DLEU2 Gene (RNA Gene)

Deleted In Lymphocytic Leukemia 2

GC13M049982
GIFtS:
22
This locus represents a microRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle vi... See more...

Aliases for DLEU2 Gene

Subcategory (RNA class) for DLEU2 Gene

lncRNA

Number of RNA Genes sources:

3 / 17

Aliases for DLEU2 Gene

  • Deleted In Lymphocytic Leukemia 2 2 3 5
  • DLEU2 2 5 165
  • Deleted In Lymphocytic Leukemia 2 (Non-Protein Coding) 2 3
  • Mir-15a-16-1 Cluster Host Gene (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 22 2 3
  • Ret Finger Protein 2 Opposite Strand 2 3
  • NCRNA00022 2 3
  • LINC00022 2 3
  • MIR15AHG 2 3
  • TRIM13OS 2 3
  • LEU2 2 3
  • Deleted In Lymphocytic Leukemia, 2 2
  • Leukemia Associated Gene 2 3
  • Non-Protein Coding RNA 22 2
  • NONHSAG013515.2 91
  • NONHSAG013511.2 91
  • HSALNG0097101 164
  • HSALNG0097094 164
  • HSALNG0097089 164
  • BCMSUN 3
  • RFP2OS 3
  • ALT1 3
  • DLB2 3
  • RFP2 3

External Ids for DLEU2 Gene

Previous HGNC Symbols for DLEU2 Gene

  • DLB2
  • BCMSUN
  • RFP2OS

Previous GeneCards Identifiers for DLEU2 Gene

  • GC13M048617
  • GC13M044605
  • GC13M049554
  • GC13M048415
  • GC13M049515
  • GC13M050558
  • GC13M031351

Summaries for DLEU2 Gene

Entrez Gene Summary for DLEU2 Gene

  • This locus represents a microRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle via angiotensin I converting enzyme 2 and cyclin D1. [provided by RefSeq, Dec 2017]

GeneCards Summary for DLEU2 Gene

DLEU2 (Deleted In Lymphocytic Leukemia 2) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with DLEU2 include Larynx Cancer and Lymphoma.

Gene Wiki entry for DLEU2 Gene

Rfam classification for DLEU2 Gene

  • Deleted in lymphocytic leukemia 1 conserved region 2
  • mir-15 microRNA precursor family
  • mir-16 microRNA precursor family
  • Deleted in lymphocytic leukemia 2 conserved region 5
  • Deleted in lymphocytic leukemia 2 conserved region 4
  • Deleted in lymphocytic leukemia 2 conserved region 3
  • Deleted in lymphocytic leukemia 2 conserved region 1
  • Deleted in lymphocytic leukemia 2 conserved region 6
  • Deleted in lymphocytic leukemia 2 conserved region 2

Additional gene information for DLEU2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for DLEU2 Gene

Genomics for DLEU2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for DLEU2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DLEU2 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the DLEU2 gene promoter:
  • C/EBPbeta
  • E47
  • Evi-1
  • p300
  • POU2F1
  • POU2F1a
  • RelA
  • Sp1
  • SRY
  • Tal-1

Genomic Locations for DLEU2 Gene

Genomic Locations for DLEU2 Gene
chr13:49,912,706-50,125,720
(GRCh38/hg38)
Size:
213,015 bases
Orientation:
Minus strand
chr13:50,556,688-50,699,856
(GRCh37/hg19)
Size:
143,169 bases
Orientation:
Minus strand

Genomic View for DLEU2 Gene

Genes around DLEU2 on UCSC Golden Path with GeneCards custom track
DLEU2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
DLEU2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLEU2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DLEU2 Gene

Proteins for DLEU2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for DLEU2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DLEU2 Gene

Domains & Families for DLEU2 Gene

Gene Families for DLEU2 Gene

HGNC:

Suggested Antigen Peptide Sequences for DLEU2 Gene

GenScript: Design optimal peptide antigens:
  • Deleted in lymphocytic leukemia 2 (LEU2_HUMAN)
genes like me logo Genes that share domains with DLEU2: view

No data available for Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DLEU2 Gene

Function for DLEU2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for DLEU2 Gene

genes like me logo Genes that share phenotypes with DLEU2: view

Animal Model Products

CRISPR Products

miRNA for DLEU2 Gene

miRTarBase miRNAs that target DLEU2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DLEU2 Gene

Localization for DLEU2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DLEU2 Gene

Pathways & Interactions for DLEU2 Gene

PathCards logo

SuperPathways for DLEU2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DLEU2 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for DLEU2 Gene

Drugs & Compounds for DLEU2 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for DLEU2 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

