Aliases for DIO3 Gene
Aliases for DIO3 Gene
External Ids for DIO3 Gene
- HGNC: 2885
- Entrez Gene: 1735
- Ensembl: ENSG00000197406
- OMIM: 601038
- UniProtKB: P55073
Previous HGNC Symbols for DIO3 Gene
- TXDI3
Previous GeneCards Identifiers for DIO3 Gene
- GC14P099418
- GC14P095843
- GC14P100017
- GC14P101097
- GC14P102027
- GC14P082210
- GC14P101881
- GC14P101905
- GC14P102216
- GC14P102383
- GC14P102561
- GC14P102733
- GC14P102903
Summaries for DIO3 Gene
-
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction, and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, May 2016]
GeneCards Summary for DIO3 Gene
DIO3 (Iodothyronine Deiodinase 3) is a Protein Coding gene. Diseases associated with DIO3 include Hypothyroidism and Neonatal Thyrotoxicosis. Among its related pathways are Amine-derived hormones and Thyroid hormone signaling pathway. Gene Ontology (GO) annotations related to this gene include thyroxine 5-deiodinase activity and thyroxine 5-deiodinase activity. An important paralog of this gene is DIO2.
UniProtKB/Swiss-Prot for DIO3 Gene
-
Responsible for the deiodination of T4 (3,5,3,5-tetraiodothyronine) into RT3 (3,3,5-triiodothyronine) and of T3 (3,5,3-triiodothyronine) into T2 (3,3-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIO3 Gene
Genomics for DIO3 Gene
GeneHancer (GH) Regulatory Elements for DIO3 Gene
Promoters and enhancers for DIO3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DIO3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DIO3 gene promoter:
Regulatory Element Products
Genomic Locations for DIO3 Gene
Genomic Locations for DIO3 Gene
- chr14:101,561,351-101,563,452
- (GRCh38/hg38)
- Size:
- 2,102 bases
- Orientation:
- Plus strand
- chr14:102,027,688-102,029,789
- (GRCh37/hg19)
Genomic View for DIO3 Gene
Genes around DIO3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.31 by Ensembl
- 14q32.31 by Entrez Gene
- 14q32.31 by HGNC
DIO3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DIO3 Gene
Proteins for DIO3 Gene
-
Protein details for DIO3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55073-IOD3_HUMAN
- Recommended name:
- Thyroxine 5-deiodinase
- Protein Accession:
- P55073
- G3XAM0
- Q8WVN5
Protein attributes for DIO3 Gene
- Size:
- 304 amino acids
- Molecular mass:
- 33947 Da
- Quaternary structure:
-
- Homodimer. May undergo minor heretodimerization with DIO1 and DIO2.
- SequenceCaution:
-
- Sequence=AAB35616.2; Type=Frameshift; Positions=21; Evidence={ECO:0000305}; Sequence=AAH17717.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for DIO3 Gene
Selected DME Specific Peptides for DIO3 Gene
- P55073:
-
- YQGGRGP
- AYGAYFERLY
- FGSCTUP
- NFGSCTUPPFMAR
- AVWHGQKLD
- RTWLERYDEQLHG
- DFLIIYI
- EAHPSDGW
- GNRPLVL
- MLWLLDFLCIRK
Post-translational modifications for DIO3 Gene
Other Protein References for DIO3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DIO3
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-
Abcam antibodies for DIO3
- Invitrogen Antibodies for DIO3
- antibodies-online: Search results for 96 available DIO3 Antibodies ranked by validation data
- Compare Top DIO3 Antibodies
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Recommended
- 1 IHC (p) Antibody (anti-human)
- 1 IHC Antibody (anti-human)
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- 1 IHC (p) Antibody (anti-rat)
- 1 IHC Antibody (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 52 WB Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 45 WB Antibodies (anti-mouse)
- Search GeneTex for Antibodies for DIO3
Protein Products
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- Search GeneTex for Proteins for DIO3
-
Abcam proteins for DIO3
Assay Products
Domains & Families for DIO3 Gene
Gene Families for DIO3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted membrane proteins
Protein Domains for DIO3 Gene
Suggested Antigen Peptide Sequences for DIO3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P55073- Family:
-
- Belongs to the iodothyronine deiodinase family.
Function for DIO3 Gene
Molecular function for DIO3 Gene
- GENATLAS Biochemistry:
- iodothyronine 5-deiodinase type III,selenocysteine containing,catalyzing tyrosyl ring deiodination,highly expressed in the placenta and several fetal tissues,restricted to the skin an central nervous system
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=4.3 nM for L-thyroxine {ECO:0000269 PubMed:12746313}; Vmax=1.4 pmol/min/mg enzyme {ECO:0000269 PubMed:12746313};
- UniProtKB/Swiss-Prot CatalyticActivity:
- 3,3,5-triiodo-L-thyronine + iodide + acceptor + H(+) = L-thyroxine + reduced acceptor.
