Aliases for DIS3 Gene
External Ids for DIS3 Gene
Previous HGNC Symbols for DIS3 Gene
Previous GeneCards Identifiers for DIS3 Gene
GeneCards Summary for DIS3 Gene
DIS3 (DIS3 Homolog, Exosome Endoribonuclease And 3'-5' Exoribonuclease) is a Protein Coding gene. Diseases associated with DIS3 include Perlman Syndrome and Axenfeld-Rieger Syndrome, Type 2. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and ATP/ITP metabolism. Gene Ontology (GO) annotations related to this gene include RNA binding and endonuclease activity. An important paralog of this gene is DIS3L.
UniProtKB/Swiss-Prot Summary for DIS3 Gene
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.