Aliases for DHX36 Gene
External Ids for DHX36 Gene
Previous HGNC Symbols for DHX36 Gene
Previous GeneCards Identifiers for DHX36 Gene
This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for DHX36 Gene
DHX36 (DEAH-Box Helicase 36) is a Protein Coding gene. Among its related pathways are Activated TLR4 signalling and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription regulatory region DNA binding. An important paralog of this gene is DHX57.
UniProtKB/Swiss-Prot for DHX36 Gene
Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.