- UniProtKB/Swiss-Prot Function:
- Responsible for the deiodination of T4 (3,5,3,5-tetraiodothyronine) into RT3 (3,3,5-triiodothyronine) and of T3 (3,5,3-triiodothyronine) into T2 (3,3-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
Enzyme Numbers (IUBMB) for DIO3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004800 | thyroxine 5-deiodinase activity | TAS | -- |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0033798 | thyroxine 5-deiodinase activity | IEA | -- |
Phenotypes for DIO3 Gene
- MGI mutant phenotypes for DIO3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for DIO3:
-
- Increased viability
- Decreased viability ratio
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased IL-8 secretion
- Decreased Salmonella enterica Typhimurium invasion
- Decreased shRNA abundance
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
Animal Models for DIO3 Gene
- MGI Knock Outs for DIO3:
-
- Dio3 tm1Stg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
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-
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- Search ViGene Biosciences for DIO3
CRISPR Products
-
OriGene CRISPR knockouts for DIO3
- genomics-online: gRNA clones - Search results for 84 available DIO3 gene related products
- Overview of 84 available DIO3 gene related products
- Applied Biological Materials CRISPR for DIO3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DIO3
- GenScript: Design CRISPR guide RNA sequences for DIO3
miRNA for DIO3 Gene
- miRTarBase miRNAs that target DIO3
miRNA Products
- Search ViGene Biosciences for DIO3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DIO3
- Browse OriGene Inhibitory RNA Products For DIO3
- genomics-online: shRNA clones - Search results for 84 available DIO3 gene related products
- Overview of 84 available DIO3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DIO3 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for DIO3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DIO3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for DIO3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DIO3
-
ViGene Biosciences adenoviral particle packaged cDNA for DIO3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DIO3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DIO3 gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DIO3 Gene
Localization for DIO3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DIO3 Gene
- Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endosome | 3 |
| mitochondrion | 2 |
| nucleus | 2 |
| golgi apparatus | 2 |
| extracellular | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005768 | endosome | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0010008 | endosome membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for DIO3 Gene
Pathways & Interactions for DIO3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Amine-derived hormones | ||
| 2 | thyroid hormone metabolism I (via deiodination) | ||
| 3 | Thyroid hormone signaling pathway | ||
| 4 | Metabolism |
.37
|
|
| 5 | Viral mRNA Translation | ||
Pathways by source for DIO3 Gene
4 BioSystems pathways for DIO3 Gene
5 Reactome pathways for DIO3 Gene
1 KEGG pathway for DIO3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006590 | thyroid hormone generation | TAS | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0008150 | biological_process | ND | -- |
| GO:0040018 | positive regulation of multicellular organism growth | IEA | -- |
| GO:0042404 | thyroid hormone catabolic process | IEA | -- |
No data available for SIGNOR curated interactions for DIO3 Gene
Drugs & Compounds for DIO3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Hydrogen Ion |
|
|
||||
| I(-) |
|
|
||||
| Thyroxine sulfate |
|
77074-49-8 |
|
Transcripts for DIO3 Gene
mRNA/cDNA for DIO3 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (38) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DIO3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DIO3
- genomics-online: gRNA clones - Search results for 84 available DIO3 gene related products
- Overview of 84 available DIO3 gene related products
- Applied Biological Materials CRISPR for DIO3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DIO3
- GenScript: Design CRISPR guide RNA sequences for DIO3
miRNA Products
- Search ViGene Biosciences for DIO3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DIO3
- Browse OriGene Inhibitory RNA Products For DIO3
- genomics-online: shRNA clones - Search results for 84 available DIO3 gene related products
- Overview of 84 available DIO3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DIO3 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for DIO3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DIO3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for DIO3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for DIO3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
- Placenta (Extraembryonic Tissues)
- Neural Tube (Nervous System)
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
mRNA differential expression in normal tissues according to GTEx for DIO3 Gene
This gene is overexpressed in Cervix - Endocervix (x5.6), Vagina (x5.2), and Ovary (x4.3).
This gene is overexpressed in Colon muscle (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DIO3 Gene
NURSA nuclear receptor signaling pathways regulating expression of DIO3 Gene:
DIO3SOURCE GeneReport for Unigene cluster for DIO3 Gene:
Hs.49322mRNA Expression by UniProt/SwissProt for DIO3 Gene:
P55073-IOD3_HUMAN
Tissue specificity:
Expressed in placenta and several fetal tissues.
