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DLEU1 Gene(RNA Gene)

Deleted In Lymphocytic Leukemia 1

GCID:
GC13P050083
GIFtS:
30
Genes Participants
UDN Logo

Aliases for DLEU1 Gene

Subcategory (RNA class) for DLEU1 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for DLEU1 Gene

  • Deleted In Lymphocytic Leukemia 1 2 2 3 4
  • Deleted In Lymphocytic Leukemia 1 (Non-Protein Coding) 2 3 5
  • B-Cell Neoplasia-Associated Gene With Multiple Splicing 2 3
  • Long Intergenic Non-Protein Coding RNA 21 2 3
  • LEU1 3 4
  • XTP6 3 4
  • HBV X-Transactivated Gene 6 Protein 4
  • HBV XAg-Transactivated Protein 6 4
  • Leukemia-Associated Protein 2 3
  • Non-Protein Coding RNA 21 2
  • NCRNA00021 3
  • LINC00021 3
  • BCMS1 3
  • DLEU2 3
  • LEU2 3
  • BCMS 3
  • DLB1 3

External Ids for DLEU1 Gene

Previous HGNC Symbols for DLEU1 Gene

  • DLB1
  • BCMS

Previous GeneCards Identifiers for DLEU1 Gene

  • GC13P048656
  • GC13P044643
  • GC13P049592
  • GC13P048454
  • GC13P049554
  • GC13P050656
  • GC13P031451

Summaries for DLEU1 Gene

GeneCards Summary for DLEU1 Gene

DLEU1 (Deleted In Lymphocytic Leukemia 1) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with DLEU1 include Leukemia, Chronic Lymphocytic and Ovarian Epithelial Cancer.

UniProtKB/Swiss-Prot for DLEU1 Gene

  • May act as a tumor suppressor.

Gene Wiki entry for DLEU1 Gene

Additional gene information for DLEU1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLEU1 Gene

Genomics for DLEU1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for DLEU1 Gene

Promoters and enhancers for DLEU1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH13J050121 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 25.2 +44.6 44587 10.1 FEZF1 DMAP1 IRF4 YY1 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 DLEU2 ENSG00000274270 SETDB2 KCNRG TRIM13 CTAGE10P DLEU1 RNASEH2B-AS1 ENSG00000176882 RNASEH2B
GH13J050075 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 13.1 -2.2 -2228 9.1 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000275559 CTAGE10P TRIM13 SETDB2 ENSG00000176882 DLEU1 KCNRG EBPL ENSG00000276089 GC13P050084
GH13J049995 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.1 -84.7 -84667 4.4 SMAD1 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF766 ZNF213 ZNF207 TRIM13 SPRYD7 MIR3613 KCNRG DLEU1 SETDB2 EBPL CTAGE10P RNASEH2B DLEU2
GH13J049934 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 7.6 -144.4 -144416 5.8 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 TRIM13 SPRYD7 CTAGE10P KCNRG ENSG00000176882 SETDB2 EBPL DLEU1 GC13P049951 RNY4P9
GH13J050119 Enhancer 0.7 dbSUPER 21.5 +37.7 37706 1 ATF1 FOXA2 ZBTB21 INSM2 FEZF1 PATZ1 ZSCAN5C SCRT2 ZNF600 ATF7 DLEU1 RNASEH2B-AS1 RNASEH2B KCNRG DLEU2 ENSG00000273541
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DLEU1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DLEU1 gene promoter:
  • AML1a

Genomic Locations for DLEU1 Gene

Genomic Locations for DLEU1 Gene
chr13:50,082,169-50,723,236
(GRCh38/hg38)
Size:
641,068 bases
Orientation:
Plus strand
chr13:50,656,307-51,297,372
(GRCh37/hg19)
Size:
641,066 bases
Orientation:
Plus strand

Genomic View for DLEU1 Gene

Genes around DLEU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLEU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLEU1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DLEU1 Gene

Proteins for DLEU1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DLEU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43261-LEU1_HUMAN
    Recommended name:
    Leukemia-associated protein 1
    Protein Accession:
    O43261
    Secondary Accessions:
    • Q547G6
    • Q8TE10
    • Q96QY5

    Protein attributes for DLEU1 Gene

    Size:
    78 amino acids
    Molecular mass:
    8962 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA75515.1; Type=Frameshift; Positions=73; Evidence={ECO:0000305};

neXtProt entry for DLEU1 Gene

Post-translational modifications for DLEU1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DLEU1 Gene

Domains & Families for DLEU1 Gene

Gene Families for DLEU1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DLEU1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for DLEU1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DLEU1: view

No data available for UniProtKB/Swiss-Prot for DLEU1 Gene

Function for DLEU1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for DLEU1 Gene

UniProtKB/Swiss-Prot Function:
May act as a tumor suppressor.

