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Aliases for DHX35 Gene

Aliases for DHX35 Gene

  • DEAH-Box Helicase 35 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 35 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 35 2 3
  • C20orf15 3 4
  • DDX35 3 4
  • Probable ATP-Dependent RNA Helicase DHX35 3
  • DEAH-Box Protein 35 3
  • DEAH Box Protein 35 4
  • EC 4
  • KAIA0875 3

External Ids for DHX35 Gene

Previous HGNC Symbols for DHX35 Gene

  • C20orf15
  • DDX35

Previous GeneCards Identifiers for DHX35 Gene

  • GC20P038229
  • GC20P038276
  • GC20P037024
  • GC20P037590
  • GC20P034328

Summaries for DHX35 Gene

Entrez Gene Summary for DHX35 Gene

  • DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for DHX35 Gene

DHX35 (DEAH-Box Helicase 35) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX8.

UniProtKB/Swiss-Prot for DHX35 Gene

  • May be involved in pre-mRNA splicing.

Additional gene information for DHX35 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX35 Gene

Genomics for DHX35 Gene

GeneHancer (GH) Regulatory Elements for DHX35 Gene

Promoters and enhancers for DHX35 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J038960 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 679.5 -0.2 -151 2.5 PKNOX1 CLOCK MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B DHX35 ENSG00000277581 ENSG00000261431 RALGAPB FAM83D SNHG17 SNORA71C RN7SKP173 ACTR5 TTI1
GH20J038139 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.6 -806.3 -806309 33.6 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 MCM3 SP3 NFYC TGM2 SNHG17 RALGAPB ACTR5 RN7SKP173 SNORA71A TTI1 SNORA71C RPN2 DHX35
GH20J038985 Enhancer 1.3 Ensembl ENCODE dbSUPER 33.3 +23.5 23465 1.5 HDAC1 ELF3 RARA YY1 ZNF614 ZNF366 SCRT2 RCOR1 RUNX3 HMG20B DHX35 NPM1P19 PIR38411
GH20J038997 Enhancer 1.1 FANTOM5 ENCODE 26.5 +35.6 35610 1.1 HDAC1 HDGF PKNOX1 SMAD1 STAT5A BATF RAD21 IRF4 EGR1 ZNF143 DHX35 FAM83D NPM1P19 PIR38411
GH20J038356 Enhancer 0.9 ENCODE 31.4 -605.8 -605797 0.2 HDGF ATF1 ARNT ZNF2 ZNF280A E2F8 ZNF143 ZFP91 KLF7 KLF13 GC20P038354 RALGAPB SNHG17 RN7SKP173 DHX35 ACTR5 SNORA71C SNORA71A CTNNBL1 ENSG00000206249
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHX35 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHX35 gene promoter:
  • STAT5B
  • Cart-1
  • USF1
  • USF-1
  • C/EBPalpha
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-3
  • GR
  • GR-alpha

Genomic Locations for DHX35 Gene

Genomic Locations for DHX35 Gene
77,425 bases
Plus strand
77,425 bases
Plus strand

Genomic View for DHX35 Gene

Genes around DHX35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX35 Gene

Proteins for DHX35 Gene

  • Protein details for DHX35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DHX35
    Protein Accession:
    Secondary Accessions:
    • A2RTX3
    • B4E0J0
    • F5GXM6
    • Q5THR0
    • Q9H4H7
    • Q9H6T6

    Protein attributes for DHX35 Gene

    703 amino acids
    Molecular mass:
    78910 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.
    • Sequence=BAB15166.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX35 Gene


neXtProt entry for DHX35 Gene

Post-translational modifications for DHX35 Gene

  • Ubiquitination at Lys591, posLast=435435, Lys413, and Lys326
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DHX35 Gene

Domains & Families for DHX35 Gene

Gene Families for DHX35 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DHX35 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DEAD box helicase family. DEAH subfamily.
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX35: view

Function for DHX35 Gene

Molecular function for DHX35 Gene

UniProtKB/Swiss-Prot Function:
May be involved in pre-mRNA splicing.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DHX35 Gene

