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Aliases for DISC1 Gene

Aliases for DISC1 Gene

  • DISC1 Scaffold Protein 2 3
  • Disrupted In Schizophrenia 1 2 5
  • Disrupted In Schizophrenia 1 Protein 3
  • C1orf136 3
  • KIAA0457 4
  • SCZD9 3

External Ids for DISC1 Gene

Previous GeneCards Identifiers for DISC1 Gene

  • GC01P230208
  • GC01P227502
  • GC01P228235
  • GC01P228797
  • GC01P228069
  • GC01P229829
  • GC01P231762
  • GC01P202246

Summaries for DISC1 Gene

Entrez Gene Summary for DISC1 Gene

  • This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for DISC1 Gene

DISC1 (DISC1 Scaffold Protein) is a Protein Coding gene. Diseases associated with DISC1 include Schizophrenia 9 and Schizophrenia.

UniProtKB/Swiss-Prot for DISC1 Gene

  • Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.

Gene Wiki entry for DISC1 Gene

Additional gene information for DISC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DISC1 Gene

Genomics for DISC1 Gene

GeneHancer (GH) Regulatory Elements for DISC1 Gene

Promoters and enhancers for DISC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J231625 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 669 +0.8 762 3.3 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 IRF4 ZNF548 FOS SP3 SP5 DISC1 C1orf131 SPRTN ARV1 COG2 RNU5A-5P TSNAX-DISC1
GH01J231693 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 657 +67.4 67445 2.3 NR2F2 DISC1 GC01P231693 RNU5A-5P LINC00582 ENSG00000274121 TSNAX-DISC1
GH01J231774 Promoter 0.7 EPDnew 650.1 +147.9 147899 0.1 SCRT2 MAFK DISC1 ENSG00000274121 GC01P231693 TSNAX-DISC1
GH01J231724 Enhancer 1.2 FANTOM5 Ensembl ENCODE 19.2 +98.4 98385 0.8 PKNOX1 ATF1 RB1 SIN3A BMI1 ZBTB40 RAD21 ZNF614 ELK1 ZNF143 DISC1 TSNAX GC01P231693 ENSG00000274121 TSNAX-DISC1
GH01J231333 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 -289.4 -289366 7.3 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SPRTN PIR33664 EXOC8 SNRPD2P2 RN7SL837P RPS24P4 LINC01737 C1orf131 LINC00582 EGLN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DISC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DISC1 gene promoter:
  • STAT3
  • CREB

Genomic Locations for DISC1 Gene

Genomic Locations for DISC1 Gene
chr1:231,626,815-232,041,272
(GRCh38/hg38)
Size:
414,458 bases
Orientation:
Plus strand
chr1:231,762,561-232,177,018
(GRCh37/hg19)
Size:
414,458 bases
Orientation:
Plus strand

Genomic View for DISC1 Gene

Genes around DISC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DISC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DISC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DISC1 Gene

Proteins for DISC1 Gene

  • Protein details for DISC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRI5-DISC1_HUMAN
    Recommended name:
    Disrupted in schizophrenia 1 protein
    Protein Accession:
    Q9NRI5
    Secondary Accessions:
    • A6NLH2
    • C4P091
    • C4P095
    • C4P0A1
    • C4P0A3
    • C4P0B3
    • C4P0B6
    • C4P0C1
    • C9J6D0
    • O75045
    • Q5VT44
    • Q5VT45
    • Q8IXJ0
    • Q8IXJ1
    • Q9BX19
    • Q9NRI3
    • Q9NRI4

    Protein attributes for DISC1 Gene

    Size:
    854 amino acids
    Molecular mass:
    93611 Da
    Quaternary structure:
    • Interacts with NDEL1 (PubMed:12506198). Interacts with CCDC88A (via C-terminus); the interaction is direct. Interacts with GSK3B (By similarity). Interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and TRAF3IP1 (PubMed:12812986). Interaction with microtubules may be mediated in part by TRAF3IP1. Interacts (via C-terminal) with PCNT (PubMed:18955030). Interacts with CHCHD6 (PubMed:22228767). Interacts with CCDC141 (By similarity). Interacts with ZNF365 (PubMed:17389905).
    SequenceCaution:
    • Sequence=BAA32302.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DISC1 Gene

    Alternative splice isoforms for DISC1 Gene

neXtProt entry for DISC1 Gene

Post-translational modifications for DISC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DISC1 Gene

Domains & Families for DISC1 Gene

Gene Families for DISC1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DISC1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DISC1: view

No data available for UniProtKB/Swiss-Prot for DISC1 Gene

Function for DISC1 Gene

Molecular function for DISC1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.

