Aliases for DIS3 Gene

Aliases for DIS3 Gene

  • DIS3 Homolog, Exosome Endoribonuclease And 3'-5' Exoribonuclease 2 3 5
  • KIAA1008 2 3 4
  • RRP44 2 3 4
  • Ribosomal RNA-Processing Protein 44 3 4
  • Exosome Complex Exonuclease RRP44 3 4
  • Exosome Component 11 2 3
  • EXOSC11 2 3
  • Dis3p 2 3
  • DIS3 Exosome Endoribonuclease And 3'-5' Exoribonuclease 3
  • DIS3 Mitotic Control Homolog (S. Cerevisiae) 2
  • Mitotic Control Protein Dis3 Homolog 3
  • DIS3 Mitotic Control Homolog 3
  • Protein DIS3 Homolog 4
  • 2810028N01Rik 3
  • EC 3.1.13.- 4
  • EC 3.1.26.- 4
  • EC 3.1.13 51
  • DIS3 5

External Ids for DIS3 Gene

Previous HGNC Symbols for DIS3 Gene

  • KIAA1008

Previous GeneCards Identifiers for DIS3 Gene

  • GC13M071296
  • GC13M067324
  • GC13M072266
  • GC13M071127
  • GC13M073329
  • GC13M054026

Summaries for DIS3 Gene

GeneCards Summary for DIS3 Gene

DIS3 (DIS3 Homolog, Exosome Endoribonuclease And 3'-5' Exoribonuclease) is a Protein Coding gene. Diseases associated with DIS3 include Perlman Syndrome and Axenfeld-Rieger Syndrome, Type 2. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and ATP/ITP metabolism. Gene Ontology (GO) annotations related to this gene include RNA binding and endonuclease activity. An important paralog of this gene is DIS3L.

UniProtKB/Swiss-Prot Summary for DIS3 Gene

  • Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.

Gene Wiki entry for DIS3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DIS3 Gene

Genomics for DIS3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DIS3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J072779 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.3 295 4.4 BRCA1 SP1 PRDM10 ZNF629 RFX1 RFX5 POLR2A BACH1 JUND LARP7 PIBF1 DIS3 lnc-MZT1-2 lnc-MZT1-1 BORA
GH13J072726 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.2 +54.2 54195 3.8 SP1 HNRNPL CREB1 PRDM10 TFE3 POLR2A FOS LARP7 ZNF143 ZIC2 BORA MZT1 HSALNG0097884 PIBF1 DIS3
GH13J073088 Enhancer 1.3 Ensembl ENCODE dbSUPER 17.3 -308.1 -308100 3.2 CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 LEF1 SOX13 IKZF1 RCOR2 DIS3 PIBF1 RNU6-66P piR-43325-027 piR-43107-083 KLF5
GH13J072970 Enhancer 0.8 Ensembl ENCODE 27 -188.9 -188897 1.8 ZNF501 ZNF140 ZXDB ZNF580 ZNF266 ZNF189 ZNF664 ZFP37 ZNF781 ZNF518A DIS3 PIBF1 BORA NONHSAG013753.2 lnc-DIS3-2 KLF5
GH13J072821 Enhancer 0.8 Ensembl ENCODE 10.4 -38.8 -38805 1 TEAD4 PRDM10 ZNF629 OSR2 ZBTB17 ATF2 TRIM28 ZNF664 MEIS2 ZBTB21 PIBF1 DIS3 piR-43104-014 KLF5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DIS3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DIS3

Top Transcription factor binding sites by QIAGEN in the DIS3 gene promoter:
  • AhR
  • Arnt
  • Brachyury
  • C/EBPalpha
  • GATA-2
  • GATA-3
  • N-Myc
  • p53
  • Pax-5

Genomic Locations for DIS3 Gene

Genomic Locations for DIS3 Gene
chr13:72,752,169-72,782,096
(GRCh38/hg38)
Size:
29,928 bases
Orientation:
Minus strand
chr13:73,329,540-73,356,344
(GRCh37/hg19)
Size:
26,805 bases
Orientation:
Minus strand

Genomic View for DIS3 Gene

Genes around DIS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIS3 Gene

Proteins for DIS3 Gene

  • Protein details for DIS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2L1-RRP44_HUMAN
    Recommended name:
    Exosome complex exonuclease RRP44
    Protein Accession:
    Q9Y2L1
    Secondary Accessions:
    • A6NI21
    • B2RBL2
    • Q5W0P7
    • Q5W0P8
    • Q658Z7
    • Q7Z481
    • Q8WWI2
    • Q9UG36

    Protein attributes for DIS3 Gene

    Size:
    958 amino acids
    Molecular mass:
    109003 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Component of the RNA exosome complex (PubMed:29906447). The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.
    SequenceCaution:
    • Sequence=BAA76852.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • The association of DIS3 with the RNA exosome complex appears to be weak explaining its absence in some complex purifications.

