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Aliases for DKK4 Gene

Aliases for DKK4 Gene

  • Dickkopf WNT Signaling Pathway Inhibitor 4 2 3 5
  • Dickkopf-4 3 4
  • HDkk-4 3 4
  • Dickkopf (Xenopus Laevis) Homolog 4 2
  • Dickkopf Homolog 4 (Xenopus Laevis) 2
  • Dickkopf-Related Protein 4 3
  • DKK-4 3
  • Dkk-4 4

External Ids for DKK4 Gene

Previous GeneCards Identifiers for DKK4 Gene

  • GC08P041716
  • GC08M042257
  • GC08M041972
  • GC08M042248
  • GC08M040754

Summaries for DKK4 Gene

Entrez Gene Summary for DKK4 Gene

  • This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for DKK4 Gene

DKK4 (Dickkopf WNT Signaling Pathway Inhibitor 4) is a Protein Coding gene. Diseases associated with DKK4 include Cleft Soft Palate. Among its related pathways are Reelin Pathway (Cajal-Retzius cells) and HIV Life Cycle. An important paralog of this gene is DKK2.

UniProtKB/Swiss-Prot for DKK4 Gene

  • Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Additional gene information for DKK4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DKK4 Gene

Genomics for DKK4 Gene

GeneHancer (GH) Regulatory Elements for DKK4 Gene

Promoters and enhancers for DKK4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J042390 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.5 -482 2.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 DKK4 VDAC3 POLB IKBKB KAT6A ENSG00000254165 PIR58107
GH08J042378 Promoter 0.5 EPDnew 650.4 +14.5 14505 0.1 DKK4 VDAC3 RPL5P23
GH08J042151 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 +237.2 237184 5.9 CLOCK ZFP64 DMAP1 IRF4 YY1 ZNF143 SP3 NFYC MEF2D ZNF610 AP3M2 ENSG00000261449 IKBKB ENSG00000254165 LOC101929897 POLB KAT6A DKK4 ENSG00000238966 PIR61234
GH08J042289 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +99.7 99689 5.6 HDGF PKNOX1 SMAD1 IRF4 ZNF207 ATF7 RUNX3 JUNB ZNF592 NBN POLB LOC101929897 IKBKB DKK4 ANK1 LOC105379395
GH08J042171 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.9 +219.9 219912 1.1 ATF1 FOXA2 ARID4B SIN3A NFXL1 ZNF2 RAD21 YY1 ZNF335 ZNF121 PIR61234 IKBKB POLB PLAT HGSNAT LOC101929897 VDAC3 KAT6A DKK4 AP3M2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DKK4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DKK4 gene promoter:
  • AREB6
  • RelA
  • NF-kappaB1
  • NF-kappaB
  • AML1a
  • NRSF form 1
  • NRSF form 2
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2

Genomic Locations for DKK4 Gene

Genomic Locations for DKK4 Gene
chr8:42,373,194-42,391,754
(GRCh38/hg38)
Size:
18,561 bases
Orientation:
Minus strand
chr8:42,231,586-42,234,750
(GRCh37/hg19)
Size:
3,165 bases
Orientation:
Minus strand

Genomic View for DKK4 Gene

Genes around DKK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DKK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DKK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DKK4 Gene

Proteins for DKK4 Gene

  • Protein details for DKK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBT3-DKK4_HUMAN
    Recommended name:
    Dickkopf-related protein 4
    Protein Accession:
    Q9UBT3
    Secondary Accessions:
    • Q3KNX0
    • Q9Y4C3

    Protein attributes for DKK4 Gene

    Size:
    224 amino acids
    Molecular mass:
    24876 Da
    Quaternary structure:
    • Interacts with LRP5 and LRP6.

neXtProt entry for DKK4 Gene

Post-translational modifications for DKK4 Gene

Other Protein References for DKK4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DKK4 Gene

Domains & Families for DKK4 Gene

Gene Families for DKK4 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for DKK4 Gene

Suggested Antigen Peptide Sequences for DKK4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBT3

UniProtKB/Swiss-Prot:

DKK4_HUMAN :
  • The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • Belongs to the dickkopf family.
Domain:
  • The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
Family:
  • Belongs to the dickkopf family.
genes like me logo Genes that share domains with DKK4: view

Function for DKK4 Gene

Molecular function for DKK4 Gene

UniProtKB/Swiss-Prot Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

LifeMap Function Summary for DKK4 Gene

During embryonic development, DKK4 as signaling molecule is secreted from the following cells

