This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramo... See more...

Aliases for DHX36 Gene

Aliases for DHX36 Gene

  • DEAH-Box Helicase 36 2 3 5
  • RNA Helicase Associated With AU-Rich Element Protein 3 4
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 36 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 36 2 3
  • ATP-Dependent DNA/RNA Helicase DHX36 3 4
  • DEAD/H Box Polypeptide 36 3 4
  • MLE-Like Protein 1 3 4
  • DDX36 3 4
  • MLEL1 3 4
  • G4R1 3 4
  • RHAU 3 4
  • RNA Helicase Associated With AU-Rich Element ARE 3
  • RNA Helicase Associated With AU-Rich Element 2
  • Probable ATP-Dependent RNA Helicase DHX36 3
  • ATP-Dependent RNA Helicase DHX36 3
  • DEAH Box Protein 36 3
  • DEAH-Box Protein 36 4
  • G4 Resolvase-1 3
  • G4-Resolvase-1 4
  • EC 3.6.4.12 4
  • EC 3.6.4.13 4
  • KIAA1488 4
  • EC 3.6.1 52

External Ids for DHX36 Gene

Previous HGNC Symbols for DHX36 Gene

  • DDX36

Previous GeneCards Identifiers for DHX36 Gene

  • GC03M155275
  • GC03M155314
  • GC03M155476
  • GC03M153990
  • GC03M151389

Summaries for DHX36 Gene

Entrez Gene Summary for DHX36 Gene

  • This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX36 Gene

DHX36 (DEAH-Box Helicase 36) is a Protein Coding gene. Diseases associated with DHX36 include Dyskeratosis Congenita, Autosomal Recessive 5 and Fanconi Anemia, Complementation Group A. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Innate Immune System. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription regulatory region DNA binding. An important paralog of this gene is DHX57.

UniProtKB/Swiss-Prot Summary for DHX36 Gene

  • Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Binds also to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity).

Gene Wiki entry for DHX36 Gene

Additional gene information for DHX36 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DHX36 Gene

Genomics for DHX36 Gene

GeneHancer (GH) Regulatory Elements for DHX36 Gene

Promoters and enhancers for DHX36 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J154320 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 511.5 +1.2 1246 4.5 ZBTB40 ZNF217 EP300 SIN3A TCF12 POLR2G SP1 GTF2E2 PHF8 JUND DHX36 lnc-ARHGEF26-2 lnc-ARHGEF26-8 ARHGEF26 ARHGEF26-AS1
GH03J153957 Enhancer 0.6 ENCODE 18 +365.2 365186 2.7 RFX1 GATA3 ZBTB11 ZNF426 ZNF34 ZC3H11A ZNF781 ZNF518A ZNF555 GATA2 DHX36 ENSG00000201398 ARHGEF26 ARHGEF26-AS1 LINC02006 piR-52914-002
GH03J154252 Enhancer 0.9 Ensembl ENCODE 11.1 +71.4 71353 0.7 ZNF217 CTCF REST CHD1 RAD21 TRIM22 SMC3 TRIM25 ZBTB17 SMARCA5 LOC105374167 DHX36 lnc-DHX36-3 ARHGEF26
GH03J154242 Enhancer 0.7 Ensembl ENCODE 11 +80.5 80496 3.6 TEAD4 RBM22 NR3C1 FOXA1 FOS JUN STAT3 DHX36 ARHGEF26 LOC105374167 ARHGEF26-AS1
GH03J154285 Enhancer 0.3 Ensembl 12.4 +39.0 38996 0.6 SPI1 lnc-GPR149-7 DHX36 ARHGEF26-AS1 lnc-GPR149-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHX36 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DHX36

Top Transcription factor binding sites by QIAGEN in the DHX36 gene promoter:
  • AML1a
  • HNF-1
  • HNF-1A
  • Ik-1
  • LyF-1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Nkx6-1
  • RORalpha1

Genomic Locations for DHX36 Gene

Genomic Locations for DHX36 Gene
chr3:154,272,546-154,324,497
(GRCh38/hg38)
Size:
51,952 bases
Orientation:
Minus strand
chr3:153,990,335-154,042,286
(GRCh37/hg19)
Size:
51,952 bases
Orientation:
Minus strand

