Aliases for DIS3L Gene
External Ids for DIS3L Gene
Previous GeneCards Identifiers for DIS3L Gene
The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016]
GeneCards Summary for DIS3L Gene
DIS3L (DIS3 Like Exosome 3'-5' Exoribonuclease) is a Protein Coding gene. Diseases associated with DIS3L include Perlman Syndrome. Among its related pathways are Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include RNA binding and 3'-5'-exoribonuclease activity. An important paralog of this gene is DIS3.
UniProtKB/Swiss-Prot Summary for DIS3L Gene
Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.