Aliases for DIRAS3 Gene
External Ids for DIRAS3 Gene
Previous HGNC Symbols for DIRAS3 Gene
Previous GeneCards Identifiers for DIRAS3 Gene
This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex. [provided by RefSeq, Nov 2015]
GeneCards Summary for DIRAS3 Gene
DIRAS3 (DIRAS Family GTPase 3) is a Protein Coding gene. Diseases associated with DIRAS3 include Glioblastoma Multiforme and Ovarian Cancer. Among its related pathways are Guidance Cues and Growth Cone Motility and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is DIRAS2.