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Aliases for DHX58 Gene

Aliases for DHX58 Gene

  • DExH-Box Helicase 58 2 3 5
  • DEXH (Asp-Glu-X-His) Box Polypeptide 58 2 3
  • Probable ATP-Dependent Helicase LGP2 3 4
  • RIG-I-Like Receptor LGP2 3 4
  • Protein D11Lgp2 Homolog 3 4
  • RIG-I-Like Receptor 3 3 4
  • RNA Helicase LGP2 2 3
  • RLR-3 3 4
  • LGP2 3 4
  • RLR 3 4
  • Probable ATP-Dependent RNA Helicase DHX58 3
  • Ortholog Of Mouse D11lgp2 3
  • EC 3.6.4.13 4
  • D11lgp2e 3
  • D11LGP2E 4
  • D11LGP2 3

External Ids for DHX58 Gene

Previous GeneCards Identifiers for DHX58 Gene

  • GC17M037507
  • GC17M040255
  • GC17M036018

Summaries for DHX58 Gene

GeneCards Summary for DHX58 Gene

DHX58 (DExH-Box Helicase 58) is a Protein Coding gene. Diseases associated with DHX58 include Measles. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Innate Immune System. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is IFIH1.

UniProtKB/Swiss-Prot for DHX58 Gene

  • Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5-triphosphorylated RNA, although it can recognize RNA lacking a 5-triphosphate.

Gene Wiki entry for DHX58 Gene

Additional gene information for DHX58 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX58 Gene

Genomics for DHX58 Gene

GeneHancer (GH) Regulatory Elements for DHX58 Gene

Promoters and enhancers for DHX58 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J042110 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 685.5 +0.3 331 3.3 HDGF HDAC1 ARID4B IRF4 RAD21 YY1 ZNF335 ZNF207 BCLAF1 RUNX3 DHX58 PIR51780 GC17P042116 CNP KCNH4 HCRT RAB5C IFI35 AOC4P KAT2A
GH17J042128 Enhancer 1.4 Ensembl ENCODE dbSUPER 44.1 -20.3 -20254 8.4 HDGF FOXA2 ARNT MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 SP5 DHX58 CNP HSPB9 CNTD1 NBR2 RETREG3 RAB5C KCNH4 HCRT ZNF385C
GH17J042419 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.4 -309.2 -309211 5.2 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B CAVIN1 LOC102725238 LINC00910 HMGN1P29 NBR2 CNTD1 RETREG3 ENSG00000267758 ACLY DHX58
GH17J042115 Enhancer 1.1 ENCODE dbSUPER 36.4 -3.6 -3621 2.6 HDGF ELF3 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 RAD21 ZNF614 ARID2 DHX58 CNP KCNH4 HCRT RAB5C AOC4P PIR51780 GC17P042116 KAT2A
GH17J041810 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 19.6 +299.9 299921 4.4 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF213 ZNF207 ZNF143 P3H4 FKBP10 PIR33798 DHX58 NT5C3B CNTD1 CAVIN1 RETREG3 KAT2A HSD17B1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHX58 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHX58 gene promoter:
  • STAT1alpha
  • Egr-4
  • ER-alpha
  • STAT1
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT6
  • STAT5A

Genomic Locations for DHX58 Gene

Genomic Locations for DHX58 Gene
chr17:42,101,404-42,112,733
(GRCh38/hg38)
Size:
11,330 bases
Orientation:
Minus strand
chr17:40,253,422-40,264,751
(GRCh37/hg19)
Size:
11,330 bases
Orientation:
Minus strand

Genomic View for DHX58 Gene

Genes around DHX58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX58 Gene

Proteins for DHX58 Gene

  • Protein details for DHX58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C10-DHX58_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DHX58
    Protein Accession:
    Q96C10
    Secondary Accessions:
    • Q9HAM6

    Protein attributes for DHX58 Gene

    Size:
    678 amino acids
    Molecular mass:
    76613 Da
    Quaternary structure:
    • Monomer in the absence of dsRNA. Homodimer in the presence of dsRNA. Interacts with DDX58/RIG-I (via CARD domain), MAVS/IPS1 and DDX60. Found in a complex with DDX58/RIG-I and IFIH1/MDA5. Interacts (via helicase C-terminal domain) with non-structural protein V of Human parainfluenza 2 virus, Human parainfluenza 5 virus, measles virus, mumps virus, hendra virus and nipah virus. Interacts with ANKRD17. Directly interacts with ATG5 and ATG12, either as ATG5 and ATG12 monomers or as ATG12-ATG5 conjugates (PubMed:17709747).

    Three dimensional structures from OCA and Proteopedia for DHX58 Gene

neXtProt entry for DHX58 Gene

Post-translational modifications for DHX58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX58 Gene

No data available for DME Specific Peptides for DHX58 Gene

Domains & Families for DHX58 Gene

Gene Families for DHX58 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DHX58 Gene

Graphical View of Domain Structure for InterPro Entry

Q96C10

UniProtKB/Swiss-Prot:

DHX58_HUMAN :
  • The RLR CTR domain is capable of inhibiting dimerization and signaling of DDX58/RIG-I and also facilitates binding of dsRNA.
  • Belongs to the helicase family. RLR subfamily.
Domain:
  • The RLR CTR domain is capable of inhibiting dimerization and signaling of DDX58/RIG-I and also facilitates binding of dsRNA.
Family:
  • Belongs to the helicase family. RLR subfamily.
genes like me logo Genes that share domains with DHX58: view

Function for DHX58 Gene

Molecular function for DHX58 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5-triphosphorylated RNA, although it can recognize RNA lacking a 5-triphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Induction:
By interferon (IFN), virus infection, or intracellular dsRNA.