Phenotypes From GWAS Catalog for DKK4 Gene

Gene Ontology (GO) - Molecular Function for DKK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0039706 co-receptor binding IBA --
GO:0048019 receptor antagonist activity IBA --
genes like me logo Genes that share ontologies with DKK4: view
genes like me logo Genes that share phenotypes with DKK4: view

Animal Models for DKK4 Gene

MGI Knock Outs for DKK4:
  • Dkk4 Dkk4<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for DKK4

miRNA for DKK4 Gene

miRTarBase miRNAs that target DKK4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DKK4 Gene

Localization for DKK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DKK4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DKK4 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for DKK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with DKK4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DKK4 Gene

Pathways & Interactions for DKK4 Gene

genes like me logo Genes that share pathways with DKK4: view

Interacting Proteins for DKK4 Gene

Gene Ontology (GO) - Biological Process for DKK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway NAS 10570958
GO:0061170 negative regulation of hair follicle placode formation IEA --
GO:0090090 negative regulation of canonical Wnt signaling pathway NAS 24431302
genes like me logo Genes that share ontologies with DKK4: view

No data available for SIGNOR curated interactions for DKK4 Gene

Drugs & Compounds for DKK4 Gene

(1) Drugs for DKK4 Gene - From:

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
KY 02111 Pharma WNT signaling inhibitor 0
genes like me logo Genes that share compounds with DKK4: view

Transcripts for DKK4 Gene

mRNA/cDNA for DKK4 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DKK4 Gene

Dickkopf homolog 4 (Xenopus laevis):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DKK4 Gene

No ASD Table

Relevant External Links for DKK4 Gene

GeneLoc Exon Structure for
DKK4
ECgene alternative splicing isoforms for
DKK4

Expression for DKK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DKK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DKK4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.8), Esophagus - Mucosa (x5.9), Brain - Cerebellum (x5.6), and Vagina (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of DKK4 Gene:

DKK4

SOURCE GeneReport for Unigene cluster for DKK4 Gene:

Hs.159311

mRNA Expression by UniProt/SwissProt for DKK4 Gene:

Q9UBT3-DKK4_HUMAN
Tissue specificity: Expressed in cerebellum, T-cells, esophagus and lung.
genes like me logo Genes that share expression patterns with DKK4: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DKK4 Gene

Orthologs for DKK4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DKK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DKK4 34 33
  • 99.55 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DKK4 34 33
  • 84.25 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dkk4 16 34 33
  • 75.72 (n)
rat
(Rattus norvegicus)
Mammalia Dkk4 33
  • 75.11 (n)
oppossum
(Monodelphis domestica)
Mammalia DKK4 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
cow
(Bos Taurus)
Mammalia DKK4 34
  • 55 (a)
OneToOne
Species where no ortholog for DKK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DKK4 Gene

ENSEMBL:
Gene Tree for DKK4 (if available)
TreeFam:
Gene Tree for DKK4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DKK4: view image

Paralogs for DKK4 Gene

Paralogs for DKK4 Gene

(2) SIMAP similar genes for DKK4 Gene using alignment to 1 proteins:

  • DKK4_HUMAN
genes like me logo Genes that share paralogs with DKK4: view

Variants for DKK4 Gene

Sequence variations from dbSNP and Humsavar for DKK4 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000007418 -- 42,381,332(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000159463 -- 42,374,564(-) G/A intron_variant
rs1000166049 -- 42,387,110(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000306647 -- 42,393,060(-) C/G upstream_transcript_variant
rs1000310780 -- 42,381,023(-) T/A/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DKK4 Gene

Variant ID Type Subtype PubMed ID
nsv831301 CNV loss 17160897

Variation tolerance for DKK4 Gene

Residual Variation Intolerance Score: 39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DKK4 Gene

Human Gene Mutation Database (HGMD)
DKK4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DKK4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DKK4 Gene

Disorders for DKK4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DKK4 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
cleft soft palate
  • cleft velum
- elite association - COSMIC cancer census association via MalaCards
Search DKK4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DKK4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DKK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DKK4 Gene

Publications for DKK4 Gene

  1. Functional and structural diversity of the human Dickkopf gene family. (PMID: 10570958) Krupnik VE … McCarthy SA (Gene 1999) 2 3 4 22 58
  2. Wnt antagonist gene polymorphisms and renal cancer. (PMID: 19562778) Hirata H … Dahiya R (Cancer 2009) 3 22 44 58
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 44 58
  4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 44 58
  5. DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3. (PMID: 18408752) Pendás-Franco N … González-Sancho JM (Oncogene 2008) 3 22 58

Products for DKK4 Gene

Sources for DKK4 Gene

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