Genomic View for DHX36 Gene

Genes around DHX36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX36 Gene

Proteins for DHX36 Gene

  • Protein details for DHX36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2U1-DHX36_HUMAN
    Recommended name:
    ATP-dependent DNA/RNA helicase DHX36
    Protein Accession:
    Q9H2U1
    Secondary Accessions:
    • B2RB00
    • Q70JU3
    • Q8IYE5
    • Q9P240

    Protein attributes for DHX36 Gene

    Size:
    1008 amino acids
    Molecular mass:
    114760 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1; this complex exists in resting cells with or without dsRNA poly(I:C) ligand stimulation (By similarity). Interacts (via C-terminus) with TICAM1 (via TIR domain) (By similarity). Interacts (via C-terminus) with DDX21; this interaction serves as bridges to TICAM1 (By similarity). Interacts with TERT; this interaction is dependent on the ability of DHX36 to bind to the G-quadruplex RNA (G4-RNA) structure present in the telomerase RNA template component (TERC) (PubMed:21846770). Interacts with DKC1; this interaction is dependent on the ability of DHX36 to bind to the G4-RNA structure present in TERC (PubMed:21846770). Interacts with PARN; this interaction stimulates PARN to enhance uPA mRNA decay (PubMed:14731398). Interacts with EXOSC3; this interaction occurs in a RNase-insensitive manner (PubMed:14731398). Interacts with EXOSC10; this interaction occurs in a RNase-insensitive manner (PubMed:14731398). Interacts with ILF3; this interaction occurs in a RNA-dependent manner (PubMed:14731398). Interacts with ELAVL1; this interaction occurs in an RNA-dependent manner (PubMed:14731398, PubMed:26489465). Interacts with DDX5; this interaction occurs in a RNA-dependent manner (PubMed:18279852). Interacts with DDX17; this interaction occurs in a RNA-dependent manner (PubMed:18279852). Interacts with HDAC1; this interaction occurs in a RNA-dependent manner (PubMed:18279852). Interacts with HDAC3; this interaction occurs in a RNA-dependent manner (PubMed:18279852). Interacts with HDAC4 (By similarity). Interacts with AGO1 (PubMed:17932509). Interacts with AGO2 (PubMed:17932509). Interacts with ERCC6 (PubMed:26030138).
    Miscellaneous:
    • [Isoform 2]: More unstable than isoform 1.

    Three dimensional structures from OCA and Proteopedia for DHX36 Gene

    Alternative splice isoforms for DHX36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHX36 Gene

Selected DME Specific Peptides for DHX36 Gene

Q9H2U1:
  • DVVYVID
  • AETSITI
  • VILMSAT
  • PEILRTPLE
  • TNIAETS
  • TQPRRISA
  • RSDLKVI

Post-translational modifications for DHX36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX36 Gene

Antibody Products

  • Abcam antibodies for DHX36

Domains & Families for DHX36 Gene

Gene Families for DHX36 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DHX36 Gene

Blocks:
  • ATP-dependent helicase, DEAH-box
  • Helicase-associated region
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DHX36 Gene

GenScript: Design optimal peptide antigens:
  • RNA helicase associated with AU-rich element ARE (DHX36_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H2U1

UniProtKB/Swiss-Prot:

DHX36_HUMAN :
  • The DHX36-specific motif (DSM) form folds into a DNA-binding-induced alpha-helix that together with the oligonucleotide and oligosaccharide-binding-fold-like (OB-fold-like) subdomain, selectively bind to Myc-promoter G4-DNA-containing structure in an ATP-dependent manner. Upon G4-DNA-binding, DHX36 pulls on DSM in the 3'-direction, inducing rearrangement of the RecA-like 1 and 2 and the degenerate-winged-helix (WH) regions; these rearrangements are propbably responsible for the ATP-independent repetitive G4-DNA unfolding activity, one residue at a time. Upon resolving of G4-DNA into separate nucleotide strands, and ATP hydrolysis, the apoprotein of DHX36 seems incompatible with G4-DNA-binding (By similarity). The N-terminus is necessary for its recruitment to cytoplasmic stress granules (SGs) upon arsenite-induced treatment (PubMed:18854321).
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Domain:
  • The DHX36-specific motif (DSM) form folds into a DNA-binding-induced alpha-helix that together with the oligonucleotide and oligosaccharide-binding-fold-like (OB-fold-like) subdomain, selectively bind to Myc-promoter G4-DNA-containing structure in an ATP-dependent manner. Upon G4-DNA-binding, DHX36 pulls on DSM in the 3'-direction, inducing rearrangement of the RecA-like 1 and 2 and the degenerate-winged-helix (WH) regions; these rearrangements are propbably responsible for the ATP-independent repetitive G4-DNA unfolding activity, one residue at a time. Upon resolving of G4-DNA into separate nucleotide strands, and ATP hydrolysis, the apoprotein of DHX36 seems incompatible with G4-DNA-binding (By similarity). The N-terminus is necessary for its recruitment to cytoplasmic stress granules (SGs) upon arsenite-induced treatment (PubMed:18854321).
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX36: view

