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Aliases for DIEXF Gene

Aliases for DIEXF Gene

  • Digestive Organ Expansion Factor Homolog (Zebrafish) 2 3 5
  • C1orf107 3 4
  • DEF 3 4
  • Digestive Organ Expansion Factor Homolog 3
  • Digestive-Organ Expansion Factor Homolog 3
  • Chromosome 1 Open Reading Frame 107 2
  • DJ434O14.5 3
  • UTP25 3

External Ids for DIEXF Gene

Previous HGNC Symbols for DIEXF Gene

  • C1orf107

Previous GeneCards Identifiers for DIEXF Gene

  • GC01P210002

Summaries for DIEXF Gene

GeneCards Summary for DIEXF Gene

DIEXF (Digestive Organ Expansion Factor Homolog (Zebrafish)) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include U3 snoRNA binding.

UniProtKB/Swiss-Prot for DIEXF Gene

  • Regulates the p53 pathway to control the expansion growth of digestive organs.

Additional gene information for DIEXF Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIEXF Gene

Genomics for DIEXF Gene

GeneHancer (GH) Regulatory Elements for DIEXF Gene

Promoters and enhancers for DIEXF Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I209822 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 566 -2.2 -2205 6.5 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 DIEXF IRF6 SYT14 C1orf74 LOC101930114 TRAF3IP3
GH01I209672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.8 -153.5 -153516 4.2 HDGF PKNOX1 SMAD1 MLX FEZF1 IRF4 YY1 POLR2B ZNF766 ZNF548 G0S2 GC01P209677 GC01P209676 DIEXF LOC101930114 LAMB3
GH01I209800 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -22.0 -22047 10.2 HDGF PKNOX1 SMAD1 ARNT SIN3A FEZF1 ZNF2 YY1 POLR2B FOS IRF6 TRAF3IP3 DIEXF SYT14 LAMB3 C1orf74
GH01I209765 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 -59.4 -59396 6.9 HDGF PKNOX1 SMAD1 YBX1 BATF IRF4 ZEB1 ZNF766 ATF7 ETV6 TRAF3IP3 G0S2 DIEXF ENSG00000224260 LAMB3 IRF6 C1orf74 LOC101930114
GH01I209882 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +56.3 56326 4.4 PKNOX1 ATF1 FEZF1 GLI4 ZNF2 ZNF213 ATF7 FOS DEK SP3 SYT14 DIEXF IRF6 TRAF3IP3 LAMB3 GC01M209934
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DIEXF on UCSC Golden Path with GeneCards custom track

Genomic Locations for DIEXF Gene

Genomic Locations for DIEXF Gene
29,599 bases
Plus strand

Genomic View for DIEXF Gene

Genes around DIEXF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIEXF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIEXF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIEXF Gene

Proteins for DIEXF Gene

  • Protein details for DIEXF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Digestive organ expansion factor homolog
    Protein Accession:
    Secondary Accessions:
    • O75992
    • Q4VY00
    • Q63HL9

    Protein attributes for DIEXF Gene

    756 amino acids
    Molecular mass:
    87055 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI95693.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DIEXF Gene

Post-translational modifications for DIEXF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DIEXF Gene

No data available for DME Specific Peptides for DIEXF Gene

Domains & Families for DIEXF Gene

Gene Families for DIEXF Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DIEXF Gene

Suggested Antigen Peptide Sequences for DIEXF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the def family.
  • Belongs to the def family.
genes like me logo Genes that share domains with DIEXF: view

Function for DIEXF Gene

Molecular function for DIEXF Gene

UniProtKB/Swiss-Prot Function:
Regulates the p53 pathway to control the expansion growth of digestive organs.