Phenotypes From GWAS Catalog for DHX35 Gene

Gene Ontology (GO) - Molecular Function for DHX35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DHX35: view
genes like me logo Genes that share phenotypes with DHX35: view

Animal Models for DHX35 Gene

MGI Knock Outs for DHX35:
  • Dhx35 Dhx35<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for DHX35

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DHX35 Gene

Localization for DHX35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX35 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nuclear bodies (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHX35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005681 spliceosomal complex IBA,IEA --
GO:0005737 cytoplasm IBA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with DHX35: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHX35 Gene

Pathways & Interactions for DHX35 Gene

SuperPathways for DHX35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006396 RNA processing IBA --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with DHX35: view

No data available for Pathways by source and SIGNOR curated interactions for DHX35 Gene

Drugs & Compounds for DHX35 Gene

(3) Drugs for DHX35 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for DHX35 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DHX35: view

Transcripts for DHX35 Gene

Unigene Clusters for DHX35 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 35:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX35 Gene

No ASD Table

Relevant External Links for DHX35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHX35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX35 Gene

Protein differential expression in normal tissues from HIPED for DHX35 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.8) and Placenta (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHX35 Gene

Protein tissue co-expression partners for DHX35 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHX35 Gene:


SOURCE GeneReport for Unigene cluster for DHX35 Gene:


Evidence on tissue expression from TISSUES for DHX35 Gene

  • Nervous system(4.6)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with DHX35: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX35 Gene

Orthologs for DHX35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DHX35 34 33
  • 99 (n)
(Canis familiaris)
Mammalia DHX35 34 33
  • 91.3 (n)
(Ornithorhynchus anatinus)
Mammalia DHX35 34
  • 91 (a)
(Monodelphis domestica)
Mammalia DHX35 34
  • 91 (a)
(Bos Taurus)
Mammalia DHX35 34 33
  • 90.31 (n)
(Mus musculus)
Mammalia Dhx35 16 34 33
  • 88.35 (n)
(Rattus norvegicus)
Mammalia Dhx35 33
  • 88.35 (n)
(Gallus gallus)
Aves DHX35 34 33
  • 79.77 (n)
(Anolis carolinensis)
Reptilia DHX35 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx35 33
  • 73.9 (n)
(Danio rerio)
Actinopterygii DHX35 34
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3225 34 33
  • 54.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010872 33
  • 54.34 (n)
(Caenorhabditis elegans)
Secernentea Y67D2.6 34 33
  • 56.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G18465 33
  • 54.98 (n)
(Oryza sativa)
Liliopsida Os01g0212100 33
  • 54.17 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06735 33
  • 55.17 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC20H4.09 33
  • 49.76 (n)
Species where no ortholog for DHX35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX35 Gene

Gene Tree for DHX35 (if available)
Gene Tree for DHX35 (if available)
Evolutionary constrained regions (ECRs) for DHX35: view image

Paralogs for DHX35 Gene

Paralogs for DHX35 Gene

(11) SIMAP similar genes for DHX35 Gene using alignment to 5 proteins:

  • F2Z2Z2_HUMAN
genes like me logo Genes that share paralogs with DHX35: view

Variants for DHX35 Gene

Sequence variations from dbSNP and Humsavar for DHX35 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000097166 -- 39,008,064(+) C/T intron_variant
rs1000182806 -- 38,999,133(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000265905 -- 38,967,010(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000267686 -- 39,013,480(+) C/T intron_variant
rs1000279986 -- 38,969,450(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DHX35 Gene

Variant ID Type Subtype PubMed ID
esv3645793 CNV gain 21293372
esv3645794 CNV loss 21293372
esv3645795 CNV gain 21293372
esv3645796 CNV loss 21293372
esv3645797 CNV gain 21293372
esv3645798 CNV loss 21293372
esv3645799 CNV loss 21293372
nsv833973 CNV loss 17160897
nsv979433 CNV duplication 23825009

Variation tolerance for DHX35 Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.71; 86.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHX35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX35 Gene

Disorders for DHX35 Gene

Additional Disease Information for DHX35

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DHX35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX35 Gene

Publications for DHX35 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica MS … Moore MJ (RNA (New York, N.Y.) 2002) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for DHX35 Gene

Sources for DHX35 Gene

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