Aliases for DLEU7 Gene

Aliases for DLEU7 Gene

  • Deleted In Lymphocytic Leukemia 7 2 3 4 5
  • Leukemia-Associated Protein 7 3 4
  • LEU7 4

External Ids for DLEU7 Gene

Previous GeneCards Identifiers for DLEU7 Gene

  • GC13M049195
  • GC13M049084
  • GC13M050184
  • GC13M051288
  • GC13M032075
  • GC13M050711

Summaries for DLEU7 Gene

GeneCards Summary for DLEU7 Gene

DLEU7 (Deleted In Lymphocytic Leukemia 7) is a Protein Coding gene. Diseases associated with DLEU7 include Leukemia, Chronic Lymphocytic.

Additional gene information for DLEU7 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DLEU7 Gene

Genomics for DLEU7 Gene

GeneHancer (GH) Regulatory Elements for DLEU7 Gene

Promoters and enhancers for DLEU7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DLEU7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DLEU7

Top Transcription factor binding sites by QIAGEN in the DLEU7 gene promoter:
  • AML1a
  • C/EBPalpha
  • HSF1 (long)
  • HSF1short
  • Lhx3a
  • LHX3b
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2

Genomic Locations for DLEU7 Gene

Genomic Locations for DLEU7 Gene
chr13:50,519,364-50,843,939
(GRCh38/hg38)
Size:
324,576 bases
Orientation:
Minus strand
chr13:51,285,144-51,418,075
(GRCh37/hg19)
Size:
132,932 bases
Orientation:
Minus strand

Genomic View for DLEU7 Gene

Genes around DLEU7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLEU7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLEU7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLEU7 Gene

Proteins for DLEU7 Gene

  • Protein details for DLEU7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UYE1-LEU7_HUMAN
    Recommended name:
    Leukemia-associated protein 7
    Protein Accession:
    Q6UYE1
    Secondary Accessions:
    • Q2M2E4
    • Q6ZT82

    Protein attributes for DLEU7 Gene

    Size:
    221 amino acids
    Molecular mass:
    23924 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DLEU7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLEU7 Gene

Post-translational modifications for DLEU7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLEU7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DLEU7 Gene

Domains & Families for DLEU7 Gene

Gene Families for DLEU7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DLEU7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DLEU7 Gene

GenScript: Design optimal peptide antigens:
  • Deleted in lymphocytic leukemia 7 (LEU7_HUMAN)
genes like me logo Genes that share domains with DLEU7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DLEU7 Gene

Function for DLEU7 Gene

Phenotypes From GWAS Catalog for DLEU7 Gene

Gene Ontology (GO) - Molecular Function for DLEU7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DLEU7: view
genes like me logo Genes that share phenotypes with DLEU7: view

Animal Models for DLEU7 Gene

MGI Knock Outs for DLEU7:
  • Dleu7 Dleu7<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DLEU7 Gene

Localization for DLEU7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DLEU7 gene
Compartment Confidence
plasma membrane 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DLEU7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with DLEU7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for DLEU7 Gene

Pathways & Interactions for DLEU7 Gene

PathCards logo

SuperPathways for DLEU7 Gene

No Data Available

Interacting Proteins for DLEU7 Gene

;

Gene Ontology (GO) - Biological Process for DLEU7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with DLEU7: view

No data available for Pathways by source and SIGNOR curated interactions for DLEU7 Gene

Drugs & Compounds for DLEU7 Gene

No Compound Related Data Available

Transcripts for DLEU7 Gene

mRNA/cDNA for DLEU7 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLEU7 Gene

No ASD Table

Relevant External Links for DLEU7 Gene

GeneLoc Exon Structure for
DLEU7

Expression for DLEU7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DLEU7 Gene

mRNA differential expression in normal tissues according to GTEx for DLEU7 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.8), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Cortex (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DLEU7 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DLEU7

SOURCE GeneReport for Unigene cluster for DLEU7 Gene:

Hs.710878

mRNA Expression by UniProt/SwissProt for DLEU7 Gene:

Q6UYE1-LEU7_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with DLEU7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DLEU7 Gene

Orthologs for DLEU7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DLEU7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLEU7 31 30
  • 100 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dleu7 30
  • 83.58 (n)
mouse
(Mus musculus)
Mammalia Dleu7 17 31 30
  • 83.33 (n)
cow
(Bos Taurus)
Mammalia DLEU7 30
  • 81.86 (n)
oppossum
(Monodelphis domestica)
Mammalia DLEU7 31
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves DLEU7 31 30
  • 50.8 (n)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii DLEU7 31
  • 17 (a)
OneToOne
Species where no ortholog for DLEU7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLEU7 Gene

ENSEMBL:
Gene Tree for DLEU7 (if available)
TreeFam:
Gene Tree for DLEU7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DLEU7: view image

Paralogs for DLEU7 Gene

No data available for Paralogs for DLEU7 Gene

Variants for DLEU7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DLEU7 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs898861 - p.Ala83Val

Additional dbSNP identifiers (rs#s) for DLEU7 Gene

Structural Variations from Database of Genomic Variants (DGV) for DLEU7 Gene

Variant ID Type Subtype PubMed ID
esv2593545 CNV deletion 19546169
esv3335461 CNV insertion 20981092
esv3580637 CNV loss 25503493
nsv1037350 CNV loss 25217958
nsv437786 CNV loss 16327808
nsv561618 CNV loss 21841781
nsv561643 CNV loss 21841781

Variation tolerance for DLEU7 Gene

Gene Damage Index Score: 5.48; 71.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DLEU7 Gene

Human Gene Mutation Database (HGMD)
DLEU7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DLEU7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLEU7 Gene

Disorders for DLEU7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DLEU7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
leukemia, chronic lymphocytic
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search DLEU7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DLEU7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DLEU7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLEU7 Gene

Publications for DLEU7 Gene

  1. Characterization of a novel B-CLL candidate gene--DLEU7--located in the 13q14 tumor suppressor locus. (PMID: 14706829) Hammarsund M … Grandér D (FEBS letters 2004) 2 3 4 54
  2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 41 54
  3. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PMID: 19266077) Sovio U … Jarvelin MR (PLoS genetics 2009) 3 41 54
  4. Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. (PMID: 19343178) Soranzo N … Deloukas P (PLoS genetics 2009) 3 41 54
  5. Genome-wide association analysis identifies 20 loci that influence adult height. (PMID: 18391952) Weedon MN … Frayling TM (Nature genetics 2008) 3 41 54

Products for DLEU7 Gene

Sources for DLEU7 Gene