Aliases for DIXDC1 Gene
External Ids for DIXDC1 Gene
Previous GeneCards Identifiers for DIXDC1 Gene
The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
GeneCards Summary for DIXDC1 Gene
DIXDC1 (DIX Domain Containing 1) is a Protein Coding gene. Diseases associated with DIXDC1 include Obesity Due To Melanocortin 4 Receptor Deficiency and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Cytoskeletal Signaling and Adhesion. Gene Ontology (GO) annotations related to this gene include actin binding and mitogen-activated protein kinase kinase kinase binding. An important paralog of this gene is DVL2.
UniProtKB/Swiss-Prot Summary for DIXDC1 Gene
Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.