Aliases for DIS3L2 Gene
External Ids for DIS3L2 Gene
Previous HGNC Symbols for DIS3L2 Gene
Previous GeneCards Identifiers for DIS3L2 Gene
The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012]
GeneCards Summary for DIS3L2 Gene
DIS3L2 (DIS3 Like 3'-5' Exoribonuclease 2) is a Protein Coding gene. Diseases associated with DIS3L2 include Perlman Syndrome and Wilms Tumor 1. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and 3'-5'-exoribonuclease activity. An important paralog of this gene is DIS3L.
UniProtKB/Swiss-Prot Summary for DIS3L2 Gene
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.