Phenotypes From GWAS Catalog for DLEU1 Gene

genes like me logo Genes that share phenotypes with DLEU1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DLEU1 Gene

Localization for DLEU1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DLEU1 gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DLEU1 Gene

Pathways & Interactions for DLEU1 Gene

SuperPathways for DLEU1 Gene

PathCards logo More details on SuperPathways for DLEU1
No Data Available

Interacting Proteins for DLEU1 Gene

Selected Interacting proteins: O43261-LEU1_HUMAN for DLEU1 Gene via IID UniProtKB

Gene Ontology (GO) - Biological Process for DLEU1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DLEU1 Gene

Drugs & Compounds for DLEU1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for DLEU1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DLEU1 Gene

(1) REFSEQ mRNAs :
(43) Additional mRNA sequences :
(145) Selected AceView cDNA sequences:
(35) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(16) RNA Central transcripts :

Unigene Clusters for DLEU1 Gene

Deleted in lymphocytic leukemia 1 (non-protein coding):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLEU1 Gene

No ASD Table

Relevant External Links for DLEU1 Gene

GeneLoc Exon Structure for
DLEU1
ECgene alternative splicing isoforms for
DLEU1

Expression for DLEU1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DLEU1 Gene

mRNA expression in normal human tissues for DLEU1 Gene
mRNA expression by GTEx for DLEU1 GenemRNA expression by BioGPS for DLEU1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DLEU1 Gene:

DLEU1

SOURCE GeneReport for Unigene cluster for DLEU1 Gene:

Hs.591229
genes like me logo Genes that share expression patterns with DLEU1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DLEU1 Gene

Orthologs for DLEU1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DLEU1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia DLEU1 34
  • 99 (a)
 OneToOne
Species where no ortholog for DLEU1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DLEU1 Gene

ENSEMBL:
Gene Tree for DLEU1 (if available)
TreeFam:
Gene Tree for DLEU1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DLEU1: view image

Paralogs for DLEU1 Gene

No data available for Paralogs for DLEU1 Gene

Variants for DLEU1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for DLEU1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000005895 -- 50,441,431(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000014326 -- 50,270,828(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000036539 -- 50,200,953(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000058859 -- 50,146,758(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000059028 -- 50,396,947(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DLEU1 Gene

Variant ID Type Subtype PubMed ID
dgv16n50 CNV loss 21212237
dgv17n47 CNV loss 21111241
dgv3143n54 CNV gain 21841781
dgv3144n54 CNV gain+loss 21841781
dgv3145n54 CNV gain 21841781
dgv328n67 CNV loss 20364138
dgv52n73 CNV deletion 24416366
dgv970n106 OTHER inversion 24896259
dgv971n106 CNV deletion 24896259
esv1004494 CNV gain 20482838
esv1010553 CNV deletion 20482838
esv2027268 CNV deletion 18987734
esv22269 CNV gain 19812545
esv2422100 CNV deletion 20811451
esv2536067 CNV deletion 19546169
esv2550436 CNV deletion 19546169
esv2598724 CNV loss 19546169
esv2661381 CNV deletion 23128226
esv2662514 CNV deletion 23128226
esv2747406 CNV deletion 23290073
esv2747407 CNV deletion 23290073
esv3248718 CNV deletion 24192839
esv32798 CNV gain 17666407
esv32857 CNV loss 17666407
esv33542 CNV gain 17666407
esv3368488 CNV insertion 20981092
esv3447651 CNV duplication 20981092
esv3550457 CNV deletion 23714750
esv3550458 CNV deletion 23714750
esv3580634 CNV loss 25503493
esv3580635 CNV loss 25503493
esv3580636 CNV loss 25503493
esv3580637 CNV loss 25503493
esv3632063 CNV loss 21293372
esv3632066 CNV loss 21293372
esv3632067 CNV loss 21293372
esv3632068 CNV loss 21293372
esv4002 CNV loss 18987735
esv6426 CNV loss 19470904
esv994199 CNV gain 20482838
nsv1035151 CNV loss 25217958
nsv1040 CNV deletion 18451855
nsv1041501 CNV loss 25217958
nsv1045237 CNV loss 25217958
nsv1069968 CNV deletion 25765185
nsv1149360 CNV deletion 26484159
nsv435640 CNV deletion 17901297
nsv472250 CNV novel sequence insertion 20440878
nsv510585 CNV deletion 20534489
nsv514699 CNV loss 21397061
nsv526482 CNV loss 19592680
nsv561618 CNV loss 21841781
nsv561631 CNV loss 21841781
nsv561632 CNV loss 21841781
nsv561635 CNV gain 21841781
nsv561636 CNV gain 21841781
nsv561641 CNV loss 21841781
nsv820810 CNV deletion 20802225
nsv826640 CNV loss 20364138
nsv832608 CNV gain 17160897
nsv832609 CNV loss 17160897
nsv951082 CNV duplication 24416366
nsv951083 CNV duplication 24416366
nsv976114 CNV duplication 23825009
nsv977238 CNV duplication 23825009

Variation tolerance for DLEU1 Gene

Gene Damage Index Score: 5.09; 69.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DLEU1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DLEU1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLEU1 Gene

Disorders for DLEU1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DLEU1 Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
leukemia, chronic lymphocytic
  • cll
ovarian epithelial cancer
  • eoc
breast cancer
  • breast cancer, familial
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search DLEU1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DLEU1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DLEU1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLEU1 Gene

Publications for DLEU1 Gene

  1. Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia. (PMID: 9395242) Liu Y … Oscier D (Oncogene 1997) 2 3 4 22 58
  2. Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14. (PMID: 11161783) Kapanadze B … Sangfelt O (Genomics 2000) 3 4 22 58
  3. Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PMID: 19260139) Polasek O … Rudan I (Croatian medical journal 2009) 3 44 58
  4. B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions. (PMID: 11406609) Wolf S … Lichter P (Human molecular genetics 2001) 2 3 58
  5. The effects of DLEU1 gene expression in Burkitt lymphoma (BL): potential mechanism of chemoimmunotherapy resistance in BL. (PMID: 28427156) Lee S … Cairo MS (Oncotarget 2017) 3 58

Products for DLEU1 Gene

Sources for DLEU1 Gene

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