Phenotypes From GWAS Catalog for DIEXF Gene

Gene Ontology (GO) - Molecular Function for DIEXF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22658674
GO:0005515 protein binding IPI 25416956
GO:0019843 rRNA binding IBA --
GO:0034511 U3 snoRNA binding IBA --
genes like me logo Genes that share ontologies with DIEXF: view
genes like me logo Genes that share phenotypes with DIEXF: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DIEXF Gene

Localization for DIEXF Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIEXF Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DIEXF gene
Compartment Confidence
nucleus 5
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DIEXF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 23357851
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with DIEXF: view

Pathways & Interactions for DIEXF Gene

genes like me logo Genes that share pathways with DIEXF: view

Gene Ontology (GO) - Biological Process for DIEXF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with DIEXF: view

No data available for SIGNOR curated interactions for DIEXF Gene

Drugs & Compounds for DIEXF Gene

No Compound Related Data Available

Transcripts for DIEXF Gene

mRNA/cDNA for DIEXF Gene

Unigene Clusters for DIEXF Gene

Digestive organ expansion factor homolog (zebrafish):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DIEXF Gene

No ASD Table

Relevant External Links for DIEXF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIEXF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DIEXF Gene

Protein differential expression in normal tissues from HIPED for DIEXF Gene

This gene is overexpressed in Lung (45.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DIEXF Gene

Protein tissue co-expression partners for DIEXF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DIEXF Gene:


SOURCE GeneReport for Unigene cluster for DIEXF Gene:


Evidence on tissue expression from TISSUES for DIEXF Gene

  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with DIEXF: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DIEXF Gene

Orthologs for DIEXF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DIEXF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DIEXF 33 34
  • 99.51 (n)
(Bos Taurus)
Mammalia DIEXF 33 34
  • 88.62 (n)
(Canis familiaris)
Mammalia DIEXF 33 34
  • 87.95 (n)
(Rattus norvegicus)
Mammalia Diexf 33
  • 85.39 (n)
(Mus musculus)
Mammalia Diexf 33 16 34
  • 85.21 (n)
(Monodelphis domestica)
Mammalia DIEXF 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia DIEXF 34
  • 76 (a)
(Gallus gallus)
Aves DIEXF 33 34
  • 68.4 (n)
(Anolis carolinensis)
Reptilia DIEXF 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia diexf 33
  • 67.42 (n)
Str.11330 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16819 33
(Danio rerio)
Actinopterygii diexf 33 34
  • 59.54 (n)
dj434o14.5l 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011170 33
  • 51.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3735 33 34
  • 51.63 (n)
(Caenorhabditis elegans)
Secernentea Y41C4A.9 34
  • 31 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08229g 33
  • 46.83 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL209C 33
  • 45.75 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP25 33 34
  • 44.99 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NOF1 33
  • 49.38 (n)
(Oryza sativa)
Liliopsida Os05g0295100 33
  • 48.95 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01022 33
  • 50.49 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1827.01c 33
  • 46.16 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1540 33
Species where no ortholog for DIEXF was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIEXF Gene

Gene Tree for DIEXF (if available)
Gene Tree for DIEXF (if available)

Paralogs for DIEXF Gene

No data available for Paralogs for DIEXF Gene

Variants for DIEXF Gene

Sequence variations from dbSNP and Humsavar for DIEXF Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000127283 -- 209,845,973(+) C/T intron_variant
rs1000296113 -- 209,835,473(+) A/G intron_variant
rs1000331843 -- 209,855,322(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000517735 -- 209,842,293(+) C/G coding_sequence_variant, missense_variant
rs1000564380 -- 209,844,037(+) TT/T intron_variant

Variation tolerance for DIEXF Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DIEXF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DIEXF Gene

Disorders for DIEXF Gene

Additional Disease Information for DIEXF

No disorders were found for DIEXF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DIEXF Gene

Publications for DIEXF Gene

  1. Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. (PMID: 16322560) Chen J … Peng J (Genes & development 2005) 2 3 22 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma. (PMID: 28263972) Tao T … Look AT (Oncogene 2017) 3 58

Products for DIEXF Gene

Sources for DIEXF Gene

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