This locus represents a microRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle vi... See more...

Aliases for DLEU2 Gene

Subcategory (RNA class) for DLEU2 Gene

lncRNA

Quality Score for this RNA gene is

15

Aliases for DLEU2 Gene

  • Deleted In Lymphocytic Leukemia 2 2 3 5
  • Deleted In Lymphocytic Leukemia 2 (Non-Protein Coding) 2 3
  • Mir-15a-16-1 Cluster Host Gene (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 22 2 3
  • Ret Finger Protein 2 Opposite Strand 2 3
  • DLEU2 2 170
  • Deleted In Lymphocytic Leukemia, 2 2
  • Leukemia Associated Gene 2 3
  • Non-Protein Coding RNA 22 2
  • HSALNG0097094 169
  • HSALNG0097089 169
  • HSALNG0097101 169
  • NONHSAG013515 94
  • NONHSAG013511 94
  • NCRNA00022 3
  • LINC00022 3
  • MIR15AHG 3
  • TRIM13OS 3
  • BCMSUN 3
  • RFP2OS 3
  • ALT1 3
  • LEU2 3
  • RFP2 3
  • DLB2 3

External Ids for DLEU2 Gene

Previous HGNC Symbols for DLEU2 Gene

  • DLB2
  • BCMSUN
  • RFP2OS

Previous GeneCards Identifiers for DLEU2 Gene

  • GC13M048617
  • GC13M044605
  • GC13M049554
  • GC13M048415
  • GC13M049515
  • GC13M050558
  • GC13M031351

Summaries for DLEU2 Gene

Entrez Gene Summary for DLEU2 Gene

  • This locus represents a microRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle via angiotensin I converting enzyme 2 and cyclin D1. [provided by RefSeq, Dec 2017]

GeneCards Summary for DLEU2 Gene

DLEU2 (Deleted In Lymphocytic Leukemia 2) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with DLEU2 include Lymphocytic Leukemia and Larynx Cancer.

Gene Wiki entry for DLEU2 Gene

Rfam classification for DLEU2 Gene

  • mir-15 microRNA precursor family
  • mir-16 microRNA precursor family
  • Deleted in lymphocytic leukemia 2 conserved region 5
  • Deleted in lymphocytic leukemia 2 conserved region 4
  • Deleted in lymphocytic leukemia 2 conserved region 3
  • Deleted in lymphocytic leukemia 2 conserved region 1
  • Deleted in lymphocytic leukemia 2 conserved region 6
  • Deleted in lymphocytic leukemia 2 conserved region 2
  • Deleted in lymphocytic leukemia 1 conserved region 2

Additional gene information for DLEU2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for DLEU2 Gene

Genomics for DLEU2 Gene

GeneHancer (GH) Regulatory Elements for DLEU2 Gene

Promoters and enhancers for DLEU2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DLEU2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DLEU2 gene promoter:
  • C/EBPbeta
  • E47
  • Evi-1
  • p300
  • POU2F1
  • POU2F1a
  • RelA
  • Sp1
  • SRY
  • Tal-1

Genomic Locations for DLEU2 Gene

Genomic Locations for DLEU2 Gene
chr13:49,912,706-50,125,720
(GRCh38/hg38)
Size:
213,015 bases
Orientation:
Minus strand
chr13:50,556,688-50,699,856
(GRCh37/hg19)
Size:
143,169 bases
Orientation:
Minus strand

Genomic View for DLEU2 Gene

Genes around DLEU2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLEU2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLEU2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLEU2 Gene

Proteins for DLEU2 Gene

Post-translational modifications for DLEU2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DLEU2 Gene

Domains & Families for DLEU2 Gene

Gene Families for DLEU2 Gene

Suggested Antigen Peptide Sequences for DLEU2 Gene

GenScript: Design optimal peptide antigens:
  • Deleted in lymphocytic leukemia 2 (LEU2_HUMAN)
genes like me logo Genes that share domains with DLEU2: view

No data available for Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DLEU2 Gene