    Three dimensional structures from OCA and Proteopedia for DIS3 Gene

    Alternative splice isoforms for DIS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DIS3 Gene

Selected DME Specific Peptides for DIS3 Gene

Q9Y2L1:
  • NKEKAIE
  • GVHIADV
  • YTHFTSPIRRY
  • PTGRVVGI
  • NDRNDRAIR
  • FHHYGLA
  • VREHYLR
  • EEFMLLAN

Post-translational modifications for DIS3 Gene

  • Ubiquitination at Lys118, Lys199, Lys236, Lys242, Lys462, Lys815, and Lys922
  • Modification sites at PhosphoSitePlus

Other Protein References for DIS3 Gene

Antibody Products

  • Abcam antibodies for DIS3
  • Santa Cruz Biotechnology (SCBT) Antibodies for DIS3

Domains & Families for DIS3 Gene

Gene Families for DIS3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DIS3 Gene

InterPro:
Blocks:
  • Ribonuclease II
  • Nucleotide binding protein, PINc
ProtoNet:

Suggested Antigen Peptide Sequences for DIS3 Gene

GenScript: Design optimal peptide antigens:
  • DIS3 protein (Q49AG4_HUMAN)
  • Ribosomal RNA-processing protein 44 (RRP44_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2L1

UniProtKB/Swiss-Prot:

RRP44_HUMAN :
  • Belongs to the RNR ribonuclease family.
Family:
  • Belongs to the RNR ribonuclease family.
genes like me logo Genes that share domains with DIS3: view

Function for DIS3 Gene

Molecular function for DIS3 Gene

UniProtKB/Swiss-Prot Function:
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.

Enzyme Numbers (IUBMB) for DIS3 Gene

Phenotypes From GWAS Catalog for DIS3 Gene

Gene Ontology (GO) - Molecular Function for DIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3'-5'-exoribonuclease activity TAS --
GO:0003723 RNA binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IBA,IMP 20531386
GO:0004527 exonuclease activity IEA --
genes like me logo Genes that share ontologies with DIS3: view
genes like me logo Genes that share phenotypes with DIS3: view

Animal Models for DIS3 Gene

MGI Knock Outs for DIS3:
  • Dis3 Dis3<tm1e.1(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for DIS3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DIS3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DIS3 Gene

Localization for DIS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIS3 Gene

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Note=Predominantly located in the nucleus (PubMed:20531386). According to PubMed:12429849, found in the nucleolus (PubMed:12429849). According to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3 (PubMed:20531386). {ECO:0000269 PubMed:12429849, ECO:0000269 PubMed:20531386}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DIS3 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000176 nuclear exosome (RNase complex) IBA,IDA 20531386
GO:0000177 cytoplasmic exosome (RNase complex) IBA 21873635
GO:0000178 exosome (RNase complex) IBA,TAS 9562621
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA 20531389
genes like me logo Genes that share ontologies with DIS3: view

Pathways & Interactions for DIS3 Gene

genes like me logo Genes that share pathways with DIS3: view

Pathways by source for DIS3 Gene

1 GeneGo (Thomson Reuters) pathway for DIS3 Gene
  • ATP/ITP metabolism

Gene Ontology (GO) - Biological Process for DIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS 9562621
GO:0016075 rRNA catabolic process IMP 20368444
GO:0043488 regulation of mRNA stability TAS --
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS --
GO:0071034 CUT catabolic process IMP 19056938
genes like me logo Genes that share ontologies with DIS3: view

No data available for SIGNOR curated interactions for DIS3 Gene

Drugs & Compounds for DIS3 Gene

No Compound Related Data Available

Transcripts for DIS3 Gene

mRNA/cDNA for DIS3 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DIS3

Alternative Splicing Database (ASD) splice patterns (SP) for DIS3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - -
SP2: -
SP3:
SP4: -
SP5: -
SP6: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for DIS3 Gene

GeneLoc Exon Structure for
DIS3

Expression for DIS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DIS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DIS3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.1) and Lymph node (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DIS3 Gene



Protein tissue co-expression partners for DIS3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DIS3

SOURCE GeneReport for Unigene cluster for DIS3 Gene:

