Aliases for DKK4 Gene
External Ids for DKK4 Gene
Previous GeneCards Identifiers for DKK4 Gene
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]
GeneCards Summary for DKK4 Gene
DKK4 (Dickkopf WNT Signaling Pathway Inhibitor 4) is a Protein Coding gene. Diseases associated with DKK4 include Cleft Soft Palate. Among its related pathways are Negative regulation of TCF-dependent signaling by WNT ligand antagonists and CDK-mediated phosphorylation and removal of Cdc6. An important paralog of this gene is DKK2.
UniProtKB/Swiss-Prot for DKK4 Gene
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).