Aliases for DISP1 Gene
External Ids for DISP1 Gene
Previous GeneCards Identifiers for DISP1 Gene
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
GeneCards Summary for DISP1 Gene
DISP1 (Dispatched RND Transporter Family Member 1) is a Protein Coding gene. Diseases associated with DISP1 include Lobar Holoprosencephaly and Microform Holoprosencephaly. Gene Ontology (GO) annotations related to this gene include hedgehog receptor activity. An important paralog of this gene is DISP2.
UniProtKB/Swiss-Prot Summary for DISP1 Gene
Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404).