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This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formatio... See more...
Aliases for DKK1 Gene
Aliases for DKK1 Gene
External Ids for DKK1 Gene
- HGNC: 2891
- Entrez Gene: 22943
- Ensembl: ENSG00000107984
- OMIM: 605189
- UniProtKB: O94907
Previous GeneCards Identifiers for DKK1 Gene
- GC10P052921
- GC10P053966
- GC10P053418
- GC10P053744
- GC10P054074
- GC10P048051
Summaries for DKK1 Gene
-
This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]
GeneCards Summary for DKK1 Gene
DKK1 (Dickkopf WNT Signaling Pathway Inhibitor 1) is a Protein Coding gene. Diseases associated with DKK1 include Chiari Malformation Type I and Osteoporosis, Juvenile. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and low-density lipoprotein particle receptor binding.
UniProtKB/Swiss-Prot Summary for DKK1 Gene
-
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
Additional gene information for DKK1 Gene
- HGNC(2891)
- Entrez Gene(22943)
- Ensembl(ENSG00000107984)
- OMIM(605189)
- UniProtKB(O94907)
- Open Targets Platform(ENSG00000107984)
- Monarch Initiative
- Search for DKK1 at DataMed
- Search for DKK1 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DKK1 Gene
Genomics for DKK1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DKK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DKK1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DKK1
- Top Transcription factor binding sites by QIAGEN in the DKK1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- GATA-6
- NCX
- Nkx2-5
Genomic Locations for DKK1 Gene
Genomic Locations for DKK1 Gene
- chr10:52,314,281-52,318,042
- (GRCh38/hg38)
- Size:
- 3,762 bases
- Orientation:
- Plus strand
- chr10:54,074,041-54,077,802
- (GRCh37/hg19)
- Size:
- 3,762 bases
- Orientation:
- Plus strand
Genomic View for DKK1 Gene
Genes around DKK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q21.1 by HGNC
- 10q21.1 by Entrez Gene
- 10q21.1 by Ensembl
DKK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DKK1 Gene
Proteins for DKK1 Gene
-
Protein details for DKK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O94907-DKK1_HUMAN
- Recommended name:
- Dickkopf-related protein 1
- Protein Accession:
- O94907
- B2RC19
Protein attributes for DKK1 Gene
- Size:
- 266 amino acids
- Molecular mass:
- 28672 Da
- Quaternary structure:
-
- Interacts with LRP6 (PubMed:11448771, PubMed:17804805, PubMed:20093360, PubMed:22000856). Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling (PubMed:19746449). Forms a ternary complex with LRP6 and KREM1 (PubMed:27524201). Interacts with KREM1 (PubMed:17804805).
Post-translational modifications for DKK1 Gene
Other Protein References for DKK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DKK1
- Novus Biologicals Antibodies for DKK1
-
Abcam antibodies for DKK1
- Invitrogen Antibodies for DKK1 (AFLGC-DKK1)
- antibodies-online: Show 75 available DKK1 Antibodies ranked by validation data
- Compare Top DKK1 Antibodies
-
Recommended
- 175 WB Antibodies (anti-human)
- 23 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 IHC Antibodies (anti-human)
- 1 Neut Antibody (anti-human)
- 44 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 50 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for DKK1
- Sino Biological Antibodies for DKK1
Protein Products
- G Biosciences Human Dickkopf-related protein 1/DKK1, Lyophilized
- RayBiotech Recombinant Human DKK1
- Search Origene for MassSpec and Protein Over-expression Lysates for DKK1
- Origene Custom Protein Services for DKK1
- Novus Biologicals lysates for DKK1
- Sino Biological Recombinant Proteins for DKK1
- Sino Biological Cell Lysates for DKK1
- ProSpec Recombinant Proteins for DKK1
-
ProSci Proteins for DKK1
- dickkopf-related protein 1 precursor [96-861]
- dickkopf WNT signaling pathway inhibitor 1 [96-236]
- dickkopf WNT signaling pathway inhibitor 1 [96-237]
- Dickkopf-related protein 1 [96-990]
- dickkopf WNT signaling pathway inhibitor 1 [91-573]
