CNV loss 21293372
esv3627048 CNV loss 21293372
esv3627050 CNV loss 21293372
esv3627051 CNV loss 21293372
esv3627052 CNV loss 21293372
esv3627054 CNV loss 21293372
esv3627056 CNV loss 21293372
esv3627059 CNV loss 21293372
esv3627060 CNV loss 21293372
esv3627061 CNV loss 21293372
esv3627062 CNV loss 21293372
esv3627063 CNV loss 21293372
esv3627064 CNV loss 21293372
esv3627065 CNV loss 21293372
esv3627067 CNV loss 21293372
esv3627068 CNV loss 21293372
esv3627070 CNV loss 21293372
esv3892040 CNV gain 25118596
esv3892041 CNV loss 25118596
esv3892042 CNV loss 25118596
esv3892043 CNV loss 25118596
esv3892044 CNV loss 25118596
esv3892045 CNV loss 25118596
esv3892046 CNV loss 25118596
esv3892047 CNV loss 25118596
esv6392 CNV gain 19470904
esv7274 CNV gain 19470904
esv8123 CNV gain 19470904
esv8265 CNV gain 19470904
esv987708 CNV deletion 20482838
nsv1035566 CNV loss 25217958
nsv1035905 CNV gain 25217958
nsv1040419 CNV loss 25217958
nsv1041726 CNV loss 25217958
nsv1041968 CNV loss 25217958
nsv1047004 CNV loss 25217958
nsv1049696 CNV loss 25217958
nsv1051279 CNV gain 25217958
nsv1052380 CNV loss 25217958
nsv1052925 CNV loss 25217958
nsv1053669 CNV loss 25217958
nsv1054310 CNV loss 25217958
nsv1069612 CNV deletion 25765185
nsv1070976 CNV deletion 25765185
nsv1122651 CNV deletion 24896259
nsv1124644 CNV duplication 24896259
nsv1127214 CNV deletion 24896259
nsv1127215 CNV deletion 24896259
nsv1145556 CNV deletion 24896259
nsv1153349 CNV deletion 26484159
nsv415 CNV deletion 18451855
nsv416 CNV insertion 18451855
nsv468765 CNV loss 19166990
nsv468766 CNV loss 19166990
nsv468767 CNV loss 19166990
nsv473873 CNV novel sequence insertion 20440878
nsv478275 CNV novel sequence insertion 20440878
nsv482998 CNV loss 15286789
nsv507605 OTHER sequence alteration 20534489
nsv508642 CNV deletion 20534489
nsv510264 OTHER sequence alteration 20534489
nsv513745 CNV insertion 21212237
nsv515581 CNV loss 19592680
nsv516146 CNV loss 19592680
nsv516717 CNV gain 19592680
nsv516859 CNV loss 19592680
nsv518780 CNV loss 19592680
nsv519411 CNV loss 19592680
nsv519456 CNV loss 19592680
nsv520103 CNV loss 19592680
nsv524869 CNV loss 19592680
nsv527778 CNV loss 19592680
nsv527928 CNV gain 19592680
nsv555607 CNV loss 21841781
nsv555608 CNV loss 21841781
nsv555609 CNV gain 21841781
nsv555610 CNV gain 21841781
nsv555611 CNV loss 21841781
nsv555612 CNV loss 21841781
nsv555613 CNV loss 21841781
nsv555614 CNV loss 21841781
nsv555615 CNV loss 21841781
nsv555616 CNV loss 21841781
nsv555617 CNV loss 21841781
nsv555618 CNV loss 21841781
nsv555619 CNV loss 21841781
nsv555625 CNV loss 21841781
nsv555626 CNV loss 21841781
nsv555627 CNV loss 21841781
nsv555628 CNV loss 21841781
nsv555629 CNV loss 21841781
nsv555630 CNV loss 21841781
nsv555631 CNV loss 21841781
nsv8849 CNV loss 18304495
nsv8850 CNV loss 18304495
nsv957210 CNV deletion 24416366
nsv957860 CNV deletion 24416366
nsv975207 CNV duplication 23825009
nsv975208 CNV duplication 23825009
nsv975209 CNV duplication 23825009
nsv975956 CNV duplication 23825009
nsv983047 CNV duplication 23825009

Variation tolerance for DLG2 Gene

Residual Variation Intolerance Score: 2.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DLG2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLG2 Gene

Disorders for DLG2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DLG2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
chronic pain
  • pain - chronic
bilateral retinoblastoma
- elite association - COSMIC cancer census association via MalaCards
Search DLG2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DLG2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DLG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLG2 Gene

Publications for DLG2 Gene

  1. An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1. (PMID: 15304517) Leyland ML … Dart C (The Journal of biological chemistry 2004) 3 4 22 58
  2. Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. (PMID: 8755482) Kim E … Sheng M (Neuron 1996) 2 3 4 58
  3. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A … EUROSPAN consortium (PLoS genetics 2012) 3 44 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E … Estivill X (Journal of psychiatric research 2010) 3 44 58

Products for DLG2 Gene

Sources for DLG2 Gene

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