Function for DHX36 Gene

Molecular function for DHX36 Gene

UniProtKB/Swiss-Prot Function:
Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Binds also to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000269 PubMed:16150737, ECO:0000269 PubMed:18842585, ECO:0000269 PubMed:21586581, ECO:0000269 PubMed:21846770, ECO:0000269 PubMed:25579584};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence={ECO:0000269 PubMed:16150737, ECO:0000269 PubMed:18842585, ECO:0000269 PubMed:21586581, ECO:0000269 PubMed:21846770, ECO:0000269 PubMed:25579584};.
UniProtKB/Swiss-Prot EnzymeRegulation:
ATPase activity is enhanced in the presence of homopolymeric poly(U) RNAs, but not by double-stranded DNA (dsDNA), double-stranded RNA (dsRNA) and tRNA.

Enzyme Numbers (IUBMB) for DHX36 Gene

Phenotypes From GWAS Catalog for DHX36 Gene

Gene Ontology (GO) - Molecular Function for DHX36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 16150737
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 21586581
GO:0002151 G-quadruplex RNA binding IMP,IBA 22238380
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with DHX36: view
genes like me logo Genes that share phenotypes with DHX36: view

Animal Models for DHX36 Gene

MGI Knock Outs for DHX36:

Clone Products

  • Addgene plasmids for DHX36

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DHX36 Gene

Localization for DHX36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX36 Gene

Nucleus. Cytoplasm. Cytoplasm, cytosol. Cytoplasm, Stress granule. Nucleus speckle. Chromosome, telomere. Mitochondrion. Perikaryon. Cell projection, dendrite. Cell projection, axon. Note=Predominantly localized in the nucleus (PubMed:18279852). Colocalizes with SRSF2 in nuclear speckles (PubMed:18279852). Colocalizes with DDX5 in nucleolar caps upon transcription inhibition (PubMed:18279852). Accumulates and colocalized with TIA1 in cytoplasmic stress granules (SGs) in an arsenite-, heat shock- and RNA-binding-dependent manner (PubMed:18854321). Shuttles into and out of SGs in an ATPase-dependent manner (PubMed:18854321). Colocalizes in the cytosol with the multi-helicase-TICAM1 complex that translocates to the mitochondria upon poly(I:C) RNA ligand stimulation (By similarity). {ECO:0000250 UniProtKB:Q8VHK9, ECO:0000269 PubMed:18279852, ECO:0000269 PubMed:18854321}.
[Isoform 1]: Nucleus. Cytoplasm. Note=Preferentially localized in the nucleus (PubMed:14731398). Excluded from nucleoli (PubMed:14731398). {ECO:0000269 PubMed:14731398}.
[Isoform 2]: Nucleus. Cytoplasm. Note=Preferentially localized in the cytoplasm (PubMed:14731398). Excluded from nucleoli (PubMed:14731398). {ECO:0000269 PubMed:14731398}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX36 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 4
endosome 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHX36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IDA,IEA 20472641
GO:0005634 nucleus IDA 14731398
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IDA,IBA 14731398
genes like me logo Genes that share ontologies with DHX36: view

Pathways & Interactions for DHX36 Gene

genes like me logo Genes that share pathways with DHX36: view

Gene Ontology (GO) - Biological Process for DHX36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification ISS --
GO:0002376 immune system process IEA --
GO:0002735 positive regulation of myeloid dendritic cell cytokine production IEA --
GO:0006359 regulation of transcription by RNA polymerase III IMP 18279852
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with DHX36: view