Phenotypes From GWAS Catalog for DISC1 Gene

Gene Ontology (GO) - Molecular Function for DISC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12812986
genes like me logo Genes that share ontologies with DISC1: view
genes like me logo Genes that share phenotypes with DISC1: view

Animal Models for DISC1 Gene

MGI Knock Outs for DISC1:
  • Disc1 Disc1<tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho>
  • Disc1 Disc1<tm1Kara>

Animal Model Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DISC1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DISC1 Gene

Localization for DISC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DISC1 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DISC1 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
plasma membrane 3
nucleus 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DISC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA 20880836
GO:0005813 centrosome IDA 18762586
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with DISC1: view

Pathways & Interactions for DISC1 Gene

SuperPathways for DISC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DISC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IMP 18955030
GO:0001764 neuron migration IMP 19502360
GO:0002052 positive regulation of neuroblast proliferation IGI 19303846
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with DISC1: view

No data available for Pathways by source and SIGNOR curated interactions for DISC1 Gene

Drugs & Compounds for DISC1 Gene

(2) Drugs for DISC1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DISC1: view

Transcripts for DISC1 Gene

Unigene Clusters for DISC1 Gene

Disrupted in schizophrenia 1:
Representative Sequences:

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DISC1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DISC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: -
SP5: - - - -
SP6: -

Relevant External Links for DISC1 Gene

GeneLoc Exon Structure for
DISC1
ECgene alternative splicing isoforms for
DISC1

Expression for DISC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DISC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DISC1 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for DISC1 Gene

This gene is overexpressed in Plasma (58.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DISC1 Gene



Protein tissue co-expression partners for DISC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DISC1 Gene:

DISC1

SOURCE GeneReport for Unigene cluster for DISC1 Gene:

Hs.13318

mRNA Expression by UniProt/SwissProt for DISC1 Gene:

Q9NRI5-DISC1_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter.

Evidence on tissue expression from TISSUES for DISC1 Gene

  • Nervous system(4.9)
  • Heart(4.1)
genes like me logo Genes that share expression patterns with DISC1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DISC1 Gene

Orthologs for DISC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DISC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DISC1 34 33
  • 98.43 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DISC1 33
  • 83.1 (n)
dog
(Canis familiaris)
Mammalia DISC1 34 33
  • 81.04 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Disc1 16 34 33
  • 70.53 (n)
rat
(Rattus norvegicus)
Mammalia Disc1 33
  • 69.83 (n)
oppossum
(Monodelphis domestica)
Mammalia DISC1 34
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves DISC1 34 33
  • 59.18 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DISC1 34
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii disc1 34
  • 17 (a)
OneToOne
Species where no ortholog for DISC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DISC1 Gene

ENSEMBL:
Gene Tree for DISC1 (if available)
TreeFam:
Gene Tree for DISC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DISC1: view image

Paralogs for DISC1 Gene

(6) SIMAP similar genes for DISC1 Gene using alignment to 27 proteins:

  • DISC1_HUMAN
  • A7E2W8_HUMAN
  • B1AM64_HUMAN
  • C4P092_HUMAN
  • C4P093_HUMAN
  • C4P094_HUMAN
  • C4P096_HUMAN
  • C4P098_HUMAN
  • C4P0A0_HUMAN
  • C4P0A4_HUMAN
  • C4P0A5_HUMAN
  • C4P0A9_HUMAN
  • C4P0B0_HUMAN
  • C4P0B1_HUMAN
  • C4P0B2_HUMAN
  • C4P0C4_HUMAN
  • C4P0C7_HUMAN
  • C4P0C8_HUMAN
  • C4P0D0_HUMAN
  • C4P0D1_HUMAN
  • C4P0D2_HUMAN
  • C4P0D3_HUMAN
  • C4P0D4_HUMAN
  • C4P0D6_HUMAN
  • C4P0D8_HUMAN
  • H0Y7U2_HUMAN
  • Q5T409_HUMAN
genes like me logo Genes that share paralogs with DISC1: view