Function for DLEU2 Gene

Phenotypes From GWAS Catalog for DLEU2 Gene

genes like me logo Genes that share phenotypes with DLEU2: view

Animal Model Products

CRISPR Products

miRNA for DLEU2 Gene

miRTarBase miRNAs that target DLEU2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DLEU2 Gene

Localization for DLEU2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DLEU2 Gene

Pathways & Interactions for DLEU2 Gene

PathCards logo

SuperPathways for DLEU2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DLEU2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DLEU2 Gene

Drugs & Compounds for DLEU2 Gene

No Compound Related Data Available

Transcripts for DLEU2 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLEU2 Gene

No ASD Table

Relevant External Links for DLEU2 Gene

GeneLoc Exon Structure for
DLEU2
ECgene alternative splicing isoforms for
DLEU2

Expression for DLEU2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DLEU2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DLEU2 Gene:

DLEU2

SOURCE GeneReport for Unigene cluster for DLEU2 Gene:

Hs.547964
genes like me logo Genes that share expression patterns with DLEU2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DLEU2 Gene

Orthologs for DLEU2 Gene

Evolution for DLEU2 Gene

ENSEMBL:
Gene Tree for DLEU2 (if available)
TreeFam:
Gene Tree for DLEU2 (if available)

No data available for Orthologs for DLEU2 Gene

Paralogs for DLEU2 Gene

No data available for Paralogs for DLEU2 Gene

Variants for DLEU2 Gene

Sequence variations from dbSNP and Humsavar for DLEU2 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000047936 -- 50,060,562(-) G/A intron_variant
rs1000064639 -- 50,102,336(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000099372 -- 50,124,300(-) G/A/C genic_upstream_transcript_variant, intron_variant
rs1000127350 -- 50,073,878(-) T/C intron_variant
rs1000138122 -- 50,091,495(-) G/A/C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DLEU2 Gene

Variant ID Type Subtype PubMed ID
esv1970441 CNV deletion 18987734
esv2085992 CNV deletion 18987734
esv2580955 CNV deletion 19546169
esv2661834 CNV deletion 23128226
esv2666533 CNV deletion 23128226
esv2747402 CNV deletion 23290073
esv2747403 CNV deletion 23290073
esv2747404 CNV deletion 23290073
esv2747405 CNV deletion 23290073
esv3550452 CNV deletion 23714750
esv3550453 CNV deletion 23714750
esv3580637 CNV loss 25503493
esv3632062 CNV loss 21293372
nsv1035151 CNV loss 25217958
nsv1041501 CNV loss 25217958
nsv1054415 CNV loss 25217958
nsv1118263 CNV deletion 24896259
nsv472293 CNV novel sequence insertion 20440878
nsv561618 CNV loss 21841781
nsv64412 CNV deletion 16902084
nsv832608 CNV gain 17160897
nsv951082 CNV duplication 24416366
nsv951083 CNV duplication 24416366

Additional Variant Information for DLEU2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DLEU2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DLEU2 Gene

Disorders for DLEU2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for DLEU2 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lymphocytic leukemia
  • lymphoblastic leukemia
larynx cancer
  • laryngeal carcinoma
lymphoma
  • lymphoid cancer
leukemia, chronic lymphocytic
  • cll
pancreatic cancer
  • pancreatic carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search DLEU2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DLEU2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DLEU2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLEU2 Gene

Publications for DLEU2 Gene

  1. BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like. (PMID: 11072235) Mertens D … Lichter P (International journal of cancer 2000) 2 3 23 56
  2. Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia. (PMID: 9395242) Liu Y … Oscier D (Oncogene 1997) 2 3 23 56
  3. A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample. (PMID: 20451256) Djurovic S … Andreassen OA (Journal of affective disorders 2010) 3 43 56
  4. Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14. (PMID: 11161783) Kapanadze B … Sangfelt O (Genomics 2000) 3 23 56
  5. Upregulated long-non-coding RNA DLEU2 exon 9 expression was an independent indicator of unfavorable overall survival in patients with esophageal adenocarcinoma. (PMID: 30849637) Ma W … Zhang LJ (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3 56

Products for DLEU2 Gene

Sources for DLEU2 Gene