- dickkopf WNT signaling pathway inhibitor 1 [91-615]
- dickkopf WNT signaling pathway inhibitor 1 [40-225]
-
Abcam proteins for DKK1
Assay Products
- RayBiotech Human Dkk-1 ELISA
- Novus Biologicals ELISA Kits for DKK1
- antibodies-online: Show 89 available DKK1 Elisa Kits ranked by validation data
- Compare Top DKK1 Elisa Kits
-
Quality Products:
- ABIN1114624
- ABIN624961
- ABIN365085
- ABIN414760
- ABIN1672821
- ABIN3032911
- ABIN1380028
- ABIN3198421
- ABIN5521800
- ABIN5521799
- ABIN1114626
- ABIN1672840
- ABIN858696
- ABIN424472
- ABIN625383
- ABIN4993048
- ABIN1569417
- ABIN3198422
- ABIN5521801
- ABIN2708497
- ABIN1114625
- ABIN431798
- ABIN1569418
- ABIN3044704
- ABIN5521802
- ABIN626936
- ABIN2748048
- ABIN5653663
- ABIN6385033
- ABIN6719679
- ABIN856927
- ABIN774717
- ABIN1561503
- ABIN6208660
-
Abcam assays for DKK1
- Sino Biological Assays for DKK1
No data available for DME Specific Peptides for DKK1 Gene
Domains & Families for DKK1 Gene
Gene Families for DKK1 Gene
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for DKK1 Gene
- InterPro:
- Blocks:
-
- Dickkopf, N-terminal cysteine-rich
- ProtoNet:
Suggested Antigen Peptide Sequences for DKK1 Gene
- GenScript: Design optimal peptide antigens:
-
- SK (DKK1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O94907UniProtKB/Swiss-Prot:
DKK1_HUMAN :- The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
- Belongs to the dickkopf family.
- Domain:
-
- The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
- Family:
-
- Belongs to the dickkopf family.
Function for DKK1 Gene
Molecular function for DKK1 Gene
- UniProtKB/Swiss-Prot Function:
- Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
LifeMap Function Summary for DKK1 Gene
During embryonic development, DKK1 as signaling molecule is secreted from the following cells
- Primitive Streak
It affects the following cells:
- Heart
- Neural Ectoderm
- Lateral Plate Mesoderm
DKK1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Heart
- Neural Tube
- Brain
- Eye
-
and also in
Phenotypes From GWAS Catalog for DKK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11448771 |
| GO:0008083 | growth factor activity | TAS | 10383463 |
| GO:0039706 | co-receptor binding | IBA,TAS | 22988876 |
| GO:0048019 | receptor antagonist activity | IBA,IDA | 20723538 |
| GO:0050750 | low-density lipoprotein particle receptor binding | IDA | 16263759 |
Phenotypes for DKK1 Gene
- MGI mutant phenotypes for DKK1:
-
inferred from 4 alleles
- nervous system phenotype
- respiratory system phenotype
- cellular phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- renal/urinary system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- embryo phenotype
- craniofacial phenotype
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for DKK1:
Animal Models for DKK1 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for DKK1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DKK1 - Select products 50% OFF >
- * DKK1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DKK1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DKK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for DKK1
miRNA for DKK1 Gene
- miRTarBase miRNAs that target DKK1
-
- hsa-miR-29a-3p (MIRT003609)
- hsa-miR-31-5p (MIRT005874)
- hsa-miR-1-3p (MIRT023613)
- hsa-miR-371a-3p (MIRT052959)
- hsa-miR-372-3p (MIRT053299)
- hsa-miR-373-3p (MIRT053300)
- mmu-miR-882 (MIRT593293)
- mmu-miR-185-5p (MIRT593294)
- mmu-miR-3473a (MIRT593295)
- mmu-miR-741-3p (MIRT599155)
- hsa-miR-493-3p (MIRT732132)
- hsa-miR-501-5p (MIRT733570)
- hsa-miR-335-5p (MIRT733738)
- hsa-miR-152-3p (MIRT734824)
- hsa-miR-9-5p (MIRT735023)
- hsa-miR-29a-5p (MIRT735175)
- hsa-let-7c-3p (MIRT735615)
- hsa-miR-3177-5p (MIRT740707)
- hsa-miR-4704-3p (MIRT747313)
- hsa-miR-511-3p (MIRT749739)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DKK1
- Browse OriGene Inhibitory RNA Products For DKK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DKK1