Non-coding RNA (ncRNA) Transcripts from RNAcentral for DLEU2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00007DAA2F_9606 lncRNA 1267 4

Ensembl: ENST00000425586 (view in UCSC) ,

LncBook: HSALNT0201704,

LNCipedia: DLEU2:1,

NONCODE: NONHSAT033787.2,

URS00007DA42D_9606 lncRNA 705 4

Ensembl: ENST00000443587 (view in UCSC) ,

LncBook: HSALNT0201731,

LNCipedia: DLEU2:19,

NONCODE: NONHSAT033798.2,

URS00007C98D6_9606 lncRNA 692 4

Ensembl: ENST00000421758 (view in UCSC) ,

LncBook: HSALNT0201736,

LNCipedia: DLEU2:18,

NONCODE: NONHSAT033804.2,

URS00007D61AD_9606 lncRNA 3068 3

Ensembl: ENST00000621282 (view in UCSC) ,

LNCipedia: DLEU2:3,

NONCODE: NONHSAT166766.1,

URS0000EF28B1_9606 lncRNA 3166 2

HGNC: 13748,

Ensembl: ENST00000668133 (view in UCSC) ,

DLEU2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for DLEU2 Gene

17 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLEU2 Gene

No ASD Table

Relevant External Links for DLEU2 Gene

GeneLoc Exon Structure for
DLEU2

Expression for DLEU2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DLEU2 Gene

mRNA expression in normal human tissues for DLEU2 Gene
mRNA expression by BioGPS for DLEU2 GenemRNA expression by GTEx for DLEU2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DLEU2

SOURCE GeneReport for Unigene cluster for DLEU2 Gene:

Hs.547964
genes like me logo Genes that share expression patterns with DLEU2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DLEU2 Gene

Orthologs for DLEU2 Gene

Evolution for DLEU2 Gene

ENSEMBL:
Gene Tree for DLEU2 (if available)
TreeFam:
Gene Tree for DLEU2 (if available)

No data available for Orthologs for DLEU2 Gene

Paralogs for DLEU2 Gene

No data available for Paralogs for DLEU2 Gene

Variants for DLEU2 Gene

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  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for DLEU2 Gene

Structural Variations from Database of Genomic Variants (DGV) for DLEU2 Gene

Variant ID Type Subtype PubMed ID
esv1970441 CNV deletion 18987734
esv2085992 CNV deletion 18987734
esv2580955 CNV deletion 19546169
esv2661834 CNV deletion 23128226
esv2666533 CNV deletion 23128226
esv2747402 CNV deletion 23290073
esv2747403 CNV deletion 23290073
esv2747404 CNV deletion 23290073
esv2747405 CNV deletion 23290073
esv3550452 CNV deletion 23714750
esv3550453 CNV deletion 23714750
esv3580637 CNV loss 25503493
esv3632062 CNV loss 21293372
nsv1035151 CNV loss 25217958
nsv1041501 CNV loss 25217958
nsv1054415 CNV loss 25217958
nsv1118263 CNV deletion 24896259
nsv472293 CNV novel sequence insertion 20440878
nsv561618 CNV loss 21841781
nsv64412 CNV deletion 16902084
nsv832608 CNV gain 17160897
nsv951082 CNV duplication 24416366
nsv951083 CNV duplication 24416366

Additional Variant Information for DLEU2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DLEU2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for DLEU2 Gene

Disorders for DLEU2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for DLEU2 Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
larynx cancer
  • laryngeal carcinoma
lymphoma
  • lymphoid cancer
leukemia, chronic lymphocytic
  • cll
pancreatic cancer
  • pancreatic carcinoma
astrocytoma
  • astrocytic tumor
- elite association - COSMIC cancer census association via MalaCards
Search DLEU2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DLEU2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with DLEU2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLEU2 Gene

Publications for DLEU2 Gene

  1. BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like. (PMID: 11072235) Mertens D … Lichter P (International journal of cancer 2000) 2 3 23
  2. Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia. (PMID: 9395242) Liu Y … Oscier D (Oncogene 1997) 2 3 23
  3. A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample. (PMID: 20451256) Djurovic S … Andreassen OA (Journal of affective disorders 2010) 3 41
  4. Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14. (PMID: 11161783) Kapanadze B … Sangfelt O (Genomics 2000) 3 23
  5. Silencing of DLEU2 suppresses pancreatic cancer cell proliferation and invasion by upregulating microRNA-455. (PMID: 30838724) Xu B … Li Y (Cancer science 2019) 3

ExternalLinks

View latest publications for DLEU2 gene in Mastermind

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