Evidence on tissue expression from TISSUES for DIO3 Gene
- Intestine(4)
- Thyroid gland(2.7)
Primer Products
-
OriGene qPCR primer pairs for DIO3
-
OriGene qPCR primer pairs and template standards for DIO3
- genomics-online: primer clones - Search results for 84 available DIO3 gene related products
- Overview of 84 available DIO3 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DIO3 Gene
Orthologs for DIO3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | DIO3 33 |
|
||
| cow (Bos Taurus) |
Mammalia | DIO3 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Dio3 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dio3 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DIO3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DIO3 33 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dio3 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397779 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dio3b 33 |
|
||
| dio3a 34 |
|
OneToOne | |||
| -- 33 |
|
- Species where no ortholog for DIO3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for DIO3 Gene
(2) SIMAP similar genes for DIO3 Gene using alignment to 2 proteins:
Variants for DIO3 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000106689 | -- | 101,559,469(+) | T/C | upstream_transcript_variant | |
| rs1000227493 | -- | 101,562,706(+) | A/G | 3_prime_UTR_variant | |
| rs1001107414 | -- | 101,560,676(+) | G/T | upstream_transcript_variant | |
| rs1001117243 | -- | 101,560,810(+) | C/A | upstream_transcript_variant | |
| rs1001925252 | -- | 101,563,588(+) | G/A | downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1978n100 | CNV | gain | 25217958 |
| dgv388n67 | CNV | gain | 20364138 |
| esv3635530 | CNV | gain | 21293372 |
| nsv1047869 | CNV | gain | 25217958 |
| nsv1071171 | CNV | deletion | 25765185 |
| nsv1143759 | CNV | deletion | 24896259 |
| nsv565879 | CNV | loss | 21841781 |
| nsv565880 | CNV | loss | 21841781 |
| nsv565882 | CNV | loss | 21841781 |
| nsv827060 | CNV | gain | 20364138 |
| nsv827061 | CNV | gain | 20364138 |
| nsv952247 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.85;
17.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DIO3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DIO3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIO3 Gene
Disorders for DIO3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypothyroidism |
|
|
| neonatal thyrotoxicosis |
|
|
| hemangioma |
|
|
| prader-willi syndrome |
|
|
| fetal alcohol spectrum disorder |
|
|
Search DIO3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DIO3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for DIO3 Gene
Publications for DIO3 Gene
- Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme. (PMID: 7593630) Salvatore D … Larsen PR (The Journal of clinical investigation 1995) 2 3 4 22 58
- The thyroid hormone-inactivating deiodinase functions as a homodimer. (PMID: 18356288) Sagar GD … Bianco AC (Molecular endocrinology (Baltimore, Md.) 2008) 3 4 22 58
- Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes. (PMID: 12419801) Baqui M … Bianco AC (The Journal of biological chemistry 2003) 3 4 22 58
- Substitution of cysteine for selenocysteine in the catalytic center of type III iodothyronine deiodinase reduces catalytic efficiency and alters substrate preference. (PMID: 12746313) Kuiper GG … Visser TJ (Endocrinology 2003) 3 4 22 58
- Localization of the type 3 iodothyronine deiodinase (DIO3) gene to human chromosome 14q32 and mouse chromosome 12F1. (PMID: 9787088) Hernandez A … St Germain DL (Genomics 1998) 2 3 22 58
Products for DIO3 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 96 available DIO3 Antibodies ranked by validation data
- Compare Top DIO3 Antibodies
- Recommended
- 45 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 52 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 52 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- antibodies-online: Search results for 22 available DIO3 Elisa Kits ranked by validation data
- Compare Top DIO3 Elisa Kits
- antibodies-online: Search results for 15 available DIO3 Proteins ranked by validation data
- Compare Top DIO3 Proteins
- Search GeneTex for Antibodies for DIO3
- Search GeneTex for Proteins for DIO3
- ViGene Biosciences adenoviral particle packaged cDNA for DIO3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for DIO3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for DIO3 gene
- Search ViGene Biosciences for DIO3
- Horizon Cell Lines for DIO3
- genomics-online: cdna clones - Search results for 84 available DIO3 gene related products
- Overview of 84 available DIO3 gene related products
- orf clones - Search results for 84 available DIO3 gene related products
- Overview of 84 available DIO3 gene related products
- genomics-online: gRNA clones - Search results for 84 available DIO3 gene related products
- Overview of 84 available DIO3 gene related products
- genomics-online: primer clones - Search results for 84 available DIO3 gene related products
- Overview of 84 available DIO3 gene related products
- genomics-online: shRNA clones - Search results for 84 available DIO3 gene related products
- Overview of 84 available DIO3 gene related products
Sources for DIO3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems