Aliases for DKKL1 Gene
External Ids for DKKL1 Gene
Previous GeneCards Identifiers for DKKL1 Gene
The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
GeneCards Summary for DKKL1 Gene
DKKL1 (Dickkopf Like Acrosomal Protein 1) is a Protein Coding gene. Diseases associated with DKKL1 include Rectum Adenocarcinoma and Rectum Cancer. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity.
UniProtKB/Swiss-Prot Summary for DKKL1 Gene
Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.