No data available for Paralogs for DISC1 Gene

Variants for DISC1 Gene

Sequence variations from dbSNP and Humsavar for DISC1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs367543082 not-provided, not provided 231,626,921(+) G/A coding_sequence_variant, synonymous_variant
rs367543083 not-provided, not provided 231,694,098(+) A/T coding_sequence_variant, intron_variant, missense_variant
rs367543084 not-provided, not provided 231,694,230(+) G/A coding_sequence_variant, intron_variant, missense_variant
rs367543085 not-provided, not provided 231,694,526(+) C/T coding_sequence_variant, intron_variant, synonymous_variant
rs367543086 not-provided, not provided 231,694,599(+) G/A coding_sequence_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for DISC1 Gene

Variant ID Type Subtype PubMed ID
dgv153e212 CNV gain 25503493
dgv293n106 CNV deletion 24896259
dgv582n100 CNV gain 25217958
dgv849n54 CNV gain 21841781
esv1761772 CNV insertion 17803354
esv2657352 CNV deletion 23128226
esv2661657 CNV deletion 23128226
esv2668388 CNV deletion 23128226
esv2672018 CNV deletion 23128226
esv2724883 CNV deletion 23290073
esv2724894 CNV deletion 23290073
esv2724905 CNV deletion 23290073
esv2724917 CNV deletion 23290073
esv2759004 CNV gain 17122850
esv2762173 CNV loss 21179565
esv2763669 CNV gain 21179565
esv3308383 CNV mobile element insertion 20981092
esv3409551 CNV duplication 20981092
esv3429698 CNV duplication 20981092
esv3434648 CNV insertion 20981092
esv3446715 CNV insertion 20981092
esv3449086 CNV insertion 20981092
esv3575783 CNV gain 25503493
esv3589116 CNV gain 21293372
esv3589119 CNV loss 21293372
esv3589120 CNV loss 21293372
esv3589121 CNV loss 21293372
esv3589124 CNV loss 21293372
esv994187 CNV insertion 20482838
nsv1003284 CNV loss 25217958
nsv1011509 CNV gain 25217958
nsv1013883 CNV gain 25217958
nsv1113226 CNV deletion 24896259
nsv1113227 CNV deletion 24896259
nsv1115033 CNV deletion 24896259
nsv1119761 CNV deletion 24896259
nsv468338 CNV gain 19166990
nsv468382 CNV loss 19166990
nsv476204 CNV novel sequence insertion 20440878
nsv477268 CNV novel sequence insertion 20440878
nsv4832 CNV insertion 18451855
nsv4843 CNV insertion 18451855
nsv4855 CNV insertion 18451855
nsv509646 CNV insertion 20534489
nsv516935 CNV gain 19592680
nsv528452 CNV loss 19592680
nsv549338 CNV loss 21841781
nsv827230 CNV gain 20364138
nsv8902 CNV gain 18304495
nsv952147 CNV duplication 24416366
nsv999063 CNV gain 25217958

Variation tolerance for DISC1 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.83; 91.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DISC1 Gene

Human Gene Mutation Database (HGMD)
DISC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DISC1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DISC1 Gene

Disorders for DISC1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for DISC1 Gene - From: HGMD, LncRNADisease, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia 9
  • sczd9
schizophrenia
  • sczd
schizophrenia 1
  • sczd1
schizoaffective disorder
  • schizo-affective psychosis
psychotic disorder
  • mental or behavioural disorder
- elite association - COSMIC cancer census association via MalaCards
Search DISC1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DISC1_HUMAN
  • Note=A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1;11)(q42.1;q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1.
  • Schizophrenia 9 (SCZD9) [MIM:604906]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269 PubMed:11468279, ECO:0000269 PubMed:14532331, ECO:0000269 PubMed:15386212, ECO:0000269 PubMed:15939883}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for DISC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DISC1: view

No data available for Genatlas for DISC1 Gene

Publications for DISC1 Gene

  1. Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. (PMID: 15386212) Hodgkinson CA … Malhotra AK (American journal of human genetics 2004) 3 4 22 44 58
  2. A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome. (PMID: 20227423) Fukuda S … Watanabe Y (Life sciences 2010) 3 22 44 58
  3. Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. (PMID: 19303846) Mao Y … Tsai LH (Cell 2009) 3 4 22 58
  4. DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. (PMID: 18317464) Hennah W … Porteous D (Molecular psychiatry 2009) 3 22 44 58
  5. The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia. (PMID: 19304459) Takahashi T … Ozaki N (Psychiatry research 2009) 3 22 44 58

Products for DISC1 Gene