This gene is one of two human homologs of a segment-polarity gene known as dispatched identified in Drosophila. The product of this gene may be required for normal Hedgehog (Hh) signaling during embryonic pattern formation. [provided by RefSeq, Jan 2017] See more...

Aliases for DISP2 Gene

Aliases for DISP2 Gene

  • Dispatched RND Transporter Family Member 2 2 3 5
  • Long Intergenic Non-Protein Coding RNA 594 2 3
  • Protein Dispatched Homolog 2 3 4
  • LINC00594 3 4
  • C15orf36 3 4
  • DISPB 3 4
  • Chromosome 15 Open Reading Frame 36 2
  • Dispatched Homolog 2 (Drosophila) 2
  • Dispatched B 3
  • HsT16908 3
  • KIAA1742 4

External Ids for DISP2 Gene

Previous HGNC Symbols for DISP2 Gene

  • LINC00594
  • C15orf36

Previous GeneCards Identifiers for DISP2 Gene

  • GC15P038366
  • GC15P038437
  • GC15P040650
  • GC15P017493

Summaries for DISP2 Gene

Entrez Gene Summary for DISP2 Gene

  • This gene is one of two human homologs of a segment-polarity gene known as dispatched identified in Drosophila. The product of this gene may be required for normal Hedgehog (Hh) signaling during embryonic pattern formation. [provided by RefSeq, Jan 2017]

GeneCards Summary for DISP2 Gene

DISP2 (Dispatched RND Transporter Family Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and CDK-mediated phosphorylation and removal of Cdc6. An important paralog of this gene is DISP1.

Additional gene information for DISP2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DISP2 Gene

Genomics for DISP2 Gene

GeneHancer (GH) Regulatory Elements for DISP2 Gene

Promoters and enhancers for DISP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DISP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DISP2

Top Transcription factor binding sites by QIAGEN in the DISP2 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • NF-kappaB
  • NF-kappaB1
  • Nkx2-5
  • RelA

Genomic Locations for DISP2 Gene

Genomic Locations for DISP2 Gene
chr15:40,354,359-40,378,621
(GRCh38/hg38)
Size:
24,263 bases
Orientation:
Plus strand
chr15:40,650,434-40,663,257
(GRCh37/hg19)
Size:
12,824 bases
Orientation:
Plus strand

Genomic View for DISP2 Gene

Genes around DISP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DISP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DISP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DISP2 Gene

Proteins for DISP2 Gene

  • Protein details for DISP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A7MBM2-DISP2_HUMAN
    Recommended name:
    Protein dispatched homolog 2
    Protein Accession:
    A7MBM2
    Secondary Accessions:
    • Q6AHW3
    • Q9C0C1

    Protein attributes for DISP2 Gene

    Size:
    1401 amino acids
    Molecular mass:
    152003 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21833.2; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

neXtProt entry for DISP2 Gene

Post-translational modifications for DISP2 Gene

  • Glycosylation at Asn239, Asn349, and Asn465
  • Modification sites at PhosphoSitePlus

Other Protein References for DISP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DISP2 Gene

Domains & Families for DISP2 Gene

Gene Families for DISP2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for DISP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DISP2 Gene

GenScript: Design optimal peptide antigens:
  • Protein dispatched homolog 2 (DISP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A7MBM2

UniProtKB/Swiss-Prot:

DISP2_HUMAN :
  • Belongs to the dispatched family.
Family:
  • Belongs to the dispatched family.
genes like me logo Genes that share domains with DISP2: view

Function for DISP2 Gene

Phenotypes From GWAS Catalog for DISP2 Gene

Gene Ontology (GO) - Molecular Function for DISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DISP2: view
genes like me logo Genes that share phenotypes with DISP2: view

Animal Model Products

miRNA for DISP2 Gene

miRTarBase miRNAs that target DISP2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DISP2 Gene

Localization for DISP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DISP2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DISP2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DISP2: view

Pathways & Interactions for DISP2 Gene

genes like me logo Genes that share pathways with DISP2: view

Pathways by source for DISP2 Gene

Interacting Proteins for DISP2 Gene

;

Gene Ontology (GO) - Biological Process for DISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007224 smoothened signaling pathway NAS 16258256
genes like me logo Genes that share ontologies with DISP2: view

No data available for SIGNOR curated interactions for DISP2 Gene

Drugs & Compounds for DISP2 Gene

No Compound Related Data Available

Transcripts for DISP2 Gene

mRNA/cDNA for DISP2 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DISP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: -
SP2:
SP3:

Relevant External Links for DISP2 Gene

GeneLoc Exon Structure for
DISP2

Expression for DISP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DISP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DISP2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.6) and Brain - Cerebellum (x9.6).

Protein differential expression in normal tissues from HIPED for DISP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (43.9) and Frontal cortex (20.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DISP2 Gene



Protein tissue co-expression partners for DISP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DISP2

SOURCE GeneReport for Unigene cluster for DISP2 Gene:

Hs.355645

Evidence on tissue expression from TISSUES for DISP2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with DISP2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DISP2 Gene

Orthologs for DISP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DISP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DISP2 31 30
  • 99.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DISP2 31 30
  • 89.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DISP2 31 30
  • 88.74 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Disp2 30
  • 79.6 (n)
mouse
(Mus musculus)
Mammalia Disp2 17 31 30
  • 79.4 (n)
oppossum
(Monodelphis domestica)
Mammalia DISP2 31
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 15 (a)
ManyToMany
chicken
(Gallus gallus)
Aves DISP2 31 30
  • 61.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DISP2 31
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia disp2 30
  • 58.42 (n)
zebrafish
(Danio rerio)
Actinopterygii disp2 31 30
  • 53.93 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta disp 31
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea che-14 31
  • 20 (a)
ManyToMany
ptd-2 31
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
OneToMany
Species where no ortholog for DISP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DISP2 Gene

ENSEMBL:
Gene Tree for DISP2 (if available)
TreeFam:
Gene Tree for DISP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DISP2: view image

Paralogs for DISP2 Gene

Paralogs for DISP2 Gene

(1) SIMAP similar genes for DISP2 Gene using alignment to 2 proteins:

  • DISP2_HUMAN
  • H0YNF0_HUMAN
genes like me logo Genes that share paralogs with DISP2: view

Variants for DISP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DISP2 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
720007 Benign: not provided 40,364,523(+) C/T SYNONYMOUS_VARIANT
rs1898882 - p.Cys56Ser
rs1898883 - p.Pro47Ala
rs2412512 - p.Gly1145Ser
rs35043215 - p.Gly388Glu

Additional dbSNP identifiers (rs#s) for DISP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for DISP2 Gene

Variant ID Type Subtype PubMed ID
esv34145 CNV loss 18971310
nsv1160287 CNV duplication 26073780
nsv472977 CNV novel sequence insertion 20440878
nsv510660 CNV deletion 20534489
nsv820173 CNV gain 19587683

Variation tolerance for DISP2 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.22; 76.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DISP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DISP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DISP2 Gene

Disorders for DISP2 Gene

Additional Disease Information for DISP2

No disorders were found for DISP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DISP2 Gene

Publications for DISP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 54
  2. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. (PMID: 10619433) Burke R … Basler K (Cell 1999) 2 3 54
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  4. Pancreatic islet and progenitor cell surface markers with cell sorting potential. (PMID: 21947380) Hald J … Madsen OD (Diabetologia 2012) 3 54
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 54

Products for DISP2 Gene

Sources for DISP2 Gene