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Aliases for DHX37 Gene

Aliases for DHX37 Gene

  • DEAH-Box Helicase 37 2 3 5
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 37 2 3
  • DEAD/DEAH Box Helicase DDX37 2 3
  • DEAH Box Protein 37 3 4
  • DDX37 3 4
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 37 3
  • Probable ATP-Dependent RNA Helicase DHX37 3
  • EC 4
  • KIAA1517 4
  • Dhr1 3

External Ids for DHX37 Gene

Previous HGNC Symbols for DHX37 Gene

  • DDX37

Previous GeneCards Identifiers for DHX37 Gene

  • GC12M125155
  • GC12M123784
  • GC12M123956
  • GC12M123997
  • GC12M125431
  • GC12M122392

Summaries for DHX37 Gene

Entrez Gene Summary for DHX37 Gene

  • This gene encodes a DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX37 Gene

DHX37 (DEAH-Box Helicase 37) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity.

Additional gene information for DHX37 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX37 Gene

Genomics for DHX37 Gene

GeneHancer (GH) Regulatory Elements for DHX37 Gene

Promoters and enhancers for DHX37 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J124988 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.2 239 1.7 PKNOX1 CLOCK ARID4B SIN3A DMAP1 BRCA1 ZNF280A GLIS2 ZNF213 E2F8 DHX37 PIR61666
GH12J124913 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 86.4 +69.9 69948 12.7 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 SCARB1 UBC DHX37 NCOR2 ENSG00000269938 ENSG00000270130 ENSG00000269997 ENSG00000270061 DNAH10OS LOC100131779
GH12J124937 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 40 +49.6 49614 5 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 UBC TRA-TGC4-1 PIR61666 TRD-GTC2-10 GC12P124940 DHX37 NCOR2 ENSG00000270130 BRI3BP ENSG00000269938
GH12J124504 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 19.2 +472.5 472527 24.5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 EIF2B1 DDX55 NCOR2 TCTN2 LOC101927415 ATP6V0A2 ENSG00000270130 GTF2H3 ENSG00000270061 DHX37
GH12J124926 Enhancer 1.5 Ensembl ENCODE dbSUPER 23.8 +60.8 60790 3.9 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 TRF-GAA1-4 TRD-GTC2-9 DHX37 NCOR2 ENSG00000270130 ENSG00000269938 RPL22P19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHX37 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHX37 gene promoter:
  • HSF2
  • AP-2gamma
  • Pax-4a
  • HNF-4alpha1
  • Elk-1
  • NRSF form 2
  • NRSF form 1
  • STAT3
  • c-Ets-1
  • NRF-2

Genomic Locations for DHX37 Gene

Genomic Locations for DHX37 Gene
42,308 bases
Minus strand
42,299 bases
Minus strand

Genomic View for DHX37 Gene

Genes around DHX37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX37 Gene

Proteins for DHX37 Gene

  • Protein details for DHX37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DHX37
    Protein Accession:
    Secondary Accessions:
    • Q9BUI7
    • Q9P211

    Protein attributes for DHX37 Gene

    1157 amino acids
    Molecular mass:
    129545 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DHX37 Gene

Post-translational modifications for DHX37 Gene

  • Ubiquitination at Lys786 and posLast=118118
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX37 Gene

No data available for DME Specific Peptides for DHX37 Gene

Domains & Families for DHX37 Gene

Gene Families for DHX37 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DHX37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DEAD box helicase family. DEAH subfamily.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX37: view

Function for DHX37 Gene

Molecular function for DHX37 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DHX37 Gene

Phenotypes From GWAS Catalog for DHX37 Gene

Gene Ontology (GO) - Molecular Function for DHX37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DHX37: view
genes like me logo Genes that share phenotypes with DHX37: view

Animal Model Products

miRNA for DHX37 Gene

miRTarBase miRNAs that target DHX37

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX37 Gene

Localization for DHX37 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX37 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHX37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DHX37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHX37 Gene

Pathways & Interactions for DHX37 Gene

genes like me logo Genes that share pathways with DHX37: view

Gene Ontology (GO) - Biological Process for DHX37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006396 RNA processing IBA --
genes like me logo Genes that share ontologies with DHX37: view