No data available for SIGNOR curated interactions for DHX36 Gene

Drugs & Compounds for DHX36 Gene

(3) Drugs for DHX36 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for DHX36 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DHX36: view

Transcripts for DHX36 Gene

mRNA/cDNA for DHX36 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for DHX36

Alternative Splicing Database (ASD) splice patterns (SP) for DHX36 Gene

No ASD Table

Relevant External Links for DHX36 Gene

GeneLoc Exon Structure for
DHX36

Expression for DHX36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DHX36 Gene

Protein differential expression in normal tissues from HIPED for DHX36 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.1), Lymph node (9.8), and Lung (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHX36 Gene



Protein tissue co-expression partners for DHX36 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DHX36

SOURCE GeneReport for Unigene cluster for DHX36 Gene:

Hs.446270

mRNA Expression by UniProt/SwissProt for DHX36 Gene:

Q9H2U1-DHX36_HUMAN
Tissue specificity: Highly expressed in testis.

Evidence on tissue expression from TISSUES for DHX36 Gene

  • Nervous system(4.6)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with DHX36: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX36 Gene

Orthologs for DHX36 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX36 31 30
  • 99.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DHX36 31 30
  • 91.02 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DHX36 31 30
  • 90.4 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx36 17 31 30
  • 88.28 (n)
rat
(Rattus norvegicus)
Mammalia Dhx36 30
  • 88.27 (n)
oppossum
(Monodelphis domestica)
Mammalia DHX36 31
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 87 (a)
OneToMany
-- 31
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves DHX36 31 30
  • 76.04 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX36 31
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx36 30
  • 72.44 (n)
Str.17981 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.16610 30
zebrafish
(Danio rerio)
Actinopterygii si:dkey-119o24.1 30
  • 65.25 (n)
DHX36 31
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9323 31 30
  • 47.61 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008239 30
  • 46.86 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 31
  • 19 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G35920 30
  • 53.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 54 (a)
OneToOne
Species where no ortholog for DHX36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX36 Gene

ENSEMBL:
Gene Tree for DHX36 (if available)
TreeFam:
Gene Tree for DHX36 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DHX36: view image

Paralogs for DHX36 Gene

(11) SIMAP similar genes for DHX36 Gene using alignment to 5 proteins:

  • DHX36_HUMAN
  • E7EWK3_HUMAN
  • F5GZS0_HUMAN
  • H7C514_HUMAN
  • H7C5F5_HUMAN
genes like me logo Genes that share paralogs with DHX36: view

Variants for DHX36 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DHX36 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs1058299 - p.Glu151Lys
rs17853513 - p.Ile583Asn
rs9438 - p.Ser416Cys

Additional dbSNP identifiers (rs#s) for DHX36 Gene

Structural Variations from Database of Genomic Variants (DGV) for DHX36 Gene

Variant ID Type Subtype PubMed ID
esv2763308 CNV loss 21179565
nsv4073 CNV insertion 18451855

Variation tolerance for DHX36 Gene

Residual Variation Intolerance Score: 2.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.56; 95.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHX36 Gene

Human Gene Mutation Database (HGMD)
DHX36
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHX36

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX36 Gene

Disorders for DHX36 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DHX36 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search DHX36 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DHX36

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DHX36: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DHX36 Gene

Publications for DHX36 Gene

  1. The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates. (PMID: 16150737) Vaughn JP … Akman SA (The Journal of biological chemistry 2005) 3 4 23 54
  2. Molecular cloning and characterization of human DDX36 and mouse Ddx36 genes, new members of the DEAD/H box superfamily. (PMID: 12198572) Fu JJ … Lu GX (Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 2002) 3 4 23 54
  3. The G-Quadruplex-Specific RNA Helicase DHX36 Regulates p53 Pre-mRNA 3'-End Processing Following UV-Induced DNA Damage. (PMID: 27940037) Newman M … Vagner S (Journal of molecular biology 2017) 3 4 54
  4. Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics. (PMID: 26030138) Nicolai S … Proietti-De-Santis L (PloS one 2015) 3 4 54
  5. Biochemical characterization of G4 quadruplex telomerase RNA unwinding by the RNA helicase RHAU. (PMID: 25579584) Booy EP … McKenna SA (Methods in molecular biology (Clifton, N.J.) 2015) 3 4 54

Products for DHX36 Gene

Sources for DHX36 Gene