Hs.744104

mRNA Expression by UniProt/SwissProt for DIS3 Gene:

Q9Y2L1-RRP44_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for DIS3 Gene

  • Nervous system(4.8)
  • Blood(4.5)
  • Lymph node(4.4)
  • Bone marrow(2.3)
  • Skin(2.3)
  • Intestine(2)
genes like me logo Genes that share expression patterns with DIS3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DIS3 Gene

Orthologs for DIS3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DIS3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DIS3 30 31
  • 99.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DIS3 30 31
  • 91.8 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DIS3 30 31
  • 90.91 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dis3 30
  • 88.57 (n)
Oppossum
(Monodelphis domestica)
Mammalia DIS3 31
  • 87 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Dis3 30 17 31
  • 86.62 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DIS3 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DIS3 30 31
  • 76.86 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DIS3 31
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dis3 30
  • 73.89 (n)
Str.18497 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.32649 30
Zebrafish
(Danio rerio)
Actinopterygii dis3 30 31
  • 68.11 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11258 30
Fruit Fly
(Drosophila melanogaster)
Insecta Dis3 30 31 32
  • 55.92 (n)
OneToOne
CG16940 32
  • 31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005191 30
  • 55.25 (n)
Worm
(Caenorhabditis elegans)
Secernentea dis-3 30 31
  • 53.51 (n)
OneToOne
C04G2.6 32
  • 45 (a)
F48E8.6 32
  • 31 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIS3 30 31 33
  • 53.57 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10835g 30
  • 53.5 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AEL031C 30
  • 51.79 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons EMB2763 30
  • 54.08 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0129200 30
  • 54.13 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 62 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dis3 30
  • 54.05 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU03065 30
  • 52.19 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.125 30
Species where no ortholog for DIS3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DIS3 Gene

ENSEMBL:
Gene Tree for DIS3 (if available)
TreeFam:
Gene Tree for DIS3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DIS3: view image

Paralogs for DIS3 Gene

Paralogs for DIS3 Gene

(2) SIMAP similar genes for DIS3 Gene using alignment to 4 proteins:

  • RRP44_HUMAN
  • F2Z2C0_HUMAN
  • G3V1J5_HUMAN
  • Q49AG4_HUMAN
genes like me logo Genes that share paralogs with DIS3: view

Variants for DIS3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DIS3 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
800341 Likely Pathogenic: Multiple myeloma 72,761,930(-) T/A MISSENSE_VARIANT
rs1413258245 Uncertain Significance: Perlman syndrome 72,768,862(-) C/T MISSENSE_VARIANT
rs4883918 - p.Asn269Ser
rs7332388 - p.Thr326Arg

Additional dbSNP identifiers (rs#s) for DIS3 Gene

Structural Variations from Database of Genomic Variants (DGV) for DIS3 Gene

Variant ID Type Subtype PubMed ID
esv2626867 CNV deletion 19546169
esv3580764 CNV loss 25503493
nsv1049859 CNV loss 25217958
nsv476290 CNV novel sequence insertion 20440878

Variation tolerance for DIS3 Gene

Residual Variation Intolerance Score: 60.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.23; 88.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DIS3 Gene

Human Gene Mutation Database (HGMD)
DIS3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DIS3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIS3 Gene

Disorders for DIS3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for DIS3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
perlman syndrome
  • nephroblastoma
axenfeld-rieger syndrome, type 2
  • rieg2
colon leiomyoma
  • colonic leiomyoma
pontocerebellar hypoplasia, type 1b
  • pch1b
nodular malignant melanoma
  • nodular melanoma
- elite association - COSMIC cancer census association via MalaCards
Search DIS3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with DIS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DIS3 Gene

Publications for DIS3 Gene

  1. A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes. (PMID: 11935316) Rozenblum E … Kallioniemi OP (Human genetics 2002) 2 3 4
  2. Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3. (PMID: 9562621) Shiomi T … Nishimoto T (Journal of biochemistry 1998) 2 3 4
  3. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. (PMID: 20531386) Tomecki R … Jensen TH (The EMBO journal 2010) 3 4
  4. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PMID: 20531389) Staals RH … Pruijn GJ (The EMBO journal 2010) 3 4
  5. RNA exosome depletion reveals transcription upstream of active human promoters. (PMID: 19056938) Preker P … Jensen TH (Science (New York, N.Y.) 2008) 3 4

Products for DIS3 Gene

  • Signalway ELISA kits for DIS3

Sources for DIS3 Gene