Enzyme Numbers (IUBMB) for DHX58 Gene

Phenotypes From GWAS Catalog for DHX58 Gene

Gene Ontology (GO) - Molecular Function for DHX58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0003725 double-stranded RNA binding IDA 18411269
GO:0003727 single-stranded RNA binding IDA 18411269
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DHX58: view
genes like me logo Genes that share phenotypes with DHX58: view

Animal Models for DHX58 Gene

MGI Knock Outs for DHX58:

Animal Model Products

Clone Products

  • Addgene plasmids for DHX58

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DHX58 Gene

Localization for DHX58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX58 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX58 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHX58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DHX58: view

Pathways & Interactions for DHX58 Gene

genes like me logo Genes that share pathways with DHX58: view

Pathways by source for DHX58 Gene

1 BioSystems pathway for DHX58 Gene
1 KEGG pathway for DHX58 Gene
1 Cell Signaling Technology pathway for DHX58 Gene

Gene Ontology (GO) - Biological Process for DHX58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0009615 response to virus ISS --
GO:0016032 viral process IEA --
GO:0032480 negative regulation of type I interferon production IDA 21525357
GO:0032481 positive regulation of type I interferon production ISS --
genes like me logo Genes that share ontologies with DHX58: view

No data available for SIGNOR curated interactions for DHX58 Gene

Drugs & Compounds for DHX58 Gene

(3) Drugs for DHX58 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for DHX58 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DHX58: view

Transcripts for DHX58 Gene

mRNA/cDNA for DHX58 Gene

Unigene Clusters for DHX58 Gene

DEXH (Asp-Glu-X-His) box polypeptide 58:
Representative Sequences:

Clone Products

  • Addgene plasmids for DHX58

Alternative Splicing Database (ASD) splice patterns (SP) for DHX58 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a ·
SP1: - - -
SP2: - - - - -
SP3: -
SP4:
SP5: - - -
SP6: - - -
SP7: - - - - -
SP8: - -
SP9: - - -

ExUns: 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for DHX58 Gene

GeneLoc Exon Structure for
DHX58
ECgene alternative splicing isoforms for
DHX58

Expression for DHX58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX58 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DHX58 Gene

This gene is overexpressed in NK cells (40.6), Breast (13.9), and Testis (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHX58 Gene



NURSA nuclear receptor signaling pathways regulating expression of DHX58 Gene:

DHX58

SOURCE GeneReport for Unigene cluster for DHX58 Gene:

Hs.55918

Evidence on tissue expression from TISSUES for DHX58 Gene

  • Intestine(4.3)
  • Spleen(2.5)
  • Nervous system(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with DHX58: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX58 Gene

Orthologs for DHX58 Gene

This gene was present in the common ancestor of animals.

Orthologs for DHX58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX58 34 33
  • 99.36 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DHX58 33
  • 85.92 (n)
LGP2 34
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX58 34 33
  • 85.5 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx58 16 34 33
  • 80.04 (n)
rat
(Rattus norvegicus)
Mammalia Dhx58 33
  • 79.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
OneToMany
-- 34
  • 61 (a)
OneToMany
-- 34
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia DHX58 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHX58 34 33
  • 62.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX58 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx58 33
  • 58.73 (n)
zebrafish
(Danio rerio)
Actinopterygii dhx58 34 33
  • 55.96 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea drh-1 34
  • 17 (a)
ManyToMany
drh-3 34
  • 14 (a)
ManyToMany
Species where no ortholog for DHX58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX58 Gene

ENSEMBL:
Gene Tree for DHX58 (if available)
TreeFam:
Gene Tree for DHX58 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DHX58: view image

Paralogs for DHX58 Gene

Paralogs for DHX58 Gene

(3) SIMAP similar genes for DHX58 Gene using alignment to 5 proteins:

  • DHX58_HUMAN
  • C9JE76_HUMAN
  • C9JG98_HUMAN
  • K7EMZ5_HUMAN
  • K7EPP0_HUMAN
genes like me logo Genes that share paralogs with DHX58: view

Variants for DHX58 Gene

Sequence variations from dbSNP and Humsavar for DHX58 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000173934 -- 42,106,650(-) A/T intron_variant
rs1000435390 -- 42,106,424(-) G/A intron_variant
rs1000765004 -- 42,104,836(-) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000784105 -- 42,112,523(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001302965 -- 42,107,253(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DHX58 Gene

Variant ID Type Subtype PubMed ID
nsv1056904 CNV gain 25217958
nsv1146669 OTHER inversion 26484159

Variation tolerance for DHX58 Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.30; 76.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHX58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHX58

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX58 Gene

Disorders for DHX58 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DHX58 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
measles
  • morbilli
- elite association - COSMIC cancer census association via MalaCards
Search DHX58 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DHX58

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DHX58: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DHX58 Gene

Publications for DHX58 Gene

  1. A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2. (PMID: 19403670) Parisien JP … Horvath CM (Journal of virology 2009) 3 4 22 58
  2. Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response. (PMID: 18411269) Murali A … Kao CC (The Journal of biological chemistry 2008) 3 4 22 58
  3. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. (PMID: 16116171) Yoneyama M … Fujita T (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 4 22 58
  4. RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium. (PMID: 21187438) Broquet AH … Kagnoff MF (Journal of immunology (Baltimore, Md. : 1950) 2011) 3 4 58
  5. DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling. (PMID: 21791617) Miyashita M … Seya T (Molecular and cellular biology 2011) 3 4 58

Products for DHX58 Gene

  • Addgene plasmids for DHX58

Sources for DHX58 Gene

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