Clone Products
- Applied Biological Materials (abm): Clones for DKK1 - Select products 50% OFF >
- * DKK1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DKK1
- Addgene plasmids for DKK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DKK1
Cell Line Products
-
Horizon Cell Lines for DKK1
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DKK1 Gene
Localization for DKK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DKK1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endosome | 4 |
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA,IDA | 11448771 |
| GO:0005886 | plasma membrane | IDA | 16263759 |
| GO:0031901 | early endosome membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for DKK1 Gene
Pathways & Interactions for DKK1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.45
|
|
| 2 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists | ||
| 3 | Signaling by Wnt |
.71
|
|
| 4 | Mesodermal Commitment Pathway | ||
| 5 | Wnt / Hedgehog / Notch | ||
Pathways by source for DKK1 Gene
1 Sino Biological pathway for DKK1 Gene
12 BioSystems pathways for DKK1 Gene
8 Reactome pathways for DKK1 Gene
2 KEGG pathways for DKK1 Gene
1 R&D Systems pathway for DKK1 Gene
3 Qiagen pathways for DKK1 Gene
- Factors Promoting Cardiogenesis in Vertebrates
- Reelin Pathway (Cajal-Retzius cells)
- WNT Signaling
1 Cell Signaling Technology pathway for DKK1 Gene
1 GeneTex pathway for DKK1 Gene
Interacting Proteins for DKK1 Gene
Selected Interacting proteins:
O94907-DKK1_HUMAN
ENSP00000363081
for DKK1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for DKK1
SIGNOR curated interactions for DKK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISS | -- |
| GO:0000904 | cell morphogenesis involved in differentiation | IEA | -- |
| GO:0001706 | endoderm formation | IEA | -- |
| GO:0001707 | mesoderm formation | IEA | -- |
| GO:0001942 | hair follicle development | IEA | -- |
Drugs & Compounds for DKK1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Altretamine | Approved | Pharma | 88 | |||
| Capecitabine | Approved, Investigational | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines | 1669 | ||
| Oxaliplatin | Approved, Investigational | Pharma | Antitumor agent, Platinum | 1944 | ||
| Paclitaxel | Approved, Vet_approved | Pharma | Tubulin and Bcl2 inhibitor, Taxanes | 3701 | ||
| Albumin-Bound Paclitaxel | Pharma | 3701 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- G Biosciences Human Dickkopf-related protein 1/DKK1, Lyophilized
- RayBiotech Recombinant Human DKK1
Transcripts for DKK1 Gene
mRNA/cDNA for DKK1 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000373970 1805 nts (view in UCSC)
- ENST00000467359 547 nts (view in UCSC)
- ENST00000494277 465 nts (view in UCSC)
- ENST00000476752 544 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DKK1 - Select products 50% OFF >
- * DKK1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DKK1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DKK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for DKK1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DKK1
- Browse OriGene Inhibitory RNA Products For DKK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DKK1
Clone Products
- Applied Biological Materials (abm): Clones for DKK1 - Select products 50% OFF >
- * DKK1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DKK1
- Addgene plasmids for DKK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DKK1
Relevant External Links for DKK1 Gene
- GeneLoc Exon Structure for
- DKK1
Expression for DKK1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- S-shaped Body Medial Cells S-shaped Body Medial Segment
- Distal Renal Vesicle Cells Renal Vesicle
- Eye (Sensory Organs)
- Hypoblast (Extraembryonic Tissues)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DKK1
SOURCE GeneReport for Unigene cluster for DKK1 Gene:
Hs.40499mRNA Expression by UniProt/SwissProt for DKK1 Gene:
O94907-DKK1_HUMAN
Tissue specificity:
Placenta.