No data available for SIGNOR curated interactions for DHX37 Gene

Drugs & Compounds for DHX37 Gene

(3) Drugs for DHX37 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for DHX37 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DHX37: view

Transcripts for DHX37 Gene

Unigene Clusters for DHX37 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 37:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX37 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^
SP1: - -
SP2: - -
SP4: - - -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b

Relevant External Links for DHX37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHX37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX37 Gene

Protein differential expression in normal tissues from HIPED for DHX37 Gene

This gene is overexpressed in Blymphocyte (20.7), Peripheral blood mononuclear cells (17.8), and CD8 Tcells (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHX37 Gene

Protein tissue co-expression partners for DHX37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DHX37 Gene:


SOURCE GeneReport for Unigene cluster for DHX37 Gene:


Evidence on tissue expression from TISSUES for DHX37 Gene

  • Nervous system(4.5)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with DHX37: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX37 Gene

Orthologs for DHX37 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX37 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC452413 33
  • 96.87 (n)
(Bos Taurus)
Mammalia DHX37 34 33
  • 85.12 (n)
(Canis familiaris)
Mammalia DHX37 34 33
  • 84.97 (n)
(Rattus norvegicus)
Mammalia Dhx37 33
  • 81.55 (n)
(Mus musculus)
Mammalia Dhx37 16 34 33
  • 81.38 (n)
(Ornithorhynchus anatinus)
Mammalia DHX37 34
  • 75 (a)
(Monodelphis domestica)
Mammalia DHX37 34
  • 75 (a)
(Gallus gallus)
Aves DHX37 34 33
  • 68.83 (n)
(Anolis carolinensis)
Reptilia DHX37 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC734015 33
  • 68.3 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6945 33
(Danio rerio)
Actinopterygii dhx37 34 33
  • 63.28 (n)
wufd11d06 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2549 33
fruit fly
(Drosophila melanogaster)
Insecta kz 34 33
  • 55.99 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002687 33
  • 47.97 (n)
(Caenorhabditis elegans)
Secernentea rha-2 34 33
  • 49.13 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM16 36 34
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons FAS4 33
  • 47.91 (n)
(Oryza sativa)
Liliopsida Os02g0736600 33
  • 48.11 (n)
Os.25200 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3778 34
  • 44 (a)
Cin.7994 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7994 33
Species where no ortholog for DHX37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX37 Gene

Gene Tree for DHX37 (if available)
Gene Tree for DHX37 (if available)
Evolutionary constrained regions (ECRs) for DHX37: view image

Paralogs for DHX37 Gene

No data available for Paralogs for DHX37 Gene

Variants for DHX37 Gene

Sequence variations from dbSNP and Humsavar for DHX37 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1060499737 likely-pathogenic, Abnormality of brain morphology 124,968,903(-) G/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs779613772 likely-pathogenic, Abnormality of brain morphology 124,967,167(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000134890 -- 124,963,043(-) G/C intron_variant
rs1000171120 -- 124,987,138(-) T/C intron_variant
rs1000365935 -- 124,986,442(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DHX37 Gene

Variant ID Type Subtype PubMed ID
dgv890n106 CNV deletion 24896259
esv1114476 CNV deletion 17803354
esv2746553 CNV deletion 23290073
esv2746554 CNV deletion 23290073
esv3169108 CNV deletion 24192839
esv3549942 CNV deletion 23714750
nsv1144663 CNV deletion 24896259
nsv1149138 CNV deletion 26484159
nsv520994 CNV gain+loss 19592680
nsv560595 CNV gain 21841781

Variation tolerance for DHX37 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.60; 95.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHX37 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX37 Gene

Disorders for DHX37 Gene

Additional Disease Information for DHX37

No disorders were found for DHX37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX37 Gene

Publications for DHX37 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3. (PMID: 27926873) Jozwik KM … Carroll JS (Cell reports 2016) 3 58
  5. Repression of rRNA transcription by PARIS contributes to Parkinson's disease. (PMID: 25315684) Kang H … Shin JH (Neurobiology of disease 2015) 3 58

Products for DHX37 Gene

Sources for DHX37 Gene