Aliases for DLG2 Gene
External Ids for DLG2 Gene
Previous GeneCards Identifiers for DLG2 Gene
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]
GeneCards Summary for DLG2 Gene
DLG2 (Discs Large MAGUK Scaffold Protein 2) is a Protein Coding gene. Diseases associated with DLG2 include Chronic Pain and Renal Oncocytoma. Among its related pathways are Hippo signaling pathway and Tight junction. Gene Ontology (GO) annotations related to this gene include kinase binding and guanylate kinase activity. An important paralog of this gene is DLG1.
UniProtKB/Swiss-Prot Summary for DLG2 Gene
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).