Evidence on tissue expression from TISSUES for DKK1 Gene
- Nervous system(4.6)
- Intestine(3.2)
- Bone(3.1)
- Lung(3)
- Skin(2.9)
- Liver(2.8)
- Bone marrow(2.8)
- Kidney(2.7)
- Blood(2.6)
- Muscle(2.5)
- Heart(2.5)
- Spleen(2.5)
- Pancreas(2.1)
- Lymph node(2.1)
- Eye(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for DKK1 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- skeleton
Regions:
Head and neck:
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- skull
Thorax:
- chest wall
- clavicle
- rib
- rib cage
- scapula
- sternum
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- spinal column
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for DKK1
-
OriGene qPCR primer pairs and template standards for DKK1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DKK1 Gene
Orthologs for DKK1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DKK1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DKK1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DKK1 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dkk1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Dkk1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | DKK1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | DKK1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | DKK-1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | DKK1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dkk1 30 |
|
||
| Str.15023 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | dkk1-A 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | dkk1b 30 31 |
|
OneToMany | |
| dkk1a 31 |
|
OneToMany | |||
| dkk1 30 |
|
- Species where no ortholog for DKK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for DKK1 Gene
- ENSEMBL:
- Gene Tree for DKK1 (if available)
- TreeFam:
- Gene Tree for DKK1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DKK1: view image
Paralogs for DKK1 Gene
(2) SIMAP similar genes for DKK1 Gene using alignment to 2 proteins:
- DKK1_HUMAN
- I1W660_HUMAN
No data available for Paralogs for DKK1 Gene
Variants for DKK1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DKK1 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 709695 | Benign: not provided | 52,314,917(+) | C/T | INTRON_VARIANT | |
| 721589 | Likely Benign: not provided | 52,316,693(+) | T/C | SYNONYMOUS_VARIANT | |
| 738698 | Likely Benign: not provided | 52,316,678(+) | G/A | SYNONYMOUS_VARIANT | |
| 756718 | Likely Benign: not provided | 52,314,545(+) | C/T | SYNONYMOUS_VARIANT | |
| 773234 | Benign: not provided | 52,316,550(+) | G/A | INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1045692 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.15;
23.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DKK1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DKK1 Gene
Disorders for DKK1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chiari malformation type i |
|
|
| osteoporosis, juvenile |
|
|
| bone disease |
|
|
| glucocorticoid-induced osteoporosis |
|
|
| placental choriocarcinoma |
|
|
Search DKK1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DKK1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for DKK1 Gene
Publications for DKK1 Gene
- Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. (PMID: 20093360) Bourhis E … Hannoush RN (The Journal of biological chemistry 2010) 3 4 23
- A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V). (PMID: 19746449) Murrills RJ … Bodine PV (Journal of cellular biochemistry 2009) 3 4 23
- Analysis of association of LRP5, LRP6, SOST, DKK1, and CTNNB1 genes with bone mineral density in a Slovenian population. (PMID: 19898734) Mencej-Bedrac S … Marc J (Calcified tissue international 2009) 3 23 41
- Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. (PMID: 11448771) Semënov MV … He X (Current biology : CB 2001) 3 4 23
- Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. (PMID: 10383463) Fedi P … Aaronson SA (The Journal of biological chemistry 1999) 3 4 23
ExternalLinks
Products for DKK1 Gene
- View all 21 R&D Systems DKK1 (Dkk-1) Products
- View all 5 R&D Systems DKK1 (Dkk-1) Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for DKK1
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- antibodies-online: Show 75 available DKK1 Antibodies ranked by validation data
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- 175 WB Antibodies (anti-human)
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- antibodies-online: Show 89 available DKK1 Elisa Kits ranked by validation data
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- ABIN1114624
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- antibodies-online: Show 52 available DKK1 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for DKK1
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- ProSci Proteins for DKK1
- dickkopf-related protein 1 precursor [96-861]
- dickkopf WNT signaling pathway inhibitor 1 [96-236]
- dickkopf WNT signaling pathway inhibitor 1 [96-237]
- Dickkopf-related protein 1 [96-990]
- dickkopf WNT signaling pathway inhibitor 1 [91-573]
- dickkopf WNT signaling pathway inhibitor 1 [91-615]
- dickkopf WNT signaling pathway inhibitor 1 [40-225]
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Sources for DKK1 Gene
- (1) GeneCards
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